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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Helicobacter Infections
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Accession:DOID:9008114 term browser browse the term
Definition:Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Synonyms:exact_synonym: Helicobacter Infection
 related_synonym: HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO
 primary_id: MESH:D016481
 alt_id: OMIM:600263
 xref: EFO:1000961


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Helicobacter Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 no_association
sexual_dimorphism 		ISO DNA:haplotype: :3435T> C,2677T>G ,1236C>T (human)
associated with peptic ulcer disease;DNA:SNP: :3435C>T(human)		 RGD PMID:22001987 PMID:27611887 RGD:39456093 RGD:39456122 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ACE angiotensin I converting enzyme susceptibility ISO DNA:insertion/deletion:intron: RGD PMID:28746216 RGD:40400710 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
G ACVR1B activin A receptor type 1B disease_progression ISO associated with stomach cancer;mRNA:increased expression:stomach: RGD PMID:32066878 RGD:151665490 NCBI chr27:3,009,710...3,029,726
Ensembl chr27:2,994,857...3,042,396 		JBrowse link
G AICDA activation induced cytidine deaminase ISO protein:increased expression:mucosa of stomach (human) RGD PMID:23591766 RGD:127285627 NCBI chr27:37,064,107...37,073,791
Ensembl chr27:37,064,080...37,073,789 		JBrowse link
G ATM ATM serine/threonine kinase ISO associated with gastritis;mRNA:increased expression:mucosa of stomach (human)
associated with stomach cancer;mRNA:increased expression:stomach (human)		 RGD PMID:25069978 PMID:29128564 RGD:126790563 RGD:126790566 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 treatment ISO associated with stomach cancer
associated with MALT lymphoma;DNA:gene fusion: (human)		 RGD PMID:11398794 PMID:27282269 RGD:153297818 RGD:153305954 NCBI chr 5:29,324,893...29,343,322
Ensembl chr 5:29,325,331...29,337,240 		JBrowse link
G CCND2 cyclin D2 treatment ISO associated with Gastrointestinal Neoplasms or gastritis
mRNA:increased expression:stomach:		 RGD PMID:11552926 PMID:12133540 RGD:151665103 RGD:151665119 NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255 		JBrowse link
G CD1D CD1d molecule ISO associated with dyspepsia;mRNA:splice variant:pyloric antrum (human) RGD PMID:26119195 RGD:11074500 NCBI chr38:23,489,169...23,491,712 JBrowse link
G CDH1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19184424 NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:15138205 NCBI chr27:33,609,154...33,613,558
Ensembl chr27:33,611,760...33,612,906 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 disease_progression ISO associated with gastritis;mRNA:increased expression:stomach (mouse, Helicobacter felis)
mRNA:altered expression:gastric antrum (mouse)		 RGD PMID:17242461 PMID:29085807 RGD:38549339 RGD:38549349 NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354 		JBrowse link
G CYBB cytochrome b-245 beta chain disease_progression ISO mRNA,protein:increased expression:mucosa of stomach (human) RGD PMID:27048452 RGD:40924640 NCBI chr  X:32,533,365...32,568,149
Ensembl chr  X:32,533,320...32,568,217 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 treatment ISO RGD PMID:18571838 RGD:40903061 NCBI chr  X:60,462,290...60,513,155
Ensembl chr  X:60,463,526...60,464,548 		JBrowse link
G DLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility ISO associated with Purpura, Thrombocytopenic, Idiopathic;DNA:polymorphisms (human)
DNA:polymorphisms: :HLA-DQB1*301, HLA-DQB1*04(human)		 RGD PMID:15833172 PMID:16011982 RGD:36049761 RGD:5147649 NCBI chr12:2,305,307...2,307,711 JBrowse link
G DUOX2 dual oxidase 2 disease_progression ISO mRNA,protein:decreased expression:mucosa of stomach (human) RGD PMID:27048452 RGD:40924640 NCBI chr30:11,521,833...11,541,719
Ensembl chr30:11,521,845...11,541,716 		JBrowse link
G EGF epidermal growth factor treatment ISO associated with gastritis; RGD PMID:25051417 RGD:38599160 NCBI chr32:30,073,541...30,166,904
Ensembl chr32:30,073,950...30,166,295 		JBrowse link
G EGFR epidermal growth factor receptor treatment ISO associated with gastritis; RGD PMID:25051417 PMID:28473630 RGD:38599160 RGD:38599214 NCBI chr18:5,983,669...6,044,092
Ensembl chr18:5,982,770...6,042,631 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 treatment ISO associated with gastritis; RGD PMID:25051417 RGD:38599160 NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294 		JBrowse link
G F2R coagulation factor II thrombin receptor ISO RGD PMID:24866378 RGD:40924630 NCBI chr 3:29,870,159...29,889,837
Ensembl chr 3:29,872,155...29,889,687 		JBrowse link
G GAB1 GRB2 associated binding protein 1 susceptibility ISO DNA:SNP:intron: RGD PMID:17211494 RGD:39128202 NCBI chr19:10,269...117,808
Ensembl chr19:12,616...156,694 		JBrowse link
G HAMP hepcidin antimicrobial peptide treatment ISO RGD PMID:21757452 RGD:11041721 NCBI chr 1:117,305,531...117,306,587
Ensembl chr 1:117,305,411...117,306,619 		JBrowse link
G HLA-DRB1 MHC class II DLA DRB1 beta chain susceptibility ISO associated with Purpura, Thrombocytopenic, Idiopathic;DNA:polymorphisms (human)
DNA:polymorphisms: :HLA-DRB1*11, HLA-DRB1*12(human)		 RGD PMID:15833172 PMID:16011982 RGD:36049761 RGD:5147649 NCBI chr12:2,151,409...2,164,564 JBrowse link
G HMOX1 heme oxygenase 1 ISO RGD PMID:16100019 RGD:1598398 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773 		JBrowse link
G IFNG interferon gamma disease_progression ISO mRNA:altered expression:gastric antrum (mouse) RGD PMID:29085807 RGD:38549349 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IFNGR1 interferon gamma receptor 1 susceptibility ISO ClinVar Annotator: match by term: Helicobacter pylori infection, susceptibility to ClinVar
OMIM		 PMID:10192386 PMID:11583830 PMID:12516030 PMID:16690980 PMID:18171304 More... NCBI chr 1:29,646,776...29,669,669
Ensembl chr 1:29,647,552...29,669,578 		JBrowse link
G IL1B interleukin 1 beta disease_progression ISO mRNA:altered expression:gastric antrum (mouse) RGD PMID:29085807 RGD:38549349 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL21 interleukin 21 ISO mRNA, protein:increased expression:mucosa of stomach (human) RGD PMID:17442980 PMID:31383743 RGD:127285542 RGD:127285544 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G IL33 interleukin 33 severity ISO associated with Helicobacter Infections;DNA:SNP: : rs1929992(human)
mRNA:increased expression:stomach		 RGD PMID:31320834 PMID:31491552 RGD:39938849 RGD:39939030 NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721 		JBrowse link
G IL6 interleukin 6 disease_progression ISO mRNA:altered expression:gastric antrum (mouse) RGD PMID:29085807 RGD:38549349 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G LCN2 lipocalin 2 ISO protein:increased expression:gastric mucosa RGD PMID:19727808 RGD:126781713 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038 		JBrowse link
G LOC100855904 mucin-6 ISO protein:increased expression:stomach epithelium RGD PMID:15280409 RGD:7364760 NCBI chr18:45,359,412...45,376,678 JBrowse link
G LTB4R leukotriene B4 receptor treatment ISO RGD PMID:18571838 RGD:40903061 NCBI chr 8:4,282,924...4,286,869
Ensembl chr 8:4,285,323...4,286,534 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO protein:increased expression:pyloric antrum (human) RGD PMID:17643099 RGD:150340691 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MIR155 microRNA mir-155 ISO miRNA:increased expression:stomach RGD PMID:28560185 PMID:29250766 RGD:21408595 RGD:25671377 NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833 		JBrowse link
G MIR222 microRNA mir-222 ISO associated with stomach cancer;RNA:increased expression:stomach: RGD PMID:29227536 RGD:151708731 NCBI chr  X:39,524,519...39,524,608
Ensembl chr  X:39,524,519...39,524,608 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase susceptibility ISO associated with stomach cancer;DNA:missense mutation:cds:g.677C>T (human) RGD PMID:20957490 PMID:23183616 RGD:38501056 RGD:38501057 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor ISO RGD PMID:28201999 RGD:150519916 NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534 		JBrowse link
G PDCD1 programmed cell death 1 severity ISO RGD PMID:21562113 RGD:40818417 NCBI chr25:51,606,559...51,618,903
Ensembl chr25:51,608,173...51,618,723 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28220687 NCBI chr 4:68,579,061...68,614,548
Ensembl chr 4:68,579,037...68,611,841 		JBrowse link
G PSCA prostate stem cell antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:28220687 NCBI chr13:36,773,434...36,776,740
Ensembl chr13:36,773,875...36,776,194 		JBrowse link
G PTEN phosphatase and tensin homolog ISO associated with gastritis;protein:increased phosphorylation:stomach (human) RGD PMID:26376616 RGD:127285599 NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 susceptibility ISO DNA:SNP:intron: rs2301756(human) RGD PMID:19589142 RGD:39128247 NCBI chr26:9,989,218...10,072,245
Ensembl chr26:9,989,425...10,067,481 		JBrowse link
G PTPRZ1 protein tyrosine phosphatase receptor type Z1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17030583 NCBI chr14:59,769,553...59,944,111
Ensembl chr14:59,827,650...59,943,315 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 ISO DNA:repeats:promoter: RGD PMID:24720453 RGD:36947385 NCBI chr 9:44,224,026...44,259,655
Ensembl chr 9:44,224,229...44,259,736 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO mRNA, protein:increased expression RGD PMID:17405912 RGD:1625683 NCBI chr 9:2,859,267...2,859,944 JBrowse link
G TFF1 trefoil factor 1 disease_progression ISO mRNA:altered expression:gastric antrum (mouse) RGD PMID:29085807 RGD:38549349 NCBI chr31:36,681,478...36,684,571
Ensembl chr31:36,681,357...36,695,665 		JBrowse link
G TFF2 trefoil factor 2 disease_progression ISO protein:increased expression:stomach epithelium
mRNA:altered expression:gastric antrum (mouse)		 RGD PMID:15280409 PMID:29085807 RGD:38549349 RGD:7364760 NCBI chr31:36,665,647...36,668,423
Ensembl chr31:36,665,514...36,668,440 		JBrowse link
G TFF3 trefoil factor 3 disease_progression ISO mRNA:altered expression:gastric antrum (mouse) RGD PMID:29085807 RGD:38549349 NCBI chr31:36,638,762...36,641,696 JBrowse link
G TFRC transferrin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16733738 PMID:17163184 NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242 		JBrowse link
G VIP vasoactive intestinal peptide ISO protein:increased expression:spinal cord, stomach RGD PMID:19906107 RGD:5685602 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  disease 17773
    disease by infectious agent 2130
      Bacterial Infections and Mycoses 1009
        bacterial infectious disease 798
          Gram-Negative Bacterial Infections 188
            Helicobacter Infections 50
              Cystic Fibrosis with Helicobacter Pylori Gastritis, Megaloblastic Anemia, and Subnormal Mentality 0
              Lubani Al Saleh Teebi Syndrome 0
paths to the root