MVP (major vault protein) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Grant Resources Citing RGD About Us Contact Us
Search by Genomic Position Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quantitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: MVP (major vault protein) Canis lupus familiaris
Analyze
Symbol: MVP
Name: major vault protein
RGD ID: 12255073
Description: ENCODES a protein that exhibits identical protein binding (inferred); protein kinase binding (inferred); protein phosphatase binding (inferred); INVOLVED IN cell population proliferation (inferred); ERBB signaling pathway (inferred); intracellular signal transduction (inferred); ASSOCIATED WITH acute myeloid leukemia (ortholog); cervical cancer (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LRP; lung resistance-associated protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,879,687 - 17,903,184 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,873,521 - 17,903,184 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha619,456,681 - 19,479,984 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0618,013,316 - 18,036,825 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,013,502 - 18,036,825 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,813,002 - 17,836,311 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,728,697 - 17,751,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,043,991 - 18,067,316 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MVP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,879,687 - 17,903,184 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,873,521 - 17,903,184 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha619,456,681 - 19,479,984 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0618,013,316 - 18,036,825 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,013,502 - 18,036,825 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,813,002 - 17,836,311 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,728,697 - 17,751,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,043,991 - 18,067,316 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MVP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381629,820,394 - 29,848,039 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1629,820,394 - 29,848,039 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371629,831,715 - 29,859,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,731,591 - 29,766,842 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341629,739,288 - 29,766,843NCBI
Celera1672,936,886 - 72,964,474 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,492,353 - 27,519,952 (+)NCBIHuRef
CHM1_11631,047,524 - 31,075,150 (+)NCBICHM1_1
T2T-CHM13v2.01630,102,554 - 30,130,675 (+)NCBIT2T-CHM13v2.0
Mvp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,586,036 - 126,613,729 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,586,032 - 126,613,793 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387126,986,860 - 127,014,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,986,860 - 127,014,621 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv377134,130,374 - 134,158,108 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367126,778,014 - 126,805,742 (-)NCBIMGSCv36mm8
Celera7126,835,060 - 126,862,722 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.26NCBI
Mvp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,025,259 - 191,052,866 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1191,025,268 - 191,052,873 (-)EnsemblGRCr8
mRatBN7.21181,594,734 - 181,622,336 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,594,734 - 181,622,380 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1189,946,088 - 189,973,678 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01197,132,171 - 197,159,761 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,799,632 - 189,827,156 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1190,337,746 - 190,365,336 (-)NCBI
Lyon_Normotensive1195,341,225 - 195,368,753 (-)NCBI
Lyon_Hypertensive1192,008,748 - 192,036,282 (-)NCBI
F344_StmMcwi1190,297,539 - 190,325,134 (-)NCBI
Rnor_6.01198,420,813 - 198,448,612 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,420,806 - 198,450,047 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01205,401,190 - 205,428,854 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41186,164,811 - 186,192,802 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1179,249,451 - 179,276,973 (-)NCBICelera
RGSC_v3.11186,314,691 - 186,342,683 (-)NCBI
Cytogenetic Map1q37NCBI
Mvp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,113,319 - 7,143,582 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554937,113,194 - 7,141,944 (-)NCBIChiLan1.0ChiLan1.0
MVP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,569,361 - 30,597,756 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,628,134 - 35,656,003 (-)NCBINHGRI_mPanPan1
PanPan1.11630,190,929 - 30,217,971 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,190,090 - 30,219,070 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
Mvp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap110124,542,168 - 124,571,618 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024409344124,501,044 - 124,512,454 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,599,036 - 12,655,910 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,598,907 - 12,610,306 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MVP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,057,177 - 18,081,155 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1318,056,548 - 18,081,169 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,509,107 - 18,534,192 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MVP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1527,082,754 - 27,110,935 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660682,694,565 - 2,723,262 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1526,805,070 - 26,833,043 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,801,753 - 26,833,199 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Mvp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,363,121 - 13,386,961 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462478213,363,000 - 13,387,086 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl2313,198,172 - 13,222,425 (-)Ensembl
Mvp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1274,878,686 - 74,906,295 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in MVP
253 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000026859   ⟹   ENSCAFP00000024962
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl617,873,521 - 17,876,724 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000026871   ⟹   ENSCAFP00000024974
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl617,877,370 - 17,903,184 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000069347   ⟹   ENSCAFP00000050198
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl617,873,521 - 17,903,184 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000069937   ⟹   ENSCAFP00000053016
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl617,879,879 - 17,903,184 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000085676   ⟹   ENSCAFP00000054207
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl617,873,585 - 17,875,193 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845001413   ⟹   ENSCAFP00845001099
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl618,013,502 - 18,036,825 (+)Ensembl
RefSeq Acc Id: NM_001287146   ⟹   NP_001274075
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1617,879,879 - 17,903,184 (+)NCBI
Dog10K_Boxer_Tasha619,456,681 - 19,479,984 (+)NCBI
ROS_Cfam_1.0618,013,502 - 18,036,825 (+)NCBI
UMICH_Zoey_3.1617,813,002 - 17,836,311 (+)NCBI
UNSW_CanFamBas_1.0617,728,697 - 17,751,998 (+)NCBI
UU_Cfam_GSD_1.0618,043,991 - 18,067,316 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038667582   ⟹   XP_038523510
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0618,013,316 - 18,036,815 (+)NCBI
RefSeq Acc Id: XM_038667583   ⟹   XP_038523511
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0618,013,316 - 18,036,815 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001274075 (Get FASTA)   NCBI Sequence Viewer  
  XP_038523510 (Get FASTA)   NCBI Sequence Viewer  
  XP_038523511 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAJ09627 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00845001099
  ENSCAFP00845001099.1
RefSeq Acc Id: NP_001274075   ⟸   NM_001287146
- UniProtKB: A0A8I3MGN1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000050198   ⟸   ENSCAFT00000069347
Ensembl Acc Id: ENSCAFP00000053016   ⟸   ENSCAFT00000069937
Ensembl Acc Id: ENSCAFP00000024962   ⟸   ENSCAFT00000026859
Ensembl Acc Id: ENSCAFP00000024974   ⟸   ENSCAFT00000026871
Ensembl Acc Id: ENSCAFP00000054207   ⟸   ENSCAFT00000085676
RefSeq Acc Id: XP_038523511   ⟸   XM_038667583
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038523510   ⟸   XM_038667582
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCAFP00845001099   ⟸   ENSCAFT00845001413
Protein Domains
Major vault protein repeat   Major vault protein shoulder

Promoters
RGD ID:13683625
Promoter ID:EPDNEW_C1693
Type:initiation region
Name:MVP_1
Description:major vault protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1617,879,981 - 17,880,041EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016970 Ensembl
  ENSCAFG00845000844 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845001413 ENTREZGENE
  ENSCAFT00845001413.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.550 UniProtKB/TrEMBL
  2.30.30.560 UniProtKB/TrEMBL
  2.30.30.570 UniProtKB/TrEMBL
  2.30.30.620 UniProtKB/TrEMBL
  3.30.479.30 UniProtKB/TrEMBL
  6.10.250.720 UniProtKB/TrEMBL
  6.20.380.10 UniProtKB/TrEMBL
InterPro Band_7/SPFH_dom_sf UniProtKB/TrEMBL
  MVP UniProtKB/TrEMBL
  MVP_rep_dom UniProtKB/TrEMBL
  MVP_rep_sf UniProtKB/TrEMBL
  MVP_shoulder UniProtKB/TrEMBL
  Vault_2 UniProtKB/TrEMBL
  Vault_2_sf UniProtKB/TrEMBL
  Vault_3 UniProtKB/TrEMBL
  Vault_4 UniProtKB/TrEMBL
  Vault_N UniProtKB/TrEMBL
KEGG Report cfa:479783 UniProtKB/TrEMBL
NCBI Gene MVP ENTREZGENE
PANTHER MAJOR VAULT PROTEIN UniProtKB/TrEMBL
  PTHR14165 UniProtKB/TrEMBL
Pfam MVP_shoulder UniProtKB/TrEMBL
  Vault UniProtKB/TrEMBL
  Vault_2 UniProtKB/TrEMBL
  Vault_3 UniProtKB/TrEMBL
  Vault_4 UniProtKB/TrEMBL
PROSITE MVP UniProtKB/TrEMBL
UniProt A0A8I3MGN1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43510 ENTREZGENE