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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:opioid abuse
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Accession:DOID:11206 term browser browse the term
Definition:A substance abuse that involves the recurring use of opioid drugs despite negative consequences. (DO)
Synonyms:exact_synonym: opioid use disorder
 xref: EFO:0010702;   ICD10CM:F11.1;   ICD9CM:305.5
For additional species annotation, visit the Alliance of Genome Resources.


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opioid abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankk1 ankyrin repeat and kinase domain containing 1 susceptibility ISO associated with phlegm syndrome;DNA:polymorphism:exon: RGD PMID:26138154 RGD:11065747 NCBI chr 8:49,779,862...49,788,024
Ensembl chr 8:49,779,862...49,788,024 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IEP
ISO		 protein:increased phosphorylation:Prefrontal Cortex, nucleus accumbens (rat) RGD PMID:30632799 PMID:31081159 RGD:401901180, RGD:401940188 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 treatment ISO RGD PMID:31081159 RGD:401940188 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Drd4 dopamine receptor D4 ISO association with inhaler;DNA:repeats:exon: RGD PMID:11054768 RGD:401960062 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:Prefrontal Cortex, nucleus accumbens (rat) RGD PMID:30632799 RGD:401901180 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO protein:increased expression:medial prefrontal cortex,lateral prefrontal cortex,orbitofrontal cortex RGD PMID:29766293 RGD:401938658 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO protein:increased expression:orbitofrontal cortex: RGD PMID:29766293 RGD:401938658 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO protein:increased expression:medial prefrontal cortex,lateral prefrontal cortex,orbitofrontal cortex RGD PMID:29766293 RGD:401938658 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO mRNA:altered expression:striatum RGD PMID:30059705 RGD:401900306 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 IMP RGD PMID:24399412 RGD:401959321 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IMP RGD PMID:9636221 RGD:401965473 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Oprd1 opioid receptor, delta 1 treatment
susceptibility		 ISO mRNA:increased expression:ventral striatum
associated with females, buprenorphine;DNA:SNP:intron (rs581111|rs529520) (human)
mRNA:altered expression:testis, omentum (human)
DNA:SNP:CDS: rs569356|rs678849 (human)		 RGD PMID:30059705 PMID:24126707 PMID:37660978 PMID:37146669 RGD:401900306, RGD:402463962, RGD:402463943, RGD:401976452 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 severity ISO mRNA:decreased expression:peripheral blood lymphocyte
DNA:SNP:CDS: rs997917|rs12548098|rs6473797|rs963549 (human)		 RGD PMID:31710992 PMID:37146669 RGD:401850570, RGD:401976452 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO mRNA:increased expression:ventral striatum RGD PMID:30059705 RGD:401900306 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 treatment
susceptibility		 ISO DNA:SNP:CDS: rs648893 (human)
DNA:methylation:exon 1 (rs1799971) (human)		 RGD PMID:37146669 PMID:37660978 RGD:401976452, RGD:402463943 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin ISO
IEP		 mRNA, protein:increased expression:peripheral blood lymphocyte
protein:increased expression:nucleus accumbens		 RGD PMID:31710992 PMID:24305833 RGD:401850570, RGD:401850592 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pomc proopiomelanocortin ISO mRNA:increased expression:ventral striatum RGD PMID:30059705 RGD:401900306 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Rgs10 regulator of G-protein signaling 10 IEP RGD PMID:22056472 RGD:13524518 NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 IEP RGD PMID:19664213 RGD:13524573 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IEP RGD PMID:22056472 RGD:13524518 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    Chemically-Induced Disorders 1394
      substance-related disorder 713
        substance abuse 235
          opioid abuse 20
Path 2
Term Annotations click to browse term
  disease 18976
    disease of anatomical entity 18260
      nervous system disease 14116
        central nervous system disease 12429
          brain disease 11666
            disease of mental health 8318
              substance-related disorder 713
                substance abuse 235
                  opioid abuse 20
paths to the root