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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fludrocortisone
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Accession:CHEBI:50885 term browser browse the term
Definition:A mineralocorticoid that has formula C21H29FO5.
Synonyms:exact_synonym: 9-fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione
 related_synonym: 9ALPHA-FLUOROCORTISOL;   Formula=C21H29FO5;   InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1;   InChIKey=AAXVEMMRQDVLJB-BULBTXNYSA-N;   SMILES=[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)CC[C@]12C;   fludrocortisona;   fludrocortisonum
 alt_id: CHEBI:46556;   CHEBI:5101
 xref: Beilstein:3014278;   CAS:127-31-1;   DrugBank:DB00687;   KEGG:C07004;   KEGG:D07967;   LIPID_MAPS_instance:LMST02030103
 xref_mesh: MESH:D005438
 xref: PDBeChem:ZK5;   Patent:GB792224;   Patent:US2852511;   Wikipedia:Fludrocortisone


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fludrocortisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO bicalutamide inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form]; Fludrocortisone binds to and results in increased activity of AR protein mutant form; Mifepristone inhibits the reaction [Fludrocortisone results in increased activity of AR protein mutant form] CTD PMID:11956172 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression ISO Fludrocortisone results in decreased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Fludrocortisone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Fludrocortisone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Fludrocortisone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ereg epiregulin decreases expression ISO Fludrocortisone results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Fludrocortisone results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Fludrocortisone results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Fludrocortisone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Fludrocortisone binds to and results in increased activity of NR3C1 protein CTD PMID:11956172 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased abundance of Hydrocortisone; [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Fludrocortisone results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Fludrocortisone binds to and results in increased activity of NR3C2 protein] which results in decreased expression of POMC protein CTD PMID:16566900 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Fludrocortisone results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Fludrocortisone results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Fludrocortisone results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Fludrocortisone results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:37,545,238...37,564,704
Ensembl chr 3:37,545,238...37,564,699
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Fludrocortisone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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  CHEBI ontology 19773
    role 19723
      application 19413
        anti-inflammatory agent 15761
          anti-inflammatory drug 13619
            fludrocortisone 18
              fludrocortisone acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      ketone 16828
                                        oxo steroid 9714
                                          3-oxo steroid 9271
                                            3-oxo-Delta(4) steroid 8410
                                              fludrocortisone 18
                                                fludrocortisone acetate 0
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