Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Keloid | | ISO | TPSB2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:20128793 | |
|
Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Keloid | | ISO | TPSB2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:20128793 | |
|
|
|
|
|
|
|
|
# | Reference Title | Reference Citation |
1. | Structural requirements and mechanism for heparin-induced activation of a recombinant mouse mast cell tryptase, mouse mast cell protease-6: formation of active tryptase monomers in the presence of low molecular weight heparin. | Hallgren J, etal., J Biol Chem 2001 Nov 16;276(46):42774-81. |
2. | cDNA sequencing and expression of rat mast cell tryptase. | Ide H, etal., J Biochem (Tokyo) 1995 Jul;118(1):210-5. |
3. | Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. | Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29. |
4. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
5. | MGDs mouse GO annotations | MGD data from the GO Consortium |
6. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
7. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
8. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
9. | Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. | Wong GW, etal., J Biol Chem 1999 Oct 22;274(43):30784-93. |
PMID:1372640 | PMID:1995638 | PMID:2326280 | PMID:7849408 | PMID:7919662 | PMID:7959952 | PMID:8098710 | PMID:8210998 | PMID:8839840 | PMID:9064323 | PMID:9398854 | PMID:9469453 |
PMID:9541598 | PMID:10783129 | PMID:12477932 | PMID:14578624 | PMID:14583634 | PMID:14706770 | PMID:15265919 | PMID:15451032 | PMID:15489334 | PMID:16257142 | PMID:16777228 | PMID:16807746 |
PMID:17456473 | PMID:18354212 | PMID:18668540 | PMID:19109198 | PMID:20832582 | PMID:20864640 | PMID:21076070 | PMID:21173247 | PMID:21267068 | PMID:21493897 | PMID:21873635 | PMID:22481124 |
PMID:23380220 | PMID:23573292 | PMID:23624557 | PMID:23817418 | PMID:23975861 | PMID:24257755 | PMID:24478313 | PMID:24507159 | PMID:24726923 | PMID:24814421 | PMID:25320274 | PMID:26917739 |
PMID:28990934 | PMID:29429965 | PMID:31894627 | PMID:34454294 | PMID:36458554 |
Tpsb2 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TPSB2 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Tpsb2 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
LOC100978423 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
MCT7 (Sus scrofa - pig) |
|
.
Variants in Tpsb2
54 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
D17Mit46 |
|
||||||||||||||||||||||||||||||||||||||||
AV011504 |
|
||||||||||||||||||||||||||||||||||||||||
UniSTS:224733 |
|
||||||||||||||||||||||||||||||||||||||||
UniSTS:225057 |
|
||||||||||||||||||||||||||||||||||||||||
Mcpt6 |
|
||||||||||||||||||||||||||||||||||||||||
PMC316772P2 |
|
||||||||||||||||||||||||||||||||||||||||
Tpsb2 |
|
||||||||||||||||||||||||||||||||||||||||
Tpsb2 |
|
||||||||||||||||||||||||||||||||||||||||
Tpsb2 |
|
RefSeq Transcripts | NM_010781 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006523740 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_030249525 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC122454 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC024374 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH466606 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU814917 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU814918 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU814919 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GU810524 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GU810525 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GU810526 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
L31853 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M57625 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M57626 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
X78542 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSMUST00000069616 ⟹ ENSMUSP00000063499 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000234057 ⟹ ENSMUSP00000157332 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000234477 ⟹ ENSMUSP00000157286 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000234712 ⟹ ENSMUSP00000157001 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249730 ⟹ ENSMUSP00000159898 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249731 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249732 ⟹ ENSMUSP00000159899 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249733 ⟹ ENSMUSP00000159900 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249734 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249735 ⟹ ENSMUSP00000159901 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249736 ⟹ ENSMUSP00000159902 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249737 ⟹ ENSMUSP00000159903 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249738 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249739 ⟹ ENSMUSP00000159904 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249740 ⟹ ENSMUSP00000159905 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249741 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249742 ⟹ ENSMUSP00000159906 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249743 ⟹ ENSMUSP00000159907 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | ENSMUST00000249744 ⟹ ENSMUSP00000159908 | ||||||||
Type: | CODING | ||||||||
Position: |
|
RefSeq Acc Id: | NM_010781 ⟹ NP_034911 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
|
||||||||||||||||||||||||
Sequence: |
RefSeq Acc Id: | XM_006523740 ⟹ XP_006523803 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
||||||||||||
Sequence: |
RefSeq Acc Id: | XM_030249525 ⟹ XP_030105385 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
|
||||||||||||
Sequence: |
Protein RefSeqs | NP_034911 | (Get FASTA) | NCBI Sequence Viewer |
XP_006523803 | (Get FASTA) | NCBI Sequence Viewer | |
XP_030105385 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA39725 | (Get FASTA) | NCBI Sequence Viewer |
AAA39987 | (Get FASTA) | NCBI Sequence Viewer | |
AAA39988 | (Get FASTA) | NCBI Sequence Viewer | |
AAH24374 | (Get FASTA) | NCBI Sequence Viewer | |
ACF24465 | (Get FASTA) | NCBI Sequence Viewer | |
ACF24466 | (Get FASTA) | NCBI Sequence Viewer | |
ACF24467 | (Get FASTA) | NCBI Sequence Viewer | |
ADE62298 | (Get FASTA) | NCBI Sequence Viewer | |
ADE62299 | (Get FASTA) | NCBI Sequence Viewer | |
ADE62300 | (Get FASTA) | NCBI Sequence Viewer | |
CAA55288 | (Get FASTA) | NCBI Sequence Viewer | |
EDL22422 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSMUSP00000063499.8 | ||
ENSMUSP00000157001.2 | |||
ENSMUSP00000157286 | |||
ENSMUSP00000157286.2 | |||
ENSMUSP00000157332.2 | |||
ENSMUSP00000159899 | |||
GenBank Protein | P21845 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_034911 ⟸ NM_010781 |
- Peptide Label: | precursor |
- UniProtKB: | Q61962 (UniProtKB/Swiss-Prot), P21845 (UniProtKB/Swiss-Prot), E9QJW9 (UniProtKB/TrEMBL), B5A5B2 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006523803 ⟸ XM_006523740 |
- Peptide Label: | isoform X1 |
- UniProtKB: | Q61962 (UniProtKB/Swiss-Prot), P21845 (UniProtKB/Swiss-Prot), E9QJW9 (UniProtKB/TrEMBL), B5A5B2 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_030105385 ⟸ XM_030249525 |
- Peptide Label: | isoform X2 |
RefSeq Acc Id: | ENSMUSP00000063499 ⟸ ENSMUST00000069616 |
RefSeq Acc Id: | ENSMUSP00000157001 ⟸ ENSMUST00000234712 |
RefSeq Acc Id: | ENSMUSP00000157286 ⟸ ENSMUST00000234477 |
RefSeq Acc Id: | ENSMUSP00000157332 ⟸ ENSMUST00000234057 |
RefSeq Acc Id: | ENSMUSP00000159903 ⟸ ENSMUST00000249737 |
RefSeq Acc Id: | ENSMUSP00000159904 ⟸ ENSMUST00000249739 |
RefSeq Acc Id: | ENSMUSP00000159905 ⟸ ENSMUST00000249740 |
RefSeq Acc Id: | ENSMUSP00000159899 ⟸ ENSMUST00000249732 |
RefSeq Acc Id: | ENSMUSP00000159901 ⟸ ENSMUST00000249735 |
RefSeq Acc Id: | ENSMUSP00000159908 ⟸ ENSMUST00000249744 |
RefSeq Acc Id: | ENSMUSP00000159900 ⟸ ENSMUST00000249733 |
RefSeq Acc Id: | ENSMUSP00000159898 ⟸ ENSMUST00000249730 |
RefSeq Acc Id: | ENSMUSP00000159907 ⟸ ENSMUST00000249743 |
RefSeq Acc Id: | ENSMUSP00000159906 ⟸ ENSMUST00000249742 |
RefSeq Acc Id: | ENSMUSP00000159902 ⟸ ENSMUST00000249736 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P21845-F1-model_v2 | AlphaFold | P21845 | 1-276 | view protein structure |
RGD ID: | 13675144 | ||||||||
Promoter ID: | EPDNEW_M21721 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Tpsb2_1 | ||||||||
Description: | Mus musculus tryptase beta 2 , mRNA. | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Alternative Promoters: | null; see alsoEPDNEW_M21722 | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
|
RGD ID: | 13675146 | ||||||||
Promoter ID: | EPDNEW_M21722 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Tpsb2_2 | ||||||||
Description: | Mus musculus tryptase beta 2 , mRNA. | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Alternative Promoters: | null; see alsoEPDNEW_M21721 | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
|
Database | Acc Id | Source(s) |
AGR Gene | MGI:96942 | AgrOrtholog |
Ensembl Genes | ENSMUSG00000033825 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSMUST00000069616.8 | UniProtKB/TrEMBL |
ENSMUST00000234057.2 | UniProtKB/TrEMBL | |
ENSMUST00000234477 | ENTREZGENE | |
ENSMUST00000234477.2 | UniProtKB/TrEMBL | |
ENSMUST00000234712.2 | UniProtKB/TrEMBL | |
ENSMUST00000249732 | ENTREZGENE | |
Gene3D-CATH | 2.40.10.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | Peptidase_S1_PA | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Peptidase_S1_PA_chymotrypsin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Peptidase_S1A | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Trypsin_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRYPSIN_HIS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRYPSIN_SER | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | mmu:17229 | UniProtKB/TrEMBL |
MGD | MGI:96942 | ENTREZGENE |
NCBI Gene | 17229 | ENTREZGENE |
PANTHER | TRANSMEMBRANE PROTEASE SERINE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TRYPTASE DELTA 1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Trypsin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Tpsb2 | PhenoGen |
PRINTS | CHYMOTRYPSIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | TRYPSIN_DOM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TRYPSIN_HIS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRYPSIN_SER | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | Tryp_SPc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF50494 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A3Q4EH65_MOUSE | UniProtKB/TrEMBL |
A0A3Q4L2Q9_MOUSE | UniProtKB/TrEMBL | |
B5A5B2 | ENTREZGENE, UniProtKB/TrEMBL | |
E9QJW9 | ENTREZGENE, UniProtKB/TrEMBL | |
P21845 | ENTREZGENE | |
Q61962 | ENTREZGENE | |
TRYB2_MOUSE | UniProtKB/Swiss-Prot | |
UniProt Secondary | Q61962 | UniProtKB/Swiss-Prot |