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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:galanthamine
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Accession:CHEBI:42944 term browser browse the term
Definition:A benzazepine alkaloid isolated from certain species of daffodils.
Synonyms:related_synonym: (4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol;   Formula=C17H21NO3;   InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1;   InChIKey=ASUTZQLVASHGKV-JDFRZJQESA-N;   SMILES=[H][C@]12C[C@@H](O)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13;   galantamina;   galantamine;   galanthaminum
 alt_id: CHEBI:42935;   CHEBI:5264
 xref: Beilstein:93736;   CAS:357-70-0;   Chemspider:9272;   DrugBank:DB00674;   Drug_Central:1272;   HMDB:HMDB0014812;   KEGG:C08526;   KEGG:D04292;   KNApSAcK:C00001570;   LINCS:LSM-5604
 xref_mesh: MESH:D005702
 xref: MetaCyc:CPD-19430;   PDBeChem:GNT;   PMID:10606746;   PMID:11060814;   PMID:11119642;   PMID:11950787;   PMID:12177686;   PMID:14674789;   PMID:15495017;   PMID:15537482;   PMID:15563167;   PMID:16437436;   PMID:17481657;   PMID:19253410;   PMID:19782102;   PMID:23035744;   PMID:5333582;   Reaxys:93736;   Wikipedia:Galantamine
 cyclic_relationship: is_conjugate_base_of CHEBI:178021



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galanthamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
EXP
ISO
Galantamine results in decreased activity of ACHE protein
Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Galantamine binds to and results in decreased activity of ACHE protein; Galantamine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Galantamine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Galantamine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
CTD PMID:14535624 PMID:18571635 PMID:18573242 PMID:19345205 PMID:25522658 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP
ISO
Galantamine results in decreased activity of BCHE protein CTD PMID:19345205 PMID:29886234 PMID:31125207 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Galantamine results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP Galantamine results in decreased expression of CHRM1 protein CTD PMID:28837785 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
ISO Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        pharmacological role 19087
          neurotransmitter agent 16522
            cholinergic drug 5202
              galanthamine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteropolycyclic compound 18272
                                    organic heterobicyclic compound 17159
                                      benzazepine 526
                                        benzazepine alkaloid 40
                                          galanthamine 8
paths to the root