Ankk1 (ankyrin repeat and kinase domain containing 1) - Rat Genome Database

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Gene: Ankk1 (ankyrin repeat and kinase domain containing 1) Rattus norvegicus
Analyze
Symbol: Ankk1
Name: ankyrin repeat and kinase domain containing 1
RGD ID: 1305538
Description: Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in regulation of cell cycle process. Predicted to be located in cell projection and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in alcohol use disorder; cocaine dependence; and heroin dependence. Orthologous to human ANKK1 (ankyrin repeat and kinase domain containing 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin repeat and protein kinase domain-containing protein 1; LOC367080; LOC690279; similar to ankyrin repeat and kinase domain containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,676,327 - 58,685,012 (-)NCBIGRCr8
mRatBN7.2849,779,862 - 49,788,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx855,283,981 - 55,292,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,562,857 - 53,571,036 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,427,117 - 51,435,296 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,750,631 - 53,758,925 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,370,801 - 52,378,944 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,714,745 - 52,722,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,734,164 - 52,741,935 (-)NCBI
Celera849,331,721 - 49,340,015 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell projection  (ISO)
cytoplasm  (IBA,ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. Bidwell LC, etal., Psychopharmacology (Berl). 2015 Apr;232(7):1177-86. doi: 10.1007/s00213-014-3748-2. Epub 2014 Oct 3.
2. Association between the traditional Chinese medicine pathological factors of opioid addiction and DRD2/ANKK1 TaqIA polymorphisms. Cai M, etal., BMC Complement Altern Med. 2015 Jul 3;15:209. doi: 10.1186/s12906-015-0727-z.
3. Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. Doehring A, etal., Pharmacogenet Genomics. 2009 Jun;19(6):407-14. doi: 10.1097/FPC.0b013e328320a3fd.
4. Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. Eicher JD, etal., PLoS One. 2013 May 15;8(5):e63762. doi: 10.1371/journal.pone.0063762. Print 2013.
5. Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers. Fagundo AB, etal., J Psychopharmacol. 2014 Dec;28(12):1170-7. doi: 10.1177/0269881114551079. Epub 2014 Sep 18.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Gelernter J, etal., Hum Mol Genet. 2006 Dec 15;15(24):3498-507. doi: 10.1093/hmg/ddl426. Epub 2006 Nov 3.
8. The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Hoenicka J, etal., Biol Psychiatry. 2010 Jan 1;67(1):3-11. doi: 10.1016/j.biopsych.2009.08.012.
9. Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Huang W, etal., Neuropsychopharmacology. 2009 Jan;34(2):319-30. doi: 10.1038/npp.2008.37. Epub 2008 Mar 19.
10. Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population. Kaminskaite M, etal., Gene. 2021 Jan 10;765:145107. doi: 10.1016/j.gene.2020.145107. Epub 2020 Sep 2.
11. The role of ANKK1 and TTC12 genes on drinking behaviour in tobacco dependent subjects. Lobo DS, etal., World J Biol Psychiatry. 2012 Mar;13(3):232-8. doi: 10.3109/15622975.2011.598560. Epub 2011 Sep 22.
12. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. Nelson EC, etal., JAMA Psychiatry. 2013 Mar;70(3):325-33. doi: 10.1001/jamapsychiatry.2013.282.
13. DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study. Ponce G, etal., Br J Psychiatry. 2008 Aug;193(2):121-5. doi: 10.1192/bjp.bp.107.041582.
14. Association of ankyrin repeats & kinase domain containing 1 (ANKK1) gene polymorphism with co-morbid alcohol & nicotine dependence: A pilot study from a tertiary care treatment centre in north India. Quraishi R, etal., Indian J Med Res. 2017 Jan;145(1):33-38. doi: 10.4103/ijmr.IJMR_458_14.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Spellicy CJ, etal., Pharmacogenet Genomics. 2013 Jul;23(7):333-40. doi: 10.1097/FPC.0b013e328361c39d.
19. Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy. Stapleton JA, etal., Pharmacogenet Genomics. 2011 Aug;21(8):447-53. doi: 10.1097/FPC.0b013e328347473a.
20. DRD2 and ANKK1 gene polymorphisms and alcohol dependence: a case-control study among a Mendelian population of East Asian ancestry. Suraj Singh H, etal., Alcohol Alcohol. 2013 Jul-Aug;48(4):409-14. doi: 10.1093/alcalc/agt014. Epub 2013 Feb 26.
21. DRD2 and ANKK1 genes associate with late-onset heroin dependence in men. Tsou CC, etal., World J Biol Psychiatry. 2019 Oct;20(8):605-615. doi: 10.1080/15622975.2017.1372630. Epub 2017 Sep 25.
22. Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. Vereczkei A, etal., PLoS One. 2013 Jun 28;8(6):e66592. doi: 10.1371/journal.pone.0066592. Print 2013.
23. A DRD2 and ANKK1 haplotype is associated with nicotine dependence. Voisey J, etal., Psychiatry Res. 2012 Apr 30;196(2-3):285-9. doi: 10.1016/j.psychres.2011.09.024. Epub 2012 Feb 29.
24. DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers. Wahlstrom LC, etal., Pharmacol Biochem Behav. 2012 Sep;102(3):471-6. doi: 10.1016/j.pbb.2012.06.012. Epub 2012 Jun 21.
25. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. Yang BZ, etal., Alcohol Clin Exp Res. 2008 Dec;32(12):2117-27. doi: 10.1111/j.1530-0277.2008.00800.x. Epub 2008 Sep 30.
26. A 35.8 kilobases haplotype spanning ANKK1 and DRD2 is associated with heroin dependence in Han Chinese males. Zhang J, etal., Brain Res. 2018 Jun 1;1688:54-64. doi: 10.1016/j.brainres.2018.03.017. Epub 2018 Mar 14.
Additional References at PubMed
PMID:8889548   PMID:27166167  


Genomics

Comparative Map Data
Ankk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,676,327 - 58,685,012 (-)NCBIGRCr8
mRatBN7.2849,779,862 - 49,788,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx855,283,981 - 55,292,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,562,857 - 53,571,036 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,427,117 - 51,435,296 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,750,631 - 53,758,925 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,370,801 - 52,378,944 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,714,745 - 52,722,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,734,164 - 52,741,935 (-)NCBI
Celera849,331,721 - 49,340,015 (-)NCBICelera
Cytogenetic Map8q23NCBI
ANKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,387,779 - 113,400,416 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11113,387,779 - 113,400,416 (+)EnsemblGRCh38hg38GRCh38
GRCh3711113,258,501 - 113,271,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,763,723 - 112,776,350 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411112,763,722 - 112,776,350NCBI
Celera11110,411,445 - 110,424,071 (+)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,186,137 - 109,198,762 (+)NCBIHuRef
CHM1_111113,141,499 - 113,154,124 (+)NCBICHM1_1
T2T-CHM13v2.011113,398,282 - 113,410,917 (+)NCBIT2T-CHM13v2.0
Ankk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,326,494 - 49,338,341 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl949,326,494 - 49,338,321 (-)EnsemblGRCm39 Ensembl
GRCm38949,415,194 - 49,427,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,415,194 - 49,427,021 (-)EnsemblGRCm38mm10GRCm38
MGSCv37949,223,327 - 49,235,126 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36949,167,452 - 49,179,251 (-)NCBIMGSCv36mm8
Celera946,712,988 - 46,724,868 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.83NCBI
Ankk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,035,388 - 15,046,139 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,036,071 - 15,046,118 (+)NCBIChiLan1.0ChiLan1.0
ANKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29114,132,094 - 114,145,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111115,226,472 - 115,240,295 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,267,717 - 108,280,635 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,111,003 - 112,125,952 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,111,003 - 112,123,382 (+)Ensemblpanpan1.1panPan2
ANKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,801,511 - 19,814,359 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,801,542 - 19,814,481 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,723,265 - 19,736,301 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0519,822,410 - 19,835,444 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,822,441 - 19,835,756 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,884,965 - 19,897,951 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,786,175 - 19,799,184 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,833,938 - 19,846,967 (-)NCBIUU_Cfam_GSD_1.0
Ankk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,531,923 - 95,543,648 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366121,161,961 - 1,173,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11104,752,023 - 104,765,071 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604321,245,489 - 21,261,506 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ankk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247848,810,559 - 8,820,444 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247848,810,409 - 8,821,732 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ankk1
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:103
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000068040
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat

Markers in Region
BM384954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,779,921 - 49,780,088 (+)MAPPERmRatBN7.2
Rnor_6.0853,750,691 - 53,750,857NCBIRnor6.0
Rnor_5.0852,370,861 - 52,371,027UniSTSRnor5.0
RGSC_v3.4852,714,798 - 52,714,964UniSTSRGSC3.4
Celera849,331,781 - 49,331,947UniSTS
RH 3.4 Map8534.9UniSTS
Cytogenetic Map8q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium
Low 4
Below cutoff 1 9 8 22 11 16 9

Sequence


RefSeq Acc Id: ENSRNOT00000068040   ⟹   ENSRNOP00000062510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)Ensembl
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)Ensembl
RefSeq Acc Id: NM_001108999   ⟹   NP_001102469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,676,327 - 58,684,489 (-)NCBI
mRatBN7.2849,779,862 - 49,788,024 (-)NCBI
RefSeq Acc Id: XM_063265876   ⟹   XP_063121946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,676,327 - 58,685,012 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102469 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95442 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062510
  ENSRNOP00000062510.3
RefSeq Acc Id: ENSRNOP00000062510   ⟸   ENSRNOT00000068040
RefSeq Acc Id: NP_001102469   ⟸   NM_001108999
- UniProtKB: D3ZDY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121946   ⟸   XM_063265876
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDY2-F1-model_v2 AlphaFold D3ZDY2 1-746 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305538 AgrOrtholog
BioCyc Gene G2FUF-30583 BioCyc
Ensembl Genes ENSRNOG00000025037 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068040 ENTREZGENE
  ENSRNOT00000068040.3 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 367080 ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Ankk1 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025037 RatGTEx
SMART ANK UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt D3ZDY2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ankk1  ankyrin repeat and kinase domain containing 1  LOC690279  similar to ankyrin repeat and kinase domain containing 1  Data merged from RGD:1582835 737654 PROVISIONAL
2008-04-30 Ankk1  ankyrin repeat and kinase domain containing 1   Ankk1_predicted  ankyrin repeat and kinase domain containing 1 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC690279  similar to ankyrin repeat and kinase domain containing 1  LOC684394  similar to ankyrin repeat and kinase domain containing 1  Data merged from RGD:1591418 1643240 APPROVED
2006-11-20 LOC684394  similar to ankyrin repeat and kinase domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690279  similar to ankyrin repeat and kinase domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Ankk1_predicted  ankyrin repeat and kinase domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED