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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fludrocortisone
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Accession:CHEBI:50885 term browser browse the term
Definition:A mineralocorticoid that has formula C21H29FO5.
Synonyms:exact_synonym: 9-fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione
 related_synonym: 9ALPHA-FLUOROCORTISOL;   Formula=C21H29FO5;   InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1;   InChIKey=AAXVEMMRQDVLJB-BULBTXNYSA-N;   SMILES=[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C;   fludrocortisona;   fludrocortisonum
 alt_id: CHEBI:46556;   CHEBI:5101
 xref: Beilstein:3014278;   CAS:127-31-1;   DrugBank:DB00687;   KEGG:C07004;   KEGG:D07967;   LIPID_MAPS_instance:LMST02030103
 xref_mesh: MESH:D005438
 xref: PDBeChem:ZK5;   Patent:GB792224;   Patent:US2852511;   Wikipedia:Fludrocortisone


show annotations for term's descendants           Sort by:
fludrocortisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO bicalutamide inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form]; Fludrocortisone binds to and results in increased activity of AR protein mutant form; Mifepristone inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form] CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Fludrocortisone results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Fludrocortisone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Fludrocortisone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Fludrocortisone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ereg epiregulin decreases expression ISO Fludrocortisone results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Fludrocortisone results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Fludrocortisone results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 increases expression ISO Fludrocortisone results in increased expression of KLK3 protein CTD PMID:11956172 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Fludrocortisone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Fludrocortisone binds to and results in increased activity of NR3C1 protein CTD PMID:11956172 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased abundance of Hydrocortisone; [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Fludrocortisone results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Fludrocortisone results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Fludrocortisone results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Fludrocortisone results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Fludrocortisone results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Fludrocortisone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      application 19653
        anti-inflammatory agent 16607
          anti-inflammatory drug 14947
            fludrocortisone 19
              fludrocortisone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            heteroorganic entity 19484
                              organochalcogen compound 19248
                                organooxygen compound 19165
                                  carbonyl compound 18890
                                    ketone 17186
                                      oxo steroid 10544
                                        3-oxo steroid 9933
                                          3-oxo-Delta(4) steroid 9173
                                            fludrocortisone 19
                                              fludrocortisone acetate 0
paths to the root