Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | TUT4 | Human | (S)-nicotine | increases expression | EXP | | 6480464 | Nicotine results in increased expression of TUT4 mRNA | CTD | PMID:16949557 | TUT4 | Human | 1,2-dimethylhydrazine | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TUT4 mRNA | CTD | PMID:22206623 | TUT4 | Human | 17beta-estradiol | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of ZCCHC11 mRNA | CTD | PMID:32145629 | TUT4 | Human | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:21394737 | TUT4 | Human | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | TUT4 | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TUT4 mRNA | CTD | PMID:21215274 | TUT4 | Human | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TUT4 mRNA | CTD | PMID:28922406 | TUT4 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TUT4 mRNA | CTD | PMID:22298810 and PMID:34747641 | TUT4 | Human | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of TUT4 mRNA | CTD | PMID:20188158 | TUT4 | Human | 4,4'-sulfonyldiphenol | increases methylation | EXP | | 6480464 | bisphenol S results in increased methylation of TUT4 gene | CTD | PMID:31601247 | TUT4 | Human | acetamide | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | acetamide results in decreased expression of TUT4 mRNA | CTD | PMID:31881176 | TUT4 | Human | acrylamide | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Acrylamide results in decreased expression of TUT4 mRNA | CTD | PMID:28959563 | TUT4 | Human | acrylamide | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Acrylamide results in decreased expression of TUT4 mRNA | CTD | PMID:30807115 | TUT4 | Human | aflatoxin B1 | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of TUT4 mRNA | CTD | PMID:19770486 | TUT4 | Human | antirheumatic drug | increases expression | EXP | | 6480464 | Antirheumatic Agents results in increased expression of TUT4 mRNA | CTD | PMID:24449571 | TUT4 | Human | aristolochic acid A | decreases expression | EXP | | 6480464 | aristolochic acid I results in decreased expression of TUT4 mRNA | CTD | PMID:33212167 | TUT4 | Human | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of TUT4 mRNA | CTD | PMID:22378314 | TUT4 | Human | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of TUT4 intron | CTD | PMID:30157460 | TUT4 | Human | benzo[a]pyrene diol epoxide I | decreases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:19150397 | TUT4 | Human | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TUT4 mRNA | CTD | PMID:20678512 | TUT4 | Human | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TUT4 gene | CTD | PMID:31601247 | TUT4 | Human | bisphenol A | increases expression | ISO | Tut4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:35598803 | TUT4 | Human | bisphenol A | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of TUT4 mRNA | CTD | PMID:33221593 | TUT4 | Human | bisphenol A | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ZCCHC11 mRNA | CTD | PMID:32145629 | TUT4 | Human | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:29275510 and PMID:33670352 | TUT4 | Human | bisphenol A | increases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:25181051 more ... | TUT4 | Human | carbon nanotube | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | TUT4 | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TUT4 gene] | CTD | PMID:28238834 | TUT4 | Human | chloroprene | increases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Chloroprene results in increased expression of TUT4 mRNA | CTD | PMID:23125180 | TUT4 | Human | choline | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUT4 gene | CTD | PMID:20938992 | TUT4 | Human | cocaine | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Cocaine results in decreased expression of TUT4 mRNA | CTD | PMID:17898221 | TUT4 | Human | copper(II) sulfate | decreases expression | EXP | | 6480464 | Copper Sulfate results in decreased expression of TUT4 mRNA | CTD | PMID:19549813 | TUT4 | Human | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of TUT4 mRNA | CTD | PMID:20106945 | TUT4 | Human | Dibutyl phosphate | affects expression | EXP | | 6480464 | di-n-butylphosphoric acid affects the expression of TUT4 mRNA | CTD | PMID:37042841 | TUT4 | Human | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of TUT4 mRNA | CTD | PMID:35967413 | TUT4 | Human | dorsomorphin | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | TUT4 | Human | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of TUT4 mRNA | CTD | PMID:29803840 | TUT4 | Human | enzyme inhibitor | multiple interactions | EXP | | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TUT4 protein | CTD | PMID:23301498 | TUT4 | Human | ethanol | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Ethanol results in decreased expression of TUT4 mRNA | CTD | PMID:29018328 | TUT4 | Human | flutamide | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of TUT4 mRNA | CTD | PMID:24136188 | TUT4 | Human | folic acid | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUT4 gene | CTD | PMID:20938992 | TUT4 | Human | folic acid | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of TUT4 mRNA | CTD | PMID:25629700 | TUT4 | Human | FR900359 | affects phosphorylation | EXP | | 6480464 | FR900359 affects the phosphorylation of TUT4 protein | CTD | PMID:37730182 | TUT4 | Human | fulvestrant | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TUT4 gene | CTD | PMID:31601247 | TUT4 | Human | gentamycin | increases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of TUT4 mRNA | CTD | PMID:22061828 | TUT4 | Human | glafenine | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Glafenine results in decreased expression of TUT4 mRNA | CTD | PMID:24136188 | TUT4 | Human | L-methionine | multiple interactions | ISO | Tut4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUT4 gene | CTD | PMID:20938992 | TUT4 | Human | methapyrilene | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Methapyrilene results in decreased expression of TUT4 mRNA | CTD | PMID:30467583 | TUT4 | Human | nicotine | increases expression | EXP | | 6480464 | Nicotine results in increased expression of TUT4 mRNA | CTD | PMID:16949557 | TUT4 | Human | oxaliplatin | multiple interactions | ISO | Tut4 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | TUT4 | Human | phenytoin | increases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Phenytoin results in increased expression of TUT4 mRNA | CTD | PMID:20345932 | TUT4 | Human | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TUT4 mRNA | CTD | PMID:19710929 | TUT4 | Human | resveratrol | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | resveratrol results in decreased expression of TUT4 mRNA | CTD | PMID:25905778 | TUT4 | Human | SB 431542 | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | TUT4 | Human | sodium arsenate | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | sodium arsenate results in decreased expression of TUT4 mRNA | CTD | PMID:30953684 | TUT4 | Human | sunitinib | increases expression | EXP | | 6480464 | Sunitinib results in increased expression of TUT4 mRNA | CTD | PMID:31533062 | TUT4 | Human | tetrachloromethane | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of TUT4 mRNA | CTD | PMID:31150632 | TUT4 | Human | tetrachloromethane | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of TUT4 mRNA | CTD | PMID:31919559 | TUT4 | Human | titanium dioxide | increases methylation | ISO | Tut4 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of ZCCHC11 gene | CTD | PMID:35295148 | TUT4 | Human | titanium dioxide | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of TUT4 mRNA | CTD | PMID:29264374 | TUT4 | Human | titanium dioxide | decreases methylation | ISO | Tut4 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of ZCCHC11 gene and titanium dioxide results in decreased methylation of ZCCHC11 promoter | CTD | PMID:35295148 | TUT4 | Human | topotecan | decreases expression | ISO | Tut4 (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | TUT4 | Human | topotecan | multiple interactions | ISO | Tut4 (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | TUT4 | Human | trichostatin A | decreases expression | EXP | | 6480464 | trichostatin A results in decreased expression of TUT4 mRNA | CTD | PMID:26272509 | TUT4 | Human | trichostatin A | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TUT4 mRNA | CTD | PMID:27188386 | TUT4 | Human | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of TUT4 mRNA | CTD | PMID:37042841 | TUT4 | Human | triptonide | affects expression | ISO | Tut4 (Mus musculus) | 6480464 | triptonide affects the expression of TUT4 mRNA | CTD | PMID:33045310 | TUT4 | Human | tungsten | decreases expression | ISO | Tut4 (Mus musculus) | 6480464 | Tungsten results in decreased expression of TUT4 mRNA | CTD | PMID:30912803 | TUT4 | Human | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of TUT4 mRNA | CTD | PMID:23179753 more ... | TUT4 | Human | valproic acid | multiple interactions | EXP | | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TUT4 mRNA | CTD | PMID:27188386 | TUT4 | Human | valproic acid | affects expression | ISO | Tut4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of TUT4 mRNA | CTD | PMID:17963808 | |