RGD Reference Report - Expression of suppressors of cytokine signaling-3 in Helicobacter pylori-infected rat gastric mucosal RGM-1cells. - Rat Genome Database

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Expression of suppressors of cytokine signaling-3 in Helicobacter pylori-infected rat gastric mucosal RGM-1cells.

Authors: Cha, B  Kim, KH  Matsui, H  Kim, H 
Citation: Cha B, etal., Ann N Y Acad Sci. 2007 Jan;1096:24-8.
RGD ID: 1625683
Pubmed: PMID:17405912   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1397.066   (Journal Full-text)

Our previous studies show that Helicobacter pylori (H. pylori) induces oxidative stress and the expression of proinflammatory cytokines in gastric epithelial cells. H. pylori induces the expression of molecular chaperones and proteins involved in protein-folding machinery as a defense mechanism against cellular stress. The suppressors of cytokine signaling (SOCS) are known as negative regulators of major immune signal pathways. The purpose of this article is to determine whether H. pylori in a Korean isolate (HP99) induces the expression of SOCS in rat gastric mucosal RGM-1 cells as a defense mechanism. As a result, HP99 induced SOCS-3 expression time-dependently in RGM-1 cells. SOCS-1 was not expressed while SOCS-2 expression was not changed by HP99 infection in RGM-1 cells. SOCS-3 might have a defensive role in H. pylori-infected gastric mucosal cells. Further study by manipulating SOCS-3 gene should be performed to investigate the physiological meaning of SOCS-3 induced by H. pylori in gastric mucosal cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SOCS3HumanHelicobacter Infections  ISOSocs3 (Rattus norvegicus)mRNA and protein:increased expressionRGD 
Socs3RatHelicobacter Infections  IEP mRNA and protein:increased expressionRGD 
Socs3MouseHelicobacter Infections  ISOSocs3 (Rattus norvegicus)mRNA and protein:increased expressionRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Socs3Ratresponse to bacterium  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Socs3  (suppressor of cytokine signaling 3)

Genes (Mus musculus)
Socs3  (suppressor of cytokine signaling 3)

Genes (Homo sapiens)
SOCS3  (suppressor of cytokine signaling 3)


Additional Information