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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hearing Loss, Noise-Induced
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Accession:DOID:9002910 term browser browse the term
Definition:Hearing loss due to exposure to explosive loud noise or chronic exposure to sound level greater than 85 dB. The hearing loss is often in the frequency range 4000-6000 hertz.
Synonyms:exact_synonym: Acoustic Trauma
 related_synonym: Noise-induced hearing loss, association with;   Noise-induced hearing loss, susceptibility to
 primary_id: MESH:D006317
 alt_id: MIM:613035
 xref: EFO:1001254;   EFO:1001338


show annotations for term's descendants           Sort by:
Hearing Loss, Noise-Induced term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARC activity regulated cytoskeleton associated protein ISO RGD PMID:17275194 RGD:8655559 NCBI chr13:36,743,027...36,744,266 JBrowse link
G BDNF brain derived neurotrophic factor ISO protein:increased expression:cochlea: RGD PMID:17275194 PMID:19925854 PMID:22723694 RGD:8636263 RGD:8655559 RGD:8655575 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480 		JBrowse link
G CALB1 calbindin 1 ISO RGD PMID:22428005 RGD:401940127 NCBI chr29:35,551,836...35,572,985
Ensembl chr29:35,552,436...35,572,925 		JBrowse link
G CAT catalase susceptibility
severity
treatment		 ISO DNA:SNPs,haplotype:: RGD PMID:17567781 PMID:18212468 PMID:23179931 RGD:9068906 RGD:9068923 RGD:9190810 NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:cochlea (mouse) RGD PMID:17081714 RGD:8549464 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:17075702 RGD:8657356 NCBI chr20:42,305,344...42,313,258
Ensembl chr20:42,307,580...42,308,698 		JBrowse link
G CDH23 cadherin related 23 no_association ISO DNA:SNPs: :rs1227049, rs1227051 (human)
DNA:SNPs: :rs1227049, rs3802711 (human)		 RGD PMID:16598924 RGD:8662283 NCBI chr 4:22,206,972...22,570,875
Ensembl chr 4:22,207,001...22,571,131 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO RGD PMID:21187137 RGD:8661793 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281 		JBrowse link
G CFI complement factor I ISO mRNA:increased expression:spiral organ of cochlea, sensory epithelium RGD PMID:23727008 RGD:8662317 NCBI chr32:29,936,447...29,986,755
Ensembl chr32:29,936,393...29,985,724 		JBrowse link
G CNTN1 contactin 1 ISO RGD PMID:22044737 RGD:5685697 NCBI chr27:12,655,021...13,005,536
Ensembl chr27:12,657,287...12,920,315 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 ISO RGD PMID:22428005 RGD:401940127 NCBI chr 4:49,006,981...49,065,205
Ensembl chr 4:49,009,495...49,062,581 		JBrowse link
G GAD1 glutamate decarboxylase 1 ISO RGD PMID:22428005 RGD:401940127 NCBI chr36:15,351,289...15,391,701
Ensembl chr36:15,349,683...15,391,824 		JBrowse link
G GAP43 growth associated protein 43 ISO RGD PMID:22428005 RGD:401940127 NCBI chr33:19,668,491...19,770,509
Ensembl chr33:19,656,835...19,770,408 		JBrowse link
G GJB2 gap junction protein beta 2 ISO protein:increased expression:cochlea: RGD PMID:15224875 RGD:7349367 NCBI chr25:17,952,851...17,958,289
Ensembl chr25:17,952,851...17,958,289 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha treatment ISO RGD PMID:21787680 RGD:8695948 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692 		JBrowse link
G HSP70 heat shock protein 70 ISO DNA:SNP, haplotype: :rs1061581 (human) RGD PMID:18813331 RGD:8662841 NCBI chr12:1,285,282...1,287,670 JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO RGD PMID:19213042 RGD:8547577 NCBI chr20:50,818,715...50,827,914
Ensembl chr20:50,818,715...50,827,914 		JBrowse link
G IGF1 insulin like growth factor 1 ISO RGD PMID:16585854 RGD:8549455 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794 		JBrowse link
G IL6 interleukin 6 ISO RGD PMID:16429448 RGD:7829818 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 ISO ClinVar Annotator: match by term: Noise induced hearing loss ClinVar PMID:7828904 PMID:9445165 PMID:12402336 PMID:14661677 PMID:14760488 More... NCBI chr31:29,858,428...29,868,315 JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16823764 NCBI chr18:46,554,390...46,830,533
Ensembl chr18:46,518,908...46,830,043 		JBrowse link
G KCNQ4 potassium voltage-gated channel subfamily Q member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16823764 NCBI chr15:2,203,938...2,257,152
Ensembl chr15:2,205,276...2,242,093 		JBrowse link
G LOC474850 heat shock 70 kDa protein 1-like ISO DNA:SNP, haplotype: :rs2227956 (human) RGD PMID:17009596 RGD:8662466 NCBI chr12:1,281,164...1,285,010
Ensembl chr12:1,281,472...1,285,440 		JBrowse link
G MIR107 microRNA mir-107 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr28:4,484,653...4,484,710
Ensembl chr28:4,484,646...4,484,718 		JBrowse link
G MIR10A microRNA mir-10a ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 9:24,842,171...24,842,233
Ensembl chr 9:24,842,145...24,842,248 		JBrowse link
G MIR146B microRNA mir-146b ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr28:14,940,550...14,940,610
Ensembl chr28:14,940,550...14,940,610 		JBrowse link
G MIR183 microRNA mir-183 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr14:7,068,542...7,068,603
Ensembl chr14:7,068,519...7,068,625 		JBrowse link
G MIR186 microRNA mir-186 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 6:74,881,615...74,881,675
Ensembl chr 6:74,881,601...74,881,686 		JBrowse link
G MIR190B microRNA mir-190b ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 7:43,037,530...43,037,607
Ensembl chr 7:43,037,530...43,037,607 		JBrowse link
G MIR200C microRNA mir-200c ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr27:38,082,097...38,082,159
Ensembl chr27:38,082,091...38,082,169 		JBrowse link
G MIR30D microRNA mir-30d ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr13:30,910,306...30,910,365
Ensembl chr13:30,910,306...30,910,365 		JBrowse link
G MIR30E microRNA mir-30e ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr15:2,283,306...2,283,369
Ensembl chr15:2,283,306...2,283,369 		JBrowse link
G MIR331 microRNA mir-331 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr15:35,234,750...35,234,839
Ensembl chr15:35,234,740...35,234,850 		JBrowse link
G MIR339-1 microRNA mir-339-1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 6:15,853,520...15,853,577
Ensembl chr 6:15,853,520...15,853,577 		JBrowse link
G MIR381 microRNA mir-381 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 8:69,274,983...69,275,057 JBrowse link
G MIR532 microRNA mir-532 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr  X:42,774,680...42,774,738
Ensembl chr  X:42,774,680...42,774,738 		JBrowse link
G MIR99B microRNA mir-99b ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 1:105,400,925...105,400,984
Ensembl chr 1:105,400,925...105,400,984 		JBrowse link
G MMP7 matrix metallopeptidase 7 ISO RGD PMID:23100416 RGD:9685340 NCBI chr 5:29,187,902...29,196,157
Ensembl chr 5:29,187,851...29,196,153 		JBrowse link
G NOB1 NIN1 (RPN12) binding protein 1 homolog ISO mRNA:increased expression:cochlea RGD PMID:21219967 RGD:10766449 NCBI chr 5:79,958,145...79,966,166
Ensembl chr 5:79,945,446...79,966,147 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO protein:increased expression:hippocampus RGD PMID:31071644 RGD:408364986 NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation:exon:p.S326C (rs1052133) (human)		 CTD
RGD		 PMID:24599382 RGD:8657374 NCBI chr20:8,486,150...8,491,448
Ensembl chr20:8,480,005...8,491,264 		JBrowse link
G PON2 paraoxonase 2 susceptibility ISO DNA:SNPs: :multiple RGD PMID:23327886 RGD:8661240 NCBI chr14:20,652,905...20,680,945
Ensembl chr14:20,652,905...20,680,980 		JBrowse link
G PROC protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:25108045 RGD:11100045 NCBI chr19:23,173,626...23,183,634
Ensembl chr19:23,173,635...23,183,563 		JBrowse link
G PTGER4 prostaglandin E receptor 4 resistance ISO RGD PMID:22198478 RGD:6483524 NCBI chr 4:68,663,362...68,676,241
Ensembl chr 4:68,663,364...68,676,358 		JBrowse link
G SELL selectin L ISO RGD PMID:22044737 RGD:5685697 NCBI chr 7:28,906,752...28,927,959
Ensembl chr 7:28,906,809...29,094,008 		JBrowse link
G SLC26A5 solute carrier family 26 member 5 ISO mRNA, protein:increased expression:cochlea (mouse) RGD PMID:24376553 RGD:9585684 NCBI chr18:16,783,795...16,841,946
Ensembl chr18:16,788,759...16,839,940 		JBrowse link
G SOD1 superoxide dismutase 1 susceptibility
severity		 ISO DNA:snps, haplotypes:introns:multiple (human)
DNA:snps:introns:IVS2+193T>G (rs10432782), IVS3-251A>G (rs2070424) (human)		 RGD PMID:10436316 PMID:19895330 PMID:22931816 RGD:8655611 RGD:8655851 RGD:8655966 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
G SOD2 superoxide dismutase 2 susceptibility ISO DNA:polymorphisms:intron:IVS3-23T>G, IVS3-60T>G (human)
DNA:SNP:cds:p.V16A(rs4880)(human)		 RGD PMID:15345661 PMID:20534900 RGD:8158044 RGD:8158046 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase treatment ISO RGD PMID:21840347 RGD:11554196 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077 		JBrowse link
G TAOK1 TAO kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23472202 NCBI chr 9:43,501,752...43,660,077
Ensembl chr 9:43,559,708...43,651,377 		JBrowse link
G TNF tumor necrosis factor ISO mRNA:increased expression:cochlea: RGD PMID:19051071 RGD:7394705 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15722
    sensory system disease 6985
      auditory system disease 1009
        inner ear disease 690
          sensorineural hearing loss 602
            Hearing Loss, Noise-Induced 51
Path 2
Term Annotations click to browse term
  disease 15722
    disease of anatomical entity 15368
      nervous system disease 13480
        Neurologic Manifestations 9958
          sensory system disease 6985
            Otorhinolaryngologic Diseases 1730
              auditory system disease 1009
                Hearing Disorders 795
                  Hearing Loss 790
                    sensorineural hearing loss 602
                      Hearing Loss, Noise-Induced 51
paths to the root