RGD Reference Report - E2F1 and KIAA0191 expression predicts breast cancer patient survival. - Rat Genome Database

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E2F1 and KIAA0191 expression predicts breast cancer patient survival.

Authors: Hallett, RM  Hassell, JA 
Citation: Hallett RM and Hassell JA, BMC Res Notes. 2011 Mar 31;4:95. doi: 10.1186/1756-0500-4-95.
RGD ID: 11530014
Pubmed: PMID:21453498   (View Abstract at PubMed)
PMCID: PMC3078871   (View Article at PubMed Central)
DOI: DOI:10.1186/1756-0500-4-95   (Journal Full-text)

BACKGROUND: Gene expression profiling of human breast tumors has uncovered several molecular signatures that can divide breast cancer patients into good and poor outcome groups. However, these signatures typically comprise many genes (~50-100), and the prognostic tests associated with identifying these signatures in patient tumor specimens require complicated methods, which are not routinely available in most hospital pathology laboratories, thus limiting their use. Hence, there is a need for more practical methods to predict patient survival. METHODS: We modified a feature selection algorithm and used survival analysis to derive a 2-gene signature that accurately predicts breast cancer patient survival. RESULTS: We developed a tree based decision method that segregated patients into various risk groups using KIAA0191 expression in the context of E2F1 expression levels. This approach led to highly accurate survival predictions in a large cohort of breast cancer patients using only a 2-gene signature. CONCLUSIONS: Our observations suggest a possible relationship between E2F1 and KIAA0191 expression that is relevant to the pathogenesis of breast cancer. Furthermore, our findings raise the prospect that the practicality of patient prognosis methods may be improved by reducing the number of genes required for analysis. Indeed, our E2F1/KIAA0191 2-gene signature would be highly amenable for an immunohistochemistry based test, which is commonly used in hospital laboratories.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast cancer severityIEP 11530014in conjunction with E2f1 expression and mRNA:increased expression:breast (humanRGD 
breast cancer severityISOTUT4 (Homo sapiens)11530014; 11530014in conjunction with E2f1 expression and mRNA:increased expression:breast (humanRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tut4  (terminal uridylyl transferase 4)

Genes (Mus musculus)
Tut4  (terminal uridylyl transferase 4)

Genes (Homo sapiens)
TUT4  (terminal uridylyl transferase 4)


Additional Information