Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fludrocortisone
go back to main search page
Accession:CHEBI:50885 term browser browse the term
Definition:A mineralocorticoid that has formula C21H29FO5.
Synonyms:exact_synonym: 9-fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione
 related_synonym: 9ALPHA-FLUOROCORTISOL;   Formula=C21H29FO5;   InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1;   InChIKey=AAXVEMMRQDVLJB-BULBTXNYSA-N;   SMILES=[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C;   fludrocortisona;   fludrocortisonum
 alt_id: CHEBI:46556;   CHEBI:5101
 xref: Beilstein:3014278;   CAS:127-31-1;   DrugBank:DB00687;   KEGG:C07004;   KEGG:D07967;   LIPID_MAPS_instance:LMST02030103
 xref_mesh: MESH:D005438
 xref: PDBeChem:ZK5;   Patent:GB792224;   Patent:US2852511;   Wikipedia:Fludrocortisone



show annotations for term's descendants           Sort by:
 
fludrocortisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO bicalutamide inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form]; Fludrocortisone binds to and results in increased activity of AR protein mutant form; Mifepristone inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form] CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Fludrocortisone results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Fludrocortisone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Fludrocortisone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Fludrocortisone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ereg epiregulin decreases expression ISO Fludrocortisone results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Fludrocortisone results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Fludrocortisone results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Fludrocortisone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Fludrocortisone binds to and results in increased activity of NR3C1 protein CTD PMID:11956172 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased abundance of Hydrocortisone; [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Fludrocortisone results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Fludrocortisone results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Fludrocortisone results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Fludrocortisone results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Fludrocortisone results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Fludrocortisone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        anti-inflammatory agent 16331
          anti-inflammatory drug 14850
            fludrocortisone 18
              fludrocortisone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      ketone 17097
                                        oxo steroid 10295
                                          3-oxo steroid 9895
                                            3-oxo-Delta(4) steroid 9130
                                              fludrocortisone 18
                                                fludrocortisone acetate 0
paths to the root