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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of Notch signaling pathway
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Accession:GO:0045746 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
Synonyms:exact_synonym: down regulation of Notch signaling pathway;   downregulation of Notch signaling pathway;   negative regulation of N signaling pathway;   negative regulation of N signalling pathway;   negative regulation of Notch signalling pathway
 narrow_synonym: inhibition of Notch signaling pathway


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negative regulation of Notch signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 involved_in IMP
ISO
IBA		 (MGI:5916812|PMID:23886940) UniProt
MGI
GO_Central		 PMID:23886940 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5916812 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978 		JBrowse link
G Arrdc1 arrestin domain containing 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:24,815,364...24,825,347
Ensembl chr 2:24,815,364...24,825,264 		JBrowse link
G Bcl6 B cell leukemia/lymphoma 6 acts_upstream_of_or_within IGI (PMID:23160044) MGI PMID:23160044 NCBI chr16:23,780,058...23,807,602
Ensembl chr16:23,783,802...23,807,602 		JBrowse link
G Bend6 BEN domain containing 6 involved_in
acts_upstream_of_or_within		 IMP
IDA
IBA		 (MGI:5688817|PMID:25561495)
(PMID:23571214)		 UniProt
MGI
GO_Central		 PMID:23571214 PMID:25561495 GO_REF:0000033 MGI:5688817 NCBI chr 1:33,891,133...33,946,925
Ensembl chr 1:33,891,133...33,946,897 		JBrowse link
G Bmp7 bone morphogenetic protein 7 acts_upstream_of_or_within IGI (PMID:16324690) MGI PMID:16324690 NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114 		JBrowse link
G Cbfa2t2 CBFA2/RUNX1 translocation partner 2 involved_in IMP (MGI:5629454|PMID:25398765) UniProt PMID:25398765 MGI:5629454 NCBI chr 2:154,278,018...154,381,276
Ensembl chr 2:154,278,401...154,381,276 		JBrowse link
G Ccnc cyclin C involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:21,727,705...21,759,917
Ensembl chr 4:21,727,701...21,759,922 		JBrowse link
G Cdk3 cyclin dependent kinase 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:116,106,828...116,111,113
Ensembl chr11:116,106,829...116,111,113 		JBrowse link
G Chac1 ChaC, cation transport regulator 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 involved_in
acts_upstream_of_or_within		 ISO
IGI
IBA		 (PMID:21419176) MGI
GO_Central		 PMID:21419176 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262 		JBrowse link
G Dlk2 delta like non-canonical Notch ligand 2 involved_in
acts_upstream_of_or_within		 ISO
IGI		 (PMID:21419176) MGI PMID:21419176 GO_REF:0000119 MGI:4834177 NCBI chr17:46,608,342...46,614,197
Ensembl chr17:46,608,347...46,614,197 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:15,587,616...15,597,275
Ensembl chr17:15,587,616...15,597,134 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 involved_in ISO
IBA		 RGD
MGI
GO_Central		 PMID:16144902 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:1599776 NCBI chr 7:27,992,980...28,001,210
Ensembl chr 7:27,992,978...28,001,663 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 involved_in IDA
IBA		 (MGI:5689216|PMID:26114479) UniProt
GO_Central		 PMID:26114479 GO_REF:0000033 MGI:5689216 NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443 		JBrowse link
G Dlx1 distal-less homeobox 1 acts_upstream_of_or_within IGI (PMID:23042297) MGI PMID:23042297 NCBI chr 2:71,358,457...71,364,325
Ensembl chr 2:71,358,457...71,364,325 		JBrowse link
G Dlx2 distal-less homeobox 2 acts_upstream_of_or_within IGI (PMID:23042297) MGI PMID:23042297 NCBI chr 2:71,373,752...71,377,095
Ensembl chr 2:71,373,752...71,377,098 		JBrowse link
G Egfl7 EGF-like domain 7 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr 2:26,471,095...26,482,694
Ensembl chr 2:26,470,026...26,483,132 		JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014 		JBrowse link
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 involved_in
acts_upstream_of_or_within		 IDA
ISO
IMP		 (MGI:5299268|PMID:21943603)
(PMID:21943603), (PMID:22951639)		 CACAO
MGI		 PMID:21943603 PMID:22951639 GO_REF:0000008 MGI:5299268 NCBI chr 7:99,027,976...99,111,082
Ensembl chr 7:99,030,621...99,111,084 		JBrowse link
G Herc2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 acts_upstream_of_or_within IDA (PMID:26355680) MGI PMID:26355680 NCBI chr 7:55,699,872...55,884,373
Ensembl chr 7:55,699,944...55,881,548 		JBrowse link
G Hey1 hairy/enhancer-of-split related with YRPW motif 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316 		JBrowse link
G Hey2 hairy/enhancer-of-split related with YRPW motif 2 involved_in IMP
IDA		 (MGI:3710697|PMID:11095750)
(MGI:5284767|PMID:18239137)		 UniProt
BHF-UCL		 PMID:11095750 PMID:18239137 MGI:3710697 MGI:5284767 NCBI chr10:30,708,355...30,718,779
Ensembl chr10:30,708,355...30,718,797 		JBrowse link
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr19:44,551,293...44,564,713
Ensembl chr19:44,551,289...44,564,713 		JBrowse link
G Kctd10 potassium channel tetramerisation domain containing 10 acts_upstream_of_or_within IMP (PMID:25401743) MGI PMID:25401743 NCBI chr 5:114,501,633...114,518,566
Ensembl chr 5:114,501,628...114,518,569 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 acts_upstream_of_or_within IDA (PMID:26355680) MGI PMID:26355680 NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323 		JBrowse link
G Magea5 MAGE family member A5 involved_in ISO (PMID:15316101) UniProt PMID:15316101 NCBI chr  X:153,836,057...153,846,147
Ensembl chr  X:153,836,057...153,846,141 		JBrowse link
G Mir1224 microRNA 1224 involved_in ISO (PMID:28717225) BHF-UCL PMID:28717225 NCBI chr16:20,423,202...20,423,286
Ensembl chr16:20,423,202...20,423,286 		JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) involved_in IMP (MGI:5013661|PMID:21572390) UniProt PMID:21572390 MGI:5013661 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821 		JBrowse link
G Neurl1a neuralized E3 ubiquitin protein ligase 1A involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr19:47,167,259...47,247,880
Ensembl chr19:47,167,259...47,247,880 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha acts_upstream_of_or_within IMP (PMID:15845452) MGI PMID:15845452 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Notch4 notch 4 acts_upstream_of_or_within IDA (PMID:24667410) MGI PMID:24667410 NCBI chr17:34,783,257...34,807,517
Ensembl chr17:34,783,242...34,807,477 		JBrowse link
G Nrarp Notch-regulated ankyrin repeat protein acts_upstream_of_or_within
involved_in		 IMP
IBA
IGI
ISO		 (PMID:21795391)
(PMID:21998026)
(PMID:12794108)		 MGI
GO_Central		 PMID:12794108 PMID:21795391 PMID:21998026 GO_REF:0000008 GO_REF:0000033 NCBI chr 2:25,070,770...25,073,351
Ensembl chr 2:25,070,770...25,073,351 		JBrowse link
G Numb NUMB endocytic adaptor protein acts_upstream_of_or_within IMP (PMID:21385765) MGI PMID:21385765 NCBI chr12:83,840,808...83,968,708
Ensembl chr12:83,840,808...83,968,708 		JBrowse link
G Ovol2 ovo like zinc finger 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:144,147,095...144,174,000
Ensembl chr 2:144,147,095...144,174,066 		JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in ISO RGD
MGI		 PMID:11165380 GO_REF:0000096 MGI:4417868 RGD:633801 NCBI chr11:120,671,571...120,675,077
Ensembl chr11:120,671,572...120,675,033 		JBrowse link
G Rian RNA imprinted and accumulated in nucleus acts_upstream_of_or_within IMP (PMID:29636669), (PMID:31711641) MGI PMID:29636669 PMID:31711641 NCBI chr12:109,570,379...109,628,150
Ensembl chr12:109,570,242...109,628,150 		JBrowse link
G Rita1 RBPJ interacting and tubulin associated 1 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 5:120,747,123...120,750,654
Ensembl chr 5:120,732,370...120,750,654 		JBrowse link
G Slc35c1 solute carrier family 35, member C1 acts_upstream_of_or_within IMP (PMID:20837470) MGI PMID:20837470 NCBI chr 2:92,283,109...92,290,863
Ensembl chr 2:92,283,109...92,290,883 		JBrowse link
G Tcim transcriptional and immune response regulator involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 8:24,927,188...24,928,962
Ensembl chr 8:24,927,196...24,929,000 		JBrowse link
G Tspan15 tetraspanin 15 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:62,021,175...62,067,055
Ensembl chr10:62,021,175...62,067,030 		JBrowse link
G Zbtb7a zinc finger and BTB domain containing 7a involved_in IMP (MGI:3710692|PMID:17495164) UniProt PMID:17495164 MGI:3710692 NCBI chr10:80,971,113...80,988,056
Ensembl chr10:80,971,054...80,988,829 		JBrowse link
negative regulation of Notch signaling pathway involved in somitogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase involved_in IMP (MGI:5545944|PMID:23072809) UniProt PMID:23072809 MGI:5545944 NCBI chr 5:140,593,096...140,601,300
Ensembl chr 5:140,593,075...140,601,300 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28576
    response to stimulus 10772
      negative regulation of response to stimulus 1931
        negative regulation of signal transduction 1503
          negative regulation of Notch signaling pathway 42
            negative regulation of Notch signaling pathway involved in somitogenesis 1
Path 2
Term Annotations click to browse term
  biological_process 28576
    biological regulation 13125
      regulation of biological process 12730
        signaling 7278
          signal transduction 6663
            cell surface receptor signaling pathway 2922
              Notch signaling pathway 197
                regulation of Notch signaling pathway 101
                  negative regulation of Notch signaling pathway 42
                    negative regulation of Notch signaling pathway involved in somitogenesis 1
paths to the root