Axl (AXL receptor tyrosine kinase) - Rat Genome Database

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Gene: Axl (AXL receptor tyrosine kinase) Chinchilla lanigera
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Symbol: Axl
Name: AXL receptor tyrosine kinase
RGD ID: 8790519
Description: ENCODES a protein that exhibits myosin heavy chain binding (ortholog); phosphatidylinositol 3-kinase binding (ortholog); phosphatidylserine binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); apoptotic process (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH amenorrhea (ortholog); Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (ortholog); cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase receptor UFO
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic cell clearance  (ISO)
apoptotic process  (ISO)
blood vessel remodeling  (ISO)
cell differentiation  (ISO)
cell maturation  (ISO)
cellular response to extracellular stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interferon-alpha  (ISO)
cellular response to lipopolysaccharide  (ISO)
dendritic cell differentiation  (ISO)
enzyme-linked receptor protein signaling pathway  (ISO)
erythrocyte homeostasis  (ISO)
establishment of localization in cell  (ISO)
forebrain cell migration  (ISO)
inflammatory response  (ISO)
lymphocyte activation  (ISO)
natural killer cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of interferon-gamma production  (ISO)
negative regulation of lymphocyte activation  (ISO)
negative regulation of macrophage cytokine production  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
neuron apoptotic process  (ISO)
neuron migration  (ISO)
neutrophil clearance  (ISO)
ovulation cycle  (ISO)
phagocytosis  (ISO)
platelet activation  (ISO)
positive regulation of cytokine-mediated signaling pathway  (ISO)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of pinocytosis  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of viral life cycle  (ISO)
protein kinase B signaling  (ISO)
response to axon injury  (ISO)
secretion by cell  (ISO)
spermatogenesis  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
vagina development  (ISO)
viral entry into host cell  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Axl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBIChiLan1.0ChiLan1.0
AXL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,219,223 - 41,261,766 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1941,219,223 - 41,261,766 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,725,128 - 41,767,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,416,948 - 46,459,511 (+)NCBINCBI36hg18NCBI36
Build 341946,416,662 - 46,459,510NCBI
Celera1938,525,268 - 38,567,818 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,157,135 - 38,200,127 (+)NCBIHuRef
CHM1_11941,724,837 - 41,767,370 (+)NCBICHM1_1
T2T-CHM13v2.01944,040,107 - 44,082,625 (+)NCBI
Axl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,455,925 - 25,488,502 (-)NCBIGRCm39mm39
GRCm39 Ensembl725,456,698 - 25,488,130 (-)Ensembl
GRCm38725,756,500 - 25,788,924 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,757,273 - 25,788,705 (-)EnsemblGRCm38mm10GRCm38
MGSCv37726,542,292 - 26,573,560 (-)NCBIGRCm37mm9NCBIm37
MGSCv36725,466,033 - 25,497,301 (-)NCBImm8
Celera720,366,185 - 20,397,512 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.02NCBI
Axl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,265,656 - 81,296,278 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl181,265,088 - 81,296,265 (-)Ensembl
Rnor_6.0182,550,892 - 82,580,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl182,549,420 - 82,580,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0183,812,118 - 83,840,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,964,751 - 80,994,300 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,045,570 - 81,045,733 (-)NCBI
Celera175,705,827 - 75,734,332 (-)NCBICelera
Cytogenetic Map1q21NCBI
AXL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11946,719,615 - 46,761,747 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,719,615 - 46,761,747 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01938,211,555 - 38,254,464 (+)NCBIMhudiblu_PPA_v0panPan3
AXL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,699,679 - 112,727,434 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,700,365 - 112,726,960 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,104,006 - 112,130,669 (-)NCBI
ROS_Cfam_1.01113,298,102 - 113,324,981 (-)NCBI
ROS_Cfam_1.0 Ensembl1113,297,567 - 113,324,929 (-)Ensembl
UMICH_Zoey_3.11112,859,212 - 112,885,893 (-)NCBI
UNSW_CanFamBas_1.01112,491,561 - 112,518,264 (-)NCBI
UU_Cfam_GSD_1.01113,484,923 - 113,511,641 (-)NCBI
Axl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934915,229,833 - 15,259,221 (+)NCBI
SpeTri2.0NW_0049366613,658,140 - 3,687,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,245,673 - 49,277,914 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,245,802 - 49,277,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,979,820 - 45,009,909 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2645,072,278 - 45,073,025 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AXL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,537,718 - 35,580,143 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl635,537,773 - 35,580,716 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607313,772,922 - 13,815,487 (+)NCBIVero_WHO_p1.0
Axl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462490777,806 - 106,228 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462490776,236 - 106,765 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000002341   ⟹   ENSCLAP00000002292
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955555189,174 - 218,565 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000002342   ⟹   ENSCLAP00000002293
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955555189,445 - 218,509 (+)Ensembl
RefSeq Acc Id: XM_005412322   ⟹   XP_005412379
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955555189,446 - 218,509 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005412323   ⟹   XP_005412380
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955555189,445 - 218,509 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005412379 (Get FASTA)   NCBI Sequence Viewer  
  XP_005412380 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005412380   ⟸   XM_005412323
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005412379   ⟸   XM_005412322
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000002293   ⟸   ENSCLAT00000002342
RefSeq Acc Id: ENSCLAP00000002292   ⟸   ENSCLAT00000002341

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001659 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000002292 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAP00000002293 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002341 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAT00000002342 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene Axl ENTREZGENE
Pfam fn3 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2ULD9_CHILA UniProtKB/TrEMBL
  A0A8C2URZ0_CHILA UniProtKB/TrEMBL