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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of ERBB signaling pathway
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Accession:GO:1901184 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of ERBB signaling pathway.
Synonyms:exact_synonym: regulation of EGF receptor family signaling pathway;   regulation of ERBB signalling pathway;   regulation of ErbB signaling
 related_synonym: regulation of EGFR family signaling pathway


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regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SH3TC2 SH3 domain and tetratricopeptide repeats 2 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:23553667) Ensembl
GO_Central
MGI		 PMID:23553667 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:59,801,240...59,905,759
Ensembl chr 4:59,801,384...59,903,135 		JBrowse link
epidermal growth factor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB7A RAB7A, member RAS oncogene family involved_in IMP
IEA		 (PMID:16282324) UniProt
Ensembl		 PMID:16282324 GO_REF:0000107 NCBI chr20:2,704,716...2,776,518
Ensembl chr20:2,704,752...2,826,636 		JBrowse link
G SNX5 sorting nexin 5 ISO RGD PMID:16487940 RGD:13508623 NCBI chr24:5,085,140...5,110,942
Ensembl chr24:5,084,986...5,110,283 		JBrowse link
negative regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBL Cbl proto-oncogene involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:14,600,409...14,676,974
Ensembl chr 5:14,607,013...14,676,956 		JBrowse link
G CBLB Cbl proto-oncogene B involved_in IBA GO_Central GO_REF:0000033 NCBI chr33:11,255,453...11,665,755
Ensembl chr33:11,199,863...11,530,810 		JBrowse link
G CBLC Cbl proto-oncogene C involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:110,590,548...110,606,775
Ensembl chr 1:110,590,804...110,606,781 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in ISO PMID:11812785 BHF-UCL PMID:11812785 RGD:632628 NCBI chr 9:60,725,887...60,918,242
Ensembl chr 9:60,726,809...60,918,139 		JBrowse link
G DUSP3 dual specificity phosphatase 3 involved_in ISO (PMID:28759036) BHF-UCL PMID:28759036 NCBI chr 9:19,518,302...19,531,000
Ensembl chr 9:19,518,746...19,527,624 		JBrowse link
G EGFR epidermal growth factor receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in ISO
IBA
IEA		 RGD
GO_Central
Ensembl		 PMID:19204184 GO_REF:0000033 GO_REF:0000107 RGD:9685562 NCBI chr 5:61,621,964...61,636,152
Ensembl chr 5:61,622,550...61,636,148 		JBrowse link
G ITGA1 integrin subunit alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:62,287,823...62,455,940
Ensembl chr 4:62,293,082...62,455,650 		JBrowse link
G MIR133A microRNA mir-133a involved_in ISO (PMID:23069713) BHF-UCL PMID:23069713 NCBI chr 7:66,217,486...66,217,572
Ensembl chr 7:66,217,486...66,217,572 		JBrowse link
G MIR133C microRNA mir-133c involved_in ISO (PMID:23069713) BHF-UCL PMID:23069713 NCBI chr24:46,490,501...46,490,586
Ensembl chr24:46,490,497...46,490,588 		JBrowse link
G MVP major vault protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,879,687...17,903,184
Ensembl chr 6:17,873,521...17,903,184 		JBrowse link
G NPPA natriuretic peptide A involved_in ISO (PMID:20353436) UniProt PMID:20353436 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G NUP62 nucleoporin 62 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:106,636,282...106,661,250 JBrowse link
G PELO pelota mRNA surveillance and ribosome rescue factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:62,440,923...62,443,598 JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (PMID:15592458) UniProt PMID:15592458 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO RGD PMID:8557682 RGD:1642757 NCBI chr15:16,590,908...16,666,673
Ensembl chr15:16,591,308...16,666,673 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:41,586,262...41,635,386
Ensembl chr18:41,586,112...41,635,308 		JBrowse link
G RNF115 ring finger protein 115 involved_in ISO (PMID:23418353) UniProt PMID:23418353 NCBI chr17:58,566,761...58,634,967
Ensembl chr17:58,571,694...58,660,663 		JBrowse link
G RNF126 ring finger protein 126 involved_in ISO (PMID:23418353) UniProt PMID:23418353 NCBI chr20:57,890,333...57,899,364
Ensembl chr20:57,891,413...57,898,863 		JBrowse link
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in ISO (PMID:24854121) ARUK-UCL PMID:24854121 NCBI chr11:37,720,793...37,769,027
Ensembl chr11:37,577,053...37,767,572 		JBrowse link
G TFAP2A transcription factor AP-2 alpha acts_upstream_of_or_within ISO (PMID:16449191) MGI PMID:16449191 NCBI chr35:10,157,043...10,180,484
Ensembl chr35:10,157,882...10,180,270 		JBrowse link
G TSG101 tumor susceptibility 101 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:40,910,870...40,952,922
Ensembl chr21:40,910,874...40,952,808 		JBrowse link
G ZFYVE28 zinc finger FYVE-type containing 28 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:61,786,160...61,919,668
Ensembl chr 3:61,805,284...61,918,602 		JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHMP6 charged multivesicular body protein 6 involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chr 9:997,951...1,001,659
Ensembl chr 9:998,653...1,002,538 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in ISO (PMID:18046415)
(PMID:16648858)
PMID:17599051		 UniProt PMID:16648858 PMID:17599051 PMID:18046415 RGD:8553726 NCBI chr 5:61,621,964...61,636,152
Ensembl chr 5:61,622,550...61,636,148 		JBrowse link
G GPRC5A G protein-coupled receptor class C group 5 member A involved_in ISO (PMID:25744720) UniProt PMID:25744720 NCBI chr27:33,438,196...33,460,062
Ensembl chr27:33,441,527...33,460,377 		JBrowse link
G PSEN1 presenilin 1 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chr 8:46,495,551...46,569,532
Ensembl chr 8:46,495,624...46,569,532 		JBrowse link
G PSEN2 presenilin 2 involved_in ISO (PMID:20208556) BHF-UCL PMID:20208556 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722 		JBrowse link
G SOCS4 suppressor of cytokine signaling 4 involved_in ISO (PMID:15590694) UniProt PMID:15590694 NCBI chr 8:30,892,663...30,898,896 JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) UniProt PMID:15590694 NCBI chr10:48,916,446...48,977,183
Ensembl chr10:48,972,842...48,974,452 		JBrowse link
G TSG101 tumor susceptibility 101 involved_in ISO (PMID:16973552) UniProt PMID:16973552 NCBI chr21:40,910,870...40,952,922
Ensembl chr21:40,910,874...40,952,808 		JBrowse link
G ZFYVE28 zinc finger FYVE-type containing 28 involved_in ISO (PMID:19460345) UniProt PMID:19460345 NCBI chr 3:61,786,160...61,919,668
Ensembl chr 3:61,805,284...61,918,602 		JBrowse link
G ZGPAT zinc finger CCCH-type and G-patch domain containing involved_in ISO (PMID:19644445) UniProt PMID:19644445 NCBI chr24:47,257,396...47,269,742
Ensembl chr24:47,175,277...47,272,281 		JBrowse link
negative regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LGMN legumain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:1,810,263...1,843,116
Ensembl chr 8:1,728,273...1,843,050 		JBrowse link
negative regulation of ERBB4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP4 acid phosphatase 4 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:106,051,901...106,056,137
Ensembl chr 1:106,051,901...106,056,137 		JBrowse link
G CADM1 cell adhesion molecule 1 ISO RGD PMID:23769722 RGD:152975632 NCBI chr 5:17,865,317...18,190,855
Ensembl chr 5:17,864,453...18,194,694 		JBrowse link
positive regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAM17 ADAM metallopeptidase domain 17 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18625725) Ensembl
BHF-UCL		 PMID:18625725 GO_REF:0000107 NCBI chr17:6,589,874...6,638,788
Ensembl chr17:6,589,878...6,638,731 		JBrowse link
G ADRA2A adrenoceptor alpha 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684 		JBrowse link
G AFAP1L2 actin filament associated protein 1 like 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr28:25,137,235...25,228,454
Ensembl chr28:25,133,296...25,194,431 		JBrowse link
G AGR2 anterior gradient 2, protein disulphide isomerase family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:31,303,784...31,316,752
Ensembl chr14:31,305,567...31,316,686 		JBrowse link
G AGT angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) AgBase PMID:23389627 NCBI chr 7:41,835,322...41,850,488
Ensembl chr 7:41,812,353...41,850,488 		JBrowse link
G B9D2 B9 domain containing 2 acts_upstream_of ISO (PMID:18625725) BHF-UCL PMID:18625725 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G CCDC88A coiled-coil domain containing 88A involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:56,167,907...56,300,974
Ensembl chr10:56,170,479...56,300,908 		JBrowse link
G CNOT9 CCR4-NOT transcription complex subunit 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,186,928...25,213,255
Ensembl chr37:25,187,066...25,212,642 		JBrowse link
G DGKD diacylglycerol kinase delta involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:44,851,827...44,961,352
Ensembl chr25:44,851,493...44,961,364 		JBrowse link
G ESR1 estrogen receptor 1 ISO RGD PMID:17928626 RGD:5128669 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544 		JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:17928626 RGD:5128669 NCBI chr 8:38,645,917...38,715,347
Ensembl chr 8:38,645,430...38,702,691 		JBrowse link
G FAM83B family with sequence similarity 83 member B involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,256,452...22,341,919
Ensembl chr12:22,257,110...22,338,231 		JBrowse link
G FASLG Fas ligand ISO RGD PMID:18471522 RGD:2315731 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224 		JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:20445128 GO_REF:0000107 RGD:4892084 NCBI chr 6:15,792,072...15,796,922
Ensembl chr 6:15,792,897...15,794,051 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:12890790 UniProt PMID:12890790 RGD:10047165 NCBI chr 9:21,065,770...21,074,462
Ensembl chr 9:21,065,846...21,072,991 		JBrowse link
G HIP1 huntingtin interacting protein 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:6,957,760...7,115,676
Ensembl chr 6:6,961,053...7,115,618 		JBrowse link
G HIP1R huntingtin interacting protein 1 related involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr26:6,623,583...6,639,107
Ensembl chr26:6,624,791...6,637,659 		JBrowse link
G MIR29A microRNA mir-29a involved_in ISO (PMID:25058496) FlyBase PMID:25058496 NCBI chr14:6,184,844...6,184,903
Ensembl chr14:6,184,830...6,184,916 		JBrowse link
G MMP9 matrix metallopeptidase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
G NEU3 neuraminidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:23,456,424...23,484,872 JBrowse link
G PDE6G phosphodiesterase 6G involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:11502744) GO_Central
MGI		 PMID:11502744 GO_REF:0000033 NCBI chr 9:525,123...529,406
Ensembl chr 9:526,577...529,526 		JBrowse link
G PDE6H phosphodiesterase 6H acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:11502744) MGI
GO_Central		 PMID:11502744 GO_REF:0000033 NCBI chr27:31,640,731...31,664,494
Ensembl chr27:31,640,737...31,664,401 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chr 1:111,476,804...111,490,876
Ensembl chr 1:111,476,893...111,490,880 		JBrowse link
G RALA RAS like proto-oncogene A involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:10,022,490...10,047,583
Ensembl chr18:10,024,311...10,039,183 		JBrowse link
G RALB RAS like proto-oncogene B involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:29,820,006...29,868,345
Ensembl chr19:29,768,359...29,868,335 		JBrowse link
G SHKBP1 SH3KBP1 binding protein 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:113,154,285...113,165,988
Ensembl chr 1:113,154,460...113,165,992 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO RGD PMID:8577724 RGD:1581110 NCBI chr17:31,007,940...31,181,569
Ensembl chr17:31,009,257...31,142,063 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 involved_in ISO (PMID:15962011) MGI PMID:15962011 NCBI chr22:33,366,139...33,371,102
Ensembl chr22:33,366,931...33,367,878 		JBrowse link
G TGFB1 transforming growth factor beta 1 acts_upstream_of
involved_in		 ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:112,629,476...112,643,885
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
positive regulation of ERBB signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:84,060,417...84,286,008
Ensembl chr 3:84,064,440...84,286,360 		JBrowse link
positive regulation of ERBB3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RTN4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:55,884,452...55,954,476
Ensembl chr10:55,885,125...55,936,574 		JBrowse link
regulation of epidermal growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH13 cadherin 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:68,491,156...69,586,119
Ensembl chr 5:68,492,022...69,489,255 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO PMID:15467833
(PMID:15467833)		 UniProt PMID:15467833 RGD:11059592 NCBI chr 1:111,902,429...111,919,191
Ensembl chr 1:111,745,413...111,917,830 		JBrowse link
G FER FER tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:2,863,804...3,295,999
Ensembl chr 3:2,867,726...3,295,999 		JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in ISO (PMID:25757571) UniProt PMID:25757571 NCBI chr 2:72,638,657...72,642,648
Ensembl chr 2:72,638,705...72,642,648 		JBrowse link
G MIR21 microRNA mir-21 involved_in ISO (PMID:24012640) BHF-UCL PMID:24012640 NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624 		JBrowse link
G MVB12A multivesicular body subunit 12A involved_in IBA GO_Central GO_REF:0000033 NCBI chr20:45,365,850...45,370,114
Ensembl chr20:45,365,852...45,370,014 		JBrowse link
G MVB12B multivesicular body subunit 12B involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:56,721,599...56,908,723
Ensembl chr 9:56,707,258...56,907,716 		JBrowse link
G PTPN12 protein tyrosine phosphatase non-receptor type 12 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr18:17,608,665...17,692,543
Ensembl chr18:17,607,936...17,692,219 		JBrowse link
G RHBDF1 rhomboid 5 homolog 1 involved_in IEA
IBA		 Ensembl
GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:40,394,654...40,413,619
Ensembl chr 6:40,395,517...40,413,606 		JBrowse link
G RHBDF2 rhomboid 5 homolog 2 involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 9:4,211,951...4,240,253
Ensembl chr 9:4,226,364...4,237,825 		JBrowse link
G WDR54 WD repeat domain 54 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:48,700,432...48,734,250
Ensembl chr17:48,700,431...48,704,344 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17997
    regulation of biological process 12136
      regulation of response to stimulus 4185
        regulation of signal transduction 3236
          regulation of ERBB signaling pathway 79
            negative regulation of ERBB signaling pathway + 35
            positive regulation of ERBB signaling pathway + 32
            regulation of ERBB3 signaling pathway + 1
            regulation of epidermal growth factor receptor signaling pathway + 73
Path 2
Term Annotations click to browse term
  biological_process 17997
    biological regulation 12521
      regulation of biological process 12136
        signaling 6918
          signal transduction 6370
            cell surface receptor signaling pathway 2800
              enzyme-linked receptor protein signaling pathway 1053
                cell surface receptor protein tyrosine kinase signaling pathway 666
                  ERBB signaling pathway 145
                    regulation of ERBB signaling pathway 79
                      negative regulation of ERBB signaling pathway + 35
                      positive regulation of ERBB signaling pathway + 32
                      regulation of ERBB3 signaling pathway + 1
                      regulation of epidermal growth factor receptor signaling pathway + 73
paths to the root