Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | increases expression | ISO | RGD:1320865 | 6480464 | Nicotine results in increased expression of TUT4 mRNA | CTD | PMID:16949557 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of TUT4 mRNA | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RGD:1310138 | 6480464 | 2 more ... | CTD | PMID:21394737 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1310138 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TUT4 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TUT4 mRNA | CTD | PMID:28922406 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1310138 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TUT4 mRNA | CTD | PMID:22298810, PMID:34747641 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of TUT4 mRNA | CTD | PMID:20188158 | 4,4'-sulfonyldiphenol | increases methylation | ISO | RGD:1320865 | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased methylation of TUT4 gene | CTD | PMID:31601247 | acetamide | decreases expression | ISO | RGD:1310138 | 6480464 | acetamide results in decreased expression of TUT4 mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | ISO | RGD:1310138 | 6480464 | Acrylamide results in decreased expression of TUT4 mRNA | CTD | PMID:28959563 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of TUT4 mRNA | CTD | PMID:30807115 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of TUT4 mRNA | CTD | PMID:19770486 | antirheumatic drug | increases expression | ISO | RGD:1320865 | 6480464 | Antirheumatic Agents results in increased expression of TUT4 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | RGD:1320865 | 6480464 | aristolochic acid I results in decreased expression of TUT4 mRNA | CTD | PMID:33212167 | atrazine | increases expression | ISO | RGD:1320865 | 6480464 | Atrazine results in increased expression of TUT4 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | affects methylation | ISO | RGD:1320865 | 6480464 | Benzo(a)pyrene affects the methylation of TUT4 intron | CTD | PMID:30157460 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1320865 | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | decreases expression | ISO | RGD:1320865 | 6480464 | bisphenol A results in decreased expression of TUT4 mRNA | CTD | PMID:20678512 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:35598803 | bisphenol A | multiple interactions | ISO | RGD:1320865 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TUT4 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TUT4 mRNA | CTD | PMID:33221593 | bisphenol A | increases expression | ISO | RGD:1320865 | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:29275510, PMID:33670352 | bisphenol A | increases expression | ISO | RGD:1310138 | 6480464 | bisphenol A results in increased expression of TUT4 mRNA | CTD | PMID:25181051 more ... | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681, PMID:25620056 | CGP 52608 | multiple interactions | ISO | RGD:1320865 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to TUT4 gene] | CTD | PMID:28238834 | chloroprene | increases expression | ISO | RGD:1310138 | 6480464 | Chloroprene results in increased expression of TUT4 mRNA | CTD | PMID:23125180 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUT4 gene | CTD | PMID:20938992 | cocaine | decreases expression | ISO | RGD:1310138 | 6480464 | Cocaine results in decreased expression of TUT4 mRNA | CTD | PMID:17898221 | copper(II) sulfate | decreases expression | ISO | RGD:1320865 | 6480464 | Copper Sulfate results in decreased expression of TUT4 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | RGD:1320865 | 6480464 | Cyclosporine results in increased expression of TUT4 mRNA | CTD | PMID:20106945 | dorsomorphin | multiple interactions | ISO | RGD:1320865 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | RGD:1320865 | 6480464 | Doxorubicin results in decreased expression of TUT4 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | RGD:1320865 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TUT4 protein | CTD | PMID:23301498 | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of TUT4 mRNA | CTD | PMID:29018328 | flutamide | decreases expression | ISO | RGD:1310138 | 6480464 | Flutamide results in decreased expression of TUT4 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUT4 gene | CTD | PMID:20938992 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of TUT4 mRNA | CTD | PMID:25629700 | fulvestrant | multiple interactions | ISO | RGD:1320865 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TUT4 gene | CTD | PMID:31601247 | gentamycin | increases expression | ISO | RGD:1310138 | 6480464 | Gentamicins results in increased expression of TUT4 mRNA | CTD | PMID:22061828 | glafenine | decreases expression | ISO | RGD:1310138 | 6480464 | Glafenine results in decreased expression of TUT4 mRNA | CTD | PMID:24136188 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TUT4 gene | CTD | PMID:20938992 | methapyrilene | decreases expression | ISO | RGD:1310138 | 6480464 | Methapyrilene results in decreased expression of TUT4 mRNA | CTD | PMID:30467583 | nicotine | increases expression | ISO | RGD:1320865 | 6480464 | Nicotine results in increased expression of TUT4 mRNA | CTD | PMID:16949557 | oxaliplatin | multiple interactions | ISO | RGD:1310138 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | phenytoin | increases expression | ISO | RGD:1310138 | 6480464 | Phenytoin results in increased expression of TUT4 mRNA | CTD | PMID:20345932 | pirinixic acid | multiple interactions | ISO | RGD:1320865 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TUT4 mRNA | CTD | PMID:19710929 | resveratrol | decreases expression | ISO | RGD:1310138 | 6480464 | resveratrol results in decreased expression of TUT4 mRNA | CTD | PMID:25905778 | SB 431542 | multiple interactions | ISO | RGD:1320865 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenate | decreases expression | EXP | | 6480464 | sodium arsenate results in decreased expression of TUT4 mRNA | CTD | PMID:30953684 | sunitinib | increases expression | ISO | RGD:1320865 | 6480464 | Sunitinib results in increased expression of TUT4 mRNA | CTD | PMID:31533062 | tetrachloromethane | decreases expression | ISO | RGD:1310138 | 6480464 | Carbon Tetrachloride results in decreased expression of TUT4 mRNA | CTD | PMID:31150632 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of TUT4 mRNA | CTD | PMID:31919559 | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of TUT4 mRNA | CTD | PMID:29264374 | topotecan | decreases expression | ISO | RGD:1310138 | 6480464 | Topotecan results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | ISO | RGD:1310138 | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of TUT4 mRNA | CTD | PMID:25729387 | trichostatin A | decreases expression | ISO | RGD:1320865 | 6480464 | trichostatin A results in decreased expression of TUT4 mRNA | CTD | PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:1320865 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TUT4 mRNA | CTD | PMID:27188386 | triptonide | affects expression | EXP | | 6480464 | triptonide affects the expression of TUT4 mRNA | CTD | PMID:33045310 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of TUT4 mRNA | CTD | PMID:30912803 | valproic acid | decreases expression | ISO | RGD:1320865 | 6480464 | Valproic Acid results in decreased expression of TUT4 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | RGD:1320865 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TUT4 mRNA | CTD | PMID:27188386 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of TUT4 mRNA | CTD | PMID:17963808 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Analyze GeneStrainQTL List |
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Gene Ontology Annotations Click to see Annotation Detail View
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Molecular Pathway Annotations Click to see Annotation Detail View
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Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis. | Fu X, etal., Oncogene. 2014 Aug 21;33(34):4296-306. doi: 10.1038/onc.2013.385. Epub 2013 Sep 23. |
| 2. | E2F1 and KIAA0191 expression predicts breast cancer patient survival. | Hallett RM and Hassell JA, BMC Res Notes. 2011 Mar 31;4:95. doi: 10.1186/1756-0500-4-95. |
| 3. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 4. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 5. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 6. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 7. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 8. | Database resources of the National Center for Biotechnology Information. | Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6. |
| 9. | The long and short of microRNA. | Yates LA, etal., Cell. 2013 Apr 25;153(3):516-9. doi: 10.1016/j.cell.2013.04.003. |
Additional References at PubMed
| PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12477932 | PMID:12520002 | PMID:12904583 | PMID:14610273 | PMID:16141072 | PMID:16141073 | PMID:16643855 | PMID:18287559 |
| PMID:18799693 | PMID:19701194 | PMID:19713958 | PMID:21677750 | PMID:21873635 | PMID:22083510 | PMID:23209448 | PMID:24316575 | PMID:26178733 | PMID:28665939 | PMID:28671666 | PMID:28792939 |
| PMID:30617251 | PMID:31138677 | PMID:31777931 | PMID:32325033 | PMID:32554809 | PMID:36417873 |
Genomics
Comparative Map Data
| Tut4 (Mus musculus - house mouse) |
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| TUT4 (Homo sapiens - human) |
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| Tut4 (Rattus norvegicus - Norway rat) |
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| Tut4 (Chinchilla lanigera - long-tailed chinchilla) |
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| TUT4 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| TUT4 (Canis lupus familiaris - dog) |
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| Tut4 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| TUT4 (Sus scrofa - pig) |
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| TUT4 (Chlorocebus sabaeus - green monkey) |
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| Tut4 (Heterocephalus glaber - naked mole-rat) |
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miRNA Target Status
Predicted Target Of
| The detailed report is available here: |  | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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QTLs in Region (GRCm39)
| The following QTLs overlap with this region. | | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Markers in Region
| 13.MMHAP54FLE1.seq |
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