F2RL1 (F2R like trypsin receptor 1) - Rat Genome Database

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Gene: F2RL1 (F2R like trypsin receptor 1) Canis lupus familiaris
Analyze
Symbol: F2RL1
Name: F2R like trypsin receptor 1
RGD ID: 12210549
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); G-protein alpha-subunit binding (ortholog); G-protein beta-subunit binding (ortholog); INVOLVED IN defense response to virus (ortholog); leukocyte proliferation (ortholog); mature conventional dendritic cell differentiation (ortholog); PARTICIPATES IN protease mediated signaling via protease-activated receptor 2; ASSOCIATED WITH asthma (ortholog); chronic obstructive pulmonary disease (ortholog); Experimental Arthritis (ortholog); FOUND IN pseudopodium (ortholog); INTERACTS WITH bisphenol A
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: proteinase-activated receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,801,119 - 29,810,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,800,211 - 29,810,180 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha331,040,276 - 31,049,162 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0329,720,255 - 29,729,156 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,719,346 - 29,729,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,656,957 - 29,665,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,637,871 - 29,646,815 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,007,024 - 30,015,914 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood coagulation  (IEA)
cell-cell junction maintenance  (IEA)
defense response to virus  (IEA,ISS)
establishment of endothelial barrier  (IEA)
G protein-coupled receptor signaling pathway  (IBA,IEA)
leukocyte migration  (IEA)
leukocyte proliferation  (IEA,ISS)
mature conventional dendritic cell differentiation  (IEA,ISS)
negative regulation of chemokine production  (IEA)
negative regulation of insulin secretion  (IEA)
negative regulation of JNK cascade  (IEA)
negative regulation of toll-like receptor 3 signaling pathway  (IEA)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
neutrophil activation  (IEA)
positive regulation of actin filament depolymerization  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell migration  (IEA,ISS)
positive regulation of chemokine production  (IEA,ISS)
positive regulation of chemotaxis  (IEA,ISS)
positive regulation of cytokine production involved in immune response  (IEA)
positive regulation of cytosolic calcium ion concentration  (IEA,ISS)
positive regulation of eosinophil degranulation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IBA,IEA,ISS)
positive regulation of glomerular filtration  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of leukocyte chemotaxis  (IEA)
positive regulation of neutrophil mediated killing of gram-negative bacterium  (IEA)
positive regulation of phagocytosis, engulfment  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISS)
positive regulation of positive chemotaxis  (IEA)
positive regulation of pseudopodium assembly  (IEA,ISS)
positive regulation of renin secretion into blood stream  (IEA,ISS)
positive regulation of Rho protein signal transduction  (IBA,IEA,ISS)
positive regulation of superoxide anion generation  (IEA)
positive regulation of toll-like receptor 2 signaling pathway  (IEA)
positive regulation of toll-like receptor 3 signaling pathway  (IEA)
positive regulation of toll-like receptor 4 signaling pathway  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of type II interferon production  (IEA,ISS)
positive regulation of vasoconstriction  (ISO)
proteolysis  (IEA)
regulation of biological quality  (IEA)
regulation of blood coagulation  (IEA)
regulation of canonical NF-kappaB signal transduction  (IEA)
regulation of chemokine (C-X-C motif) ligand 2 production  (IEA)
regulation of JNK cascade  (IEA)
signal transduction  (IEA)
T cell activation involved in immune response  (IEA,ISS)
thrombin-activated receptor signaling pathway  (IEA)
vasodilation  (IEA,ISO,ISS)

Cellular Component
early endosome  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IEA)
pseudopodium  (IEA,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17766477   PMID:19359428   PMID:19498282   PMID:22301074   PMID:23465358   PMID:24829081   PMID:30032202  


Genomics

Comparative Map Data
F2RL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,801,119 - 29,810,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,800,211 - 29,810,180 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha331,040,276 - 31,049,162 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0329,720,255 - 29,729,156 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,719,346 - 29,729,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,656,957 - 29,665,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,637,871 - 29,646,815 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,007,024 - 30,015,914 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
F2RL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,819,030 - 76,835,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,818,933 - 76,835,315 (+)Ensemblhg38GRCh38
GRCh37576,114,855 - 76,131,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,150,610 - 76,166,896 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34576,150,609 - 76,166,895NCBI
Celera572,008,729 - 72,025,166 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,322,693 - 71,339,004 (+)NCBIHuRef
CHM1_1575,547,934 - 75,564,299 (+)NCBICHM1_1
T2T-CHM13v2.0577,300,842 - 77,317,122 (+)NCBIT2T-CHM13v2.0
F2rl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,648,226 - 95,661,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,648,240 - 95,661,735 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381395,511,718 - 95,525,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,511,732 - 95,525,227 (-)Ensemblmm10GRCm38
MGSCv371396,281,673 - 96,295,195 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361396,612,431 - 96,634,965 (-)NCBIMGSCv36mm8
Celera1399,130,515 - 99,143,639 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.53NCBI
F2rl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,507,003 - 28,519,954 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl228,507,003 - 28,519,954 (-)EnsemblGRCr8
mRatBN7.2226,772,274 - 26,785,226 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,772,278 - 26,785,226 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx233,810,431 - 33,823,386 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,910,649 - 31,923,604 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,726,513 - 26,739,491 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,222,324 - 25,235,275 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,222,328 - 25,235,275 (-)Ensemblrn6Rnor6.0
Rnor_5.0244,378,262 - 44,391,213 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4225,886,177 - 25,899,128 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera222,836,384 - 22,849,335 (-)NCBICelera
RGSC_v3.1225,808,013 - 25,819,410 (-)NCBI
Cytogenetic Map2q12NCBI
F2rl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542524,050,901 - 24,054,039 (-)NCBIChiLan1.0ChiLan1.0
F2RL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,466,053 - 38,482,458 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,619,680 - 36,636,075 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl539,006,331 - 39,024,265 (-)EnsemblpanPan2panpan1.1
F2rl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,705,232 - 190,716,606 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549141,512 - 153,602 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936549142,281 - 153,575 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2RL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,732,189 - 85,750,858 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1285,732,082 - 85,747,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,348,813 - 87,364,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F2RL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,095,446 - 71,109,832 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,095,500 - 71,110,005 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604919,926,695 - 19,941,181 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F2rl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248691,326,605 - 1,337,195 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in F2RL1
124 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 32 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000014742   ⟹   ENSCAFP00000013636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl329,800,211 - 29,810,180 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845018002   ⟹   ENSCAFP00845014025
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl329,719,346 - 29,729,322 (-)Ensembl
RefSeq Acc Id: NM_001145991   ⟹   NP_001139463
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1329,801,119 - 29,810,006 (-)NCBI
Dog10K_Boxer_Tasha331,040,276 - 31,049,162 (-)NCBI
ROS_Cfam_1.0329,720,255 - 29,729,156 (-)NCBI
UMICH_Zoey_3.1329,656,957 - 29,665,844 (-)NCBI
UNSW_CanFamBas_1.0329,637,871 - 29,646,815 (-)NCBI
UU_Cfam_GSD_1.0330,007,024 - 30,015,914 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001139463 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAH28894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000013636.2
  ENSCAFP00030017370.1
  ENSCAFP00845014025
  ENSCAFP00845014025.1
RefSeq Acc Id: NP_001139463   ⟸   NM_001145991
- Peptide Label: precursor
- UniProtKB: C4TGH8 (UniProtKB/TrEMBL),   A0A8C0MVA6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000013636   ⟸   ENSCAFT00000014742
Ensembl Acc Id: ENSCAFP00845014025   ⟸   ENSCAFT00845018002
Protein Domains
G-protein coupled receptors family 1 profile

Promoters
RGD ID:13682704
Promoter ID:EPDNEW_C774
Type:single initiation site
Name:F2RL1_1
Description:F2R like trypsin receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1329,810,119 - 29,810,179EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009281 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010794 UniProtKB/TrEMBL
  ENSCAFG00845010229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014742.4 UniProtKB/TrEMBL
  ENSCAFT00030019929.1 UniProtKB/TrEMBL
  ENSCAFT00845018002 ENTREZGENE
  ENSCAFT00845018002.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Pro_rcpt_2 UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/TrEMBL
KEGG Report cfa:488940 UniProtKB/TrEMBL
NCBI Gene F2RL1 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  PROTEINASE-ACTIVATED RECEPTOR 2 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/TrEMBL
  PROTEASEAR2 UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C0MVA6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NEI6_CANLF UniProtKB/TrEMBL
  C4TGH8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:40549 ENTREZGENE