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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of interleukin-1 beta production
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Accession:GO:0032731 term browser browse the term
Definition:Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.
Synonyms:exact_synonym: positive regulation of IL-1 beta production;   up regulation of interleukin-1 beta production;   upregulation of interleukin-1 beta production
 narrow_synonym: activation of interleukin-1 beta production;   positive regulation of interleukin-1 beta biosynthetic process;   positive regulation of interleukin-1 beta secretion;   stimulation of interleukin-1 beta production
 alt_id: GO:0050718;   GO:0050725


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positive regulation of interleukin-1 beta production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129 		JBrowse link
G APP amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
G CASP4 caspase 4, apoptosis-related cysteine peptidase involved_in
acts_upstream_of_or_within		 ISS
ISO		 (PMID:22002608) UniProt
MGI		 PMID:22002608 GO_REF:0000024 NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736 		JBrowse link
G CASP8 caspase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) BHF-UCL PMID:15845453 MGI:3576832 NCBI chr11:51,357,706...51,359,207
Ensembl chr11:51,340,530...51,359,365 		JBrowse link
G CCN1 cellular communication network factor 1 ISO RGD PMID:27653023 RGD:150429754 NCBI chr 6:62,443,285...62,446,246
Ensembl chr 6:62,443,675...62,445,994 		JBrowse link
G CCR5 C-C motif chemokine receptor 5 ISO RGD PMID:16790532 RGD:1598562 NCBI chr20:42,293,288...42,297,952
Ensembl chr20:42,294,996...42,297,952 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:20,299,808...20,375,856
Ensembl chr18:20,339,050...20,372,639 		JBrowse link
G CLEC7A C-type lectin domain containing 7A involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:35,852,685...35,885,673
Ensembl chr27:35,853,099...36,007,157 		JBrowse link
G CLEC7A C-type lectin domain containing 7A involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:35,896,421...35,920,649
Ensembl chr27:35,853,099...36,007,157 		JBrowse link
G EGR1 early growth response 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180 		JBrowse link
G FZD5 frizzled class receptor 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:16,123,788...16,126,634
Ensembl chr37:16,123,798...16,125,567 		JBrowse link
G GBP5 guanylate binding protein 5 involved_in ISO (PMID:22461501)
(MGI:5319585|PMID:22461501)		 UniProt PMID:22461501 MGI:5319585 NCBI chr 6:59,273,699...59,292,563
Ensembl chr 6:59,273,592...59,393,229 		JBrowse link
G GSDMD gasdermin D involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,221,219...37,226,912
Ensembl chr13:37,193,022...37,228,360 		JBrowse link
G HK1 hexokinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:20,396,761...20,516,889
Ensembl chr 4:20,421,526...20,518,211 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (MGI:4367121|PMID:19890330) UniProt PMID:19890330 MGI:4367121 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:7,487,164...7,488,576
Ensembl chr 6:7,487,250...7,488,576 		JBrowse link
G IFNAR1 interferon alpha and beta receptor subunit 1 acts_upstream_of_or_within ISO (PMID:23997220) MGI PMID:23997220 NCBI chr31:28,854,765...28,876,399 JBrowse link
G IFNG interferon gamma involved_in
acts_upstream_of_or_within		 ISO (MGI:5776417|PMID:26227742)
(PMID:12925700)		 ARUK-UCL
MGI		 PMID:12925700 PMID:26227742 MGI:5776417 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL17A interleukin 17A acts_upstream_of_or_within ISO (PMID:29734196) ARUK-UCL PMID:29734196 NCBI chr12:19,854,129...19,862,521
Ensembl chr12:19,854,129...19,862,513 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:17623049 RGD:4889480 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G IL6 interleukin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G INAVA innate immunity activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:2,264,120...2,284,196 JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:63,638,009...63,648,492
Ensembl chr 4:63,637,443...63,648,183 		JBrowse link
G JAK2 Janus kinase 2 involved_in ISO
IEA		 during cerulein-induced pancreatitis RGD
Ensembl		 PMID:16934228 GO_REF:0000107 RGD:1641810 NCBI chr 1:93,321,055...93,438,898
Ensembl chr 1:93,142,635...93,435,997 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chr 9:42,154,613...42,170,423
Ensembl chr 9:42,154,702...42,170,391 		JBrowse link
G LOC100685620 alpha-1-acid glycoprotein 1 involved_in ISO (PMID:8774350) UniProt PMID:8774350 NCBI chr11:68,557,340...68,560,079 JBrowse link
G LOC102153882 NLR family CARD domain-containing protein 4 involved_in ISO (MGI:3662989|PMID:16648853), (MGI:3662990|PMID:16648852), (MGI:5428366|PMID:22484733) UniProt PMID:16648852 PMID:16648853 PMID:22484733 MGI:3662989 MGI:3662990 MGI:5428366 NCBI chr17:25,517,051...25,518,224 JBrowse link
G LOC102154691 short transmembrane mitochondrial protein 1 involved_in ISO (MGI:6384515|PMID:31836654) UniProt PMID:31836654 MGI:6384515 NCBI chr10:5,562,521...5,563,107
Ensembl chr16:12,586,975...12,602,256 		JBrowse link
G LOC119876002 caspase recruitment domain-containing protein 8-like involved_in IEA Ensembl GO_REF:0000107
G LOC480600 chemokine (C-C motif) ligand 3 involved_in ISO (MGI:5301204|PMID:21784977) UniProt PMID:21784977 MGI:5301204 NCBI chr 9:37,708,561...37,710,209
Ensembl chr 9:37,676,966...37,710,209 		JBrowse link
G LOC484309 leukocyte immunoglobulin-like receptor subfamily A member 6 involved_in ISO (PMID:12393390) UniProt PMID:12393390 NCBI chr 1:102,995,743...103,014,085 JBrowse link
G LOC488622 myeloid cell nuclear differentiation antigen involved_in ISO (PMID:21575908) UniProt PMID:21575908 NCBI chr38:22,874,345...22,892,362 JBrowse link
G LOC491519 caspase recruitment domain family, member 8 involved_in ISO (PMID:15030775) HGNC-UCL PMID:15030775 NCBI chr 1:107,994,215...108,025,875 JBrowse link
G LPL lipoprotein lipase involved_in ISO (MGI:6282927|PMID:22963823) ARUK-UCL PMID:22963823 MGI:6282927 NCBI chr25:37,078,306...37,102,729
Ensembl chr25:37,079,756...37,102,700 		JBrowse link
G MALT1 MALT1 paracaspase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:17,351,458...17,412,591
Ensembl chr 1:17,354,926...17,403,927 		JBrowse link
G MEFV MEFV innate immunity regulator, pyrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:37,964,776...37,984,830
Ensembl chr 6:37,970,608...37,983,737 		JBrowse link
G MIR144 microRNA mir-144 involved_in ISO (PMID:24733347) ARUK-UCL PMID:24733347 NCBI chr 9:43,031,035...43,031,094
Ensembl chr 9:43,031,035...43,031,094 		JBrowse link
G MIR206 microRNA mir-206 involved_in ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chr12:19,805,523...19,805,582
Ensembl chr12:19,805,523...19,805,582 		JBrowse link
G MIR23A microRNA mir-23a ISO RGD PMID:33403590 RGD:155882539 NCBI chr20:48,620,335...48,620,386
Ensembl chr20:48,620,323...48,620,397 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534 		JBrowse link
G NLRC4 NLR family CARD domain containing 4 involved_in ISO (PMID:15882992) HGNC-UCL PMID:15882992
G NLRP1 NLR family pyrin domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:31,264,554...31,299,538
Ensembl chr 5:31,266,621...31,299,304 		JBrowse link
G NLRP2 NLR family pyrin domain containing 2 involved_in ISO (PMID:15030775) HGNC-UCL PMID:15030775 NCBI chr 1:102,613,871...102,637,379 JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in
acts_upstream_of_or_within		 ISO (MGI:5790524|PMID:27374331)
(PMID:28847925)
(MGI:5492224|PMID:23582325), (MGI:6095076|PMID:28847925), (MGI:6112461|PMID:29255148), (MGI:6260219|PMID:30487600)
(PMID:15030775), (PMID:16407889), (PMID:17483456), (PMID:18403674), (PMID:18604214), (PMID:23582325), (PMID:25686105), (PMID:30487600), (PMID:31086327), (PMID:31086329), (PMID:31189953)
(PMID:23997220)
(PMID:22002608)		 CAFA
UniProt
ComplexPortal
MGI		 PMID:15030775 PMID:16407889 PMID:17483456 PMID:18403674 PMID:18604214 More... MGI:5492224 MGI:5790524 MGI:6095076 MGI:6112461 MGI:6260219 NCBI chr 8:251,776...313,290
Ensembl chr 8:253,407...313,059 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:22450316 RGD:9831170 NCBI chr14:43,162,671...43,226,948
Ensembl chr14:43,163,571...43,227,103 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:64,636,850...64,667,232
Ensembl chr 2:64,635,519...64,667,232 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:18490713)
(PMID:15905573)
(PMID:11016935)		 RGD
Ensembl
MGI		 PMID:11016935 PMID:15883745 PMID:15905573 PMID:18490713 GO_REF:0000107 RGD:1642715 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740 		JBrowse link
G PANX1 pannexin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18490713) Ensembl
MGI		 PMID:18490713 GO_REF:0000107 NCBI chr21:6,665,730...6,715,272
Ensembl chr21:6,668,269...6,715,858 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23997220)
(PMID:22002608)		 Ensembl
MGI		 PMID:22002608 PMID:23997220 GO_REF:0000107 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit acts_upstream_of
involved_in		 ISO
IEA		 (PMID:27203220) ARUK-UCL
Ensembl		 PMID:27203220 GO_REF:0000107 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:35,283,209...35,311,608
Ensembl chr29:35,282,072...35,311,333 		JBrowse link
G SMAD3 SMAD family member 3 ISO TGFbeta-1 dependent, in pancreatic stellate cells RGD PMID:16371439 RGD:2300404 NCBI chr30:31,246,313...31,360,098
Ensembl chr30:31,245,657...31,363,337 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:20,539,660...20,614,631
Ensembl chr 9:20,539,697...20,612,672 		JBrowse link
G TLR2 toll like receptor 2 involved_in ISO (MGI:5307186|PMID:22198949) ARUK-UCL PMID:22198949 MGI:5307186 NCBI chr15:51,454,557...51,465,429
Ensembl chr15:51,454,695...51,465,241 		JBrowse link
G TLR4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (MGI:5546292|PMID:23812099) UniProt PMID:23812099 MGI:5546292 NCBI chr 3:73,504,357...73,523,964
Ensembl chr 3:73,520,706...73,523,099 		JBrowse link
G TLR8 toll like receptor 8 involved_in ISO (PMID:24942581), (PMID:33718825) UniProt PMID:24942581 PMID:33718825 NCBI chr  X:9,381,159...9,399,938 JBrowse link
G TMEM106A transmembrane protein 106A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:19,917,591...19,926,578
Ensembl chr 9:19,915,973...19,958,789 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G TRIM16 tripartite motif containing 16 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:39,146,505...39,167,857
Ensembl chr 5:39,148,868...39,213,203 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in ISO (MGI:5638298|PMID:25690660) ARUK-UCL PMID:25690660 MGI:5638298 NCBI chr 1:116,757,271...116,760,453
Ensembl chr 1:116,757,289...116,772,325 		JBrowse link
G USP50 ubiquitin specific peptidase 50 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:28094437) MGI
Ensembl		 PMID:28094437 GO_REF:0000107 NCBI chr30:16,409,293...16,453,788
Ensembl chr30:16,409,294...16,453,728 		JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:34,756,430...34,790,937
Ensembl chr20:34,769,930...34,786,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17919
    multicellular organismal process 8092
      cytokine production 899
        interleukin-1 production 133
          interleukin-1 beta production 110
            positive regulation of interleukin-1 beta production 65
Path 2
Term Annotations click to browse term
  biological_process 17919
    biological regulation 12448
      regulation of biological process 12084
        regulation of metabolic process 6413
          regulation of biosynthetic process 5262
            regulation of cellular biosynthetic process 5176
              regulation of macromolecule biosynthetic process 5080
                regulation of gene expression 4963
                  regulation of cytokine production 891
                    regulation of interleukin-1 production 133
                      regulation of interleukin-1 beta production 110
                        positive regulation of interleukin-1 beta production 65
paths to the root