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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-6-mediated signaling pathway
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Accession:GO:0070102 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-6 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: interleukin-6-mediated signalling pathway
 related_synonym: IL-6-mediated signaling pathway
 xref: Reactome:R-HSA-1059683 "Interleukin-6 signaling"


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interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpa CCAAT/enhancer binding protein alpha involved_in ISO (PMID:24429361) RGD PMID:24429361 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in ISO (PMID:17911113) RGD PMID:17911113 NCBI chr 1:165,137,277...165,167,303 JBrowse link
G Fer FER tyrosine kinase involved_in ISO (PMID:19147545) RGD PMID:19147545 NCBI chr 9:110,967,317...111,274,315 JBrowse link
G Gab1 GRB2-associated binding protein 1 acts_upstream_of_or_within ISO MGI:1926435 (PMID:10779359) RGD PMID:10779359 NCBI chr19:27,131,262...27,239,236 JBrowse link
G Il6 interleukin 6 involved_in
acts_upstream_of_or_within		 ISS
ISO
IDA		 GO_REF:0000024
(PMID:11884403), (PMID:12552091), (PMID:12829785), (PMID:16946298), (PMID:28433754), (PMID:30670152), (PMID:31145836)
(PMID:16330325), (PMID:27893700), (PMID:8910279)
PMID:29702085
(PMID:1312474)		 UniProt
RGD		 PMID:1312474 PMID:8910279 PMID:11884403 PMID:12552091 PMID:12829785 More... GO_REF:0000024, RGD:13800534 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Il6r interleukin 6 receptor involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:11884403), (PMID:12643274)
(PMID:27893700)
(PMID:1312474)
GO_REF:0000033
(PMID:31145836)
(PMID:12829785)
GO_REF:0000107		 UniProt
RGD
GO_Central
Ensembl		 PMID:1312474 PMID:11884403 PMID:12643274 PMID:12829785 PMID:27893700 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:175,289,157...175,347,719 JBrowse link
G Il6st interleukin 6 cytokine family signal transducer involved_in IMP
ISO
IEA		 (PMID:11884403), (PMID:12643274), (PMID:12829785), (PMID:2261637), (PMID:25731159)
(PMID:25731159)
GO_REF:0000107		 RGD
Ensembl		 PMID:2261637 PMID:11884403 PMID:12643274 PMID:12829785 PMID:25731159 More... GO_REF:0000107, RGD:5686900 NCBI chr 2:44,065,979...44,106,255 JBrowse link
G Jak1 Janus kinase 1 involved_in ISO (PMID:8272873) RGD PMID:8272873 NCBI chr 5:115,780,248...115,888,841 JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16330325)		 Ensembl
RGD		 PMID:16330325 GO_REF:0000107 NCBI chr18:67,243,742...67,274,438 JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO
IEA		 (PMID:24429361)
GO_REF:0000107		 RGD
Ensembl		 PMID:24429361 GO_REF:0000107 NCBI chr 3:77,059,744...77,093,730 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:25731159) RGD PMID:25731159 NCBI chr 3:146,091,969...146,139,492 JBrowse link
G St18 ST18 C2H2C-type zinc finger transcription factor involved_in ISO
IEA		 (PMID:18676404)
GO_REF:0000107		 RGD
Ensembl		 PMID:18676404 GO_REF:0000107 NCBI chr 5:12,582,493...12,914,221 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:12359225), (PMID:12552091), (PMID:16285960), (PMID:16835372), (PMID:16946298), (PMID:17324931), (PMID:24429361)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:12359225 PMID:12552091 PMID:16285960 PMID:16835372 PMID:16946298 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Tut4 terminal uridylyl transferase 4 involved_in ISO (PMID:19701194) RGD PMID:19701194 NCBI chr 5:123,201,723...123,306,582 JBrowse link
G Yap1 Yes1 associated transcriptional regulator involved_in IEA
ISO		 GO_REF:0000107
(PMID:25731159)		 Ensembl
RGD		 PMID:25731159 GO_REF:0000107 NCBI chr 8:5,095,705...5,166,808 JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6st interleukin 6 cytokine family signal transducer involved_in ISO (PMID:8353278) RGD PMID:8353278 NCBI chr 2:44,065,979...44,106,255 JBrowse link
G Mir125a microRNA 125a acts_upstream_of_or_within ISO UniProtKB:P05231 (PMID:30670152) RGD PMID:30670152 NCBI chr 1:58,677,626...58,677,710 JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr 8:41,952,966...41,953,052 JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir146a microRNA 146a involved_in ISO (PMID:28433754) RGD PMID:28433754 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir26a microRNA 26a involved_in ISO (PMID:23389848) RGD PMID:23389848 NCBI chr 8:118,755,289...118,755,378 JBrowse link
G Mir98 microRNA 98 involved_in ISO UniProtKB:P05231 (PMID:26587789), (PMID:31886314) RGD PMID:26587789 PMID:31886314 NCBI chr  X:20,981,235...20,981,342 JBrowse link
G Mir99a microRNA 99a involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,200,443...16,200,523 JBrowse link
G Mirlet7a1 microRNA let-7a-1 involved_in ISO (PMID:19878981) RGD PMID:19878981 NCBI chr17:16,113,766...16,113,859 JBrowse link
G Mirlet7c1 microRNA let-7c-1 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,201,163...16,201,256 JBrowse link
G Mirlet7c2 microRNA let7c-2 involved_in ISO (PMID:19878981) RGD PMID:19878981 NCBI chr 7:116,803,771...116,803,865 JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS		 (PMID:12359225)
(PMID:20484139)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:12359225 PMID:20484139 GO_REF:0000024 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662 JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf4 C1q and TNF related 4 involved_in ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:76,854,368...76,872,991 JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor involved_in ISO
IEA		 (PMID:11060035)
GO_REF:0000107		 RGD
Ensembl		 PMID:11060035 GO_REF:0000107 NCBI chr14:2,040,576...2,056,874 JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:31827280)
(PMID:31827281)		 RGD PMID:31827280 PMID:31827281 NCBI chr17:30,839,639...30,871,824 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      signal transduction 7251
        cell surface receptor signaling pathway 2882
          cytokine-mediated signaling pathway 546
            interleukin-6-mediated signaling pathway 29
              negative regulation of interleukin-6-mediated signaling pathway 12
              positive regulation of interleukin-6-mediated signaling pathway 3
              regulation of interleukin-6-mediated signaling pathway + 15
Path 2
Term Annotations click to browse term
  biological_process 20536
    response to stimulus 11014
      response to chemical 5936
        response to peptide 1296
          response to cytokine 1277
            cellular response to cytokine stimulus 1138
              cytokine-mediated signaling pathway 546
                interleukin-6-mediated signaling pathway 29
                  negative regulation of interleukin-6-mediated signaling pathway 12
                  positive regulation of interleukin-6-mediated signaling pathway 3
                  regulation of interleukin-6-mediated signaling pathway + 15
paths to the root