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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of tumor necrosis factor production
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Accession:GO:0032720 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
Comment:Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
Synonyms:exact_synonym: down regulation of tumor necrosis factor production;   downregulation of tumor necrosis factor production;   negative regulation TNF production;   negative regulation TNF-alpha production;   negative regulation tumor necrosis factor-alpha production
 narrow_synonym: inhibition of cachectin production;   inhibition of tumor necrosis factor production;   negative regulation of tumor necrosis factor biosynthetic process;   negative regulation of tumor necrosis factor secretion
 alt_id: GO:0042536;   GO:1904468

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negative regulation of tumor necrosis factor production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant acts_upstream_of_or_within ISO (PMID:11168643) MGI PMID:11168643 NCBI chrNW_004955495:2,418,113...2,421,181
Ensembl chrNW_004955495:2,418,364...2,421,538 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO (PMID:10961870) BHF-UCL PMID:10961870 NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402 		JBrowse link
G Adrb2 adrenoceptor beta 2 ISO RGD PMID:11096136 RGD:8548521 NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980 		JBrowse link
G Akap8 A-kinase anchoring protein 8 involved_in ISO (PMID:19531803) UniProt PMID:19531803 NCBI chrNW_004955495:7,874,655...7,893,209
Ensembl chrNW_004955495:7,874,746...7,892,944 		JBrowse link
G Arg2 arginase 2 involved_in ISO (PMID:28614294)
(PMID:27074721)		 UniProt PMID:27074721 PMID:28614294 NCBI chrNW_004955466:2,549,557...2,577,060
Ensembl chrNW_004955466:2,549,557...2,577,060 		JBrowse link
G Arrb2 arrestin beta 2 involved_in ISO (PMID:16378096) UniProt PMID:16378096 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022 		JBrowse link
G Axl AXL receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:16831897) MGI PMID:16831897 NCBI chrNW_004955555:189,445...218,509
Ensembl chrNW_004955555:189,174...218,565 		JBrowse link
G Bcl3 BCL3 transcription coactivator acts_upstream_of_or_within ISO (PMID:15465827) MGI PMID:15465827 NCBI chrNW_004955555:1,898,280...1,911,466
Ensembl chrNW_004955555:1,856,250...1,911,466 		JBrowse link
G Bpi bactericidal permeability increasing protein involved_in ISO (PMID:8409400) BHF-UCL PMID:8409400 NCBI chrNW_004955445:18,393,854...18,433,948
Ensembl chrNW_004955445:18,391,215...18,427,980 		JBrowse link
G C5ar2 complement C5a receptor 2 involved_in ISO (PMID:16204243) UniProt PMID:16204243 NCBI chrNW_004955574:1,221,950...1,242,547 JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO (PMID:20829348) UniProt PMID:20829348 NCBI chrNW_004955495:5,561,359...5,571,945
Ensembl chrNW_004955495:5,561,979...5,571,682 		JBrowse link
G Cd24 CD24 molecule involved_in ISO (PMID:19264983) UniProt PMID:19264983 NCBI chrNW_004955411:32,270,881...32,275,236
Ensembl chrNW_004955411:32,270,881...32,275,236 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in
acts_upstream_of_or_within		 ISO (PMID:12508119)
(PMID:12508119), (PMID:16785311)		 MGI PMID:12508119 PMID:16785311 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700 		JBrowse link
G Cidea cell death inducing DFFA like effector a involved_in ISO (PMID:15919794) BHF-UCL PMID:15919794 NCBI chrNW_004955402:1,090,372...1,096,621
Ensembl chrNW_004955402:1,090,518...1,096,569 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in ISO (PMID:10652441) ARUK-UCL PMID:10652441 NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711 		JBrowse link
G Dicer1 dicer 1, ribonuclease III acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chrNW_004955438:17,374,899...17,431,599
Ensembl chrNW_004955438:17,382,493...17,431,797 		JBrowse link
G Elf4 E74 like ETS transcription factor 4 involved_in ISO (PMID:35266071) UniProt PMID:35266071 NCBI chrNW_004955473:4,934,770...4,986,283
Ensembl chrNW_004955473:4,942,385...4,986,433 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 ISO RGD PMID:19204184 RGD:9685562 NCBI chrNW_004955486:4,941,143...4,955,693
Ensembl chrNW_004955486:4,941,143...4,955,693 		JBrowse link
G Flt3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (PMID:20457904) MGI PMID:20457904 NCBI chrNW_004955497:7,357,533...7,441,215
Ensembl chrNW_004955497:7,357,212...7,461,439 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Fxr1 FMR1 autosomal homolog 1 involved_in ISO (PMID:15548538) UniProt PMID:15548538 NCBI chrNW_004955420:9,903,736...9,966,100
Ensembl chrNW_004955420:9,903,736...9,966,100 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO (PMID:19657094), (PMID:20103767) UniProt PMID:19657094 PMID:20103767 NCBI chrNW_004955404:276,397...303,864
Ensembl chrNW_004955404:275,946...304,809 		JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO RGD PMID:32428552 RGD:405878062 NCBI chrNW_004955426:22,386,613...22,412,324
Ensembl chrNW_004955426:22,386,450...22,412,324 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide involved_in ISO (PMID:15232612) RGD
UniProt		 PMID:15232612 PMID:19620309 RGD:12905041 NCBI chrNW_004955561:1,676,475...1,682,205
Ensembl chrNW_004955561:1,676,576...1,681,812 		JBrowse link
G Ghsr growth hormone secretagogue receptor involved_in ISO (PMID:15232612) RGD
UniProt		 PMID:15232612 PMID:17911350 RGD:12907501 NCBI chrNW_004955420:2,483,173...2,486,414
Ensembl chrNW_004955420:2,478,877...2,487,215 		JBrowse link
G Gpnmb glycoprotein nmb involved_in ISO (PMID:17475886) CACAO PMID:17475886 NCBI chrNW_004955410:25,554,279...25,583,368
Ensembl chrNW_004955410:25,553,973...25,582,500 		JBrowse link
G Gpr18 G protein-coupled receptor 18 acts_upstream_of_or_within ISO (PMID:25348153) MGI PMID:25348153 NCBI chrNW_004955404:11,293,897...11,321,072
Ensembl chrNW_004955404:11,293,897...11,321,072 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISO (PMID:18962899)
(PMID:16023107), (PMID:18962899)		 BHF-UCL PMID:16023107 PMID:18962899 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:25578313) UniProt PMID:25578313 NCBI chrNW_004955408:11,289,920...11,311,216
Ensembl chrNW_004955408:11,291,937...11,311,320 		JBrowse link
G Hdac3 histone deacetylase 3 ISO RGD PMID:22772764 RGD:9590127 NCBI chrNW_004955415:12,138,520...12,154,234
Ensembl chrNW_004955415:12,138,870...12,154,234 		JBrowse link
G Hsf1 heat shock transcription factor 1 acts_upstream_of_or_within ISO (PMID:10545106) MGI PMID:10545106 NCBI chrNW_004955454:2,907,265...2,932,352
Ensembl chrNW_004955454:2,907,265...2,932,351 		JBrowse link
G Igf1 insulin like growth factor 1 involved_in ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
G Il10 interleukin 10 acts_upstream_of_or_within ISO (PMID:12452830) RGD
MGI		 PMID:12452830 PMID:17017555 RGD:1598631 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha involved_in ISO (PMID:22927332) BHF-UCL PMID:22927332 NCBI chrNW_004955415:32,749,682...32,762,532
Ensembl chrNW_004955415:32,749,094...32,761,882 		JBrowse link
G Il4 interleukin 4 involved_in ISO (PMID:29061364) ARUK-UCL PMID:29061364 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains involved_in ISO (PMID:29802199) UniProt PMID:29802199 NCBI chrNW_004955437:2,697,998...2,769,998
Ensembl chrNW_004955437:2,694,945...2,769,998 		JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 involved_in ISO (PMID:15728517)
(PMID:12150927)		 BHF-UCL PMID:12150927 PMID:15728517 NCBI chrNW_004955458:12,839,995...12,880,285
Ensembl chrNW_004955458:12,846,237...12,879,316 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:25578313) UniProt PMID:25578313 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
G Nfkbil1 NFKB inhibitor like 1 involved_in ISO (PMID:20829348) UniProt PMID:20829348 NCBI chrNW_004955437:90,623...100,918
Ensembl chrNW_004955437:90,577...100,918 		JBrowse link
G Nlrc3 NLR family CARD domain containing 3 involved_in ISO (PMID:22863753) CACAO PMID:22863753 NCBI chrNW_004955442:13,795,322...13,834,362
Ensembl chrNW_004955442:13,814,434...13,833,222 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within ISO (PMID:19139201) MGI PMID:19139201 NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 involved_in ISO (PMID:21242261)
(PMID:18972444)		 UniProt PMID:18972444 PMID:21242261 NCBI chrNW_004955405:36,160,360...36,236,258
Ensembl chrNW_004955405:36,160,049...36,237,751 		JBrowse link
G Orm1 orosomucoid 1 involved_in ISO (PMID:23973664) CACAO PMID:23973664 NCBI chrNW_004955419:13,262,119...13,264,986 JBrowse link
G Pomc proopiomelanocortin involved_in ISO (PMID:10233018) BHF-UCL PMID:10233018 NCBI chrNW_004955469:7,217,233...7,220,401
Ensembl chrNW_004955469:7,217,363...7,220,386 		JBrowse link
G Ptger4 prostaglandin E receptor 4 ISO RGD PMID:15560120 RGD:10043380 NCBI chrNW_004955426:24,997,811...25,010,822
Ensembl chrNW_004955426:24,997,811...25,010,822 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in ISO (PMID:23991106) UniProt PMID:23991106 NCBI chrNW_004955435:17,082,762...17,139,067 JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 involved_in ISO (PMID:17954568) ARUK-UCL PMID:17954568 NCBI chrNW_004955413:4,525,954...4,547,177
Ensembl chrNW_004955413:4,525,954...4,547,177 		JBrowse link
G Rad21 RAD21 cohesin complex component ISO RGD PMID:36538854 RGD:243065265 NCBI chrNW_004955417:22,941,549...22,966,395
Ensembl chrNW_004955417:22,941,479...22,966,837 		JBrowse link
G Rara retinoic acid receptor alpha involved_in ISO (PMID:18416830) BHF-UCL PMID:18416830 NCBI chrNW_004955451:14,876,663...14,917,134
Ensembl chrNW_004955451:14,897,726...14,917,134 		JBrowse link
G Selenos selenoprotein S involved_in ISO (PMID:16227999) BHF-UCL PMID:16227999 NCBI chrNW_004955416:28,152,984...28,162,173
Ensembl chrNW_004955416:28,153,460...28,162,095 		JBrowse link
G Sirpa signal regulatory protein alpha involved_in ISO (PMID:17954568) ARUK-UCL PMID:17954568 NCBI chrNW_004955415:13,030,752...13,072,735 JBrowse link
G Sirt1 sirtuin 1 ISO RGD PMID:19299582 RGD:9585771 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663 		JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:16317102) UniProt PMID:16317102 NCBI chrNW_004955468:12,336,744...12,383,917
Ensembl chrNW_004955468:12,334,307...12,370,334 		JBrowse link
G Syt11 synaptotagmin 11 involved_in ISO (PMID:23303671), (PMID:25063865)
(PMID:28686317)		 ParkinsonsUK-UCL
UniProt		 PMID:23303671 PMID:25063865 PMID:28686317 NCBI chrNW_004955545:2,054,720...2,074,526
Ensembl chrNW_004955545:2,054,721...2,074,526 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:14568985) UniProt PMID:14568985 NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419 		JBrowse link
G Tlr4 toll like receptor 4 involved_in ISO (PMID:20051628) BHF-UCL PMID:20051628 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (PMID:22198949) ARUK-UCL PMID:22198949 NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:21088135) BHF-UCL PMID:21088135 NCBI chrNW_004955436:21,566,591...21,581,551
Ensembl chrNW_004955436:21,566,423...21,578,469 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:28592261) UniProt PMID:28592261 NCBI chrNW_004955437:7,780,886...7,785,597
Ensembl chrNW_004955437:7,780,679...7,785,697 		JBrowse link
G Trim27 tripartite motif containing 27 involved_in ISO (PMID:22128329) UniProt PMID:22128329 NCBI chrNW_004955465:13,891,001...13,902,767
Ensembl chrNW_004955465:13,890,900...13,903,016 		JBrowse link
G Tspo translocator protein ISO RGD PMID:14678758 RGD:2317158 NCBI chrNW_004955413:28,309,105...28,315,075
Ensembl chrNW_004955413:28,308,658...28,315,075 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 acts_upstream_of_or_within ISO (PMID:16831897) MGI PMID:16831897 NCBI chrNW_004955410:22,003,981...22,005,483 JBrowse link
G Twist2 twist family bHLH transcription factor 2 acts_upstream_of_or_within ISO (PMID:16831897) MGI PMID:16831897 NCBI chrNW_004955542:1,959,765...2,000,665
Ensembl chrNW_004955542:1,959,765...2,000,665 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) UniProt PMID:24691993 NCBI chrNW_004955437:19,716,466...19,743,428 JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in ISO (PMID:18178554)
(PMID:21616078)		 BHF-UCL
UniProt		 PMID:18178554 PMID:21616078 NCBI chrNW_004955452:15,306,398...15,314,959
Ensembl chrNW_004955452:15,305,775...15,314,959 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12572
    negative regulation of biological process 4799
      negative regulation of multicellular organismal process 1124
        negative regulation of cytokine production 277
          negative regulation of tumor necrosis factor superfamily cytokine production 66
            negative regulation of tumor necrosis factor production 65
Path 2
Term Annotations click to browse term
  biological_process 12572
    biological regulation 9067
      regulation of biological process 8766
        regulation of cellular process 8474
          regulation of metabolic process 5075
            regulation of biosynthetic process 3915
              regulation of macromolecule biosynthetic process 3726
                regulation of gene expression 3616
                  regulation of cytokine production 702
                    regulation of tumor necrosis factor superfamily cytokine production 173
                      regulation of tumor necrosis factor production 169
                        negative regulation of tumor necrosis factor production 65
paths to the root