PTGER4 (prostaglandin E receptor 4) - Rat Genome Database

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Gene: PTGER4 (prostaglandin E receptor 4) Canis lupus familiaris
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Symbol: PTGER4
Name: prostaglandin E receptor 4
RGD ID: 12400625
Description: ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); bone development (ortholog); cellular response to glucose stimulus (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Alzheimer's disease (ortholog); ankylosing spondylitis (ortholog); FOUND IN neuron projection terminus (ortholog); neuronal cell body (ortholog); nuclear membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,663,362 - 68,676,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,663,364 - 68,676,358 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,339,460 - 68,352,693 (-)NCBI
ROS_Cfam_1.0469,169,559 - 69,182,795 (-)NCBI
UMICH_Zoey_3.1468,929,030 - 68,942,269 (-)NCBI
UNSW_CanFamBas_1.0469,042,114 - 69,055,368 (-)NCBI
UU_Cfam_GSD_1.0469,581,192 - 69,594,491 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISS)
bone development  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to prostaglandin E stimulus  (IBA,ISO)
chemokinesis  (ISO)
ductus arteriosus closure  (ISO)
ERK1 and ERK2 cascade  (ISO)
female pregnancy  (ISO)
immune response  (ISO)
inflammatory response  (IBA)
JNK cascade  (ISO)
maternal process involved in parturition  (ISO)
negative regulation of circadian sleep/wake cycle, REM sleep  (ISO)
negative regulation of cytokine production  (IEA)
negative regulation of ductus arteriosus closure  (ISO)
negative regulation of endothelin production  (ISO)
negative regulation of eosinophil extravasation  (ISS)
negative regulation of hydrogen peroxide metabolic process  (ISO)
negative regulation of inflammatory response  (IBA,ISO,ISS)
negative regulation of integrin activation  (ISS)
negative regulation of interleukin-1 alpha production  (ISO)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO)
negative regulation of peptide secretion  (ISO)
negative regulation of small intestine smooth muscle contraction  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of antral ovarian follicle growth  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of calcitonin secretion  (ISO)
positive regulation of cAMP-mediated signaling  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokinesis  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of matrix metallopeptidase secretion  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of ossification  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of ovarian follicle development  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of renal sodium excretion  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of substance P secretion  (ISO)
positive regulation of substance P secretion, neurotransmission  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of urine volume  (ISO)
positive regulation of wound healing  (ISO)
regulation of circadian sleep/wake cycle, wakefulness  (ISO)
regulation of ossification  (IEA,ISO)
regulation of stress fiber assembly  (IEA)
response to amino acid  (ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (IEA,ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to progesterone  (ISO)
response to prostaglandin E  (ISO)
response to salt  (ISO)
response to water-immersion restraint stress  (ISO)
response to xenobiotic stimulus  (ISO)
T-helper cell differentiation  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11444589   PMID:18280063   PMID:26073024   PMID:30190508   PMID:33390656  


Genomics

Comparative Map Data
PTGER4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,663,362 - 68,676,241 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,663,364 - 68,676,358 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,339,460 - 68,352,693 (-)NCBI
ROS_Cfam_1.0469,169,559 - 69,182,795 (-)NCBI
UMICH_Zoey_3.1468,929,030 - 68,942,269 (-)NCBI
UNSW_CanFamBas_1.0469,042,114 - 69,055,368 (-)NCBI
UU_Cfam_GSD_1.0469,581,192 - 69,594,491 (-)NCBI
PTGER4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl540,679,915 - 40,693,735 (+)EnsemblGRCh38hg38GRCh38
GRCh38540,679,915 - 40,740,936 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37540,680,017 - 40,693,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,715,789 - 40,729,594 (+)NCBINCBI36hg18NCBI36
Build 34540,715,788 - 40,729,592NCBI
Celera540,568,598 - 40,582,403 (+)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,632,020 - 40,645,825 (+)NCBIHuRef
CHM1_1540,681,992 - 40,695,797 (+)NCBICHM1_1
Ptger4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,262,880 - 5,273,668 (-)NCBIGRCm39mm39
GRCm39 Ensembl155,236,142 - 5,273,668 (-)Ensembl
GRCm38155,233,399 - 5,244,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,206,661 - 5,244,187 (-)EnsemblGRCm38mm10GRCm38
MGSCv37155,183,404 - 5,193,831 (-)NCBIGRCm37mm9NCBIm37
MGSCv36155,181,080 - 5,191,046 (-)NCBImm8
Celera155,082,719 - 5,093,146 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.99NCBI
Ptger4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,330,563 - 54,347,451 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl254,335,424 - 54,346,670 (-)Ensembl
Rnor_6.0254,951,625 - 54,966,470 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl254,952,821 - 54,963,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0273,974,390 - 73,987,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,423,280 - 54,433,907 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1254,351,507 - 54,362,753 (-)NCBI
Celera249,982,896 - 49,993,523 (-)NCBICelera
Cytogenetic Map2q16NCBI
Ptger4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542624,997,811 - 25,010,822 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542624,997,811 - 25,010,822 (+)NCBIChiLan1.0ChiLan1.0
PTGER4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1574,731,470 - 74,745,121 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,731,470 - 74,745,148 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0569,686,906 - 69,700,739 (-)NCBIMhudiblu_PPA_v0panPan3
Ptger4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,454,672 - 229,468,133 (+)NCBI
SpeTri2.0NW_0049365181,903,636 - 1,916,746 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,670,862 - 25,686,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,670,832 - 25,686,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PTGER4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,440,697 - 39,453,983 (+)NCBI
ChlSab1.1 Ensembl439,440,276 - 39,454,004 (+)Ensembl
Vero_WHO_p1.0NW_02366607129,862,058 - 29,876,121 (+)NCBI
Ptger4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475914,243,887 - 14,259,090 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 1 1 2 1 1
Low 5 18 3 5 3 4 2 6 9 6
Below cutoff 3 3 3 4 5 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000029558   ⟹   ENSCAFP00000027474
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl468,663,364 - 68,676,241 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062256   ⟹   ENSCAFP00000046114
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl468,663,364 - 68,676,358 (-)Ensembl
RefSeq Acc Id: NM_001003054   ⟹   NP_001003054
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1468,663,362 - 68,676,241 (-)NCBI
Dog10K_Boxer_Tasha468,339,460 - 68,352,693 (-)NCBI
ROS_Cfam_1.0469,169,564 - 69,182,795 (-)NCBI
UMICH_Zoey_3.1468,929,030 - 68,942,269 (-)NCBI
UNSW_CanFamBas_1.0469,042,114 - 69,055,368 (-)NCBI
UU_Cfam_GSD_1.0469,581,192 - 69,594,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038662198   ⟹   XP_038518126
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0469,169,559 - 69,182,618 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001003054 (Get FASTA)   NCBI Sequence Viewer  
  XP_038518126 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF00470 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003054   ⟸   NM_001003054
- UniProtKB: Q9TU16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000027474   ⟸   ENSCAFT00000029558
RefSeq Acc Id: ENSCAFP00000046114   ⟸   ENSCAFT00000062256
RefSeq Acc Id: XP_038518126   ⟸   XM_038662198
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018619 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000027474 ENTREZGENE
Ensembl Transcript ENSCAFT00000029558 ENTREZGENE
NCBI Gene PTGER4 ENTREZGENE
UniProt Q9TU16 ENTREZGENE
VGNC ID VGNC:45144 ENTREZGENE