RGD Reference Report - Expression of CD25(high) regulatory T cells and PD-1 in gastric infiltrating CD4(+) T lymphocytes in patients with Helicobacter pylori infection. - Rat Genome Database

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Expression of CD25(high) regulatory T cells and PD-1 in gastric infiltrating CD4(+) T lymphocytes in patients with Helicobacter pylori infection.

Authors: Wu, Yi-Ying  Chen, Jiunn-Horng  Kao, Jung-Ta  Liu, Kuo-Ching  Lai, Chih-Ho  Wang, Yuan-Min  Hsieh, Chin-Tung  Tzen, Jason T C  Hsu, Ping-Ning 
Citation: Wu YY, etal., Clin Vaccine Immunol. 2011 Jul;18(7):1198-201. doi: 10.1128/CVI.00422-10. Epub 2011 May 11.
RGD ID: 40818417
Pubmed: PMID:21562113   (View Abstract at PubMed)
PMCID: PMC3147316   (View Article at PubMed Central)
DOI: DOI:10.1128/CVI.00422-10   (Journal Full-text)

We observed by flow cytometry that the frequency of both gastric infiltrating Tregs and PD-1-positive CD4 T cells is correlated with the density of Helicobacter pylori, suggesting that cellular immunity against this pathogen is inhibited.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Helicobacter Infections severityIEP 40818417 RGD 
Helicobacter Infections severityISOPDCD1 (Homo sapiens)40818417; 40818417 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdcd1  (programmed cell death 1)

Genes (Mus musculus)
Pdcd1  (programmed cell death 1)

Genes (Homo sapiens)
PDCD1  (programmed cell death 1)


Additional Information