 Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE | multiple interactions | ISO | RGD:61969 | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of HPSE mRNA | CTD | PMID:25729387 | 1,1-dichloroethene | increases expression | EXP | | 6480464 | vinylidene chloride results in increased expression of HPSE mRNA | CTD | PMID:26682919 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of HPSE mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPSE mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | RGD:736250 | 6480464 | Estradiol results in increased expression of HPSE mRNA, Estradiol results in increased expression of HPSE protein | CTD | PMID:18191855 | 17beta-estradiol | multiple interactions | ISO | RGD:736250 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of HPSE mRNA | CTD | PMID:30165855 | 17beta-estradiol | multiple interactions | ISO | RGD:61969 | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of HPSE mRNA | CTD | PMID:26496021 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HPSE mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of HPSE mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:736250 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HPSE mRNA | CTD | PMID:20106945 | 2-hydroxypropanoic acid | decreases expression | ISO | RGD:736250 | 6480464 | Lactic Acid results in decreased expression of HPSE mRNA | CTD | PMID:30851411 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | increases expression | ISO | RGD:61969 | 6480464 | Puromycin Aminonucleoside results in increased expression of HPSE mRNA, Puromycin Aminonucleoside results in increased expression of HPSE protein | CTD | PMID:11576343 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:736250 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HPSE mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | decreases expression | EXP | | 6480464 | Fenretinide results in decreased expression of HPSE mRNA | CTD | PMID:28973697 | 7H-xanthine | multiple interactions | ISO | RGD:61969 | 6480464 | [Xanthine co-treated with XDH protein] results in increased expression of HPSE mRNA, [Xanthine co-treated with XDH protein] results in increased expression of HPSE protein | CTD | PMID:19429930 | 9H-xanthine | multiple interactions | ISO | RGD:61969 | 6480464 | [Xanthine co-treated with XDH protein] results in increased expression of HPSE mRNA, [Xanthine co-treated with XDH protein] results in increased expression of HPSE protein | CTD | PMID:19429930 | acrylamide | increases expression | ISO | RGD:61969 | 6480464 | Acrylamide results in increased expression of HPSE mRNA | CTD | PMID:28959563 | aflatoxin B1 | affects expression | ISO | RGD:736250 | 6480464 | Aflatoxin B1 affects the expression of HPSE protein | CTD | PMID:20106945 | aflatoxin B1 | decreases methylation | ISO | RGD:736250 | 6480464 | Aflatoxin B1 results in decreased methylation of HPSE intron | CTD | PMID:30157460 | aldosterone | increases expression | ISO | RGD:61969 | 6480464 | Aldosterone results in increased expression of HPSE mRNA, Aldosterone results in increased expression of HPSE protein | CTD | PMID:19429930 | aldosterone | multiple interactions | ISO | RGD:61969 | 6480464 | Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA], Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein] | CTD | PMID:19429930 | all-trans-retinoic acid | increases expression | ISO | RGD:736250 | 6480464 | Tretinoin results in increased expression of HPSE mRNA | CTD | PMID:21934132 | amitriptyline | decreases expression | ISO | RGD:61969 | 6480464 | Amitriptyline results in decreased expression of HPSE mRNA | CTD | PMID:22341215 | antirheumatic drug | decreases expression | ISO | RGD:736250 | 6480464 | Antirheumatic Agents results in decreased expression of HPSE mRNA | CTD | PMID:24449571 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of HPSE mRNA | CTD | PMID:22228805 | Benzo[k]fluoranthene | decreases expression | EXP | | 6480464 | benzo(k)fluoranthene results in decreased expression of HPSE mRNA | CTD | PMID:26377693 | bisphenol A | multiple interactions | ISO | RGD:61969 | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of HPSE mRNA | CTD | PMID:26496021 | bisphenol A | increases methylation | ISO | RGD:61969 | 6480464 | bisphenol A results in increased methylation of HPSE gene | CTD | PMID:28505145 | bisphenol A | multiple interactions | ISO | RGD:736250 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HPSE mRNA | CTD | PMID:28628672 | bisphenol A | increases expression | ISO | RGD:61969 | 6480464 | bisphenol A results in increased expression of HPSE mRNA | CTD | PMID:25181051 | butanal | increases expression | ISO | RGD:736250 | 6480464 | butyraldehyde results in increased expression of HPSE mRNA | CTD | PMID:26079696 | cadmium dichloride | increases methylation | ISO | RGD:61969 | 6480464 | Cadmium Chloride results in increased methylation of HPSE promoter | CTD | PMID:22457795 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes, Carbon analog results in increased expression of HPSE mRNA, Nanotubes, Carbon results in increased expression of HPSE mRNA | CTD | PMID:25554681 | cisplatin | increases expression | ISO | RGD:736250 | 6480464 | Cisplatin results in increased expression of HPSE mRNA | CTD | PMID:27392435 | cobalt dichloride | multiple interactions | ISO | RGD:736250 | 6480464 | cobaltous chloride results in increased expression of and results in increased activity of HPSE protein, phosphomannopentaose sulfate inhibits the reaction [cobaltous chloride results in increased activity of HPSE protein] | CTD | PMID:22956610 | cobalt dichloride | increases expression | ISO | RGD:61969 | 6480464 | cobaltous chloride results in increased expression of HPSE mRNA | CTD | PMID:24386269 | dexamethasone | multiple interactions | ISO | RGD:736250 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HPSE mRNA | CTD | PMID:28628672 | dibutyl phthalate | increases expression | ISO | RGD:61969 | 6480464 | Dibutyl Phthalate results in increased expression of HPSE mRNA | CTD | PMID:21266533 | dioxygen | multiple interactions | EXP | | 6480464 | phosphomannopentaose sulfate affects the reaction [Oxygen affects the expression of HPSE mRNA], phosphomannopentaose sulfate affects the reaction [Oxygen affects the expression of HPSE protein] | CTD | PMID:22956610 | dioxygen | affects expression | EXP | | 6480464 | Oxygen affects the expression of HPSE mRNA, Oxygen affects the expression of HPSE protein | CTD | PMID:22956610 | dorsomorphin | multiple interactions | ISO | RGD:736250 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | RGD:61969 | 6480464 | Doxorubicin results in increased expression of HPSE mRNA, Doxorubicin results in increased expression of HPSE protein | CTD | PMID:18095597, PMID:19429930 | doxorubicin | multiple interactions | ISO | RGD:61969 | 6480464 | [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] more ... | CTD | PMID:19429930 | flavonoids | decreases expression | ISO | RGD:61969 | 6480464 | Flavonoids results in decreased expression of HPSE mRNA | CTD | PMID:18035473 | genistein | decreases methylation | ISO | RGD:61969 | 6480464 | Genistein results in decreased methylation of HPSE gene | CTD | PMID:28505145 | heparan sulfate | multiple interactions | ISO | RGD:736250 | 6480464 | [Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate, [phosphomannopentaose sulfate results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate | CTD | PMID:17121850 | heparan sulfate | decreases abundance | ISO | RGD:61969 | 6480464 | HPSE protein results in decreased abundance of Heparitin Sulfate | CTD | PMID:16899518 | heparan sulfate | affects abundance | ISO | RGD:736250 | 6480464 | HPSE protein affects the abundance of Heparitin Sulfate | CTD | PMID:17121850 | heparin | multiple interactions | ISO | RGD:736250 | 6480464 | [Heparin results in decreased activity of HPSE protein] which affects the abundance of Heparitin Sulfate | CTD | PMID:17121850 | hydralazine | multiple interactions | ISO | RGD:736250 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of HPSE mRNA | CTD | PMID:17183730 | indole-3-methanol | affects expression | ISO | RGD:61969 | 6480464 | indole-3-carbinol affects the expression of HPSE mRNA | CTD | PMID:21396975 | indometacin | multiple interactions | ISO | RGD:736250 | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of HPSE mRNA | CTD | PMID:28628672 | isoprenaline | increases expression | ISO | RGD:61969 | 6480464 | Isoproterenol results in increased expression of HPSE protein | CTD | PMID:16327176 | lisinopril dihydrate | multiple interactions | ISO | RGD:61969 | 6480464 | [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein], Lisinopril inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] | CTD | PMID:19429930 | methamphetamine | increases methylation | EXP | | 6480464 | Methamphetamine results in increased methylation of HPSE promoter | CTD | PMID:26307267 | methotrexate | affects expression | EXP | | 6480464 | Methotrexate affects the expression of HPSE mRNA | CTD | PMID:18502557 | NAD zwitterion | increases expression | ISO | RGD:61969 | 6480464 | NAD results in increased expression of HPSE mRNA, NAD results in increased expression of HPSE protein | CTD | PMID:19429930 | NAD(+) | increases expression | ISO | RGD:61969 | 6480464 | NAD results in increased expression of HPSE mRNA, NAD results in increased expression of HPSE protein | CTD | PMID:19429930 | nickel atom | decreases expression | ISO | RGD:736250 | 6480464 | Nickel results in decreased expression of HPSE mRNA | CTD | PMID:23195993 | nickel atom | increases expression | ISO | RGD:736250 | 6480464 | Nickel results in increased expression of HPSE mRNA | CTD | PMID:24768652, PMID:25583101 | oxaliplatin | multiple interactions | ISO | RGD:61969 | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of HPSE mRNA | CTD | PMID:25729387 | paracetamol | increases expression | ISO | RGD:736250 | 6480464 | Acetaminophen results in increased expression of HPSE mRNA | CTD | PMID:21420995 | pentanal | increases expression | ISO | RGD:736250 | 6480464 | pentanal results in increased expression of HPSE mRNA | CTD | PMID:26079696 | phenylmercury acetate | increases expression | ISO | RGD:736250 | 6480464 | Phenylmercuric Acetate results in increased expression of HPSE mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:736250 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HPSE mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | RGD:736250 | 6480464 | potassium chromate(VI) results in decreased expression of HPSE mRNA | CTD | PMID:22714537 | potassium dichromate | increases expression | ISO | RGD:736250 | 6480464 | Potassium Dichromate results in increased expression of HPSE protein | CTD | PMID:23718831 | propanal | increases expression | ISO | RGD:736250 | 6480464 | propionaldehyde results in increased expression of HPSE mRNA | CTD | PMID:26079696 | quercetin | decreases expression | ISO | RGD:736250 | 6480464 | Quercetin results in decreased expression of HPSE mRNA | CTD | PMID:20596804 | rac-lactic acid | decreases expression | ISO | RGD:736250 | 6480464 | Lactic Acid results in decreased expression of HPSE mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | RGD:736250 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of HPSE mRNA | CTD | PMID:29203145 | sodium arsenite | increases expression | ISO | RGD:736250 | 6480464 | sodium arsenite results in increased expression of HPSE mRNA | CTD | PMID:29301061 | spironolactone | multiple interactions | ISO | RGD:61969 | 6480464 | [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] more ... | CTD | PMID:19429930 | sulforaphane | increases expression | ISO | RGD:736250 | 6480464 | sulforafan results in increased expression of HPSE mRNA | CTD | PMID:26833863 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of HPSE mRNA | CTD | PMID:17484886 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of HPSE mRNA | CTD | PMID:18458672 | thioacetamide | increases expression | ISO | RGD:61969 | 6480464 | Thioacetamide results in increased expression of HPSE protein | CTD | PMID:15095483 | topotecan | multiple interactions | ISO | RGD:61969 | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of HPSE mRNA | CTD | PMID:25729387 | trichostatin A | increases expression | ISO | RGD:736250 | 6480464 | trichostatin A results in increased expression of HPSE mRNA | CTD | PMID:24935251 | valproic acid | multiple interactions | ISO | RGD:736250 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of HPSE mRNA more ... | CTD | PMID:17183730, PMID:27188386 | valproic acid | increases expression | ISO | RGD:736250 | 6480464 | Valproic Acid results in increased expression of HPSE mRNA | CTD | PMID:24383497 more ... | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of HPSE mRNA | CTD | PMID:17963808 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of HPSE mRNA | CTD | PMID:24896083 | vorinostat | decreases expression | ISO | RGD:736250 | 6480464 | vorinostat results in decreased expression of HPSE mRNA | CTD | PMID:18769122 | | 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Gene Ontology AnnotationsBiological Process
Cellular Component
Molecular Function
Molecular Pathway AnnotationsImported Annotations - PID (archival)
Phenotype AnnotationsMammalian Phenotype
