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Gene: GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1) Canis lupus familiaris

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Symbol:

GABRA1

Name:

gamma-aminobutyric acid type A receptor subunit alpha1

RGD ID:

12055108

Description:

ENCODES a protein that exhibits diazepam binding (ortholog); GABA receptor activity (ortholog); GABA-gated chloride ion channel activity (ortholog); INVOLVED IN cellular response to histamine (ortholog); response to auditory stimulus (ortholog); response to methamphetamine hydrochloride (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Ataxia (ortholog); autistic disorder (ortholog); FOUND IN dendritic spine (ortholog); GABA receptor complex (ortholog); GABA-ergic synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

gamma-aminobutyric acid A receptor alpha 1; gamma-aminobutyric acid receptor subunit alpha-1; gamma-aminobutyric acid receptor subunit alpha-1-like; gamma-aminobutyric acid type A receptor alpha1 subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	49,006,981 - 49,065,205 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	49,009,495 - 49,062,581 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	48,898,592 - 48,956,801 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	49,439,269 - 49,497,701 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	49,421,345 - 49,497,509 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	49,246,182 - 49,304,589 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	49,379,685 - 49,437,823 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	49,902,613 - 49,960,850 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

Ataxia (ISO)

autistic disorder (ISO)

Binge Drinking (ISO)

childhood absence epilepsy (ISO)

Childhood Absence Epilepsy 2 (ISO)

developmental and epileptic encephalopathy 19 (ISO)

Dysbiosis (ISO)

epilepsy (ISO)

essential tremor (ISO)

Generalized Epilepsy (ISO)

genetic disease (ISO)

Hearing Loss, Noise-Induced (ISO)

hepatic encephalopathy (ISO)

idiopathic generalized epilepsy (ISO)

idiopathic generalized epilepsy 13 (ISO)

intellectual disability (ISO)

juvenile myoclonic epilepsy (ISO)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

Neurodevelopmental Disorders (ISO)

ovarian cyst (ISO)

sensorineural hearing loss (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to histamine (ISO)

chloride transmembrane transport (IBA,IEA)

chloride transport (IEA)

gamma-aminobutyric acid signaling pathway (IBA,IEA)

inhibitory synapse assembly (IBA,IEA)

monoatomic ion transmembrane transport (IEA)

response to auditory stimulus (ISO)

response to methamphetamine hydrochloride (ISO)

synaptic transmission, GABAergic (IBA,IEA)

Cellular Component

chloride channel complex (IEA)

dendrite membrane (IBA)

dendritic spine (IEA,ISO)

GABA receptor complex (ISO)

GABA-A receptor complex (IBA,IEA)

GABA-ergic synapse (ISO)

membrane (IEA)

plasma membrane (IEA)

postsynapse (IBA)

postsynaptic membrane (IEA)

postsynaptic specialization membrane (ISO)

synapse (IEA)

Molecular Function

benzodiazepine receptor activity (IBA)

chloride channel activity (IBA,IEA)

diazepam binding (ISO)

extracellular ligand-gated monoatomic ion channel activity (IEA)

GABA receptor activity (ISO)

GABA-A receptor activity (IBA,IEA)

GABA-gated chloride ion channel activity (IBA,IEA,ISO)

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ISO)

protein binding (ISO)

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:29089046	PMID:30032202

Genomics

Comparative Map Data

GABRA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	49,006,981 - 49,065,205 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	49,009,495 - 49,062,581 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	48,898,592 - 48,956,801 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	49,439,269 - 49,497,701 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	49,421,345 - 49,497,509 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	49,246,182 - 49,304,589 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	49,379,685 - 49,437,823 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	49,902,613 - 49,960,850 (-)	NCBI		UU_Cfam_GSD_1.0

GABRA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	161,847,191 - 161,899,971 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	161,847,063 - 161,899,981 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	161,274,197 - 161,326,977 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	161,206,983 - 161,258,992 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	161,206,982 - 161,258,990	NCBI
Celera	5	157,305,487 - 157,357,959 (+)	NCBI		Celera
Cytogenetic Map	5	q34	NCBI
HuRef	5	156,366,532 - 156,419,379 (+)	NCBI		HuRef
CHM1_1	5	160,706,630 - 160,759,375 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	162,376,027 - 162,428,794 (+)	NCBI		T2T-CHM13v2.0

Gabra1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	42,021,766 - 42,073,893 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	42,021,766 - 42,073,757 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	42,130,939 - 42,183,066 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	42,130,939 - 42,182,930 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	41,944,982 - 41,996,432 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	41,974,903 - 42,026,353 (-)	NCBI		MGSCv36	mm8
Celera	11	45,953,528 - 46,009,149 (-)	NCBI		Celera
Cytogenetic Map	11	A5	NCBI
cM Map	11	24.97	NCBI

Gabra1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	27,096,731 - 27,152,563 (-)	NCBI		GRCr8
mRatBN7.2	10	26,595,151 - 26,650,611 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	26,595,160 - 26,650,864 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	31,330,824 - 31,385,752 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	30,819,357 - 30,874,277 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	26,306,024 - 26,360,948 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	27,310,718 - 27,371,802 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	27,310,725 - 27,366,665 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	27,154,354 - 27,209,873 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	27,258,813 - 27,313,725 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	27,261,880 - 27,312,049 (-)	NCBI
Celera	10	26,109,305 - 26,164,180 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

Gabra1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	15,608,984 - 15,662,597 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	15,608,984 - 15,662,309 (+)	NCBI	ChiLan1.0	ChiLan1.0

GABRA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	157,030,426 - 157,083,204 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	155,169,973 - 155,222,751 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	157,234,725 - 157,287,475 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	163,928,392 - 163,981,127 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	163,928,392 - 163,981,117 (+)	Ensembl	panpan1.1		panPan2

Gabra1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	103,356,153 - 103,409,858 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936515	1,805,239 - 1,859,600 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936515	1,806,721 - 1,859,227 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GABRA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	61,656,587 - 61,723,119 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	61,656,583 - 61,723,428 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	66,816,724 - 66,883,547 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GABRA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	64,199,372 - 64,255,996 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	64,200,752 - 64,255,996 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	13,304,237 - 13,354,528 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gabra1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	27,708,271 - 27,763,523 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	27,708,364 - 27,763,824 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GABRA1
634 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	21	15	5	6	5	6	29	19	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022417728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038473758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038534838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038599139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038663444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY550368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000027295 ⟹ ENSCAFP00000025386

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	4	49,009,495 - 49,062,581 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845001265 ⟹ ENSCAFP00845000969

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	4	49,421,345 - 49,497,276 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845001282 ⟹ ENSCAFP00845000986

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	4	49,421,345 - 49,495,092 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845001295 ⟹ ENSCAFP00845000996

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	4	49,439,274 - 49,497,509 (-)	Ensembl

RefSeq Acc Id:

XM_022417728 ⟹ XP_022273436

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	4	49,006,981 - 49,065,205 (-)	NCBI
Dog10K_Boxer_Tasha	4	48,898,592 - 48,956,801 (-)	NCBI

Sequence:

show sequence

AGTCTGCAGCCAGAGAGAAGGGGATTAGGGCCAGAGCGGTGCAAGTTAAATTGTGCTGCATATA
AAAAATGGGCGGATTGGTCTCCAGATCCAGAGGCTGGTACCACCTTCCTTTCTAAAATAAAATC
TCTCTGGCATGAAGTCACCGCCTATTTCACATCCGGTTTGCCCTGGGACGTATTACTACTGTCT
TGGTAAAGAGAAATCTTTTGTTGTATAGCTGCAGATCGGATACCGGGAAGCAAATTTGGGTGTG
AGATCTTCAGCAGAGGAGCACGCAGAGTCCATGATGGCTCAGACCGAGTGAGCGAGGGGAGAGC
GAGGCCGCCCCCGGCTCCGGCGCGCCCGCCCCGCGCCCAGCGCCCCGCGCCCCGCGCCCCGCGC
TGCTCCCGGCTCTCCGCGGTCCGCGCTCGCTCGCACACTTTTCCCGGGTCTTGAGCGATCCTGT
GCCCAGAGGGGGCCCGAGCTGCACAAGCCCGCGATGAAGAAAAGTCTGGGTCTCTCTGACTATC
TTTGGGCCTGGACCCTCCTTCTGAGCACATTGATTGGAAGAAGCTATGGACAACCCTCATTACA
AGATGAACTTAAAGACAATACCACTGTCTTCACCAGGATTTTGGACCGACTCCTAGATGGTTAT
GACAATCGTCTAAGACCAGGATTGGGAGAGCGTGTAACTGAAGTGAAGACTGACATCTTCGTCA
CCAGTTTCGGACCTGTTTCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAG
CTGGAAGGATGAAAGATTAAAATTTAAAGGACCCATGACAGTTCTCCGGTTAAATAACCTAATG
GCAAGTAAAATCTGGACTCCGGATACCTTCTTTCACAATGGAAAGAAGTCTGTGGCACACAACA
TGACCATGCCAAACAAACTCCTGAGGATCACAGAGGATGGTACCTTGTTGTACACCATGAGGCT
GACGGTGAGAGCTGAGTGTCCAATGCATTTGGAGGACTTTCCTATGGATGCCCATGCCTGCCCA
CTAAAATTTGGAAGCTATGCGTATACTAGAGCAGAAGTTGTTTATGAGTGGACCAGAGAGCCAG
CACGCTCAGTTGTTGTAGCAGAAGATGGGTCACGCCTAAATCAGTATGATCTTCTTGGACAAAC
AGTAGACTCTGGAATTGTTCAGTCTAGTACAGGAGAATATGTTGTTATGACCACTCATTTCCAC
TTGAAGAGAAAGATTGGCTATTTTGTTATTCAAACATATCTGCCATGCATAATGACAGTCATTC
TCTCCCAAGTCTCGTTCTGGCTCAACAGAGAGTCTGTACCAGCGAGGACTGTCTTTGGAGTAAC
AACTGTGCTCACCATGACAACTTTGAGTATCAGTGCCAGAAATTCCCTCCCTAAGGTGGCTTAT
GCCACTGCTATGGATTGGTTCATTGCAGTGTGCTATGCCTTTGTCTTCTCGGCTCTGATTGAGT
TTGCCACAGTCAATTATTTCACCAAGAGAGGTTATGCATGGGATGGCAAAAGCGTGGTTCCAGA
AAAGCCAAAGAAAGTGAAAGATCCTCTCATTAAGAAAAACAACACTTATGCTCCAACAGCAACC
AGCTACACCCCTAATTTGGCCAGGGGTGACCCTGGCTTAGCCACGATTGCTAAAAGTGCAACCA
TAGAACCAAAAGAAGTCAAGCCGGAAACAAAACCACCAGAACCCAAGAAAACCTTTAACAGTGT
CAGCAAAATTGACCGACTGTCAAGAATAGCTTTCCCGCTGCTATTTGGAATCTTTAACTTGGTC
TATTGGGCTACATATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACCCCACATCAATAGGTCC
TTTTATTCACATCCTGTTGTTCAGTCCTCTGCACTGGGAATTGCTTTCTGTTCTCAACGCAGTG
ATTCCCACCTGCTTTATTGCCTCTGTCTTAAAGAATTTGAAGGTTTCCTTATTTCCATAATTCA
TAGAAGAACAACAGACCCCTGTCCAGCAGTCCAGAGCAAAGCAGAACATATAGCTGAGAGACAG
GATTCTGAGAGGAAGCAAAAGAGAAAAAGCACGACAGAAGGAGACAGAATGAGAGAGGAAAGGT
ATGTGAGTAGGTCCAGACTGTAGGGAAAAGTAGAAGGAAAATAAAACTTAACTCTATAACTCCA
GGTCATTTGTAGATATATATTTCCAAATGTTCTAAAAAAAGATACTGTATATGTCAAAAATATT
TTTATGTGGAGGTGTTTCAAAGAATAAATTATAAATGTTTAATGAAAGAAATTTTAAAAATCTA
TTGTCTTTATTGCACAAACTTCAGTGTGCTTTACATTTTGTTTTGTTTTTTAAACTGATGTATA
GCTTTAACACTTTGTTTCCAAAGCTGAAGACCCCCAATTTTTCTCCTTTTAAAAATAGCTAATG
CATTACTCTGTTGTTAAAGGCTATTTTAAAATTCATGGAAATGGCATACGCAAACGTGCAGTTC
CTTACCGTTAAGCACATTTAGTCCAAAAGAGACAAATGCTTTAAATAGGCTACTTCACCATCAT
CTGACCTTTTATCACTAGATTCAATGAGGAATCATTTTAACAGAGACATACACTCAATAAAAAC
TAAAAACTAAAAAAAAATTAAATAAAACAATTAAAAAATACTTTCTTTGCTGCCCTGTCTATAT
CCAGATAGCACATGGGTCCAATAATCACTTGATTCTCATTATAAAAAGATGTTCTTAGAGGGGC
AAACATATTTTGCAAGCTCTAGAATTGTTGAATGTATTATTTTATATAACAGTACATTAAAAGC
TTTAGATTGAAATTTATGACTAGTAAACAAATATAGAATATATAAATTATATATGTAAATATAC
AGCATGAGATTGTACATTTTTTACTTTTTTAAAGTTATGTTCTTAAAATATTGTGTAGGACTCA
CCGCTCTTAGCTGTTAGAATGTTGTAAAGTGCTATGGAAATACCTTTAGAGCCTGAATTAAAAA
CAGAACAGCCTGTGGGAATCAGATGGAAATTAAACAGATGGGTATAAAGTCCGCTTATGTAGAG
AAAGCTTATAATTTCAAACTATCGCCCGGTGTACAGTAGTAAATCCGTTGCTCTCTGCTCAAGT
CATGCCACATTTCCCTATCTGAGGCTCTTGTAAAATAGAAAGAAAATGGAAAAGCATTAGTTGG
AGCTAGAATATATTATTGCTATAATTGCTGATACCAACTATCTCAATAAGTGTTGTACCATATG
TAGCATTAAATATAAAAACACATGAAAGAATGTACAGGAAATAGCTTTTATTGAGTAACATTAT
TATATTTCATTTATACTGTAGCAATATATTTGTAGGTATACTATGTAAGGGCTTTAACTACAAG
AGGTCCATTAATACTCCCTATAAAAATTCTGGTCTGTTTCATTACTTCCCAGATGTTTTAGAGA
TGAATATTTATTCAGAAGGTATTTTTGAAGTCTCCTTTTGTCTGACAGAATTTCAGAGATGTTT
AAAATTAGCATCCAGAATCCACAGGTCATAGTCTAACCACATTTAGAATACTACAGCATAAACC
TATCAGCATAATTGCCAAATAAGTCTGTTGGGATGAGTACCCAAGTTTTGAGCAATGTTTCTTT
CAAAAAGCTGCTATCCAATGATGTAGGAAAAAACACAGTTTGTGTTTTCCTAAGCAAACTCTGG
TTTTCTTTTTAAATGTGCTTTATTGTTTGATTTGGTCCTGCCTAAATTCAATGAGCTAGGCCAA
TAAAGACTGAACCAAGGACATTTCATCCTCTGGTATCATGTGTAGATATCATGTATAGAAAATA
AAATAAAATATGGCTCTAACTTCTGTGTTGCTGTTTATATGTGTTATTTTTCGGCGTTAACCTA
ATGTGTTTATAAAGAGCATTTTATCTTCCAGGCTCCTCATGGATAACATTTGGTCTGTATTTTG
CTCACTAGATGTGAATATTTCTTATTAGTCTGCTTTTTGCTATGCAATGATTGCATTTCTATCA
TTTCTTAGTTTGTTAGTATGTGTGATAGTATTCTATTGTATAAATTGATTGCACAGTTTATCAA
AGACCAATTATTCTATGTAGCTTTTCTACAGTGCTTTGCTAAACCATGTAATACTAGTTAAGTC
TTCCTTGAAAATAAAGATACACTCTTATAGAGGACAGTTCCTGTTTACTCCCAGGAACATTTTT
TAAAAGATGACACTGAATGTTTATTGCACCTTAGTGCAGTGAAGTGGCAATAAAACCTAACATG
AATCGAGGTTGTTTATGGCAGATGCATGTATTGCTTTACAGAGTTTAGCAAAAGCTCTTAATTT
TATGTCATACTGTATTCTATTATAATAATAAAGCTAACATTATTCAATAACCAAA

hide sequence

RefSeq Acc Id:

XM_038473758 ⟹ XP_038329686

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	4	49,246,182 - 49,304,589 (-)	NCBI

RefSeq Acc Id:

XM_038534838 ⟹ XP_038390766

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	4	49,902,613 - 49,960,850 (-)	NCBI

RefSeq Acc Id:

XM_038599139 ⟹ XP_038455067

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	4	49,379,685 - 49,437,823 (-)	NCBI

RefSeq Acc Id:

XM_038663444 ⟹ XP_038519372

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	4	49,439,269 - 49,497,701 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_022273436	(Get FASTA)	NCBI Sequence Viewer
	XP_038329686	(Get FASTA)	NCBI Sequence Viewer
	XP_038390766	(Get FASTA)	NCBI Sequence Viewer
	XP_038455067	(Get FASTA)	NCBI Sequence Viewer
	XP_038519372	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ATV93513	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000025386.3
	ENSCAFP00000068826.1
	ENSCAFP00000072572.1
	ENSCAFP00030024084.1
	ENSCAFP00040004631.1
	ENSCAFP00845000969
	ENSCAFP00845000969.1
	ENSCAFP00845000986.1
	ENSCAFP00845000996.1

RefSeq Acc Id:

XP_022273436 ⟸ XM_022417728

- UniProtKB:

A0A2H4NNI8 (UniProtKB/TrEMBL), A0A8P0TR22 (UniProtKB/TrEMBL), A0A8I3RR17 (UniProtKB/TrEMBL), A0A8P0TKV8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKKSLGLSDYLWAWTLLLSTLIGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGER
VTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFF
HNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRA
EVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQ
TYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVC
YAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDP
GLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQ
LKAPTPHQ

hide sequence

Ensembl Acc Id:

ENSCAFP00000025386 ⟸ ENSCAFT00000027295

RefSeq Acc Id:

XP_038329686 ⟸ XM_038473758

RefSeq Acc Id:

XP_038455067 ⟸ XM_038599139

RefSeq Acc Id:	XP_038519372 ⟸ XM_038663444
- UniProtKB:	A0A2H4NNI8 (UniProtKB/TrEMBL), A0A8P0TR22 (UniProtKB/TrEMBL), A0A8I3RR17 (UniProtKB/TrEMBL), A0A8P0TKV8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038390766 ⟸ XM_038534838
- UniProtKB:	A0A2H4NNI8 (UniProtKB/TrEMBL), A0A8I3RR17 (UniProtKB/TrEMBL), A0A8P0TKV8 (UniProtKB/TrEMBL), A0A8P0TR22 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845000986 ⟸ ENSCAFT00845001282

Ensembl Acc Id:

ENSCAFP00845000969 ⟸ ENSCAFT00845001265

Ensembl Acc Id:

ENSCAFP00845000996 ⟸ ENSCAFT00845001295

Protein Domains

Neurotransmitter-gated ion-channel ligand-binding Neurotransmitter-gated ion-channel transmembrane

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000001883	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030014878	UniProtKB/TrEMBL
	ENSCAFG00040002826	UniProtKB/TrEMBL
	ENSCAFG00845000763	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000027295.4	UniProtKB/TrEMBL
	ENSCAFT00000095642.1	UniProtKB/TrEMBL
	ENSCAFT00000103505.1	UniProtKB/TrEMBL
	ENSCAFT00030027599.1	UniProtKB/TrEMBL
	ENSCAFT00040005388.1	UniProtKB/TrEMBL
	ENSCAFT00845001265	ENTREZGENE
	ENSCAFT00845001265.1	UniProtKB/TrEMBL
	ENSCAFT00845001282.1	UniProtKB/TrEMBL
	ENSCAFT00845001295.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.390	UniProtKB/TrEMBL
	2.70.170.10	UniProtKB/TrEMBL
InterPro	GABAA/Glycine_rcpt	UniProtKB/TrEMBL
	GABAAa_rcpt	UniProtKB/TrEMBL
	GABBAa1_rcpt	UniProtKB/TrEMBL
	Gabra-1-6_TM	UniProtKB/TrEMBL
	GABRA1_ECD	UniProtKB/TrEMBL
	Neur_chan_lig-bd	UniProtKB/TrEMBL
	Neur_chan_lig-bd_sf	UniProtKB/TrEMBL
	Neur_channel	UniProtKB/TrEMBL
	Neuro-gated_channel_TM_sf	UniProtKB/TrEMBL
	Neuro_actylchol_rec	UniProtKB/TrEMBL
	Neurotrans-gated_channel_TM	UniProtKB/TrEMBL
	Neurotransmitter_ion_chnl_CS	UniProtKB/TrEMBL
NCBI Gene	GABRA1	ENTREZGENE
PANTHER	GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1	UniProtKB/TrEMBL
	PTHR18945	UniProtKB/TrEMBL
Pfam	Neur_chan_LBD	UniProtKB/TrEMBL
	Neur_chan_memb	UniProtKB/TrEMBL
PRINTS	GABAARALPHA	UniProtKB/TrEMBL
	GABAARALPHA1	UniProtKB/TrEMBL
	GABAARECEPTR	UniProtKB/TrEMBL
	NRIONCHANNEL	UniProtKB/TrEMBL
PROSITE	NEUROTR_ION_CHANNEL	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63712	UniProtKB/TrEMBL
	SSF90112	UniProtKB/TrEMBL
UniProt	A0A2H4NNI8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0PW00_CANLF	UniProtKB/TrEMBL
	A0A8I3MM39_CANLF	UniProtKB/TrEMBL
	A0A8I3RR17	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TKV8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TR22	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:41053	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-05-11	GABRA1	gamma-aminobutyric acid type A receptor subunit alpha1	GABRA1	gamma-aminobutyric acid type A receptor alpha1 subunit	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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