LOC474850 (heat shock 70 kDa protein 1-like) - Rat Genome Database

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Gene: LOC474850 (heat shock 70 kDa protein 1-like) Canis lupus familiaris
Analyze
Symbol: LOC474850 (Ensembl: HSPA1L)
Name: heat shock 70 kDa protein 1-like (Ensembl:heat shock protein family A (Hsp70) member 1 like)
RGD ID: 12199089
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent protein folding chaperone (inferred); heat shock protein binding (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); Crohn's disease (ortholog); drug allergy (ortholog); FOUND IN COP9 signalosome (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heat shock 70kDa protein 1-like; HSPA1L
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,281,164 - 1,285,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,281,472 - 1,285,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,416,835 - 1,420,649 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,424,019 - 1,427,833 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,423,961 - 1,428,295 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,283,032 - 1,286,847 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,350,176 - 1,353,991 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,414,602 - 1,418,416 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC474850
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,281,164 - 1,285,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,281,472 - 1,285,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,416,835 - 1,420,649 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,424,019 - 1,427,833 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,423,961 - 1,428,295 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,283,032 - 1,286,847 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,350,176 - 1,353,991 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,414,602 - 1,418,416 (-)NCBIUU_Cfam_GSD_1.0
HSPA1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,809,619 - 31,815,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,809,619 - 31,815,283 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,777,396 - 31,783,060 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,885,375 - 31,890,814 (-)NCBINCBI36Build 36hg18NCBI36
Build 34631,885,374 - 31,890,786NCBI
Celera633,375,646 - 33,381,084 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,563,804 - 31,569,242 (-)NCBIHuRef
CHM1_1631,779,530 - 31,784,969 (-)NCBICHM1_1
T2T-CHM13v2.0631,662,676 - 31,668,340 (-)NCBIT2T-CHM13v2.0
Hspa1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,191,679 - 35,198,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,191,679 - 35,198,261 (+)EnsemblGRCm39 Ensembl
GRCm381734,972,703 - 34,979,228 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,972,703 - 34,979,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,109,648 - 35,116,173 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,580,788 - 34,587,281 (+)NCBIMGSCv36mm8
Celera1738,068,927 - 38,075,454 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
Hspa1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,853,496 - 3,860,223 (-)NCBIGRCr8
mRatBN7.2203,848,843 - 3,855,571 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,848,843 - 3,855,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,548,331 - 4,555,029 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,910,388 - 3,917,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,448,330 - 4,454,924 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,879,998 - 4,965,191 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,959,294 - 4,964,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,032,557 - 7,038,454 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera204,171,282 - 4,177,670 (+)NCBICelera
Cytogenetic Map20p12NCBI
HSPA1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,286,601 - 46,299,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,248,104 - 42,260,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,470,745 - 31,483,615 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,357,626 - 32,370,055 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,358,054 - 32,359,979 (-)Ensemblpanpan1.1panPan2
LOC101956412
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,816,113 - 35,825,083 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,736,243 - 1,745,231 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,735,880 - 1,745,231 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,909,960 - 23,914,629 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,909,960 - 23,938,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103221744
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,206,365 - 40,211,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,209,754 - 40,211,676 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,724,065 - 31,729,529 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,416,738 - 24,424,613 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,403,438 - 24,423,477 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LOC474850
43 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8 1
Low 5 5 21 5 6 5 6 6 12 10 5
Below cutoff 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005627163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038491375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038553570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038553571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038553572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038617459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038617460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038617461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038671524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038683044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038683045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038683046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_532082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000000983   ⟹   ENSCAFP00000000900
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl121,281,472 - 1,285,440 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845022951   ⟹   ENSCAFP00845017991
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl121,423,961 - 1,428,295 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845022967   ⟹   ENSCAFP00845018004
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl121,424,019 - 1,427,730 (-)Ensembl
RefSeq Acc Id: XM_005627163   ⟹   XP_005627220
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1121,281,164 - 1,285,010 (-)NCBI
Dog10K_Boxer_Tasha121,416,835 - 1,420,649 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038491375   ⟹   XP_038347303
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1121,283,032 - 1,286,847 (-)NCBI
RefSeq Acc Id: XM_038553570   ⟹   XP_038409498
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0121,414,602 - 1,418,416 (-)NCBI
RefSeq Acc Id: XM_038553571   ⟹   XP_038409499
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0121,414,602 - 1,418,335 (-)NCBI
RefSeq Acc Id: XM_038553572   ⟹   XP_038409500
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0121,414,602 - 1,418,353 (-)NCBI
RefSeq Acc Id: XM_038617459   ⟹   XP_038473387
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0121,350,176 - 1,353,991 (-)NCBI
RefSeq Acc Id: XM_038617460   ⟹   XP_038473388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0121,350,176 - 1,353,910 (-)NCBI
RefSeq Acc Id: XM_038617461   ⟹   XP_038473389
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0121,350,176 - 1,353,928 (-)NCBI
RefSeq Acc Id: XM_038671524   ⟹   XP_038527452
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha121,416,835 - 1,420,586 (-)NCBI
RefSeq Acc Id: XM_038683044   ⟹   XP_038538972
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0121,424,019 - 1,427,833 (-)NCBI
RefSeq Acc Id: XM_038683045   ⟹   XP_038538973
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0121,424,019 - 1,427,752 (-)NCBI
RefSeq Acc Id: XM_038683046   ⟹   XP_038538974
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0121,424,019 - 1,427,770 (-)NCBI
RefSeq Acc Id: XM_532082   ⟹   XP_532082
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1121,281,164 - 1,284,913 (-)NCBI
Dog10K_Boxer_Tasha121,416,835 - 1,420,568 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005627220   ⟸   XM_005627163
- Peptide Label: isoform X1
- UniProtKB: A0A8P0N3U3 (UniProtKB/TrEMBL),   A0A8I3NQW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_532082   ⟸   XM_532082
- Peptide Label: isoform X2
- UniProtKB: A0A8P0N501 (UniProtKB/TrEMBL),   A0A8I3NQW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000900   ⟸   ENSCAFT00000000983
RefSeq Acc Id: XP_038347303   ⟸   XM_038491375
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038473387   ⟸   XM_038617459
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038473389   ⟸   XM_038617461
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038473388   ⟸   XM_038617460
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038538972   ⟸   XM_038683044
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NE39 (UniProtKB/TrEMBL),   A0A8I3NQW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538974   ⟸   XM_038683046
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NQP8 (UniProtKB/TrEMBL),   A0A8I3NQW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038538973   ⟸   XM_038683045
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NQP8 (UniProtKB/TrEMBL),   A0A8I3NQW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038527452   ⟸   XM_038671524
- Peptide Label: isoform X2
- UniProtKB: A0A8P0N501 (UniProtKB/TrEMBL),   A0A8I3NQW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038409498   ⟸   XM_038553570
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NQW2 (UniProtKB/TrEMBL),   A0A8P0N3U3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038409500   ⟸   XM_038553572
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NQW2 (UniProtKB/TrEMBL),   A0A8P0N501 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038409499   ⟸   XM_038553571
- Peptide Label: isoform X2
- UniProtKB: A0A8I3NQW2 (UniProtKB/TrEMBL),   A0A8P0N501 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845017991   ⟸   ENSCAFT00845022951
RefSeq Acc Id: ENSCAFP00845018004   ⟸   ENSCAFT00845022967


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000639 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845012910 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFG00845012950 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000983.4 UniProtKB/TrEMBL
  ENSCAFT00000002983.3 UniProtKB/TrEMBL
  ENSCAFT00845022951 ENTREZGENE
  ENSCAFT00845022951.1 UniProtKB/TrEMBL
  ENSCAFT00845022967 ENTREZGENE
  ENSCAFT00845022967.1 UniProtKB/TrEMBL
  ENSCAFT00845023074.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/TrEMBL
KEGG Report cfa:474850 UniProtKB/TrEMBL
NCBI Gene LOC474850 ENTREZGENE
PANTHER HEAT SHOCK 70 KDA PROTEIN 1-LIKE UniProtKB/TrEMBL
  HEAT SHOCK 70 KDA PROTEIN 1A-RELATED UniProtKB/TrEMBL
  PTHR19375 UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/TrEMBL
PRINTS HEATSHOCK70 UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/TrEMBL
  HSP70_2 UniProtKB/TrEMBL
  HSP70_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/TrEMBL
  SSF100934 UniProtKB/TrEMBL
  SSF53067 UniProtKB/TrEMBL
UniProt A0A8I3NE39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NQP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NQW2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N3U3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N501 ENTREZGENE, UniProtKB/TrEMBL