Trem2 (triggering receptor expressed on myeloid cells 2) - Rat Genome Database

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Gene: Trem2 (triggering receptor expressed on myeloid cells 2) Chinchilla lanigera
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Symbol: Trem2
Name: triggering receptor expressed on myeloid cells 2
RGD ID: 8827192
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); apolipoprotein A-I binding (ortholog); apolipoprotein binding (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); amyloid-beta clearance by cellular catabolic process (ortholog); apoptotic cell clearance (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); dementia (ortholog); Nasu-Hakola disease (ortholog); FOUND IN integral component of membrane (ortholog); integral component of plasma membrane (ortholog); intrinsic component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,780,679 - 7,785,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554377,780,886 - 7,785,597 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
amyloid-beta clearance by cellular catabolic process  (ISO)
apoptotic cell clearance  (ISO)
astrocyte activation  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipoteichoic acid  (ISO)
cellular response to oxidised low-density lipoprotein particle stimulus  (ISO)
cellular response to peptidoglycan  (ISO)
complement-mediated synapse pruning  (ISO)
CXCL12-activated CXCR4 signaling pathway  (ISO)
defense response to bacterium  (ISO)
defense response to Gram-negative bacterium  (ISO)
dendritic cell differentiation  (ISO)
dendritic spine maintenance  (ISO)
detection of lipopolysaccharide  (ISO)
detection of lipoteichoic acid  (ISO)
detection of peptidoglycan  (ISO)
excitatory synapse pruning  (ISO)
import into cell  (ISO)
lipid homeostasis  (ISO)
memory  (ISO)
microglial cell activation  (ISO)
microglial cell activation involved in immune response  (ISO)
microglial cell proliferation  (ISO)
negative regulation of amyloid fibril formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of astrocyte activation  (ISO)
negative regulation of autophagic cell death  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of cell activation  (ISO)
negative regulation of cholesterol storage  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of fat cell proliferation  (ISO)
negative regulation of glial cell apoptotic process  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of macrophage colony-stimulating factor signaling pathway  (ISO)
negative regulation of neuroinflammatory response  (ISO)
negative regulation of NLRP3 inflammasome complex assembly  (ISO)
negative regulation of p38MAPK cascade  (ISO)
negative regulation of phosphatidylinositol 3-kinase signaling  (ISO)
negative regulation of sequestering of triglyceride  (ISO)
negative regulation of toll-like receptor 2 signaling pathway  (ISO)
negative regulation of toll-like receptor 4 signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
neuroinflammatory response  (ISO)
osteoclast differentiation  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of amyloid-beta clearance  (ISO)
positive regulation of antigen processing and presentation of peptide antigen via MHC class II  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of C-C chemokine receptor CCR7 signaling pathway  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of CAMKK-AMPK signaling cascade  (ISO)
positive regulation of CD40 signaling pathway  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of complement activation, classical pathway  (ISO)
positive regulation of engulfment of apoptotic cell  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of establishment of protein localization  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of high-density lipoprotein particle clearance  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of inward rectifier potassium channel activity  (ISO)
positive regulation of kinase activity  (ISO)
positive regulation of low-density lipoprotein particle clearance  (ISO)
positive regulation of macrophage fusion  (ISO)
positive regulation of microglial cell activation  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of mitochondrion organization  (ISO)
positive regulation of neuroinflammatory response  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of synapse pruning  (ISO)
positive regulation of TOR signaling  (ISO)
pyroptosis  (ISO)
regulation of cytokine production involved in inflammatory response  (ISO)
regulation of gene expression  (ISO)
regulation of hippocampal neuron apoptotic process  (ISO)
regulation of innate immune response  (ISO)
regulation of interleukin-6 production  (ISO)
regulation of intracellular signal transduction  (ISO)
regulation of macrophage inflammatory protein 1 alpha production  (ISO)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of plasma membrane bounded cell projection organization  (ISO)
regulation of resting membrane potential  (ISO)
regulation of toll-like receptor 6 signaling pathway  (ISO)
regulation of TOR signaling  (ISO)
respiratory burst after phagocytosis  (ISO)
response to axon injury  (ISO)
response to ischemia  (ISO)
social behavior  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Trem2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,780,679 - 7,785,697 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554377,780,886 - 7,785,597 (-)NCBIChiLan1.0ChiLan1.0
TREM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl641,158,506 - 41,163,186 (-)EnsemblGRCh38hg38GRCh38
GRCh38641,158,508 - 41,163,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,126,246 - 41,130,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,234,230 - 41,238,892 (-)NCBINCBI36hg18NCBI36
Build 34641,234,230 - 41,238,892NCBI
Celera642,678,948 - 42,683,624 (-)NCBI
Cytogenetic Map6p21.1NCBI
HuRef640,844,044 - 40,848,724 (-)NCBIHuRef
CHM1_1641,129,139 - 41,133,819 (-)NCBICHM1_1
Trem2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,653,429 - 48,659,304 (+)NCBIGRCm39mm39
GRCm39 Ensembl1748,653,429 - 48,661,175 (+)Ensembl
GRCm381748,346,401 - 48,352,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,346,401 - 48,354,147 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,485,726 - 48,491,598 (+)NCBIGRCm37mm9NCBIm37
MGSCv361747,811,968 - 47,817,840 (+)NCBImm8
Celera1751,775,275 - 51,781,147 (+)NCBICelera
Cytogenetic Map17CNCBI
Trem2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2912,647,605 - 12,654,190 (-)NCBI
Rnor_6.0 Ensembl914,611,561 - 14,618,013 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0914,611,541 - 14,618,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0913,532,905 - 13,539,382 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,059,023 - 8,065,585 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.198,059,020 - 8,065,484 (-)NCBI
Celera910,419,918 - 10,426,480 (-)NCBICelera
Cytogenetic Map9q12NCBI
TREM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1642,043,887 - 42,048,578 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,043,900 - 42,048,578 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0640,735,483 - 40,740,208 (-)NCBIMhudiblu_PPA_v0panPan3
Trem2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,295,126 - 45,300,504 (-)NCBI
SpeTri2.0NW_00493647618,659,725 - 18,665,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,464,034 - 36,471,516 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,465,921 - 36,471,509 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,763,412 - 41,767,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREM2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,965,091 - 30,999,073 (+)NCBI
ChlSab1.1 Ensembl1730,994,357 - 30,999,087 (+)Ensembl
Vero_WHO_p1.0NW_02366604441,158,611 - 41,163,469 (-)NCBI
Trem2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475417,643,397 - 17,649,255 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014081   ⟹   ENSCLAP00000013925
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554377,780,679 - 7,785,697 (-)Ensembl
RefSeq Acc Id: XM_005389679   ⟹   XP_005389736
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554377,780,886 - 7,785,597 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005389736 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005389736   ⟸   XM_005389679
- Sequence:
RefSeq Acc Id: ENSCLAP00000013925   ⟸   ENSCLAT00000014081


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009639 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000013925 ENTREZGENE
Ensembl Transcript ENSCLAT00000014081 ENTREZGENE
NCBI Gene Trem2 ENTREZGENE