PON2 (paraoxonase 2) - Rat Genome Database

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Gene: PON2 (paraoxonase 2) Canis lupus familiaris
Analyze
Symbol: PON2
Name: paraoxonase 2
RGD ID: 12139653
Description: ENCODES a protein that exhibits acyl-L-homoserine-lactone lactonohydrolase activity (inferred); arylesterase activity (inferred); hydrolase activity (inferred); INVOLVED IN response to oxidative stress (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN extracellular region (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-esterase 2; aromatic esterase 2; serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,652,905 - 20,680,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,652,905 - 20,680,980 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1420,212,086 - 20,240,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01420,475,174 - 20,503,227 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1420,474,039 - 20,503,262 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,619,843 - 20,648,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01420,355,194 - 20,383,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,612,464 - 20,640,503 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:8661009   PMID:22301074  


Genomics

Comparative Map Data
PON2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,652,905 - 20,680,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,652,905 - 20,680,980 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1420,212,086 - 20,240,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01420,475,174 - 20,503,227 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1420,474,039 - 20,503,262 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,619,843 - 20,648,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01420,355,194 - 20,383,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,612,464 - 20,640,503 (-)NCBIUU_Cfam_GSD_1.0
PON2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38795,404,862 - 95,435,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl795,404,862 - 95,435,329 (-)EnsemblGRCh38hg38GRCh38
GRCh37795,034,174 - 95,064,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,872,110 - 94,902,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 34794,678,825 - 94,708,946NCBI
Celera789,732,873 - 89,763,084 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef789,641,241 - 89,671,460 (-)NCBIHuRef
CHM1_1794,964,201 - 94,994,411 (-)NCBICHM1_1
T2T-CHM13v2.0796,641,007 - 96,671,530 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2794,363,169 - 94,393,380 (-)NCBI
Pon2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3965,264,620 - 5,298,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl65,264,147 - 5,298,455 (-)EnsemblGRCm39 Ensembl
GRCm3865,264,620 - 5,298,345 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,264,147 - 5,298,455 (-)EnsemblGRCm38mm10GRCm38
MGSCv3765,214,624 - 5,248,373 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3665,214,624 - 5,248,373 (-)NCBIMGSCv36mm8
Celera65,411,917 - 5,445,790 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.99NCBI
Pon2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8434,356,270 - 34,391,684 (-)NCBIGRCr8
mRatBN7.2433,389,702 - 33,425,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl433,389,714 - 33,425,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx438,348,742 - 38,384,154 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0434,274,880 - 34,310,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0432,684,666 - 32,720,086 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0430,344,705 - 30,380,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,344,709 - 30,380,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,251,589 - 30,287,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4430,033,229 - 30,068,643 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1430,072,559 - 30,107,973 (-)NCBI
Celera428,916,533 - 28,951,951 (-)NCBICelera
Cytogenetic Map4q21NCBI
Pon2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,987,919 - 12,020,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,988,009 - 12,020,702 (-)NCBIChiLan1.0ChiLan1.0
PON2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26113,247,154 - 113,277,476 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17161,511,793 - 161,542,058 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0787,362,447 - 87,392,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17100,950,074 - 100,980,433 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7100,950,074 - 100,980,433 (-)Ensemblpanpan1.1panPan2
Pon2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511833,969,230 - 34,000,895 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365854,862,364 - 4,895,323 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365854,862,378 - 4,894,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PON2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl975,027,097 - 75,051,422 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1975,027,270 - 75,051,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2982,405,444 - 82,429,620 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PON2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12153,607,353 - 53,637,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2153,607,541 - 53,639,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604250,709,094 - 50,738,898 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pon2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248132,053,310 - 2,086,086 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248132,055,871 - 2,086,046 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PON2
241 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000003349   ⟹   ENSCAFP00000003109
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1420,652,905 - 20,680,980 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000084395   ⟹   ENSCAFP00000062002
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1420,652,905 - 20,672,266 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845036763   ⟹   ENSCAFP00845028785
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1420,474,039 - 20,503,262 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845036845   ⟹   ENSCAFP00845028847
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1420,474,039 - 20,494,531 (-)Ensembl
RefSeq Acc Id: NM_001003205   ⟹   NP_001003205
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11420,652,905 - 20,680,945 (-)NCBI
Dog10K_Boxer_Tasha1420,212,086 - 20,240,124 (-)NCBI
ROS_Cfam_1.01420,475,174 - 20,503,227 (-)NCBI
UMICH_Zoey_3.11420,619,843 - 20,648,083 (-)NCBI
UNSW_CanFamBas_1.01420,355,194 - 20,383,210 (-)NCBI
UU_Cfam_GSD_1.01420,612,464 - 20,640,503 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001003205   ⟸   NM_001003205
- Peptide Label: precursor
- UniProtKB: P54832 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSCAFP00000062002   ⟸   ENSCAFT00000084395
Ensembl Acc Id: ENSCAFP00000003109   ⟸   ENSCAFT00000003349
Ensembl Acc Id: ENSCAFP00845028847   ⟸   ENSCAFT00845036845
Ensembl Acc Id: ENSCAFP00845028785   ⟸   ENSCAFT00845036763

Promoters
RGD ID:13685756
Promoter ID:EPDNEW_C3826
Type:initiation region
Name:PON2_1
Description:paraoxonase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11420,680,956 - 20,681,016EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002123 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018287 UniProtKB/TrEMBL
  ENSCAFG00040013903 UniProtKB/TrEMBL
  ENSCAFG00845020811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003349.5 UniProtKB/TrEMBL
  ENSCAFT00000084395.2 UniProtKB/TrEMBL
  ENSCAFT00030033986.1 UniProtKB/TrEMBL
  ENSCAFT00030034044.1 UniProtKB/TrEMBL
  ENSCAFT00040025865.1 UniProtKB/TrEMBL
  ENSCAFT00040025949.1 UniProtKB/TrEMBL
  ENSCAFT00845036763 ENTREZGENE
  ENSCAFT00845036763.1 UniProtKB/TrEMBL
  ENSCAFT00845036845.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paraoxonase2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serum_paraoxonase/arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene PON2 ENTREZGENE
PANTHER PARAOXONASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERUM PARAOXONASE/ARYLESTERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PARAOXONASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PARAOXONASE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Calcium-dependent phosphotriesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0SJB8_CANLF UniProtKB/TrEMBL
  A0A8C0SKX3_CANLF UniProtKB/TrEMBL
  A0A8I3PDM9_CANLF UniProtKB/TrEMBL
  A0A8I3PDS2_CANLF UniProtKB/TrEMBL
  A0A8P0TDS7_CANLF UniProtKB/TrEMBL
  P54832 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:44813 ENTREZGENE