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ONTOLOGY REPORT - ANNOTATIONS

Term:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
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Accession:GO:0031146 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
Synonyms:exact_synonym: SCF-dependent proteasomal ubiquitin-dependent protein breakdown;   SCF-dependent proteasomal ubiquitin-dependent protein catabolism;   SCF-dependent proteasomal ubiquitin-dependent protein degradation


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SCF-dependent proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amn1 antagonist of mitotic exit network 1 homolog involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:182,155,140...182,182,085
Ensembl chr 4:182,155,142...182,182,016 		JBrowse link
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within		 ISO (MGI:5299399|PMID:21911472)
(PMID:22017875), (PMID:22017876), (PMID:22017877), (PMID:36608670)
(PMID:32558204)		 RGD PMID:21911472 PMID:22017875 PMID:22017876 PMID:22017877 PMID:32558204 More... MGI:5299399 NCBI chr 1:244,210,299...244,380,126
Ensembl chr 1:244,210,314...244,376,721 		JBrowse link
G Ccnf cyclin F involved_in ISS
ISO		 GO_REF:0000024
(PMID:20596027), (PMID:25557911)		 UniProt
RGD		 PMID:20596027 PMID:25557911 GO_REF:0000024 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Cul1 cullin 1 involved_in ISO
IBA		 (MGI:4821082|PMID:12140560)
(PMID:11961546), (PMID:15103331), (PMID:22017875), (PMID:22017876), (PMID:36608670)
GO_REF:0000033		 RGD
GO_Central		 PMID:11961546 PMID:12140560 PMID:15103331 PMID:22017875 PMID:22017876 More... GO_REF:0000033 MGI:4821082 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980 		JBrowse link
G Cul2 cullin 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968 		JBrowse link
G Cul5 cullin 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666 		JBrowse link
G Dmac2 distal membrane arm assembly component 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:81,128,760...81,134,810
Ensembl chr 1:81,128,857...81,134,812 		JBrowse link
G Fbxl15 F-box and leucine-rich repeat protein 15 involved_in ISO
ISS
IBA		 (PMID:21572392)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:21572392 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:245,189,732...245,191,973
Ensembl chr 1:245,189,736...245,192,007 		JBrowse link
G Fbxl16 F-box and leucine-rich repeat protein 16 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:14,829,453...14,841,739
Ensembl chr10:14,829,449...14,840,986 		JBrowse link
G Fbxl17 F-box and leucine-rich repeat protein 17 involved_in ISO (PMID:24035498), (PMID:27234298) RGD PMID:24035498 PMID:27234298 NCBI chr 9:102,780,573...103,206,978
Ensembl chr 9:102,782,440...103,208,950 		JBrowse link
G Fbxl18 F-box and leucine-rich repeat protein 18 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:11,674,538...11,701,317
Ensembl chr12:11,676,115...11,699,181 		JBrowse link
G Fbxl18l1 F-box and leucine-rich repeat protein 18 like 1 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:95,460,480...95,464,873
Ensembl chr 5:95,462,188...95,465,129 		JBrowse link
G Fbxl2 F-box and leucine-rich repeat protein 2 involved_in ISO
IBA		 (PMID:23604317), (PMID:26037928)
(MGI:5488521|PMID:23542741)
GO_REF:0000033		 RGD
GO_Central		 PMID:23542741 PMID:23604317 PMID:26037928 GO_REF:0000033 MGI:5488521 NCBI chr 8:113,916,660...113,965,137
Ensembl chr 8:113,913,373...113,965,066 		JBrowse link
G Fbxl21 F-box and leucine-rich repeat protein 21 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:8,060,412...8,077,415
Ensembl chr17:8,060,414...8,073,359 		JBrowse link
G Fbxl22 F-box and leucine-rich repeat protein 22 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:67,069,998...67,076,685
Ensembl chr 8:67,069,998...67,076,685 		JBrowse link
G Fbxl3 F-box and leucine-rich repeat protein 3 involved_in ISO
IBA		 (PMID:17463251)
(MGI:5470183|PMID:23452855), (MGI:5487698|PMID:23452856)
GO_REF:0000033		 RGD
GO_Central		 PMID:17463251 PMID:23452855 PMID:23452856 GO_REF:0000033 MGI:5470183 MGI:5487698 NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867 		JBrowse link
G Fbxl4 F-box and leucine-rich repeat protein 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:35,955,801...36,029,446
Ensembl chr 5:35,955,812...36,029,443 		JBrowse link
G Fbxl5 F-box and leucine-rich repeat protein 5 involved_in ISO
IBA		 (PMID:17532294), (PMID:19762596), (PMID:19762597)
GO_REF:0000033		 RGD
GO_Central		 PMID:17532294 PMID:19762596 PMID:19762597 GO_REF:0000033 NCBI chr14:67,305,109...67,347,383
Ensembl chr14:67,267,801...67,347,383 		JBrowse link
G Fbxl6 F-box and leucine-rich repeat protein 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,259,097...108,262,528
Ensembl chr 7:108,257,160...108,262,513 		JBrowse link
G Fbxl7 F-box and leucine-rich repeat protein 7 involved_in ISO
IBA		 (PMID:25778398), (PMID:28218735)
(MGI:5426128|PMID:22306998), (MGI:6368091|PMID:25778398)
GO_REF:0000033		 RGD
GO_Central		 PMID:22306998 PMID:25778398 PMID:28218735 GO_REF:0000033 MGI:5426128 MGI:6368091 NCBI chr 2:77,139,775...77,509,223
Ensembl chr 2:77,140,826...77,509,223 		JBrowse link
G Fbxl8 F-box and leucine-rich repeat protein 8 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:33,142,705...33,147,266
Ensembl chr19:33,142,715...33,147,262 		JBrowse link
G Fbxo17 F-box protein 17 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:84,002,276...84,024,455
Ensembl chr 1:84,002,267...84,024,453 		JBrowse link
G Fbxo2 F-box protein 2 involved_in ISO
IBA		 (MGI:4821082|PMID:12140560)
GO_REF:0000033		 RGD
GO_Central		 PMID:12140560 GO_REF:0000033 MGI:4821082 NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355 		JBrowse link
G Fbxo27 F-box protein 27 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:83,965,426...83,987,781
Ensembl chr 1:83,965,986...83,987,778 		JBrowse link
G Fbxo3 F-box protein 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5488521|PMID:23542741)
(PMID:26037928)		 UniProt
RGD		 PMID:23542741 PMID:26037928 GO_REF:0000024 MGI:5488521 NCBI chr 3:90,417,262...90,449,557
Ensembl chr 3:90,417,297...90,449,557 		JBrowse link
G Fbxo31 F-box protein 31 involved_in ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:19412162)
GO_REF:0000107
GO_REF:0000033		 UniProt
RGD
Ensembl
GO_Central		 PMID:19412162 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr19:49,624,813...49,656,052
Ensembl chr19:49,627,686...49,656,010 		JBrowse link
G Fbxo38 F-box protein 38 involved_in ISO
IBA		 (PMID:30487606)
GO_REF:0000033		 RGD
GO_Central		 PMID:30487606 GO_REF:0000033 NCBI chr18:55,956,950...56,004,013
Ensembl chr18:55,956,959...56,003,961 		JBrowse link
G Fbxo39 F-box protein 39 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:56,929,699...56,934,911
Ensembl chr10:56,932,297...56,934,906 		JBrowse link
G Fbxo4 F-box protein 4 involved_in ISO
IBA		 (PMID:20159592), (PMID:29142209)
GO_REF:0000033		 RGD
GO_Central		 PMID:20159592 PMID:29142209 GO_REF:0000033 NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792 		JBrowse link
G Fbxo44 F-box protein 44 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:158,583,363...158,592,510
Ensembl chr 5:158,583,366...158,592,363 		JBrowse link
G Fbxo48 F-box protein 48 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:91,380,857...91,382,314
Ensembl chr14:91,380,857...91,382,314 		JBrowse link
G Fbxo6 F-box protein 6 involved_in ISO
ISS
IBA		 (PMID:19716789)
GO_REF:0000024
(MGI:2679753|PMID:12939278)
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:12939278 PMID:19716789 GO_REF:0000024 GO_REF:0000033 MGI:2679753 NCBI chr 5:158,576,729...158,582,520
Ensembl chr 5:158,576,759...158,582,525 		JBrowse link
G Fbxo9 f-box protein 9 involved_in ISO
ISS
IEA
IBA		 (PMID:23263282)
GO_REF:0000024
GO_REF:0000104
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:23263282 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr 8:78,958,482...78,984,015
Ensembl chr 8:78,958,483...78,983,949 		JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 involved_in ISO (MGI:2176150|PMID:11896578)
(PMID:20347421), (PMID:22017875), (PMID:22017876), (PMID:36608670)		 RGD PMID:11896578 PMID:20347421 PMID:22017875 PMID:22017876 PMID:36608670 MGI:2176150 NCBI chr10:17,232,735...17,330,574
Ensembl chr10:17,227,181...17,330,571 		JBrowse link
G Fbxw4 F-box and WD repeat domain containing 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:244,426,892...244,514,188
Ensembl chr 1:244,426,896...244,514,163 		JBrowse link
G Fbxw5 F-box and WD repeat domain containing 5 involved_in ISS
ISO		 GO_REF:0000024
(PMID:21725316)
(MGI:5476881|PMID:23314863)		 UniProt
RGD		 PMID:21725316 PMID:23314863 GO_REF:0000024 MGI:5476881 NCBI chr 3:8,322,543...8,327,092
Ensembl chr 3:8,322,543...8,327,092 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISS
ISO		 PMID:21953459
(MGI:6107392|PMID:21953459)
(PMID:28007894)
(PMID:15103331), (PMID:17434132)		 RGD PMID:15103331 PMID:17434132 PMID:21953459 PMID:28007894 PMID:21953459 MGI:6107392, RGD:13464262 NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Kif14 kinesin family member 14 involved_in ISO (PMID:24854087) RGD PMID:24854087 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164 		JBrowse link
G Lrrc29 leucine rich repeat containing 29 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:33,181,713...33,203,583
Ensembl chr19:33,188,352...33,203,545 		JBrowse link
G Nccrp1 NCCRP1, F-box associated domain containing involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:83,835,083...83,838,620
Ensembl chr 1:83,835,083...83,838,676 		JBrowse link
G Rbx1 ring-box 1 involved_in ISO (MGI:4821082|PMID:12140560)
(PMID:15103331), (PMID:22017875), (PMID:22017876), (PMID:36608670)		 RGD PMID:12140560 PMID:15103331 PMID:22017875 PMID:22017876 PMID:36608670 MGI:4821082 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(PMID:15103331), (PMID:20347421)
(MGI:4821082|PMID:12140560)
GO_REF:0000033		 UniProt
Ensembl
RGD
GO_Central		 PMID:12140560 PMID:15103331 PMID:20347421 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:4821082 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388 		JBrowse link
G Skp2 S-phase kinase associated protein 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Tmem249 transmembrane protein 249 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:108,256,535...108,259,429
Ensembl chr 7:108,257,160...108,262,513 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 acts_upstream_of_or_within ISO MGI:3759999 (PMID:17636028) RGD PMID:17636028 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968 		JBrowse link
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pabpn1l PABPN1 like acts_upstream_of_or_within ISO (PMID:32558204) RGD PMID:32558204 NCBI chr19:50,669,965...50,673,409
Ensembl chr19:50,669,967...50,673,366 		JBrowse link
G Styx serine/threonine/tyrosine interacting protein involved_in ISO
IBA		 (PMID:28007894)
GO_REF:0000033		 RGD
GO_Central		 PMID:28007894 GO_REF:0000033 NCBI chr15:18,565,214...18,595,797
Ensembl chr15:18,564,633...18,593,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    metabolic process 11456
      primary metabolic process 10016
        protein metabolic process 4606
          protein catabolic process 1065
            proteasomal protein catabolic process 538
              proteasome-mediated ubiquitin-dependent protein catabolic process 408
                SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 47
                  negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 2
                  positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 0
                  regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + 2
Path 2
Term Annotations click to browse term
  biological_process 19694
    metabolic process 11456
      organic substance metabolic process 10971
        organic substance catabolic process 2307
          organonitrogen compound catabolic process 1512
            protein catabolic process 1065
              proteolysis involved in protein catabolic process 795
                modification-dependent protein catabolic process 626
                  ubiquitin-dependent protein catabolic process 611
                    proteasome-mediated ubiquitin-dependent protein catabolic process 408
                      SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 47
                        negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 2
                        positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process 0
                        regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + 2
paths to the root