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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-6-mediated signaling pathway
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Accession:GO:0070102 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: interleukin-6-mediated signalling pathway
 related_synonym: IL-6-mediated signaling pathway


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interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEBPA CCAAT enhancer binding protein alpha involved_in IDA (PMID:24429361) ARUK-UCL PMID:24429361 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CTR9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:10,751,246...10,779,746
Ensembl chr11:10,751,018...10,801,625 		JBrowse link
G FER FER tyrosine kinase involved_in IMP (PMID:19147545) UniProt PMID:19147545 NCBI chr 5:108,747,897...109,196,841
Ensembl chr 5:108,747,841...109,196,841 		JBrowse link
G GAB1 GRB2 associated binding protein 1 acts_upstream_of_or_within ISO (PMID:10779359) MGI PMID:10779359 NCBI chr 4:143,336,876...143,474,565
Ensembl chr 4:143,336,876...143,474,565 		JBrowse link
G IL6 interleukin 6 involved_in
acts_upstream_of_or_within		 IDA
IMP
ISO
ISS		 (PMID:12552091), (PMID:12829785), (PMID:16946298), (PMID:30670152), (PMID:31145836)
(PMID:28433754)
(PMID:1312474)
(PMID:27893700)		 ARUK-UCL
MGI
UniProt		 PMID:1312474 PMID:12552091 PMID:12829785 PMID:16946298 PMID:27893700 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6R interleukin 6 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IDA
ISS
IMP		 (PMID:1312474)
(PMID:12829785), (PMID:31145836)
(PMID:27893700)
(PMID:12643274)		 Ensembl
MGI
GO_Central
UniProt
BHF-UCL		 PMID:1312474 PMID:12643274 PMID:12829785 PMID:27893700 PMID:31145836 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer involved_in ISO
IDA
ISS
IEA
IMP
TAS		 (PMID:12829785), (PMID:25731159)
(PMID:27893700)
(PMID:12643274), (PMID:2261637)
(PMID:31145836)		 RGD
UniProt
Ensembl
BHF-UCL
ARUK-UCL		 PMID:2261637 PMID:12643274 PMID:12829785 PMID:18280048 PMID:25731159 More... GO_REF:0000107 RGD:5686900 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G JAK1 Janus kinase 1 involved_in TAS
IDA		 (PMID:8272873) Reactome
UniProt		 PMID:8272873 Reactome:R-HSA-1059683 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754 		JBrowse link
G JAK2 Janus kinase 2 involved_in TAS Reactome Reactome:R-HSA-1059683 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G SMAD4 SMAD family member 4 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:51,030,213...51,085,042
Ensembl chr18:51,028,528...51,085,045 		JBrowse link
G SPI1 Spi-1 proto-oncogene involved_in IDA (PMID:24429361) ARUK-UCL PMID:24429361 NCBI chr11:47,354,860...47,378,547
Ensembl chr11:47,354,860...47,409,369 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA
IDA		 (PMID:25731159) Ensembl
UniProt		 PMID:25731159 GO_REF:0000107 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G ST18 ST18 C2H2C-type zinc finger transcription factor involved_in IMP (PMID:18676404) UniProt PMID:18676404 NCBI chr 8:52,110,838...52,409,879
Ensembl chr 8:52,110,838...52,460,959 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IMP
IDA		 (PMID:16835372), (PMID:16946298)
(PMID:12359225), (PMID:12552091), (PMID:16285960), (PMID:17324931), (PMID:24429361)		 BHF-UCL PMID:12359225 PMID:12552091 PMID:16285960 PMID:16835372 PMID:16946298 More... NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TUT4 terminal uridylyl transferase 4 involved_in ISO (PMID:19701194) UniProt PMID:19701194 NCBI chr 1:52,423,275...52,553,463
Ensembl chr 1:52,408,282...52,553,487 		JBrowse link
G YAP1 Yes1 associated transcriptional regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:102,110,447...102,233,424
Ensembl chr11:102,110,447...102,233,424 		JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6ST interleukin 6 cytokine family signal transducer involved_in IDA (PMID:8353278) BHF-UCL PMID:8353278 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G MIR125A microRNA 125a acts_upstream_of_or_within IGI (PMID:30670152) ARUK-UCL PMID:30670152 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339 		JBrowse link
G MIR125B1 microRNA 125b-1 involved_in IDA (PMID:26455324) ARUK-UCL PMID:26455324 NCBI chr11:122,099,757...122,099,844
Ensembl chr11:122,099,757...122,099,844 		JBrowse link
G MIR125B2 microRNA 125b-2 involved_in IDA (PMID:26455324) ARUK-UCL PMID:26455324 NCBI chr21:16,590,237...16,590,325
Ensembl chr21:16,590,237...16,590,325 		JBrowse link
G MIR146A microRNA 146a involved_in IMP (PMID:28433754) ARUK-UCL PMID:28433754 NCBI chr 5:160,485,352...160,485,450
Ensembl chr 5:160,485,352...160,485,450 		JBrowse link
G MIR26A1 microRNA 26a-1 involved_in IDA (PMID:23389848) ARUK-UCL PMID:23389848 NCBI chr 3:37,969,404...37,969,480
Ensembl chr 3:37,969,404...37,969,480 		JBrowse link
G MIR26A2 microRNA 26a-2 involved_in IDA (PMID:23389848) ARUK-UCL PMID:23389848 NCBI chr12:57,824,609...57,824,692
Ensembl chr12:57,824,609...57,824,692 		JBrowse link
G MIR98 microRNA 98 involved_in IDA
IGI		 (PMID:26587789)
(PMID:31886314)		 ARUK-UCL PMID:26587789 PMID:31886314 NCBI chr  X:53,556,223...53,556,341
Ensembl chr  X:53,556,223...53,556,341 		JBrowse link
G MIR99A microRNA 99a involved_in IDA (PMID:26455324) ARUK-UCL PMID:26455324 NCBI chr21:16,539,089...16,539,169
Ensembl chr21:16,539,089...16,539,169 		JBrowse link
G MIRLET7A1 microRNA let-7a-1 involved_in IDA (PMID:19878981) ARUK-UCL PMID:19878981 NCBI chr 9:94,175,957...94,176,036
Ensembl chr 9:94,175,957...94,176,036 		JBrowse link
G MIRLET7A2 microRNA let-7a-2 involved_in IDA (PMID:19878981) ARUK-UCL PMID:19878981 NCBI chr11:122,146,522...122,146,593
Ensembl chr11:122,146,522...122,146,593 		JBrowse link
G MIRLET7A3 microRNA let-7a-3 involved_in IDA (PMID:19878981) ARUK-UCL PMID:19878981 NCBI chr22:46,112,749...46,112,822
Ensembl chr22:46,112,749...46,112,822 		JBrowse link
G MIRLET7C microRNA let-7c involved_in IDA (PMID:26455324) ARUK-UCL PMID:26455324 NCBI chr21:16,539,828...16,539,911
Ensembl chr21:16,539,828...16,539,911 		JBrowse link
G MIRLET7E microRNA let-7e acts_upstream_of_or_within IGI
IDA		 (PMID:30670152) ARUK-UCL PMID:30670152 NCBI chr19:51,692,786...51,692,864
Ensembl chr19:51,692,786...51,692,864 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IMP
IEA		 (PMID:12359225) UniProt
Ensembl		 PMID:12359225 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QTNF4 C1q and TNF related 4 involved_in IDA (PMID:21658842) UniProt PMID:21658842 NCBI chr11:47,589,667...47,595,304
Ensembl chr11:47,589,667...47,594,411 		JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor involved_in IDA (PMID:11060035) UniProt PMID:11060035 NCBI chr 1:92,473,043...92,486,925
Ensembl chr 1:92,473,043...92,486,925 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IMP
IEA		 (PMID:31827280) UniProt
Ensembl		 PMID:31827280 GO_REF:0000107 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19715
    cellular process 18967
      signal transduction 6636
        cell surface receptor signaling pathway 3204
          cytokine-mediated signaling pathway 620
            interleukin-6-mediated signaling pathway 33
              negative regulation of interleukin-6-mediated signaling pathway 15
              positive regulation of interleukin-6-mediated signaling pathway 3
              regulation of interleukin-6-mediated signaling pathway + 18
Path 2
Term Annotations click to browse term
  biological_process 19715
    response to stimulus 10257
      response to chemical 5043
        response to peptide 1389
          response to cytokine 1363
            cellular response to cytokine stimulus 1232
              cytokine-mediated signaling pathway 620
                interleukin-6-mediated signaling pathway 33
                  negative regulation of interleukin-6-mediated signaling pathway 15
                  positive regulation of interleukin-6-mediated signaling pathway 3
                  regulation of interleukin-6-mediated signaling pathway + 18
paths to the root