PTPRZ1 (protein tyrosine phosphatase receptor type Z1) - Rat Genome Database

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Gene: PTPRZ1 (protein tyrosine phosphatase receptor type Z1) Canis lupus familiaris
Analyze
Symbol: PTPRZ1
Name: protein tyrosine phosphatase receptor type Z1
RGD ID: 12223899
Description: ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); phosphatase activity (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN axonal fasciculation (ortholog); axonogenesis (ortholog); hematopoietic progenitor cell differentiation (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Brain Hypoxia-Ischemia (ortholog); Brain Injuries (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); dendritic spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein tyrosine phosphatase, receptor-type, Z polypeptide 1; receptor-type tyrosine-protein phosphatase zeta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11459,769,553 - 59,944,111 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1459,827,650 - 59,943,315 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1459,203,408 - 59,361,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01459,825,102 - 59,979,392 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1459,863,616 - 59,979,379 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11459,916,795 - 60,071,051 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01459,543,462 - 59,698,673 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01459,919,950 - 60,076,006 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPRZ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11459,769,553 - 59,944,111 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1459,827,650 - 59,943,315 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1459,203,408 - 59,361,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01459,825,102 - 59,979,392 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1459,863,616 - 59,979,379 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11459,916,795 - 60,071,051 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01459,543,462 - 59,698,673 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01459,919,950 - 60,076,006 (+)NCBIUU_Cfam_GSD_1.0
PTPRZ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387121,873,161 - 122,062,036 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7121,873,089 - 122,062,036 (+)EnsemblGRCh38hg38GRCh38
GRCh377121,513,215 - 121,702,090 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367121,300,395 - 121,489,326 (+)NCBINCBI36Build 36hg18NCBI36
Build 347121,107,357 - 121,296,039NCBI
Celera7116,322,385 - 116,511,311 (+)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7115,876,018 - 116,065,533 (+)NCBIHuRef
CHM1_17121,446,481 - 121,635,390 (+)NCBICHM1_1
T2T-CHM13v2.07123,189,006 - 123,377,936 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27120,907,807 - 121,096,757 (+)NCBI
Ptprz1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39622,875,302 - 23,052,915 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl622,875,501 - 23,052,915 (+)EnsemblGRCm39 Ensembl
GRCm38622,875,315 - 23,052,916 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl622,875,502 - 23,052,916 (+)EnsemblGRCm38mm10GRCm38
MGSCv37622,825,502 - 23,002,916 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36622,825,503 - 23,002,917 (+)NCBIMGSCv36mm8
Celera622,923,288 - 23,100,277 (+)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map69.92NCBI
Ptprz1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8452,363,006 - 52,560,905 (+)NCBIGRCr8
mRatBN7.2451,397,316 - 51,595,220 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl451,397,601 - 51,595,218 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx456,378,267 - 56,560,689 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0452,299,317 - 52,481,722 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0450,726,932 - 50,924,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0449,941,046 - 50,140,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl449,941,304 - 50,140,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0449,730,302 - 49,927,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4449,267,521 - 49,468,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1449,498,094 - 49,699,266 (+)NCBI
Celera446,598,237 - 46,787,500 (+)NCBICelera
Cytogenetic Map4q22NCBI
Ptprz1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554793,624,993 - 3,733,183 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554793,611,658 - 3,734,225 (+)NCBIChiLan1.0ChiLan1.0
PTPRZ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26158,743,511 - 158,934,195 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1710,753,753 - 10,944,449 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07113,882,557 - 114,073,283 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17126,569,630 - 126,758,155 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7126,569,630 - 126,758,155 (+)Ensemblpanpan1.1panPan2
Ptprz1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511848,835,842 - 49,007,255 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366053,196,548 - 3,368,175 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366053,195,893 - 3,368,102 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRZ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1825,045,742 - 25,168,053 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11825,046,027 - 25,228,276 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21826,650,579 - 26,832,837 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRZ1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12190,686,091 - 90,877,538 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2190,686,167 - 90,877,649 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604212,666,623 - 12,858,179 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptprz1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478313,912,332 - 14,105,292 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478313,911,525 - 14,105,403 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTPRZ1
3894 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000005646   ⟹   ENSCAFP00000005230
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1459,828,237 - 59,943,315 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000045335   ⟹   ENSCAFP00000038572
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1459,828,237 - 59,943,315 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000061948   ⟹   ENSCAFP00000058615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1459,827,650 - 59,943,315 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000068657   ⟹   ENSCAFP00000043960
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1459,870,806 - 59,943,315 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000078719   ⟹   ENSCAFP00000059908
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1459,915,407 - 59,943,315 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000092091   ⟹   ENSCAFP00000052052
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1459,828,237 - 59,943,315 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845024977   ⟹   ENSCAFP00845019647
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,863,616 - 59,979,379 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025203   ⟹   ENSCAFP00845019819
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,863,616 - 59,979,379 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025429   ⟹   ENSCAFP00845020018
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,864,100 - 59,979,379 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025482   ⟹   ENSCAFP00845020065
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,864,203 - 59,979,379 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025534   ⟹   ENSCAFP00845020102
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,864,203 - 59,979,379 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025648   ⟹   ENSCAFP00845020210
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,864,203 - 59,979,379 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025882   ⟹   ENSCAFP00845020398
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,864,203 - 59,979,379 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845025954   ⟹   ENSCAFP00845020458
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,864,203 - 59,979,379 (+)Ensembl
RefSeq Acc Id: XM_038434751   ⟹   XP_038290679
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1459,203,408 - 59,361,617 (+)NCBI
RefSeq Acc Id: XM_038494101   ⟹   XP_038350029
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11459,916,795 - 60,071,051 (+)NCBI
RefSeq Acc Id: XM_038556356   ⟹   XP_038412284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01459,919,950 - 60,076,006 (+)NCBI
RefSeq Acc Id: XM_038620283   ⟹   XP_038476211
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01459,543,462 - 59,698,673 (+)NCBI
RefSeq Acc Id: XM_038685960   ⟹   XP_038541888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01459,825,102 - 59,979,392 (+)NCBI
Ensembl Acc Id: ENSCAFP00000005230   ⟸   ENSCAFT00000005646
Ensembl Acc Id: ENSCAFP00000059908   ⟸   ENSCAFT00000078719
Ensembl Acc Id: ENSCAFP00000038572   ⟸   ENSCAFT00000045335
Ensembl Acc Id: ENSCAFP00000043960   ⟸   ENSCAFT00000068657
Ensembl Acc Id: ENSCAFP00000052052   ⟸   ENSCAFT00000092091
Ensembl Acc Id: ENSCAFP00000058615   ⟸   ENSCAFT00000061948
RefSeq Acc Id: XP_038350029   ⟸   XM_038494101
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038476211   ⟸   XM_038620283
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038541888   ⟸   XM_038685960
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QIR8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038290679   ⟸   XM_038434751
- Peptide Label: isoform X5
- UniProtKB: A0A8P0ST17 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412284   ⟸   XM_038556356
- Peptide Label: isoform X4
- UniProtKB: A0A8C0QCT5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845019647   ⟸   ENSCAFT00845024977
Ensembl Acc Id: ENSCAFP00845019819   ⟸   ENSCAFT00845025203
Ensembl Acc Id: ENSCAFP00845020102   ⟸   ENSCAFT00845025534
Ensembl Acc Id: ENSCAFP00845020065   ⟸   ENSCAFT00845025482
Ensembl Acc Id: ENSCAFP00845020458   ⟸   ENSCAFT00845025954
Ensembl Acc Id: ENSCAFP00845020210   ⟸   ENSCAFT00845025648
Ensembl Acc Id: ENSCAFP00845020398   ⟸   ENSCAFT00845025882
Ensembl Acc Id: ENSCAFP00845020018   ⟸   ENSCAFT00845025429
Protein Domains
Alpha-carbonic anhydrase   Fibronectin type-III   Protein-tyrosine phosphatase catalytic   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003510 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040007365 UniProtKB/TrEMBL
  ENSCAFG00845012086 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005646.6 UniProtKB/TrEMBL
  ENSCAFT00000045335.3 UniProtKB/TrEMBL
  ENSCAFT00000061948.2 UniProtKB/TrEMBL
  ENSCAFT00000068657.2 UniProtKB/TrEMBL
  ENSCAFT00000078719.2 UniProtKB/TrEMBL
  ENSCAFT00000092091.2 UniProtKB/TrEMBL
  ENSCAFT00000098451.1 UniProtKB/TrEMBL
  ENSCAFT00000101298.1 UniProtKB/TrEMBL
  ENSCAFT00040013715.1 UniProtKB/TrEMBL
  ENSCAFT00040013936.1 UniProtKB/TrEMBL
  ENSCAFT00845024977.1 UniProtKB/TrEMBL
  ENSCAFT00845025203.1 UniProtKB/TrEMBL
  ENSCAFT00845025429.1 UniProtKB/TrEMBL
  ENSCAFT00845025482 ENTREZGENE
  ENSCAFT00845025482.1 UniProtKB/TrEMBL
  ENSCAFT00845025534.1 UniProtKB/TrEMBL
  ENSCAFT00845025648.1 UniProtKB/TrEMBL
  ENSCAFT00845025882.1 UniProtKB/TrEMBL
  ENSCAFT00845025954.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.10.200.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Alpha_CARP_receptor-type UniProtKB/TrEMBL
  CA_dom UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Protein-Tyr_Phosphatase UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
NCBI Gene PTPRZ1 ENTREZGENE
PANTHER RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE ALPHA_CA_2 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
  SSF51069 UniProtKB/TrEMBL
  SSF52799 UniProtKB/TrEMBL
UniProt A0A8C0QCT5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QIR8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NHY1_CANLF UniProtKB/TrEMBL
  A0A8I3NN34_CANLF UniProtKB/TrEMBL
  A0A8I3NNB3_CANLF UniProtKB/TrEMBL
  A0A8I3NNJ4_CANLF UniProtKB/TrEMBL
  A0A8I3NQ16_CANLF UniProtKB/TrEMBL
  A0A8I3NW88_CANLF UniProtKB/TrEMBL
  A0A8I3NWE6_CANLF UniProtKB/TrEMBL
  A0A8I3S0L2_CANLF UniProtKB/TrEMBL
  A0A8P0P7R6_CANLF UniProtKB/TrEMBL
  A0A8P0P904_CANLF UniProtKB/TrEMBL
  A0A8P0PP99_CANLF UniProtKB/TrEMBL
  A0A8P0S955_CANLF UniProtKB/TrEMBL
  A0A8P0ST17 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SX60_CANLF UniProtKB/TrEMBL
  A0A8P0T4M1_CANLF UniProtKB/TrEMBL
  A0A8P0TV13_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54793 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 PTPRZ1  protein tyrosine phosphatase receptor type Z1    protein tyrosine phosphatase, receptor type Z1  Symbol and/or name change 5135510 APPROVED