RGD Reference Report - Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats. - Rat Genome Database

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Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats.

Authors: Hayashi, N  Oohira, A  Miyata, S 
Citation: Hayashi N, etal., Brain Res. 2005 Jul 19;1050(1-2):163-9.
RGD ID: 9590117
Pubmed: PMID:15982644   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2005.05.047   (Journal Full-text)

Receptor-type protein tyrosine phosphatase (RPTP) zeta/beta is a nervous tissue-specific chondroitin sulfate proteoglycan. In this study, we investigated the immunohistochemical localization of RPTPzeta/beta in adult rat cerebral cortex and hippocampus at light and electron microscopic levels. Double labeling immunofluorescence microscopy revealed that the immunoreactivity of RPTPzeta/beta was observed at MAP2-positive dendrites and PSD-95-positive spines of pyramidal neurons in the cerebral cortex and hippocampus. Electron microscopic observation demonstrated a strong immunoreactivity of RPTPzeta/beta at the postsynaptic membrane of dendritic spines and shafts, and its moderate immunoreactivity at the dendritic membrane. In cultured cortical neurons, the immunoreactivity of RPTPzeta/beta was observed at some of PSD-95-positive spines. These results demonstrate that RPTPzeta/beta is localized mainly at the postsynaptic membrane of pyramidal neurons in adult cerebral cortex and hippocampus.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ptprz1Ratdendritic spine  IDA  RGD 
Ptprz1Ratglutamatergic synapse is_active_inIDA PMID:15982644SynGO 
Ptprz1Ratpostsynaptic density membrane is_active_inIDA PMID:15982644SynGO 
Ptprz1Ratpostsynaptic membrane  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptprz1  (protein tyrosine phosphatase, receptor type Z1)


Additional Information