RGD Reference Report - Expression of brain specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the developing and adult hippocampus of Ihara's epileptic rats. - Rat Genome Database

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Expression of brain specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the developing and adult hippocampus of Ihara's epileptic rats.

Authors: Kurazono, S  Okamoto, M  Sakiyama, J  Mori, S  Nakata, Y  Fukuoka, J  Amano, S  Oohira, A  Matsui, H 
Citation: Kurazono S, etal., Brain Res. 2001 Apr 13;898(1):36-48.
RGD ID: 9589829
Pubmed: PMID:11292447   (View Abstract at PubMed)

Ihara's epileptic rats (IER) is an animal model of temporal lobe epilepsy with mycrodysgenesis, that exhibit abnormal migration of hippocampal neurons and recurrent spontaneous seizures. As an attempt to elucidate the roles of extracellular matrix molecules in the epileptogenecity and mossy fiber sprouting, immunohistochemical localization of brain specific chondroitin sulfate proteoglycans (CSPGs), neurocan and phosphacan, was examined in the hippocampus of postnatal IER and Sprague-Dawley (SD) rats using monoclonal antibodies 1G2 against neurocan and 6B4 against phosphacan. There was no difference in the expression of these two CSPGs between IER and SD rats in the 1st postnatal week. However, the expression of neurocan was poor in the hippocampus of IER in the 2nd and 3rd weeks whereas intense labeling of neurocan was present throughout the hippocampus of SD rats. Labeling of neurocan was almost absent in the hippocampus, while phosphacan was diffusely expressed in the stratum oriens and radiatum of Ammon's horn, and in the hilus and inner one-third molecular layer of the dentate gyrus at the 2nd month after birth. There was no difference in the expression of neurocan and phosphacan between IER and SD rats at the 2nd month after birth. By contrast, phosphacan was reduced in the inner molecular layer of the dentate gyrus in 8-month-old IER, while neurocan was reexpressed in the outer molecular layer and hilus in 3- and 8-month-old IER. It was suggested that the insufficient expression of neurocan may affect the development of neuronal organization in the hippocampus, and that the remodeling of extracellular matrix in the dentate gyrus may contribute to the mossy fiber sprouting into the inner molecular layer.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTPRZ1Humantemporal lobe epilepsy  ISOPtprz1 (Rattus norvegicus) RGD 
Ptprz1Rattemporal lobe epilepsy  IEP  RGD 
Ptprz1Mousetemporal lobe epilepsy  ISOPtprz1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptprz1  (protein tyrosine phosphatase, receptor type Z1)

Genes (Mus musculus)
Ptprz1  (protein tyrosine phosphatase receptor type Z, polypeptide 1)

Genes (Homo sapiens)
PTPRZ1  (protein tyrosine phosphatase receptor type Z1)


Additional Information