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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(E)-dimethomorph
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Accession:CHEBI:83426 term browser browse the term
Definition:An enamide resulting from the formal condensation of (2E)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acrylic acid with the amino group of morpholine. The agricultural fungicide dimethomorph is a mixture of (E)- and (Z)-dimethomorph; only the Z isomer has fungicidal activity.
Synonyms:exact_synonym: (2E)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-(morpholin-4-yl)prop-2-en-1-one
 related_synonym: Formula=C21H22ClNO4;   InChI=1S/C21H22ClNO4/c1-25-19-8-5-16(13-20(19)26-2)18(15-3-6-17(22)7-4-15)14-21(24)23-9-11-27-12-10-23/h3-8,13-14H,9-12H2,1-2H3/b18-14+;   InChIKey=QNBTYORWCCMPQP-NBVRZTHBSA-N;   SMILES=COc1ccc(cc1OC)C(=C\\C(=O)N1CCOCC1)\\c1ccc(Cl)cc1
 xref: CAS:113210-97-2;   PMID:12033804;   PMID:20623489;   PMID:22902184;   PMID:23496017;   Reaxys:8794474



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dimethomorph term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa10 annexin A10 increases expression ISO dimethomorph results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr16:27,738,712...27,805,648
Ensembl chr16:27,738,712...27,805,648
JBrowse link
G Ar androgen receptor multiple interactions ISO dimethomorph inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; dimethomorph inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA] CTD PMID:21310686 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 decreases expression ISO dimethomorph results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO dimethomorph results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO dimethomorph results in decreased expression of CYP7A1 mRNA; dimethomorph results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO dimethomorph binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO dimethomorph results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO dimethomorph binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Pde4a phosphodiesterase 4A decreases activity ISO dimethomorph results in decreased activity of PDE4A protein CTD PMID:21251949 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO dimethomorph binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      atom 20054
        nonmetal atom 19945
          carbon atom 19875
            organic molecular entity 19875
              olefinic compound 16506
                enamide 6717
                  (E)-dimethomorph 10
                    dimethomorph 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                alpha,beta-unsaturated carboxylic acid amide 6717
                                                  enamide 6717
                                                    (E)-dimethomorph 10
                                                      dimethomorph 10
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