Ms4a4a (membrane-spanning 4-domains, subfamily A, member 4A) - Rat Genome Database

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Gene: Ms4a4a (membrane-spanning 4-domains, subfamily A, member 4A) Mus musculus
Analyze
Symbol: Ms4a4a
Name: membrane-spanning 4-domains, subfamily A, member 4A
RGD ID: 1623399
MGI Page MGI
Description: Predicted to be located in endoplasmic reticulum and plasma membrane raft. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to several human genes including MS4A4A (membrane spanning 4-domains A4A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG666907; membrane-spanning 4-domains subfamily A member 4A
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,352,827 - 11,370,682 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,352,887 - 11,370,154 (+)EnsemblGRCm39 Ensembl
GRCm381911,375,488 - 11,392,915 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,375,523 - 11,392,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv371911,450,013 - 11,467,280 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,442,568 - 11,461,022 (+)NCBIMGSCv36mm8
Celera1912,053,621 - 12,070,889 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635   PMID:31263276   PMID:32589266   PMID:38355793  


Genomics

Comparative Map Data
Ms4a4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,352,827 - 11,370,682 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,352,887 - 11,370,154 (+)EnsemblGRCm39 Ensembl
GRCm381911,375,488 - 11,392,915 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,375,523 - 11,392,790 (+)EnsemblGRCm38mm10GRCm38
MGSCv371911,450,013 - 11,467,280 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,442,568 - 11,461,022 (+)NCBIMGSCv36mm8
Celera1912,053,621 - 12,070,889 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.44NCBI
MS4A4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,280,666 - 60,308,970 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,185,657 - 60,318,080 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,048,139 - 60,076,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,804,715 - 59,833,021 (+)NCBINCBI36Build 36hg18NCBI36
Build 341159,804,714 - 59,833,020NCBI
Celera1157,412,537 - 57,440,831 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,394,859 - 56,423,279 (+)NCBIHuRef
CHM1_11159,914,051 - 59,942,486 (+)NCBICHM1_1
T2T-CHM13v2.01160,231,961 - 60,260,258 (+)NCBIT2T-CHM13v2.0
Ms4a4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,495,704 - 217,510,019 (+)NCBIGRCr8
mRatBN7.21208,060,507 - 208,085,121 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1208,046,971 - 208,085,119 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01227,574,789 - 227,606,958 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1227,217,552 - 227,232,341 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1227,592,635 - 227,607,042 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01234,640,163 - 234,672,339 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,937,922 - 213,959,942 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11214,096,424 - 214,122,694 (+)NCBI
Celera1205,536,179 - 205,559,774 (+)NCBICelera
Cytogenetic Map1q43NCBI

Variants

.
Variants in Ms4a4a
523 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000188995   ⟹   ENSMUSP00000140768
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1911,352,887 - 11,370,154 (+)Ensembl
GRCm38.p6 Ensembl1911,375,523 - 11,392,790 (+)Ensembl
RefSeq Acc Id: NM_001310331   ⟹   NP_001297260
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391911,352,852 - 11,370,279 (+)NCBI
GRCm381911,375,488 - 11,392,915 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161653   ⟹   XP_036017546
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391911,352,827 - 11,370,682 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001297260 (Get FASTA)   NCBI Sequence Viewer  
  XP_036017546 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000140768
  ENSMUSP00000140768.2
RefSeq Acc Id: NP_001297260   ⟸   NM_001310331
- UniProtKB: A0A087WRT7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000140768   ⟸   ENSMUST00000188995
RefSeq Acc Id: XP_036017546   ⟸   XM_036161653
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A087WRT7-F1-model_v2 AlphaFold A0A087WRT7 1-236 view protein structure

Promoters
RGD ID:13678970
Promoter ID:EPDNEW_M23633
Type:initiation region
Name:Ms4a4a_1
Description:Mus musculus membrane-spanning 4-domains, subfamily A, member4A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381911,375,521 - 11,375,581EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3643932 AgrOrtholog
Ensembl Genes ENSMUSG00000101389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000188995 ENTREZGENE
  ENSMUST00000188995.2 UniProtKB/TrEMBL
InterPro CD20-like UniProtKB/TrEMBL
  MS4A UniProtKB/TrEMBL
KEGG Report mmu:666907 UniProtKB/TrEMBL
MGD MGI:3643932 ENTREZGENE
NCBI Gene 666907 ENTREZGENE
PANTHER MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 4A UniProtKB/TrEMBL
  PTHR23320 UniProtKB/TrEMBL
Pfam CD20 UniProtKB/TrEMBL
PhenoGen Ms4a4a PhenoGen
UniProt A0A087WRT7 ENTREZGENE, UniProtKB/TrEMBL