MIR146B (microRNA mir-146b) - Rat Genome Database

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Gene: MIR146B (microRNA mir-146b) Canis lupus familiaris
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Symbol: MIR146B
Name: microRNA mir-146b (Ensembl:microRNA 146b)
RGD ID: 12108820
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-146b; microRNA 146b
RGD Orthologs
Human
Mouse
Rat
Pig
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,940,550 - 14,940,610 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,940,550 - 14,940,610 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,112,894 - 15,112,954 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,414,567 - 15,414,627 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,414,567 - 15,414,627 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,959,606 - 14,959,666 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,998,706 - 14,998,766 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,131,325 - 15,131,385 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18392026  


Genomics

Comparative Map Data
MIR146B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,940,550 - 14,940,610 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,940,550 - 14,940,610 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,112,894 - 15,112,954 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,414,567 - 15,414,627 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,414,567 - 15,414,627 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,959,606 - 14,959,666 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,998,706 - 14,998,766 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,131,325 - 15,131,385 (+)NCBIUU_Cfam_GSD_1.0
MIR146B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,436,512 - 102,436,584 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,436,512 - 102,436,584 (+)EnsemblGRCh38hg38GRCh38
GRCh3710104,196,269 - 104,196,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,186,258 - 104,186,330 (+)NCBINCBI36Build 36hg18NCBI36
Celera1097,937,172 - 97,937,244 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,829,357 - 97,829,429 (+)NCBIHuRef
CHM1_110104,479,721 - 104,479,793 (+)NCBICHM1_1
T2T-CHM13v2.010103,321,484 - 103,321,556 (+)NCBIT2T-CHM13v2.0
Mir146b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,331,201 - 46,331,309 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,331,201 - 46,331,309 (+)EnsemblGRCm39 Ensembl
GRCm381946,342,762 - 46,342,870 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,342,762 - 46,342,870 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,417,252 - 46,417,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1947,106,096 - 47,106,204 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.82NCBI
Mir146b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,144,860 - 255,144,947 (+)NCBIGRCr8
mRatBN7.21245,203,438 - 245,203,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,203,438 - 245,203,525 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,324,855 - 253,324,942 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,019,535 - 260,019,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,671,287 - 252,671,374 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,089,488 - 266,089,575 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,089,488 - 266,089,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,520,429 - 273,520,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,558,047 - 251,558,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1240,986,212 - 240,986,299 (+)NCBICelera
Cytogenetic Map1q54NCBI
MIR146B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114113,446,854 - 113,446,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,301,752 - 123,301,850 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system integumental system nervous system reproductive system
High
Medium
Low 1 2 6
Below cutoff 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000034924
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2814,940,550 - 14,940,610 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845043134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2815,414,567 - 15,414,627 (+)Ensembl
RefSeq Acc Id: NR_049300
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12814,940,550 - 14,940,610 (+)NCBI
Dog10K_Boxer_Tasha2815,112,894 - 15,112,954 (+)NCBI
ROS_Cfam_1.02815,414,567 - 15,414,627 (+)NCBI
UMICH_Zoey_3.12814,959,606 - 14,959,666 (+)NCBI
UNSW_CanFamBas_1.02814,998,706 - 14,998,766 (+)NCBI
UU_Cfam_GSD_1.02815,131,325 - 15,131,385 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000022817 Ensembl
  ENSCAFG00845024427 Ensembl, ENTREZGENE
Ensembl Transcript ENSCAFT00845043134 ENTREZGENE
miRBase MI0008073 ENTREZGENE
NCBI Gene MIR146B ENTREZGENE
RNAcentral URS000061B694 RNACentral
  URS00007E3F18 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR146B  microRNA mir-146b    microRNA 146b  Symbol and/or name change 5135510 APPROVED