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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:benzazepine
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Accession:CHEBI:35676 term browser browse the term
Definition:A group of two-ring heterocyclic compounds consisting of a benzene ring fused to an azepine ring.
Synonyms:related_synonym: benzazepines;   benzoazepines


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benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity
affects response to substance
ISO benazepril results in decreased activity of ACE protein
ACE gene polymorphism affects the susceptibility to benazepril
CTD PMID:8359184 PMID:11007831 PMID:12652327 PMID:12848919 PMID:15498266 PMID:15555355 PMID:15788353 PMID:15793787 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 affects response to substance
increases response to substance
multiple interactions
ISO ACE2 gene SNP affects the susceptibility to benazepril
ACE2 gene SNP results in increased susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril
CTD PMID:20559404 PMID:21449848 PMID:27121444 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein; benazepril inhibits the reaction [Doxorubicin results in increased expression of ACTA2 mRNA] CTD PMID:15149348 PMID:20493835 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adrb2 adrenoceptor beta 2 affects response to substance ISO ADRB2 protein polymorphism affects the susceptibility to benazepril CTD PMID:15554460 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression EXP benazepril results in decreased expression of AGER mRNA; benazepril results in decreased expression of AGER protein CTD PMID:19018797 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
affects response to substance
ISO
EXP
benazepril results in decreased expression of AGT protein; benazepril results in decreased expression of AGT protein modified form
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Particulate Matter results in increased expression of AGT protein modified form]; benazepril inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]
AGT gene SNP affects the susceptibility to benazepril
[AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril; [AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril; [benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]
CTD PMID:10515446 PMID:11501062 PMID:11798627 PMID:12676074 PMID:17177138 PMID:17261659 PMID:18390891 PMID:19018797 PMID:20718632 PMID:20844835 PMID:21449848 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
EXP
ISO
benazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]
benazepril results in decreased expression of AGTR1A mRNA; benazepril results in decreased expression of AGTR1A protein
[AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril
CTD PMID:9596920 PMID:15157388 PMID:21449848 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions
ISO benazepril results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]
CTD PMID:16303729 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP benazepril inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP benazepril results in decreased expression of BAX protein CTD PMID:20026869 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP benazepril results in increased expression of BCL2 protein CTD PMID:20026869 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases activity
multiple interactions
ISO
EXP
benazepril results in increased activity of BDKRB2 protein
[icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to benazepril
CTD PMID:15339989 PMID:16982965 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein] CTD PMID:16284884 PMID:19553526 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP benazepril results in decreased expression of CCN2 mRNA CTD PMID:17121042 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cd36 CD36 molecule increases expression EXP benazepril results in increased expression of CD36 mRNA CTD PMID:14871019 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression
multiple interactions
EXP benazepril results in decreased expression of COL4A1 mRNA
benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]
CTD PMID:11798618 PMID:16191423 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP benazepril inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance ISO CYP11B2 gene polymorphism affects the susceptibility to benazepril CTD PMID:16765146 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
increases activity
EXP benazepril results in decreased expression of EDN1 mRNA; benazepril results in decreased expression of EDN1 protein
[Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein
benazepril results in increased activity of EDN1 protein
CTD PMID:7528292 PMID:11136700 PMID:16191423 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP benazepril results in increased expression of EGLN3 mRNA CTD PMID:14871019 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
EXP benazepril results in decreased expression of FN1 mRNA; benazepril results in decreased expression of FN1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
CTD PMID:10515446 PMID:11798618 PMID:16191423 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP benazepril results in increased expression of FOS mRNA CTD PMID:8539265 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP benazepril results in increased expression of GOT2 mRNA CTD PMID:14871019 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP benazepril results in increased expression of HGF mRNA CTD PMID:16696918 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP benazepril results in increased expression of HSPE1 mRNA CTD PMID:14871019 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Il6 interleukin 6 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein] CTD PMID:16284884 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kng2 kininogen 2 multiple interactions
increases expression
EXP benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form] CTD PMID:11509473 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression EXP benazepril results in increased expression of MAPK1 mRNA CTD PMID:14871019 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Me1 malic enzyme 1 increases expression EXP benazepril results in increased expression of ME1 mRNA CTD PMID:14871019 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP2 protein]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in decreased expression of MMP2 protein] CTD PMID:16732983 PMID:19357873 PMID:20821936 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
increases activity
multiple interactions
ISO
EXP
benazepril results in decreased expression of MMP9 protein
benazepril results in increased activity of MMP9 protein
benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 mRNA]; benazepril inhibits the reaction [Doxorubicin results in decreased expression of MMP9 protein]
CTD PMID:15339989 PMID:19357873 PMID:20981132 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to benazepril; MTHFR gene SNP affects the susceptibility to benazepril CTD PMID:16081343 PMID:20445573 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects response to substance ISO MTR gene SNP affects the susceptibility to benazepril; MTR protein polymorphism affects the susceptibility to benazepril CTD PMID:15148588 PMID:20445573 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP benazepril results in increased expression of MYC mRNA CTD PMID:8539265 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP [Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA CTD PMID:11136700 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression EXP benazepril results in decreased expression of NCF1 mRNA CTD PMID:19018797 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP benazepril inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in decreased expression of NFKBIA mRNA] CTD PMID:17900838 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP benazepril results in decreased expression of NOS2 mRNA; benazepril results in decreased expression of NOS2 protein CTD PMID:16191423 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression
EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA
benazepril results in decreased expression of NPPA mRNA
CTD PMID:8763405 PMID:11136700 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
EXP [Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
benazepril results in decreased expression of NPPB mRNA
CTD PMID:11136700 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO benazepril inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP benazepril results in decreased expression of PCNA protein CTD PMID:17121042 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP benazepril results in increased expression of PDK4 mRNA CTD PMID:14871019 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pla2g5 phospholipase A2, group V decreases expression EXP benazepril results in decreased expression of PLA2G5 mRNA CTD PMID:14871019 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAU mRNA] CTD PMID:15322501 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of PLAUR mRNA] CTD PMID:15322501 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Plg plasminogen increases activity
multiple interactions
ISO benazepril results in increased activity of PLG protein
FR 173657 inhibits the reaction [benazepril results in increased activity of PLG protein]
CTD PMID:15339989 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Prcp prolylcarboxypeptidase affects response to substance ISO PRCP gene SNP affects the susceptibility to benazepril CTD PMID:20079160 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
decreases phosphorylation
EXP benazepril inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]
benazepril results in decreased expression of RELA mRNA; benazepril results in decreased expression of RELA protein
benazepril results in decreased phosphorylation of RELA protein
CTD PMID:15157388 PMID:17900838 PMID:19018797 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases expression
increases activity
multiple interactions
ISO
EXP
benazepril results in increased expression of REN protein
benazepril results in increased activity of REN protein
[benazepril co-treated with Valsartan] results in increased activity of REN protein
CTD PMID:1316404 PMID:10836730 PMID:11501062 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression EXP benazepril results in decreased expression of RSAD2 mRNA CTD PMID:14871019 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Serpine1 serpin family E member 1 decreases expression
multiple interactions
ISO
EXP
benazepril results in decreased expression of SERPINE1 mRNA; benazepril results in decreased expression of SERPINE1 protein
FR 173657 inhibits the reaction [benazepril results in decreased expression of SERPINE1 mRNA]
benazepril inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA]
CTD PMID:15322501 PMID:15339989 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Serpinh1 serpin family H member 1 increases expression EXP benazepril results in increased expression of SERPINH1 mRNA CTD PMID:14871019 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions ISO benazepril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO
EXP
benazepril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Smad2 SMAD family member 2 affects expression
multiple interactions
EXP benazepril affects the expression of SMAD2 mRNA; benazepril affects the expression of SMAD2 protein
[benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein
CTD PMID:16635409 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 affects expression
multiple interactions
EXP benazepril affects the expression of SMAD3 mRNA; benazepril affects the expression of SMAD3 protein
[benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein; [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein
CTD PMID:16635409 PMID:19487956 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snrpn small nuclear ribonucleoprotein polypeptide N decreases expression EXP benazepril results in decreased expression of SNRPN mRNA CTD PMID:14871019 NCBI chr 1:195,074,328...195,096,460
Ensembl chr 1:195,074,330...195,096,460
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein CTD PMID:20445533 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP benazepril results in decreased expression of SPP1 mRNA CTD PMID:11867951 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
affects expression
ISO
EXP
benazepril results in decreased expression of TGFB1 protein
benazepril results in decreased expression of TGFB1 mRNA; benazepril results in decreased expression of TGFB1 protein
[benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; [benazepril co-treated with Irbesartan] affects the expression of TGFB1 mRNA; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
benazepril affects the expression of TGFB1 mRNA
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
CTD PMID:10515446 PMID:11798627 PMID:11867951 PMID:16191423 PMID:16409969 PMID:16523407 PMID:16635409 PMID:17177138 PMID:18390891 PMID:19018797 PMID:19487956 PMID:20493835 PMID:20844835 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TGFBR1 protein] CTD PMID:11798618 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression
multiple interactions
EXP benazepril results in decreased expression of TIMP1 mRNA; benazepril results in decreased expression of TIMP1 protein
benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 mRNA]; benazepril inhibits the reaction [Doxorubicin results in increased expression of TIMP1 protein]
CTD PMID:11867951 PMID:18471418 PMID:19357873 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein] CTD PMID:16732983 PMID:20821936 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO benazepril results in decreased expression of TLR4 protein CTD PMID:20981132 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
benazepril results in decreased expression of TNF protein
[benazepril co-treated with Amlodipine] results in decreased expression of TNF protein
CTD PMID:16775501 PMID:20981132 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP benazepril results in decreased expression of VCAM1 mRNA; benazepril results in decreased expression of VCAM1 protein CTD PMID:19018797 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP benazepril inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:20844835 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
capsazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA] CTD PMID:32652086 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein] CTD PMID:32652086 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]
capsazepine inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]
CTD PMID:19059400 PMID:32652086 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ar androgen receptor multiple interactions ISO capsazepine inhibits the reaction [Capsaicin results in increased expression of AR protein] CTD PMID:19059400 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO capsazepine inhibits the reaction [Acrolein results in increased expression of BAX protein] CTD PMID:24376112 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO capsazepine inhibits the reaction [Acrolein results in decreased expression of BCL2 protein] CTD PMID:24376112 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP capsazepine inhibits the reaction [Capsaicin results in increased expression of BDKRB1 mRNA] CTD PMID:22264228 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions ISO
EXP
capsazepine inhibits the reaction [Capsaicin results in increased expression of CALCA mRNA]
capsazepine inhibits the reaction [1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea results in increased secretion of CALCA protein]; capsazepine inhibits the reaction [arachidonyl dopamine results in increased secretion of CALCA protein]; capsazepine inhibits the reaction [Capsaicin results in increased expression of CALCA protein]; capsazepine inhibits the reaction [Capsaicin results in increased secretion of [CALCA protein co-treated with CALCB protein]]; capsazepine inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]; capsazepine inhibits the reaction [Carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein]]; capsazepine inhibits the reaction [ICI 118551 results in increased secretion of [CALCA protein co-treated with CALCB protein]]; capsazepine inhibits the reaction [NPPA protein results in increased secretion of CALCA protein]; capsazepine inhibits the reaction [Streptozocin results in decreased expression of CALCA protein]
capsazepine inhibits the reaction [Lidocaine results in increased secretion of CALCA protein]; TRPV1 protein affects the reaction [capsazepine results in decreased secretion of CALCA protein]
CTD PMID:14764656 PMID:15615864 PMID:17082722 PMID:17522345 PMID:17693108 PMID:17984664 PMID:18172555 PMID:18508045 PMID:18584893 PMID:19096234 PMID:30583000 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Calcb calcitonin-related polypeptide, beta multiple interactions ISO
EXP
capsazepine inhibits the reaction [Capsaicin results in increased expression of CALCB mRNA]
capsazepine inhibits the reaction [Capsaicin results in increased secretion of [CALCA protein co-treated with CALCB protein]]; capsazepine inhibits the reaction [carvedilol results in increased secretion of [CALCA protein co-treated with CALCB protein]]; capsazepine inhibits the reaction [ICI 118551 results in increased secretion of [CALCA protein co-treated with CALCB protein]]
CTD PMID:14764656 PMID:18584893 NCBI chr 1:184,271,116...184,276,480
Ensembl chr 1:184,271,590...184,276,475
JBrowse link
G Casp3 caspase 3 multiple interactions ISO capsazepine inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]
capsazepine inhibits the reaction [Capsaicin results in increased cleavage of and results in increased activity of CASP3 protein]
CTD PMID:17442041 PMID:24376112 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO capsazepine inhibits the reaction [Acrolein results in increased expression of CASP8 protein] CTD PMID:24376112 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO capsazepine inhibits the reaction [Capsaicin results in decreased secretion of CCL2 protein] CTD PMID:19798065 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO capsazepine inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; capsazepine inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA] CTD PMID:19853001 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO capsazepine promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]] CTD PMID:27556861 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Faslg Fas ligand multiple interactions ISO capsazepine inhibits the reaction [Acrolein results in increased expression of FASL protein] CTD PMID:24376112 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP capsazepine inhibits the reaction [anandamide results in increased expression of FOS protein] CTD PMID:15601931 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP
ISO
capsazepine inhibits the reaction [Capsaicin results in increased expression of GFAP protein]
capsazepine inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]
CTD PMID:20826152 PMID:32652086 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Ghsr growth hormone secretagogue receptor multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] CTD PMID:32652086 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of GRIN2B protein] CTD PMID:18577691 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO capsazepine inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA] CTD PMID:22198381 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO capsazepine inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]; capsazepine inhibits the reaction [IFNG results in increased activity of STAT1 protein]; capsazepine inhibits the reaction [IFNG results in increased expression of NOS2 protein] CTD PMID:14530214 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP capsazepine inhibits the reaction [Capsaicin results in increased expression of IGF1 protein] CTD PMID:17693108 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO capsazepine promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]] CTD PMID:27556861 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases expression ISO capsazepine results in increased expression of IL2 CTD PMID:17306834 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO capsazepine inhibits the reaction [[Ovalbumin co-treated with Formaldehyde] results in increased expression of and results in increased secretion of IL4 protein] CTD PMID:23671638 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions ISO capsazepine inhibits the reaction [Capsaicin results in increased expression of IL6 mRNA]; capsazepine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; capsazepine inhibits the reaction [Capsaicin results in increased secretion of IL6 protein]
capsazepine inhibits the reaction [Capsaicin results in decreased secretion of IL6 protein]; capsazepine inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
CTD PMID:16173059 PMID:17306835 PMID:17560936 PMID:19798065 PMID:20619260 PMID:21474332 PMID:32652086 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions EXP capsazepine inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Lep leptin multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAP3K7 protein] CTD PMID:22171160 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]
capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; capsazepine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]
capsazepine inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK1 protein]
CTD PMID:12196597 PMID:14530214 PMID:19059400 PMID:30583000 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
capsazepine inhibits the reaction [Lipopolysaccharides results in increased activity of MAPK3 protein]
capsazepine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]
capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]
CTD PMID:14530214 PMID:19059400 PMID:30583000 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO capsazepine inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of MAPK8 protein] CTD PMID:22171160 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression
multiple interactions
ISO capsazepine affects the expression of MMP1 mRNA; capsazepine affects the expression of MMP1 protein
capsazepine inhibits the reaction [Capsaicin results in increased expression of MMP1 protein]
CTD PMID:17508023 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression
affects activity
ISO
EXP
capsazepine inhibits the reaction [Acids results in increased activity of MPO protein]
capsazepine results in increased expression of MPO protein
Indomethacin inhibits the reaction [capsazepine affects the activity of MPO protein]
CTD PMID:12024109 PMID:12893632 PMID:16091555 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO capsazepine inhibits the reaction [Citric Acid results in increased secretion of MUC5AC protein] CTD PMID:22566028 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] CTD PMID:32652086 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO capsazepine inhibits the reaction [[IFNG protein results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Nitric Oxide] which results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [IFNG results in increased expression of NOS2 protein]; capsazepine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; capsazepine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:14530214 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP capsazepine inhibits the reaction [NPPA protein results in increased secretion of CALCA protein] CTD PMID:17522345 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] CTD PMID:32652086 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP
ISO
capsazepine inhibits the reaction [Capsaicin results in increased secretion of POMC protein]
capsazepine inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]
CTD PMID:8925284 PMID:32652086 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions ISO capsazepine inhibits the reaction [Colforsin results in increased phosphorylation of PPP1R12A protein] CTD PMID:21474433 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 multiple interactions ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] CTD PMID:32652086 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO capsazepine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; capsazepine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; capsazepine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:14530214 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO capsazepine inhibits the reaction [IFNG results in increased activity of STAT1 protein] CTD PMID:14530214 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions ISO
EXP
capsazepine inhibits the reaction [[Ovalbumin co-treated with Formaldehyde] results in increased expression of TAC1 protein]; capsazepine inhibits the reaction [Acids results in increased secretion of TAC1 protein]
capsazepine inhibits the reaction [Capsaicin results in increased secretion of TAC1 protein]; capsazepine inhibits the reaction [GR 73632 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]]; capsazepine inhibits the reaction [Streptozocin results in decreased expression of TAC1 protein]
CTD PMID:15750287 PMID:16091555 PMID:18809416 PMID:22198006 PMID:23671638 PMID:30583000 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO capsazepine inhibits the reaction [Acids affects the localization of TACR1 protein] CTD PMID:16091555 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions EXP capsazepine inhibits the reaction [methanandamide affects the expression of THY1 mRNA] CTD PMID:17591864 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO capsazepine inhibits the reaction [methanandamide results in increased expression of TIMP1 protein] CTD PMID:18159069 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
affects activity
ISO
EXP
capsazepine inhibits the reaction [Capsaicin results in increased secretion of TNF protein]
capsazepine inhibits the reaction [Olanzapine results in increased expression of TNF protein]
capsazepine results in increased expression of TNF protein
capsazepine inhibits the reaction [1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; capsazepine inhibits the reaction [Capsaicin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
capsazepine affects the activity of TNF protein
CTD PMID:12024109 PMID:18508045 PMID:20383154 PMID:21474332 PMID:32652086 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO capsazepine inhibits the reaction [Capsaicin results in increased expression of TNFRSF1A protein]; capsazepine inhibits the reaction [resiniferatoxin results in increased expression of TNFRSF1A protein] CTD PMID:19531269 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 multiple interactions EXP capsazepine binds to and results in decreased activity of TRPM8 protein; capsazepine inhibits the reaction [Phenylephrine results in increased activity of TRPM8 protein]; capsazepine inhibits the reaction [Potassium Chloride results in increased activity of TRPM8 protein] CTD PMID:19363131 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
decreases activity
affects binding
ISO
EXP
capsazepine binds to and results in decreased activity of TRPV1 protein; capsazepine inhibits the reaction [[Cannabidiol results in increased activity of TRPV1 protein] which results in increased uptake of Calcium]; capsazepine inhibits the reaction [anandamide binds to and results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Cannabidiol results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Capsaicin binds to and results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased abundance of Calcium]]; capsazepine inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]]; capsazepine inhibits the reaction [Citric Acid results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [N-(4-hydroxyphenyl)arachidonylamide binds to and results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Phosphatidylinositol 4,5-Diphosphate affects the reaction [Capsaicin results in increased activity of TRPV1 protein]]; capsazepine inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]]; capsazepine promotes the reaction [Capsaicin results in increased activity of TRPV1 protein]
capsazepine results in decreased activity of TRPV1 protein
capsazepine binds to and results in decreased activity of TRPV1 protein; capsazepine inhibits the reaction [[Docosahexaenoic Acids co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form]; capsazepine inhibits the reaction [[Eicosapentaenoic Acid co-treated with Phorbol 12,13-Dibutyrate] results in increased activity of TRPV1 protein modified form]; capsazepine inhibits the reaction [[Formaldehyde results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]; capsazepine inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium]; capsazepine inhibits the reaction [Acrylamide analog inhibits the reaction [Protons results in increased activity of TRPV1 protein]]; capsazepine inhibits the reaction [adenosine 5'-O-(3-thiotriphosphate) results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [benzimidazole analog inhibits the reaction [Protons results in increased activity of TRPV1 protein]]; capsazepine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [dodecyl sulfate results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Lidocaine results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [N-(4-hydroxyphenyl)arachidonylamide results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [Protons results in increased activity of TRPV1 protein]]; capsazepine inhibits the reaction [resiniferatoxin promotes the reaction [TRPV1 protein binds to TRPV1 protein]]; capsazepine inhibits the reaction [Surface-Active Agents results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [TRPV1 protein results in increased susceptibility to Melitten]
capsazepine binds to TRPV1 protein
capsazepine binds to and results in decreased activity of TRPV1 protein; capsazepine inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein]; capsazepine inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]; TRPV1 protein affects the reaction [capsazepine results in decreased secretion of CALCA protein]; TRPV1 protein affects the susceptibility to [Phenylephrine co-treated with capsazepine]
CTD PMID:10822052 PMID:11140687 PMID:11278420 PMID:11358970 PMID:11606325 PMID:12196566 PMID:12922928 PMID:15363968 PMID:15601931 PMID:15978575 PMID:16135784 PMID:16446039 PMID:16513770 PMID:17038422 PMID:17082722 PMID:17442041 PMID:17984664 PMID:18172555 PMID:18230619 PMID:19540328 PMID:19847360 PMID:19904815 PMID:21453681 PMID:21908651 PMID:22566028 PMID:23747933 PMID:32652086 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
epinastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A affects the transport of epinastine CTD PMID:15100174 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects transport ISO ABCB1B affects the transport of epinastine CTD PMID:15100174 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] CTD PMID:12832840 PMID:19075512 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Ifng interferon gamma multiple interactions ISO epinastine inhibits the reaction [IL4 results in decreased expression of IFNG] CTD PMID:16534218 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il13 interleukin 13 decreases expression ISO epinastine results in decreased expression of IL13 mRNA; epinastine results in decreased expression of IL13 protein CTD PMID:16534218 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 multiple interactions ISO
EXP
epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]
epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]
CTD PMID:16534218 PMID:19075512 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 decreases expression ISO epinastine results in decreased expression of IL5 mRNA; epinastine results in decreased expression of IL5 protein CTD PMID:16534218 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 decreases expression ISO epinastine results in decreased expression of IL6 mRNA; epinastine results in decreased expression of IL6 protein CTD PMID:16534218 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO epinastine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Ngf nerve growth factor decreases expression ISO epinastine results in decreased expression of NGF protein CTD PMID:19937255 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO epinastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
fenoldopam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A3galt2 alpha 1,3-galactosyltransferase 2 increases expression EXP Fenoldopam results in increased expression of A3GALT2 mRNA CTD PMID:21983523 NCBI chr 5:146,933,592...146,945,882
Ensembl chr 5:146,933,592...146,945,880
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase increases expression EXP Fenoldopam results in increased expression of ABL2 mRNA CTD PMID:21983523 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Fenoldopam results in increased expression of ACTG1 mRNA CTD PMID:21983523 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 increases expression EXP Fenoldopam results in increased expression of ADAM9 mRNA CTD PMID:21983523 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 decreases expression EXP Fenoldopam results in decreased expression of ADAMTS4 mRNA CTD PMID:21983523 NCBI chr13:89,622,996...89,632,485
Ensembl chr13:89,622,632...89,634,419
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 decreases expression EXP Fenoldopam results in decreased expression of ATP2B2 mRNA CTD PMID:21983523 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression EXP Fenoldopam results in increased expression of B4GALT1 mRNA CTD PMID:21983523 NCBI chr 5:57,121,768...57,168,610
Ensembl chr 5:57,121,769...57,168,610
JBrowse link
G Calu calumenin increases expression EXP Fenoldopam results in increased expression of CALU mRNA CTD PMID:21983523 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Cbx7 chromobox 7 decreases expression EXP Fenoldopam results in decreased expression of CBX7 mRNA CTD PMID:21983523 NCBI chr 7:121,136,067...121,153,503
Ensembl chr 7:121,136,058...121,153,383
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression EXP Fenoldopam results in increased expression of CD55 mRNA CTD PMID:21983523 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression EXP Fenoldopam results in increased expression of CKAP4 mRNA CTD PMID:21983523 NCBI chr 7:24,935,243...24,947,595
Ensembl chr 7:24,939,498...24,947,595
JBrowse link
G Clic1 chloride intracellular channel 1 increases expression EXP Fenoldopam results in increased expression of CLIC1 mRNA CTD PMID:21983523 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
JBrowse link
G Col12a1 collagen type XII alpha 1 chain increases expression EXP Fenoldopam results in increased expression of COL12A1 mRNA CTD PMID:21983523 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Drd1 dopamine receptor D1 affects response to substance
multiple interactions
EXP DRD1 protein affects the susceptibility to Fenoldopam
Fenoldopam binds to and results in increased activity of DRD1 protein
CTD PMID:1724532 PMID:8103596 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Ecm2 extracellular matrix protein 2 decreases expression EXP Fenoldopam results in decreased expression of ECM2 mRNA CTD PMID:21983523 NCBI chr17:15,533,760...15,566,403
Ensembl chr17:15,533,972...15,566,332
JBrowse link
G Eng endoglin increases expression EXP Fenoldopam results in increased expression of ENG mRNA CTD PMID:21983523 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Fenoldopam results in increased expression of ENPP3 mRNA CTD PMID:21983523 NCBI chr 1:21,613,148...21,684,483
Ensembl chr 1:21,613,148...21,684,480
JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression EXP Fenoldopam results in increased expression of ERP29 mRNA CTD PMID:21983523 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Fenoldopam results in increased expression of FGF2 protein CTD PMID:12180796 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Fenoldopam results in increased expression of FN1 mRNA CTD PMID:21983523 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Fenoldopam results in decreased expression of HMGCS2 mRNA CTD PMID:21983523 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression EXP Fenoldopam results in increased expression of KDELR3 mRNA CTD PMID:21983523 NCBI chr 7:120,749,680...120,760,163
Ensembl chr 7:120,749,752...120,760,160
JBrowse link
G Kpna2 karyopherin subunit alpha 2 increases expression EXP Fenoldopam results in increased expression of KPNA2 mRNA CTD PMID:21983523 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Lgmn legumain increases expression EXP Fenoldopam results in increased expression of LGMN mRNA CTD PMID:21983523 NCBI chr 6:126,282,246...126,308,207
Ensembl chr 6:126,282,233...126,320,726
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression EXP Fenoldopam results in increased expression of LITAF mRNA CTD PMID:21983523 NCBI chr10:4,753,546...4,763,272
Ensembl chr10:4,719,713...4,763,510
JBrowse link
G Loxl2 lysyl oxidase-like 2 increases expression EXP Fenoldopam results in increased expression of LOXL2 mRNA CTD PMID:21983523 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234
JBrowse link
G Lrat lecithin retinol acyltransferase increases expression EXP Fenoldopam results in increased expression of LRAT mRNA CTD PMID:21983523 NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300
JBrowse link
G Myct1 myc target 1 increases expression EXP Fenoldopam results in increased expression of MYCT1 mRNA CTD PMID:21983523 NCBI chr 1:42,121,572...42,132,131
Ensembl chr 1:42,121,636...42,131,547
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression EXP Fenoldopam results in increased expression of NFKBIZ mRNA CTD PMID:21983523 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Fenoldopam results in increased expression of NOS2 protein CTD PMID:12180796 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nrip3 nuclear receptor interacting protein 3 increases expression EXP Fenoldopam results in increased expression of NRIP3 mRNA CTD PMID:21983523 NCBI chr 1:174,385,424...174,411,141
Ensembl chr 1:174,385,424...174,411,141
JBrowse link
G Omd osteomodulin decreases expression EXP Fenoldopam results in decreased expression of OMD mRNA CTD PMID:21983523 NCBI chr17:15,476,100...15,484,324
Ensembl chr17:15,475,710...15,484,269
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression EXP Fenoldopam results in increased expression of PDIA6 mRNA CTD PMID:21983523 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression EXP Fenoldopam results in increased expression of PGK1 mRNA CTD PMID:21983523 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Plp2 proteolipid protein 2 increases expression EXP Fenoldopam results in increased expression of PLP2 mRNA CTD PMID:21983523 NCBI chr  X:15,679,254...15,682,653
Ensembl chr  X:15,679,254...15,682,652
JBrowse link
G Pros1 protein S increases expression EXP Fenoldopam results in increased expression of PROS1 mRNA CTD PMID:21983523 NCBI chr 7:1,206,648...1,288,140
Ensembl chr 7:1,206,648...1,288,134
JBrowse link
G Ptrh1 peptidyl-tRNA hydrolase 1 homolog increases expression EXP Fenoldopam results in increased expression of PTRH1 mRNA CTD PMID:21983523 NCBI chr 3:11,811,303...11,817,007
Ensembl chr 3:11,811,962...11,825,640
JBrowse link
G Ran RAN, member RAS oncogene family increases expression EXP Fenoldopam results in increased expression of RAN mRNA CTD PMID:21983523 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rangap1 RAN GTPase activating protein 1 increases expression EXP Fenoldopam results in increased expression of RANGAP1 mRNA CTD PMID:21983523 NCBI chr 7:122,939,266...122,967,178
Ensembl chr 7:122,940,376...122,967,178
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression EXP Fenoldopam results in increased expression of S100A11 mRNA CTD PMID:21983523 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Fenoldopam results in increased expression of S100A4 mRNA CTD PMID:21983523 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP Fenoldopam results in decreased expression of SLC2A4 mRNA CTD PMID:21983523 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc39a11 solute carrier family 39, member 11 increases expression EXP Fenoldopam results in increased expression of SLC39A11 mRNA CTD PMID:21983523 NCBI chr10:101,754,842...102,169,100
Ensembl chr10:101,754,830...102,084,035
JBrowse link
G Slc41a2 solute carrier family 41 member 2 increases expression EXP Fenoldopam results in increased expression of SLC41A2 mRNA CTD PMID:21983523 NCBI chr 7:26,522,314...26,607,861
Ensembl chr 7:26,522,314...26,607,861
JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Fenoldopam results in increased activity of TAAR1 protein
[Fenoldopam results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP Fenoldopam results in increased expression of TGFB1 protein CTD PMID:12180796 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 increases expression EXP Fenoldopam results in increased expression of THBS1 mRNA CTD PMID:21983523 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Fenoldopam results in increased expression of TIMP1 mRNA CTD PMID:21983523 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Fenoldopam results in increased expression of TLR2 mRNA CTD PMID:21983523 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tmem97 transmembrane protein 97 increases expression EXP Fenoldopam results in increased expression of TMEM97 mRNA CTD PMID:21983523 NCBI chr10:65,811,455...65,820,538
Ensembl chr10:65,811,456...65,820,538
JBrowse link
G Tnc tenascin C increases expression EXP Fenoldopam results in increased expression of TNC mRNA CTD PMID:21983523 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression EXP Fenoldopam results in decreased expression of TNFSF10 mRNA CTD PMID:21983523 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tpm4 tropomyosin 4 increases expression EXP Fenoldopam results in increased expression of TPM4 mRNA CTD PMID:21983523 NCBI chr16:19,385,810...19,399,851
Ensembl chr16:19,385,736...19,399,903
JBrowse link
G Tubb4b tubulin, beta 4B class IVb increases expression EXP Fenoldopam results in increased expression of TUBB4B mRNA CTD PMID:21983523 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression EXP Fenoldopam results in increased expression of TUBB5 mRNA CTD PMID:21983523 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tubb6 tubulin, beta 6 class V increases expression EXP Fenoldopam results in increased expression of TUBB6 mRNA CTD PMID:21983523 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression EXP Fenoldopam results in increased expression of UBE2L3 mRNA CTD PMID:21983523 NCBI chr11:88,047,186...88,088,477
Ensembl chr11:88,047,832...88,088,476
JBrowse link
G Vcan versican increases expression EXP Fenoldopam results in increased expression of VCAN mRNA CTD PMID:21983523 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Vwf von Willebrand factor affects expression EXP Fenoldopam affects the expression of VWF protein CTD PMID:11026604 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
galanthamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions
EXP
ISO
Galantamine results in decreased activity of ACHE protein
Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Galantamine binds to and results in decreased activity of ACHE protein; Galantamine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Galantamine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Galantamine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
CTD PMID:14535624 PMID:18571635 PMID:18573242 PMID:19345205 PMID:25522658 PMID:27238725 PMID:28837785 PMID:29886234 PMID:30905860 PMID:31125207 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP
ISO
Galantamine results in decreased activity of BCHE protein CTD PMID:19345205 PMID:29886234 PMID:31125207 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Galantamine results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP Galantamine results in decreased expression of CHRM1 protein CTD PMID:28837785 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions
ISO Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions
ISO Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD PMID:15733544 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
ivabradine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E affects response to substance ISO APOE affects the susceptibility to ivabradine CTD PMID:21821843 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO ivabradine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
lorcaserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions ISO UGT2B17 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO UGT2B7 protein results in increased carbamoylation of and results in increased glucuronidation of lorcaserin CTD PMID:22259019 NCBI chr14:22,597,103...22,619,968 JBrowse link
mirtazapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of mirtazapine CTD PMID:14550684 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:28623179 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Cat catalase multiple interactions EXP mirtazapine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:19034656 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP mirtazapine results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein] CTD PMID:12523492 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein] CTD PMID:12523492 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO mirtazapine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression
ISO 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]; mirtazapine binds to and affects the activity of HTR2C protein CTD PMID:18083778 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:41,019,898...41,181,070
Ensembl chr 3:41,019,898...41,181,070
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:33,435,493...33,463,410
Ensembl chr 8:33,433,905...33,463,467
JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP mirtazapine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:19034656 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein] CTD PMID:28623179 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Prl prolactin increases expression ISO mirtazapine results in increased expression of PRL protein CTD PMID:15105766 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO mirtazapine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO mirtazapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO mirtazapine results in increased expression of SLC2A4 mRNA CTD PMID:16002093 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc2a5 solute carrier family 2 member 5 increases expression ISO mirtazapine results in increased expression of SLC2A5 mRNA CTD PMID:16002093 NCBI chr 5:167,142,182...167,174,203
Ensembl chr 5:167,141,875...167,174,310
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO mirtazapine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein] CTD PMID:28623179 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd1 dopamine receptor D1 multiple interactions ISO SK&F 77434 binds to and results in increased activity of DRD1 protein CTD PMID:15985612 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]; SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]; SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein] CTD PMID:19217379 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO SK&F 83959 binds to and results in increased activity of DRD1 protein CTD PMID:15985612 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]; SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]; SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein] CTD PMID:19217379 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
omacetaxine mepesuccinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 increases expression ISO Homoharringtonine results in increased expression of AHI1 protein alternative form CTD PMID:19379585 NCBI chr 1:16,478,127...16,601,769
Ensembl chr 1:16,478,127...16,601,769
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of AKT1 protein CTD PMID:31726078 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Homoharringtonine results in increased expression of BAD protein CTD PMID:31726078 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Homoharringtonine results in increased expression of BAX protein CTD PMID:31726078 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Homoharringtonine results in decreased expression of BCL2 protein CTD PMID:23980369 PMID:31726078 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
ISO Homoharringtonine results in increased expression of CASP3 protein
Homoharringtonine results in increased cleavage of CASP3 protein
CTD PMID:23980369 PMID:31726078 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases cleavage ISO Homoharringtonine results in increased cleavage of CASP7 protein CTD PMID:31726078 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
ISO Homoharringtonine results in increased expression of CASP9 protein
Homoharringtonine results in increased cleavage of CASP9 protein
CTD PMID:23980369 PMID:31726078 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Homoharringtonine results in decreased expression of CCNA2 protein CTD PMID:31726078 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Homoharringtonine results in decreased expression of CCNB1 protein CTD PMID:31726078 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Homoharringtonine results in increased expression of CCNE1 protein CTD PMID:31726078 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Homoharringtonine results in increased expression of CDK1 protein CTD PMID:31726078 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Homoharringtonine results in increased expression of CDK2 protein CTD PMID:31726078 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Ephb4 EPH receptor B4 multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein] CTD PMID:31726078 NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK1 protein CTD PMID:31726078 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK3 protein CTD PMID:31726078 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Homoharringtonine results in decreased expression of MCL1 protein CTD PMID:23980369 PMID:31726078 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Homoharringtonine results in decreased expression of MKI67 protein CTD PMID:31726078 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MTOR protein CTD PMID:31726078 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Homoharringtonine results in decreased expression of PIK3CA protein CTD PMID:31726078 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Homoharringtonine results in increased expression of PTEN protein CTD PMID:31726078 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Tyr tyrosinase increases expression ISO Homoharringtonine results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
SCH 23390 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ABCC6 mRNA CTD PMID:19564919 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcd4 ATP binding cassette subfamily D member 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ABCD4 mRNA CTD PMID:19564919 NCBI chr 6:108,315,026...108,329,550
Ensembl chr 6:108,315,035...108,329,464
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ABCG2 mRNA CTD PMID:19564919 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abra actin-binding Rho activating protein multiple interactions EXP [Methamphetamine co-treated with SCH 23390] affects the expression of ABRA mRNA CTD PMID:19564919 NCBI chr 7:80,792,615...80,796,683
Ensembl chr 7:80,792,600...80,796,670
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ACOT1 mRNA CTD PMID:19564919 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of ADAMTS9 mRNA
SCH 23390 results in decreased expression of ADAMTS9 mRNA
CTD PMID:19564919 NCBI chr 4:124,660,254...124,860,997
Ensembl chr 4:124,660,262...124,858,250
JBrowse link
G Adcy5 adenylate cyclase 5 multiple interactions ISO SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Clozapine]; SCH 23390 inhibits the reaction [ADCY5 protein affects the susceptibility to Haloperidol] CTD PMID:12223546 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Ahsa2 activator of HSP90 ATPase homolog 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of AHSA2 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of AHSA2 mRNA] CTD PMID:19564919 NCBI chr14:108,262,795...108,274,000
Ensembl chr14:108,265,207...108,273,938
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of AIF1 protein] CTD PMID:30922767 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Alg1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ALG1 mRNA CTD PMID:19564919 NCBI chr10:10,539,930...10,550,178
Ensembl chr10:10,539,930...10,550,138
JBrowse link
G Ankrd44 ankyrin repeat domain 44 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ANKRD44 mRNA
SCH 23390 results in decreased expression of ANKRD44 mRNA
CTD PMID:19564919 NCBI chr 9:61,229,252...61,529,532
Ensembl chr 9:61,231,988...61,528,882
JBrowse link
G Aplnr apelin receptor multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of APLNR mRNA CTD PMID:19564919 NCBI chr 3:72,540,538...72,544,183
Ensembl chr 3:72,540,538...72,544,182
JBrowse link
G Apold1 apolipoprotein L domain containing 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of APOLD1 mRNA CTD PMID:19564919 NCBI chr 4:168,752,142...168,755,024
Ensembl chr 4:168,752,133...168,755,023
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions
decreases expression
EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ARC mRNA]
SCH 23390 results in decreased expression of ARC mRNA
CTD PMID:11085305 PMID:19564919 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Arl5b ADP-ribosylation factor like GTPase 5B multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of ARL5B mRNA
SCH 23390 results in increased expression of ARL5B mRNA
CTD PMID:19564919 NCBI chr17:82,065,893...82,092,693
Ensembl chr17:82,065,937...82,091,362
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of ATF3 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF3 mRNA]
SCH 23390 results in decreased expression of ATF3 mRNA
CTD PMID:19564919 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 protein] CTD PMID:19564919 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Avp arginine vasopressin affects expression
multiple interactions
EXP SCH 23390 affects the expression of AVP mRNA
[Methamphetamine co-treated with SCH 23390] affects the expression of AVP mRNA
CTD PMID:19564919 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G B3galt4 Beta-1,3-galactosyltransferase 4 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of B3GALT4 mRNA
SCH 23390 results in decreased expression of B3GALT4 mRNA
CTD PMID:19564919 NCBI chr20:5,446,104...5,447,679
Ensembl chr20:5,446,104...5,447,673
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of BAX protein] CTD PMID:30922767 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
SCH 23390 inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]
SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of BCL2 protein]
CTD PMID:19879923 PMID:30922767 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l15 BCL2-like 15 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of BCL2L15 mRNA CTD PMID:19564919 NCBI chr 2:206,307,778...206,319,662
Ensembl chr 2:206,314,213...206,319,332
JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of BCL6 mRNA CTD PMID:19564919 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 affects expression
multiple interactions
EXP SCH 23390 affects the expression of BHMT2 mRNA
[Methamphetamine co-treated with SCH 23390] affects the expression of BHMT2 mRNA
CTD PMID:19564919 NCBI chr 2:23,272,320...23,289,266
Ensembl chr 2:23,272,328...23,289,266
JBrowse link
G C1qtnf7 C1q and TNF related 7 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of C1QTNF7 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of C1QTNF7 mRNA
CTD PMID:19564919 NCBI chr14:72,011,518...72,122,257
Ensembl chr14:72,011,461...72,122,158
JBrowse link
G Ca4 carbonic anhydrase 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CAR4 mRNA CTD PMID:19564919 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 multiple interactions ISO SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CACNA2D1 protein] CTD PMID:20340177 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP SCH 23390 inhibits the reaction [Dextroamphetamine results in increased expression of CALCA protein] CTD PMID:11398184 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869
JBrowse link
G Casp3 caspase 3 multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased cleavage of CASP3 protein] CTD PMID:30922767 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cc2d1b coiled-coil and C2 domain containing 1B multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CC2D1B mRNA CTD PMID:19564919 NCBI chr 5:128,215,711...128,229,762
Ensembl chr 5:128,215,711...128,229,737
JBrowse link
G Ccdc117 coiled-coil domain containing 117 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CCDC117 mRNA CTD PMID:19564919 NCBI chr14:85,763,396...85,772,762
Ensembl chr14:85,763,397...85,772,762
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CCN1 mRNA CTD PMID:19564919 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CCR5 mRNA CTD PMID:19564919 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd86 CD86 molecule multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of CD86 mRNA] CTD PMID:30922767 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
EXP SCH 23390 results in increased expression of CDKN1A mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of CDKN1A mRNA
CTD PMID:19564919 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CEBPB mRNA CTD PMID:19564919 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cep104 centrosomal protein 104 multiple interactions
affects expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CEP104 mRNA
SCH 23390 affects the expression of CEP104 mRNA
CTD PMID:19564919 NCBI chr 5:171,262,278...171,294,560
Ensembl chr 5:171,262,278...171,294,559
JBrowse link
G Chordc1 cysteine and histidine rich domain containing 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CHORDC1 mRNA CTD PMID:19564919 NCBI chr 8:17,421,552...17,445,513
Ensembl chr 8:17,421,557...17,446,165
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit decreases expression EXP SCH 23390 results in decreased expression of CHRNB1 mRNA CTD PMID:19564919 NCBI chr10:56,390,671...56,403,255
Ensembl chr10:56,390,671...56,403,188
JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CHRNE mRNA
SCH 23390 results in increased expression of CHRNE mRNA
CTD PMID:19564919 NCBI chr10:57,238,960...57,246,750
Ensembl chr10:57,238,946...57,243,435
JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of CHTF18 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of CHTF18 mRNA
CTD PMID:19564919 NCBI chr10:15,090,762...15,098,825
Ensembl chr10:15,090,316...15,098,791
JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CITED4 mRNA CTD PMID:19564919 NCBI chr 5:139,597,731...139,598,622
Ensembl chr 5:139,597,731...139,598,622
JBrowse link
G Clvs2 clavesin 2 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CLVS2 mRNA
SCH 23390 results in decreased expression of CLVS2 mRNA
CTD PMID:19564919 NCBI chr 1:25,173,089...25,217,625
Ensembl chr 1:25,173,242...25,296,927
JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CNOT6L mRNA
SCH 23390 results in increased expression of CNOT6L mRNA
CTD PMID:19564919 NCBI chr14:15,059,101...15,148,255
Ensembl chr14:15,059,387...15,146,586
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP SCH 23390 results in decreased expression of COL3A1 mRNA CTD PMID:19564919 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Coq10b coenzyme Q10B multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of COQ10B mRNA CTD PMID:19564919 NCBI chr 9:61,655,963...61,675,880
Ensembl chr 9:61,655,963...61,675,873
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP SCH 23390 inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]; SCH 23390 inhibits the reaction [[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]; SCH 23390 inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein] CTD PMID:14622123 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crem cAMP responsive element modulator multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CREM mRNA CTD PMID:19564919 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CRH mRNA; SCH 23390 affects the reaction [Cocaine affects the expression of CRH mRNA]
SCH 23390 results in increased expression of CRH mRNA
CTD PMID:11597771 PMID:19564919 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crispld1 cysteine-rich secretory protein LCCL domain containing 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CRISPLD1 mRNA CTD PMID:19564919 NCBI chr 5:663,750...711,033
Ensembl chr 5:670,754...711,033
JBrowse link
G Cryab crystallin, alpha B multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of CRYAB mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of CRYAB mRNA]
SCH 23390 results in increased expression of CRYAB mRNA
CTD PMID:19564919 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CSRP2 mRNA CTD PMID:19564919 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Cwc25 CWC25 spliceosome-associated protein homolog decreases expression EXP SCH 23390 results in decreased expression of CWC25 mRNA CTD PMID:19564919 NCBI chr10:85,684,898...85,709,568
Ensembl chr10:85,684,898...85,709,568
JBrowse link
G Cyp2j10 cytochrome P450, family 2, subfamily j, polypeptide 10 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CYP2J10 mRNA CTD PMID:19564919 NCBI chr 5:115,067,847...115,101,961
Ensembl chr 5:115,021,723...115,222,084
JBrowse link
G Cyyr1 cysteine and tyrosine rich 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of CYYR1 mRNA CTD PMID:19564919 NCBI chr11:24,967,936...25,078,740
Ensembl chr11:24,967,937...25,078,740
JBrowse link
G Dad1 defender against cell death 1 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DAD1 mRNA] CTD PMID:19564919 NCBI chr15:32,868,136...32,887,933
Ensembl chr15:32,868,087...32,888,095
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of DDIT3 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA] CTD PMID:19564919 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of DDIT4 mRNA CTD PMID:19564919 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx58 DEXD/H-box helicase 58 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of DDX58 mRNA CTD PMID:19564919 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Dmkn dermokine decreases expression EXP SCH 23390 results in decreased expression of DMKN mRNA CTD PMID:19564919 NCBI chr 1:89,215,266...89,229,696
Ensembl chr 1:89,215,266...89,229,696
JBrowse link
G Dnah1 dynein, axonemal, heavy chain 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of DNAH1 mRNA CTD PMID:19564919 NCBI chr16:7,345,131...7,407,009
Ensembl chr16:7,345,978...7,408,265
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of DNAJA1 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJA1 mRNA] CTD PMID:19564919 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of DNAJB1 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJB1 mRNA] CTD PMID:19564919 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of DNAJB4 mRNA CTD PMID:19564919 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJB5 mRNA] CTD PMID:19564919 NCBI chr 5:58,393,197...58,402,162
Ensembl chr 5:58,393,233...58,401,870
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJC3 mRNA] CTD PMID:19564919 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Dnase1 deoxyribonuclease 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of DNASE1 mRNA CTD PMID:19564919 NCBI chr10:11,757,681...11,760,672
Ensembl chr10:11,757,682...11,760,620
JBrowse link
G Dok3 docking protein 3 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of DOK3 mRNA
SCH 23390 results in increased expression of DOK3 mRNA
CTD PMID:19564919 NCBI chr17:9,639,064...9,644,090
Ensembl chr17:9,639,330...9,644,090
JBrowse link
G Drd1 dopamine receptor D1 affects binding
decreases activity
multiple interactions
ISO
EXP
SCH 23390 binds to DRD1 protein
SCH 23390 results in decreased activity of DRD1 protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [SCH 23390 binds to DRD1 protein]; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate]; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA]; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]; [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to A 86929; [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Amphetamine; [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methamphetamine; [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate; [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine; Aluminum inhibits the reaction [SCH 23390 binds to DRD1 protein]; boldine analog inhibits the reaction [SCH 23390 binds to DRD1 protein]; Cadmium inhibits the reaction [SCH 23390 binds to DRD1 protein]; Cocaine affects the reaction [SCH 23390 binds to DRD1 protein]; Copper inhibits the reaction [SCH 23390 binds to DRD1 protein]; Dopamine deficiency inhibits the reaction [SCH 23390 binds to DRD1 protein]; Gadolinium inhibits the reaction [SCH 23390 binds to DRD1 protein]; glyphosate inhibits the reaction [SCH 23390 binds to DRD1 protein]; Lanthanum inhibits the reaction [SCH 23390 binds to DRD1 protein]; Methamphetamine inhibits the reaction [SCH 23390 binds to DRD1 protein]; Pilocarpine inhibits the reaction [SCH 23390 binds to DRD1 protein]; SCH 23390 binds to and results in decreased activity of DRD1 protein; SCH 23390 inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]; SCH 23390 inhibits the reaction [[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]; SCH 23390 inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]; SCH 23390 inhibits the reaction [A 86929 binds to and results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]]; SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]]; SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]]; SCH 23390 inhibits the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]; Zinc Acetate inhibits the reaction [SCH 23390 binds to DRD1 protein]; zinc chloride inhibits the reaction [SCH 23390 binds to DRD1 protein]; Zinc Sulfate inhibits the reaction [SCH 23390 binds to DRD1 protein]
[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to A 86929; [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to adrogolide hydrochloride; [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methamphetamine; Amlodipine inhibits the reaction [SCH 23390 binds to DRD1 protein]; Diltiazem inhibits the reaction [SCH 23390 binds to DRD1 protein]; Flunarizine inhibits the reaction [SCH 23390 binds to DRD1 protein]; manidipine inhibits the reaction [SCH 23390 binds to DRD1 protein]; NR3C1 protein promotes the reaction [SCH 23390 binds to DRD1 protein]; SCH 23390 binds to and results in decreased activity of DRD1 protein; SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; Verapamil inhibits the reaction [SCH 23390 binds to DRD1 protein]
SCH 23390 inhibits the reaction [A 68930 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [A 77636 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [A 77636 results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [A 86929 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [A 86929 results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [Apomorphine results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; SCH 23390 inhibits the reaction [dihydrexidine results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [dinapsoline affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [dinapsoline results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [Dopamine affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [Dopamine results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [Isoquinolines affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [Isoquinolines results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [SK&F 81297 affects the localization of DRD1 protein]; SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; SCH 23390 inhibits the reaction [SK&F 82958 affects the localization of DRD1 protein]
CTD PMID:1418306 PMID:1724532 PMID:1833784 PMID:2213551 PMID:2891082 PMID:8103596 PMID:8103921 PMID:8558425 PMID:8829135 PMID:8997599 PMID:9109525 PMID:9533112 PMID:9537685 PMID:10785418 PMID:11226678 PMID:11421588 PMID:11454915 PMID:11701771 PMID:11927170 PMID:12617968 PMID:12673668 PMID:12813475 PMID:12946566 PMID:14622123 PMID:15075630 PMID:15711596 PMID:15985612 PMID:16137708 PMID:17161392 PMID:17948891 PMID:18363855 PMID:19120057 PMID:19733155 PMID:20053903 PMID:20340177 PMID:20956312 PMID:21999579 PMID:22292096 PMID:25522657 PMID:29458138 PMID:31323226 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] CTD PMID:8103921 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of DUSP1 mRNA; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA] CTD PMID:11701771 PMID:19564919 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp14 dual specificity phosphatase 14 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of DUSP14 mRNA
SCH 23390 results in increased expression of DUSP14 mRNA
CTD PMID:19564919 NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions EXP [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA] CTD PMID:11701771 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Efnb1 ephrin B1 increases expression EXP SCH 23390 results in increased expression of EFNB1 mRNA CTD PMID:19564919 NCBI chr  X:68,891,227...68,904,034
Ensembl chr  X:68,891,227...68,904,038
JBrowse link
G Egfl7 EGF-like-domain, multiple 7 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of EGFL7 mRNA CTD PMID:19564919 NCBI chr 3:4,034,759...4,044,280
Ensembl chr 3:4,034,921...4,043,936
JBrowse link
G Egflam EGF-like, fibronectin type III and laminin G domains multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of EGFLAM mRNA CTD PMID:19564919 NCBI chr 2:56,503,002...56,681,334
Ensembl chr 2:56,502,807...56,679,955
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP SCH 23390 inhibits the reaction [[Reserpine co-treated with Levodopa] results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of EGR1 mRNA]] CTD PMID:1347779 PMID:9890435 PMID:16549270 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 decreases expression EXP SCH 23390 results in decreased expression of EGR2 mRNA CTD PMID:19564919 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Egr4 early growth response 4 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of EGR4 mRNA
SCH 23390 results in decreased expression of EGR4 mRNA
CTD PMID:19564919 NCBI chr 4:117,293,620...117,296,082
Ensembl chr 4:117,293,620...117,296,082
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP SCH 23390 inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein] CTD PMID:17303341 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO SCH 23390 inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of ELK1 protein] CTD PMID:11553284 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of EPCAM mRNA CTD PMID:19564919 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP SCH 23390 inhibits the reaction [Cocaine results in increased expression of ERN1 protein] CTD PMID:17303341 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of ERRFI1 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of ERRFI1 mRNA
CTD PMID:19564919 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Faah fatty acid amide hydrolase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of FAAH mRNA CTD PMID:19564919 NCBI chr 5:134,852,899...134,872,095
Ensembl chr 5:134,852,875...134,871,775
JBrowse link
G Fadd Fas associated via death domain increases expression EXP SCH 23390 results in increased expression of FADD protein CTD PMID:18580876 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fam126b family with sequence similarity 126, member B multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of FAM126B mRNA CTD PMID:19564919 NCBI chr 9:65,406,136...65,478,399
Ensembl chr 9:65,406,138...65,442,257
JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of FCGR3 mRNA] CTD PMID:30922767 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in increased expression of FCGR2B mRNA] CTD PMID:30922767 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815
JBrowse link
G Fgf4 fibroblast growth factor 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of FGF4 mRNA CTD PMID:19564919 NCBI chr 1:218,024,537...218,029,539
Ensembl chr 1:218,025,810...218,027,220
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of FMO2 mRNA
SCH 23390 results in increased expression of FMO2 mRNA
CTD PMID:19564919 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of FOS mRNA; [Pilocarpine co-treated with SCH 23390] results in increased expression of FOS protein; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]; SCH 23390 inhibits the reaction [A 68930 results in increased expression of FOS mRNA]; SCH 23390 inhibits the reaction [Amphetamine results in increased expression of FOS protein]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOS protein]; SCH 23390 inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; SCH 23390 inhibits the reaction [dihydrexidine results in increased expression of FOS mRNA]
SCH 23390 results in decreased expression of FOS mRNA
CTD PMID:2118661 PMID:8511714 PMID:8864302 PMID:9751140 PMID:11172061 PMID:11421588 PMID:12807422 PMID:14960337 PMID:18822274 PMID:19564919 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO
SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein alternative form]; SCH 23390 inhibits the reaction [Cocaine results in increased expression of FOSB protein]
SCH 23390 inhibits the reaction [Amphetamine results in increased expression of FOSB mRNA]
CTD PMID:16674926 PMID:18822274 PMID:19710318 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of FTCD mRNA
SCH 23390 results in increased expression of FTCD mRNA
CTD PMID:19564919 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of GABRR3 mRNA CTD PMID:19564919 NCBI chr11:43,046,987...43,099,754
Ensembl chr11:43,046,987...43,099,412
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of GADD45B mRNA CTD PMID:19564919 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of GADD45G mRNA CTD PMID:19564919 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gas8 growth arrest specific 8 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of GAS8 mRNA
SCH 23390 results in decreased expression of GAS8 mRNA
CTD PMID:19564919 NCBI chr19:56,316,367...56,335,873
Ensembl chr19:56,316,268...56,335,870
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of GDF15 mRNA CTD PMID:19564919 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of GEM mRNA
SCH 23390 results in decreased expression of GEM mRNA
CTD PMID:19564919 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] CTD PMID:16088948 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gfra4 GDNF family receptor alpha 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of GFRA4 mRNA CTD PMID:19564919 NCBI chr 3:123,573,394...123,582,431
Ensembl chr 3:123,578,997...123,581,518
JBrowse link
G Gja4 gap junction protein, alpha 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of GJA4 mRNA CTD PMID:19564919 NCBI chr 5:145,374,688...145,377,221
Ensembl chr 5:145,374,690...145,377,221
JBrowse link
G Gpr150 G protein-coupled receptor 150 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of GPR150 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of GPR150 mRNA
CTD PMID:19564919 NCBI chr 2:2,810,280...2,815,991
Ensembl chr 2:2,812,554...2,814,690
JBrowse link
G Gpr4 G protein-coupled receptor 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of GPR4 mRNA CTD PMID:19564919 NCBI chr 1:80,125,639...80,136,786
Ensembl chr 1:80,135,391...80,136,880
JBrowse link
G Gpr65 G-protein coupled receptor 65 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of GPR65 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of GPR65 mRNA
CTD PMID:19564919 NCBI chr 6:122,248,528...122,256,115
Ensembl chr 6:122,254,841...122,256,251
JBrowse link
G Gtsf2 gametocyte specific factor 2 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of GTSF2 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of GTSF2 mRNA
CTD PMID:19564919 NCBI chr 7:145,056,697...145,064,502
Ensembl chr 7:145,056,693...145,062,956
JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of HCRT mRNA
SCH 23390 results in decreased expression of HCRT mRNA
CTD PMID:19564919 NCBI chr10:88,669,216...88,670,430
Ensembl chr10:88,669,214...88,670,430
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of HERPUD1 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HERPUD1 mRNA] CTD PMID:19564919 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hes5 hes family bHLH transcription factor 5 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of HES5 mRNA CTD PMID:19564919 NCBI chr 5:172,364,421...172,365,188
Ensembl chr 5:172,364,421...172,365,188
JBrowse link
G Hist1h4b histone cluster 1 H4 family member B multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of HIST1H4B mRNA
SCH 23390 results in increased expression of HIST1H4B mRNA
CTD PMID:19564919 NCBI chr17:44,522,144...44,526,587
Ensembl chr17:44,522,140...44,526,583
JBrowse link
G Hmga1 high mobility group AT-hook 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of HMGA1 mRNA CTD PMID:19564919 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of HMOX1 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HMOX1 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HMOX1 protein] CTD PMID:19564919 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA] CTD PMID:16549270 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Hrc histidine rich calcium binding protein decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of HRC mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of HRC mRNA
CTD PMID:19564919 NCBI chr 1:101,324,788...101,328,391
Ensembl chr 1:101,324,652...101,328,435
JBrowse link
G Hsf2bp heat shock transcription factor 2 binding protein multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of HSF2BP mRNA
SCH 23390 results in decreased expression of HSF2BP mRNA
CTD PMID:19564919 NCBI chr20:10,757,172...10,844,177
Ensembl chr20:10,757,854...10,844,178
JBrowse link
G Hspa12b heat shock protein family A (Hsp70) member 12B multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in decreased expression of HSPA12B mRNA] CTD PMID:19564919 NCBI chr 3:123,670,219...123,688,640
Ensembl chr 3:123,670,275...123,687,691
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of HSPA5 mRNA; SCH 23390 inhibits the reaction [Cocaine results in increased expression of HSPA5 protein]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA] CTD PMID:17303341 PMID:19564919 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of HSPB1 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPB1 mRNA] CTD PMID:19564919 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of HSPB8 mRNA] CTD PMID:19564919 NCBI chr12:45,905,371...45,920,014
Ensembl chr12:45,905,371...45,920,013
JBrowse link
G Icam2 intercellular adhesion molecule 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ICAM2 mRNA CTD PMID:19564919 NCBI chr10:94,569,889...94,581,218
Ensembl chr10:94,569,890...94,576,512
JBrowse link
G Idnk Idnk, gluconokinase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of IDNK mRNA CTD PMID:19564919 NCBI chr17:6,885,323...6,892,603
Ensembl chr17:6,885,221...6,892,497
JBrowse link
G Il10 interleukin 10 multiple interactions ISO SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 mRNA]; SCH 23390 inhibits the reaction [Reserpine results in decreased expression of IL10 protein] CTD PMID:16985181 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of IL1A mRNA
SCH 23390 results in increased expression of IL1A mRNA
CTD PMID:19564919 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Impg1 interphotoreceptor matrix proteoglycan 1 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of IMPG1 mRNA
SCH 23390 results in decreased expression of IMPG1 mRNA
CTD PMID:19564919 NCBI chr 8:87,733,374...87,879,958
Ensembl chr 8:87,733,545...87,879,888
JBrowse link
G Iqcf1 IQ motif containing F1 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of IQCF1 mRNA
SCH 23390 results in increased expression of IQCF1 mRNA
CTD PMID:19564919 NCBI chr 8:115,191,919...115,195,599
Ensembl chr 8:115,193,146...115,195,668
JBrowse link
G Jaml junction adhesion molecule like multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of JAML mRNA
SCH 23390 results in increased expression of JAML mRNA
CTD PMID:19564919 NCBI chr 8:49,378,644...49,408,894
Ensembl chr 8:49,378,644...49,410,088
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of JUNB mRNA; SCH 23390 inhibits the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]; SCH 23390 inhibits the reaction [Reserpine promotes the reaction [Dextroamphetamine results in increased expression of JUNB mRNA]] CTD PMID:1347779 PMID:19564919 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kif15 kinesin family member 15 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of KIF15 mRNA
SCH 23390 results in decreased expression of KIF15 mRNA
CTD PMID:19564919 NCBI chr 8:132,033,117...132,103,528
Ensembl chr 8:132,032,944...132,103,927
JBrowse link
G Klf5 Kruppel-like factor 5 decreases expression EXP SCH 23390 results in decreased expression of KLF5 mRNA CTD PMID:19564919 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Klhl15 kelch-like family member 15 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of KLHL15 mRNA
SCH 23390 results in increased expression of KLHL15 mRNA
CTD PMID:19564919 NCBI chr  X:63,342,277...63,390,915
Ensembl chr  X:63,343,546...63,389,989
JBrowse link
G Krt7 keratin 7 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of KRT7 mRNA
SCH 23390 results in decreased expression of KRT7 mRNA
CTD PMID:19564919 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G L3mbtl1 L3MBTL histone methyl-lysine binding protein 1 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of L3MBTL1 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of L3MBTL1 mRNA
CTD PMID:19564919 NCBI chr 3:159,316,580...159,348,914
Ensembl chr 3:159,321,310...159,347,631
JBrowse link
G Lgals9 galectin 9 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of LGALS9 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of LGALS9 mRNA
CTD PMID:19564919 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Lrrc28 leucine rich repeat containing 28 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of LRRC28 mRNA CTD PMID:19564919 NCBI chr 1:128,486,164...128,604,190
Ensembl chr 1:128,486,166...128,604,188
JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of LTBP1 mRNA
SCH 23390 results in decreased expression of LTBP1 mRNA
CTD PMID:19564919 NCBI chr 6:21,203,502...21,600,441
Ensembl chr 6:21,203,502...21,600,451
JBrowse link
G Ltc4s leukotriene C4 synthase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of LTC4S mRNA CTD PMID:19564919 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Ltk leukocyte receptor tyrosine kinase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of LTK mRNA CTD PMID:19564919 NCBI chr 3:111,553,679...111,560,556
Ensembl chr 3:111,553,680...111,560,556
JBrowse link
G Lurap1 leucine rich adaptor protein 1 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of LURAP1 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of LURAP1 mRNA
CTD PMID:19564919 NCBI chr 5:134,991,997...135,001,720
Ensembl chr 5:134,991,997...135,001,720
JBrowse link
G Lyrm9 LYR motif containing 9 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of LYRM9 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of LYRM9 mRNA
CTD PMID:19564919 NCBI chr10:66,099,478...66,113,559
Ensembl chr10:66,099,531...66,113,559
JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of MAFF mRNA CTD PMID:19564919 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of MANF mRNA] CTD PMID:19564919 NCBI chr 8:115,623,175...115,626,408
Ensembl chr 8:115,623,178...115,626,380
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]
SCH 23390 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of MAPK1 protein]; SCH 23390 inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]
CTD PMID:11553284 PMID:19187092 PMID:20956312 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]
SCH 23390 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of MAPK3 protein]; SCH 23390 inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]
CTD PMID:11553284 PMID:19187092 PMID:20956312 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mastl microtubule associated serine/threonine kinase-like multiple interactions
affects expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of MASTL mRNA
SCH 23390 affects the expression of MASTL mRNA
CTD PMID:19564919 NCBI chr17:89,839,562...89,875,855
Ensembl chr17:89,742,140...89,876,825
JBrowse link
G Mc4r melanocortin 4 receptor multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of MC4R mRNA CTD PMID:19564919 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of MCM8 mRNA
SCH 23390 results in decreased expression of MCM8 mRNA
CTD PMID:19564919 NCBI chr 3:125,470,499...125,500,795
Ensembl chr 3:125,470,551...125,500,795
JBrowse link
G Mfsd10 major facilitator superfamily domain containing 10 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of MFSD10 mRNA CTD PMID:19564919 NCBI chr14:81,362,594...81,366,208
Ensembl chr14:81,362,618...81,366,055
JBrowse link
G Mn1 MN1 proto-oncogene, transcriptional regulator multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of MN1 mRNA CTD PMID:19564919 NCBI chr12:51,214,192...51,250,230
Ensembl chr12:51,214,192...51,250,230
JBrowse link
G Mpg N-methylpurine-DNA glycosylase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of MPG mRNA CTD PMID:19564919 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of MUS81 mRNA CTD PMID:19564919 NCBI chr 1:220,862,474...220,867,973
Ensembl chr 1:220,862,386...220,867,815
JBrowse link
G Mylk myosin light chain kinase multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of MYLK mRNA
SCH 23390 results in decreased expression of MYLK mRNA
CTD PMID:19564919 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158
JBrowse link
G Nab2 Ngfi-A binding protein 2 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of NAB2 mRNA
SCH 23390 results in increased expression of NAB2 mRNA
CTD PMID:19564919 NCBI chr 7:70,963,580...70,971,471
Ensembl chr 7:70,961,575...70,969,905
JBrowse link
G Ndst3 N-deacetylase and N-sulfotransferase 3 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of NDST3 mRNA
SCH 23390 results in decreased expression of NDST3 mRNA
CTD PMID:19564919 NCBI chr 2:227,736,491...227,903,657
Ensembl chr 2:227,738,650...227,890,077
JBrowse link
G Neurl2 neuralized E3 ubiquitin protein ligase 2 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of NEURL2 mRNA
SCH 23390 results in decreased expression of NEURL2 mRNA
CTD PMID:19564919 NCBI chr 3:161,296,303...161,299,024
Ensembl chr 3:161,296,304...161,299,024
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 affects expression
multiple interactions
EXP SCH 23390 affects the expression of NFATC3 mRNA
SCH 23390 inhibits the reaction [Methamphetamine affects the localization of NFATC3 protein]
CTD PMID:15644446 PMID:19564919 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of NFATC4 mRNA; SCH 23390 inhibits the reaction [Methamphetamine affects the localization of NFATC4 protein] CTD PMID:15644446 PMID:19564919 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine affects the localization of NFE2L2 protein]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of NFE2L2 mRNA] CTD PMID:19564919 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of NFIL3 mRNA CTD PMID:19564919 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP SCH 23390 inhibits the reaction [Cocaine results in increased activity of NFKBIA protein] CTD PMID:19183502 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nkx2-6 NK2 homeobox 6 affects expression
multiple interactions
EXP SCH 23390 affects the expression of NKX2-6 mRNA
[Methamphetamine co-treated with SCH 23390] affects the expression of NKX2-6 mRNA
CTD PMID:19564919 NCBI chr15:51,034,620...51,038,715
Ensembl chr15:51,034,620...51,038,704
JBrowse link
G Nkx6-2 NK6 homeobox 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of NKX6-2 mRNA CTD PMID:19564919 NCBI chr 1:211,922,389...211,923,929
Ensembl chr 1:211,922,389...211,923,929
JBrowse link
G Notum NOTUM, palmitoleoyl-protein carboxylesterase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of NOTUM mRNA CTD PMID:19564919 NCBI chr10:109,832,977...109,840,661
Ensembl chr10:109,832,981...109,840,047
JBrowse link
G Npas4 neuronal PAS domain protein 4 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of NPAS4 mRNA CTD PMID:19564919 NCBI chr 1:220,260,310...220,278,177
Ensembl chr 1:220,261,008...220,265,772
JBrowse link
G Nptx2 neuronal pentraxin 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of NPTX2 mRNA CTD PMID:19564919 NCBI chr12:12,014,638...12,025,547
Ensembl chr12:12,013,911...12,025,549
JBrowse link
G Npy neuropeptide Y increases expression
multiple interactions
EXP SCH 23390 results in increased expression of NPY protein
[Prazosin co-treated with SCH 23390] inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein]
CTD PMID:7644023 PMID:21989786 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO NR3C1 protein promotes the reaction [SCH 23390 binds to DRD1 protein] CTD PMID:11226678 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of NR4A2 mRNA
SCH 23390 results in increased expression of NR4A2 mRNA
CTD PMID:19564919 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of NR4A3 mRNA CTD PMID:19564919 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nrm nurim multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of NRM mRNA CTD PMID:19564919 NCBI chr20:3,397,834...3,402,264
Ensembl chr20:3,397,834...3,401,315
JBrowse link
G Nup210l nucleoporin 210-like multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of NUP210L mRNA
SCH 23390 results in increased expression of NUP210L mRNA
CTD PMID:19564919 NCBI chr 2:189,453,932...189,571,918
Ensembl chr 2:189,454,340...189,571,529
JBrowse link
G Obsl1 obscurin like cytoskeletal adaptor 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of OBSL1 mRNA CTD PMID:19564919 NCBI chr 9:82,673,871...82,699,577
Ensembl chr 9:82,680,384...82,699,551
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of OGG1 mRNA CTD PMID:19564919 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Olr1708 olfactory receptor 1708 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of OLR1708 mRNA
SCH 23390 results in increased expression of OLR1708 mRNA
CTD PMID:19564919 NCBI chr20:1,172,891...1,173,805
Ensembl chr20:1,172,867...1,173,805
JBrowse link
G Olr1724 olfactory receptor 1724 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of OLR1724 mRNA
SCH 23390 results in increased expression of OLR1724 mRNA
CTD PMID:19564919 NCBI chr20:1,601,134...1,602,056
Ensembl chr20:1,601,129...1,602,065
JBrowse link
G Oxgr1 oxoglutarate receptor 1 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of OXGR1 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of OXGR1 mRNA
CTD PMID:19564919 NCBI chr15:105,399,596...105,422,559
Ensembl chr15:105,401,695...105,402,708
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide multiple interactions
affects expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of OXT mRNA
SCH 23390 affects the expression of OXT mRNA
CTD PMID:19564919 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of P4HA1 mRNA CTD PMID:19564919 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of P4HA2 mRNA
SCH 23390 results in increased expression of P4HA2 mRNA
CTD PMID:19564919 NCBI chr10:39,435,227...39,464,134
Ensembl chr10:39,435,227...39,464,188
JBrowse link
G Padi6 peptidyl arginine deiminase 6 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of PADI6 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of PADI6 mRNA
CTD PMID:19564919 NCBI chr 5:159,241,276...159,256,749
Ensembl chr 5:159,241,413...159,256,699
JBrowse link
G Pard6g par-6 family cell polarity regulator gamma multiple interactions
affects expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of PARD6G mRNA
SCH 23390 affects the expression of PARD6G mRNA
CTD PMID:19564919 NCBI chr18:76,559,877...76,627,843
Ensembl chr18:76,559,811...76,628,041
JBrowse link
G Pclaf PCNA clamp associated factor multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PCLAF mRNA CTD PMID:19564919 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 multiple interactions
affects expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PCSK1 mRNA
SCH 23390 affects the expression of PCSK1 mRNA
CTD PMID:19564919 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pde8a phosphodiesterase 8A multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PDE8A mRNA CTD PMID:19564919 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PDIA4 mRNA] CTD PMID:19564919 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of PDK4 mRNA
SCH 23390 results in increased expression of PDK4 mRNA
CTD PMID:19564919 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PEMT mRNA
SCH 23390 results in decreased expression of PEMT mRNA
CTD PMID:19564919 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
JBrowse link
G Pgap6 post-glycosylphosphatidylinositol attachment to proteins 6 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PGAP6 mRNA CTD PMID:19564919 NCBI chr10:15,484,952...15,495,380
Ensembl chr10:15,484,795...15,495,377
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PIK3R5 mRNA CTD PMID:19564919 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of PIK3R6 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of PIK3R6 mRNA
CTD PMID:19564919 NCBI chr10:55,085,269...55,135,069
Ensembl chr10:55,085,259...55,135,092
JBrowse link
G Pitx3 paired-like homeodomain 3 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of PITX3 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of PITX3 mRNA
CTD PMID:19564919 NCBI chr 1:265,886,766...265,899,947
Ensembl chr 1:265,887,230...265,899,958
JBrowse link
G Pkp2 plakophilin 2 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of PKP2 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of PKP2 mRNA
CTD PMID:19564919 NCBI chr11:88,912,163...88,972,213 JBrowse link
G Pla1a phospholipase A1 member A multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of PLA1A mRNA CTD PMID:19564919 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Plagl1 PLAG1 like zinc finger 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of PLAGL1 mRNA CTD PMID:19564919 NCBI chr 1:7,219,587...7,270,169
Ensembl chr 1:7,252,349...7,259,035
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP
ISO
[Methamphetamine co-treated with SCH 23390] results in increased expression of PLAT mRNA
SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA]
CTD PMID:15659235 PMID:19564919 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of PLEKHF1 mRNA CTD PMID:19564919 NCBI chr 1:94,609,041...94,616,565
Ensembl chr 1:94,609,377...94,610,854
JBrowse link
G Pmch pro-melanin-concentrating hormone multiple interactions
affects expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of PMCH mRNA
SCH 23390 affects the expression of PMCH mRNA
CTD PMID:19564919 NCBI chr 7:28,655,206...28,656,522
Ensembl chr 7:28,654,733...28,657,522
JBrowse link
G Ppip5k2 diphosphoinositol pentakisphosphate kinase 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of PPIP5K2 mRNA CTD PMID:19564919 NCBI chr 9:111,232,967...111,249,613
Ensembl chr 9:111,220,858...111,286,185
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP1R15A mRNA] CTD PMID:19564919 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CA protein] CTD PMID:15644446 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CB protein] CTD PMID:15644446 NCBI chr15:4,209,702...4,236,895
Ensembl chr15:4,209,703...4,236,895
JBrowse link
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3R2 protein] CTD PMID:15644446 NCBI chr 5:64,945,583...64,946,578
Ensembl chr 5:64,945,583...64,946,580
JBrowse link
G Prg4 proteoglycan 4 affects expression
multiple interactions
EXP SCH 23390 affects the expression of PRG4 mRNA
[Methamphetamine co-treated with SCH 23390] affects the expression of PRG4 mRNA
CTD PMID:19564919 NCBI chr13:67,672,588...67,688,902
Ensembl chr13:67,672,878...67,688,477
JBrowse link
G Prkx protein kinase, X-linked increases expression EXP SCH 23390 results in increased expression of PRKX mRNA CTD PMID:19564919 NCBI chr  X:45,080,963...45,125,095
Ensembl chr  X:45,080,963...45,124,270
JBrowse link
G Prok2 prokineticin 2 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of PROK2 mRNA
SCH 23390 results in increased expression of PROK2 mRNA
CTD PMID:19564919 NCBI chr 4:132,157,556...132,171,244
Ensembl chr 4:132,157,556...132,171,153
JBrowse link
G Prom1 prominin 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PROM1 mRNA CTD PMID:19564919 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PTH1R mRNA CTD PMID:19564919 NCBI chr 8:118,984,531...119,012,803
Ensembl chr 8:118,988,053...119,012,671
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of PYCARD mRNA
SCH 23390 results in decreased expression of PYCARD mRNA
CTD PMID:19564919 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rab3d RAB3D, member RAS oncogene family multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RAB3D mRNA CTD PMID:19564919 NCBI chr 8:22,920,238...22,929,368
Ensembl chr 8:22,918,699...22,929,294
JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression EXP SCH 23390 results in increased expression of RASD1 mRNA CTD PMID:19564919 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Rasl11a RAS-like family 11 member A multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RASL11A mRNA CTD PMID:19564919 NCBI chr12:9,986,150...9,990,284
Ensembl chr12:9,985,928...9,990,284
JBrowse link
G Rassf9 Ras association domain family member 9 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RASSF9 mRNA CTD PMID:19564919 NCBI chr 7:44,146,345...44,178,179
Ensembl chr 7:44,146,237...44,181,201
JBrowse link
G Rbm3 RNA binding motif protein 3 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RBM3 mRNA CTD PMID:19564919 NCBI chr  X:15,098,880...15,102,344
Ensembl chr  X:15,098,904...15,102,340
JBrowse link
G Rbm43 RNA binding motif protein 43 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of RBM43 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of RBM43 mRNA
CTD PMID:19564919 NCBI chr 3:37,434,616...37,446,777
Ensembl chr 3:37,434,620...37,445,907
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP SCH 23390 inhibits the reaction [Cocaine results in increased activity of RELA protein] CTD PMID:19183502 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RGD1305347 similar to RIKEN cDNA 2610528J11 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RGD1305347 mRNA CTD PMID:19564919 NCBI chr 5:137,356,777...137,360,636
Ensembl chr 5:137,356,801...137,360,580
JBrowse link
G RGD1308117 similar to 9930012K11Rik protein multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RGD1308117 mRNA
SCH 23390 results in decreased expression of RGD1308117 mRNA
CTD PMID:19564919 NCBI chr15:51,834,703...51,841,412
Ensembl chr15:51,834,703...51,839,341
JBrowse link
G RGD1565166 similar to MGC45438 protein multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RGD1565166 mRNA
SCH 23390 results in decreased expression of RGD1565166 mRNA
CTD PMID:19564919 NCBI chr10:10,555,337...10,564,433
Ensembl chr10:10,555,337...10,564,433
JBrowse link
G Rgs1 regulator of G-protein signaling 1 multiple interactions
affects expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of RGS1 mRNA
SCH 23390 affects the expression of RGS1 mRNA
CTD PMID:19564919 NCBI chr13:61,066,196...61,070,772
Ensembl chr13:61,066,153...61,070,599
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions EXP SCH 23390 inhibits the reaction [Amphetamine results in increased expression of RGS2 mRNA] CTD PMID:10098858 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rgs4 regulator of G-protein signaling 4 affects expression
increases expression
multiple interactions
EXP SCH 23390 affects the expression of RGS4 protein
SCH 23390 results in increased expression of RGS4 mRNA
Dextroamphetamine promotes the reaction [SCH 23390 results in increased expression of RGS4 mRNA]
CTD PMID:16539683 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RHBDF1 mRNA
SCH 23390 results in decreased expression of RHBDF1 mRNA
CTD PMID:19564919 NCBI chr10:15,672,370...15,685,285
Ensembl chr10:15,672,382...15,685,284
JBrowse link
G Rhod ras homolog family member D multiple interactions EXP [Methamphetamine co-treated with SCH 23390] affects the expression of RHOD mRNA CTD PMID:19564919 NCBI chr 1:219,668,352...219,682,287
Ensembl chr 1:219,668,352...219,682,287
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of RIMS2 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of RIMS2 mRNA
CTD PMID:19564919 NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138
JBrowse link
G Ripply2 ripply transcriptional repressor 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RIPPLY2 mRNA CTD PMID:19564919 NCBI chr 8:94,676,579...94,691,125
Ensembl chr 8:94,686,938...94,691,041
JBrowse link
G Rnf225 ring finger protein 225 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of RNF225 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of RNF225 mRNA
CTD PMID:19564919 NCBI chr 1:65,656,265...65,660,272
Ensembl chr 1:65,657,276...65,659,945
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions ISO SCH 23390 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of RPS6KA5 protein] CTD PMID:19187092 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Rpusd3 RNA pseudouridine synthase D3 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RPUSD3 mRNA CTD PMID:19564919 NCBI chr 4:145,361,937...145,370,992
Ensembl chr 4:145,366,765...145,370,992
JBrowse link
G Rtp1 receptor (chemosensory) transporter protein 1 multiple interactions
affects expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of RTP1 mRNA
SCH 23390 affects the expression of RTP1 mRNA
CTD PMID:19564919 NCBI chr11:80,823,989...80,826,505
Ensembl chr11:80,823,989...80,826,505
JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO SCH 23390 inhibits the reaction [SK&F 82958 results in increased expression of RYR1 protein] CTD PMID:22504960 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions ISO SCH 23390 inhibits the reaction [SK&F 82958 results in increased expression of RYR2 protein] CTD PMID:22504960 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of S100A11 mRNA
SCH 23390 results in decreased expression of S100A11 mRNA
CTD PMID:19564919 NCBI chr 2:193,863,185...193,868,646
Ensembl chr 2:193,866,951...193,868,502
JBrowse link
G Serpinb9 serpin family B member 9 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SERPINB9 mRNA CTD PMID:19564919 NCBI chr17:32,648,846...32,673,047
Ensembl chr17:32,650,441...32,661,865
JBrowse link
G Sertad1 SERTA domain containing 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of SERTAD1 mRNA CTD PMID:19564919 NCBI chr 1:84,293,102...84,296,370
Ensembl chr 1:84,293,102...84,296,367
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of SFRP2 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of SFRP2 mRNA
CTD PMID:19564919 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of SGK1 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of SGK1 mRNA
CTD PMID:19564919 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sigirr single Ig and TIR domain containing multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SIGIRR mRNA CTD PMID:19564919 NCBI chr 1:213,898,395...213,907,697
Ensembl chr 1:213,898,401...213,907,144
JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 multiple interactions ISO SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]; SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]] CTD PMID:20956312 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
JBrowse link
G Sik1 salt-inducible kinase 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of SIK1 mRNA CTD PMID:19564919 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Six4 SIX homeobox 4 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of SIX4 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of SIX4 mRNA
CTD PMID:19564919 NCBI chr 6:95,984,868...95,999,709
Ensembl chr 6:95,984,868...95,998,529
JBrowse link
G Slc16a11 solute carrier family 16, member 11 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC16A11 mRNA
SCH 23390 results in decreased expression of SLC16A11 mRNA
CTD PMID:19564919 NCBI chr10:56,822,697...56,826,480
Ensembl chr10:56,822,756...56,826,479
JBrowse link
G Slc16a13 solute carrier family 16, member 13 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC16A13 mRNA CTD PMID:19564919 NCBI chr10:56,827,591...56,831,324
Ensembl chr10:56,827,594...56,831,243
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC18A2 protein] CTD PMID:30922767 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc22a13 solute carrier family 22 member 13 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of SLC22A13 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC22A13 mRNA
CTD PMID:19564919 NCBI chr 8:127,885,268...127,900,829
Ensembl chr 8:127,885,268...127,900,463
JBrowse link
G Slc35b2 solute carrier family 35 member B2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC35B2 mRNA CTD PMID:19564919 NCBI chr 9:17,823,399...17,827,032
Ensembl chr 9:17,823,400...17,827,032
JBrowse link
G Slc38a5 solute carrier family 38, member 5 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC38A5 mRNA CTD PMID:19564919 NCBI chr  X:14,963,919...14,972,675
Ensembl chr  X:14,963,921...14,972,675
JBrowse link
G Slc39a12 solute carrier family 39 member 12 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of SLC39A12 mRNA CTD PMID:19564919 NCBI chr17:81,455,731...81,541,742
Ensembl chr17:81,455,955...81,541,759
JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC40A1 mRNA CTD PMID:19564919 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of SLC5A3 mRNA CTD PMID:19564919 NCBI chr11:32,229,366...32,231,812 JBrowse link
G Slc66a1 solute carrier family 66 member 1 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of SLC66A1 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC66A1 mRNA
CTD PMID:19564919 NCBI chr 5:157,744,945...157,759,370
Ensembl chr 5:157,745,490...157,759,322
JBrowse link
G Slc6a13 solute carrier family 6 member 13 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of SLC6A13 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC6A13 mRNA
CTD PMID:19564919 NCBI chr 4:153,874,942...153,912,185
Ensembl chr 4:153,874,852...153,912,155
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of SLC6A3 protein] CTD PMID:30922767 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Smad3 SMAD family member 3 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of SMAD3 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA
CTD PMID:19564919 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snx27 sorting nexin 27 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of SNX27 mRNA alternative form] CTD PMID:12740601 NCBI chr 2:195,738,613...195,821,608
Ensembl chr 2:195,738,619...195,821,608
JBrowse link
G Sox17 SRY-box transcription factor 17 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SOX17 mRNA CTD PMID:19564919 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
G Sox18 SRY-box transcription factor 18 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SOX18 mRNA CTD PMID:19564919 NCBI chr 3:177,177,237...177,179,039
Ensembl chr 3:177,177,310...177,179,127
JBrowse link
G Spaca9 sperm acrosome associated 9 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SPACA9 mRNA
SCH 23390 results in decreased expression of SPACA9 mRNA
CTD PMID:19564919 NCBI chr 3:7,269,851...7,279,253
Ensembl chr 3:7,269,853...7,278,758
JBrowse link
G Spag8 sperm associated antigen 8 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SPAG8 mRNA CTD PMID:19564919 NCBI chr 5:59,147,412...59,149,625
Ensembl chr 5:59,147,337...59,149,699
JBrowse link
G Spata6l spermatogenesis associated 6-like multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of SPATA6L mRNA CTD PMID:19564919 NCBI chr 1:247,037,004...247,088,124
Ensembl chr 1:247,046,650...247,088,012
JBrowse link
G St13 ST13, Hsp70 interacting protein multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ST13 mRNA] CTD PMID:19564919 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ST8SIA6 mRNA CTD PMID:19564919 NCBI chr17:80,960,785...81,002,830
Ensembl chr17:80,960,785...81,002,838
JBrowse link
G Steap1 STEAP family member 1 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of STEAP1 mRNA
SCH 23390 results in increased expression of STEAP1 mRNA
CTD PMID:19564919 NCBI chr 4:25,435,885...25,446,393
Ensembl chr 4:25,435,873...25,446,461
JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 affects expression EXP SCH 23390 affects the expression of STRA6 mRNA CTD PMID:19564919 NCBI chr 8:62,925,364...62,944,438
Ensembl chr 8:62,925,357...62,944,437
JBrowse link
G Sv2c synaptic vesicle glycoprotein 2c increases expression
multiple interactions
EXP SCH 23390 results in increased expression of SV2C mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of SV2C mRNA
CTD PMID:19564919 NCBI chr 2:26,495,757...26,707,691
Ensembl chr 2:26,501,833...26,699,333
JBrowse link
G Swt1 SWT1 RNA endoribonuclease homolog multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of SWT1 mRNA CTD PMID:19564919 NCBI chr13:68,728,266...68,785,800
Ensembl chr13:68,728,266...68,785,771
JBrowse link
G Syt2 synaptotagmin 2 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] affects the expression of SYT2 mRNA
SCH 23390 results in increased expression of SYT2 mRNA
CTD PMID:19564919 NCBI chr13:51,569,248...51,577,824
Ensembl chr13:51,534,025...51,578,052
JBrowse link
G Tas1r1 taste 1 receptor member 1 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TAS1R1 mRNA
SCH 23390 results in decreased expression of TAS1R1 mRNA
CTD PMID:19564919 NCBI chr 5:169,200,389...169,212,113
Ensembl chr 5:169,200,287...169,212,170
JBrowse link
G Tecta tectorin alpha multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TECTA mRNA CTD PMID:19564919 NCBI chr 8:46,603,728...46,675,658
Ensembl chr 8:46,603,728...46,675,544
JBrowse link
G Tent5a terminal nucleotidyltransferase 5A multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of TENT5A mRNA CTD PMID:19564919 NCBI chr 8:92,935,474...92,942,267
Ensembl chr 8:92,937,739...92,942,076
JBrowse link
G Terf1 telomeric repeat binding factor 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TERF1 mRNA CTD PMID:19564919 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO SCH 23390 inhibits the reaction [1-(2-thienyl)-2-(methylamino)propane results in decreased expression of TH protein]; SCH 23390 inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:16088948 PMID:30922767 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TIE1 mRNA CTD PMID:19564919 NCBI chr 5:137,294,544...137,321,116
Ensembl chr 5:137,294,544...137,321,121
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TLR2 mRNA CTD PMID:19564919 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tmem123 transmembrane protein 123 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TMEM123 mRNA CTD PMID:19564919 NCBI chr 8:5,967,373...5,997,387
Ensembl chr 8:5,967,463...5,997,383
JBrowse link
G Tmem125 transmembrane protein 125 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TMEM125 mRNA CTD PMID:19564919 NCBI chr 5:137,371,825...137,373,229
Ensembl chr 5:137,371,825...137,373,205
Ensembl chr 5:137,371,825...137,373,205
JBrowse link
G Tmem18 transmembrane protein 18 decreases expression
multiple interactions
EXP SCH 23390 results in decreased expression of TMEM18 mRNA
[Methamphetamine co-treated with SCH 23390] results in decreased expression of TMEM18 mRNA
CTD PMID:19564919 NCBI chr 6:49,529,228...49,534,960
Ensembl chr 6:49,529,228...49,536,648
JBrowse link
G Tmem252 transmembrane protein 252 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of TMEM252 mRNA
SCH 23390 results in increased expression of TMEM252 mRNA
CTD PMID:19564919 NCBI chr 1:242,572,558...242,577,817
Ensembl chr 1:242,572,533...242,577,817
JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TMTC3 mRNA
SCH 23390 results in increased expression of TMTC3 mRNA
CTD PMID:19564919 NCBI chr 7:40,171,957...40,217,056
Ensembl chr 7:40,171,963...40,217,056
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of TSC22D3 mRNA CTD PMID:19564919 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Ttk Ttk protein kinase multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TTK mRNA CTD PMID:19564919 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Ttll9 tubulin tyrosine ligase like 9 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of TTLL9 mRNA CTD PMID:19564919 NCBI chr 3:148,426,008...148,485,370
Ensembl chr 3:148,438,939...148,485,360
JBrowse link
G Uba2 ubiquitin-like modifier activating enzyme 2 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of UBA2 mRNA
SCH 23390 results in increased expression of UBA2 mRNA
CTD PMID:19564919 NCBI chr 1:90,010,681...90,035,522
Ensembl chr 1:90,011,306...90,035,522
JBrowse link
G Upp1 uridine phosphorylase 1 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of UPP1 mRNA CTD PMID:19564919 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276
JBrowse link
G Uspl1 ubiquitin specific peptidase like 1 increases expression
multiple interactions
EXP SCH 23390 results in increased expression of USPL1 mRNA
[Methamphetamine co-treated with SCH 23390] results in increased expression of USPL1 mRNA
CTD PMID:19564919 NCBI chr12:6,930,018...6,957,027
Ensembl chr12:6,929,978...6,956,984
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of VEGFA mRNA] CTD PMID:19564919 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP SCH 23390 inhibits the reaction [Methamphetamine results in increased splicing of XBP1 mRNA] CTD PMID:19564919 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Ybx1 Y box binding protein 1 multiple interactions
increases expression
EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of YBX1 mRNA
SCH 23390 results in increased expression of YBX1 mRNA
CTD PMID:19564919 NCBI chr 5:138,319,754...138,336,721
Ensembl chr 5:138,319,762...138,336,475
JBrowse link
G Zfp189 zinc finger protein 189 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of ZFP189 mRNA CTD PMID:19564919 NCBI chr 5:64,789,432...64,801,079
Ensembl chr 5:64,789,456...64,800,810
JBrowse link
G Zfp287 zinc finger protein 287 multiple interactions
decreases expression
EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ZFP287 mRNA
SCH 23390 results in decreased expression of ZFP287 mRNA
CTD PMID:19564919 NCBI chr10:49,131,764...49,150,930
Ensembl chr10:49,135,277...49,149,479
JBrowse link
G Zfp324 zinc finger protein 324 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ZFP324 mRNA CTD PMID:19564919 NCBI chr 1:65,604,342...65,612,196
Ensembl chr 1:65,606,520...65,611,815
JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in increased expression of ZFP36 mRNA CTD PMID:19564919 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
G Zfp688 zinc finger protein 688 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ZFP688 mRNA CTD PMID:19564919 NCBI chr 1:198,865,950...198,869,068
Ensembl chr 1:198,866,137...198,869,009
JBrowse link
G Zic2 Zic family member 2 multiple interactions EXP [Methamphetamine co-treated with SCH 23390] results in decreased expression of ZIC2 mRNA CTD PMID:19564919 NCBI chr15:108,908,366...108,913,812
Ensembl chr15:108,908,607...108,912,737
JBrowse link
SKF 38393 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy5 adenylate cyclase 5 increases response to substance ISO ADCY5 protein results in increased susceptibility to 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine CTD PMID:12223546 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the localization of ALDOC mRNA] CTD PMID:18299792 NCBI chr10:65,586,504...65,590,093
Ensembl chr10:65,586,504...65,590,126
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of ARC mRNA CTD PMID:17499349 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:17136323 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP7 protein; Acetylcysteine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of and results in increased cleavage of CASP7 protein] CTD PMID:17136323 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine CTD PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein; Calcium promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]; KN 62 inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]; SCH 23390 inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein] CTD PMID:14622123 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO
EXP
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD1 protein]; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Eugenol; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased abundance of Calcium; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein; [SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]; SCH 23390 inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein]; SCH 23390 inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]
[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Pilocarpine; [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine
CTD PMID:7906944 PMID:9537685 PMID:10432116 PMID:14622123 PMID:15075630 PMID:15985612 PMID:18489579 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP
ISO
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD2 protein]
DRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]
CTD PMID:9547254 PMID:18489579 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of EGR1 mRNA
[Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of EGR1 mRNA
CTD PMID:8861055 PMID:20452347 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO
EXP
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS mRNA
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine promotes the reaction [Reserpine results in increased expression of FOS protein]; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein; [Pilocarpine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS protein; [Scopolamine co-treated with 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine] results in increased expression of FOS mRNA; Quinpirole inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS mRNA]; Reserpine inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] results in increased expression of FOS protein]; Reserpine promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS protein]
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS mRNA; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS protein
BP 897 promotes the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOS mRNA]
CTD PMID:7637573 PMID:7845612 PMID:8102797 PMID:8511714 PMID:8861055 PMID:8864302 PMID:9751140 PMID:10432116 PMID:10700011 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression
multiple interactions
EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOSL1 protein
olanzapine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOSL1 protein]
CTD PMID:11425506 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases secretion ISO 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased secretion of GDNF protein CTD PMID:12770616 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein] CTD PMID:14622123 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Ngf nerve growth factor increases secretion
increases expression
ISO 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased secretion of NGF protein
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of NGF mRNA
CTD PMID:12770616 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Npy neuropeptide Y multiple interactions ISO NPY protein results in decreased susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole] CTD PMID:12183048 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Pvalb parvalbumin affects expression EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of PVALB protein CTD PMID:15238432 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Snca synuclein alpha affects localization EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the localization of SNCA protein CTD PMID:25852303 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine co-treated with Quinpirole] results in increased expression of TAC1 mRNA; [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Reserpine] results in increased expression of TAC1 mRNA CTD PMID:9751140 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions EXP 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the localization of UBA1 mRNA] CTD PMID:18299792 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18335
                organonitrogen heterocyclic compound 17481
                  benzazepine 506
                    (3aR,10bR)-3a-[2-(benzenesulfonyl)ethyl]-2-[4-(3-hydroxypropoxy)phenyl]-5-prop-2-enyl-6,10b-dihydrooxazolo[4,5-d][2]benzazepin-4-one 0
                    (3aR,10bR)-5-[2-(benzenesulfonyl)ethyl]-2-[4-(3-hydroxypropoxy)phenyl]-3a-(phenylmethyl)-6,10b-dihydrooxazolo[4,5-d][2]benzazepin-4-one 0
                    (4R,5'R)-2-benzoyl-2'-[4-(3-hydroxypropoxy)phenyl]-5'-phenyl-3-spiro[1,5-dihydro-2-benzazepine-4,4'-5H-oxazole]one 0
                    (5R)-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 0
                    (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol 0
                    (5R)-9-bromo-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol 0
                    (5R)-9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 0
                    (5S)-5-(7-benzofuranyl)-8-chloro-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol 0
                    (6aS,13bR)-11-chloro-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-12-ol 0
                    1-benzazepine 0
                    1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol + 20
                    11alpha-Hydroxygalanthamine 0
                    3-[(3aS,10bS)-2-[4-(3-hydroxypropoxy)phenyl]-4-oxo-5-prop-2-enyl-6,10b-dihydrooxazolo[4,5-d][2]benzazepin-3a-yl]propanoic acid tert-butyl ester 0
                    3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one 0
                    4-(8-bromo-7-methoxy-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-5-yl)aniline 0
                    4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid 0
                    4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid 0
                    5-[4-[bis(2-chloroethyl)amino]phenyl]-8-bromo-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol 0
                    5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 0
                    6-chloro-3-methyl-9-(3-methylbut-2-enoxy)-1,2,4,5-tetrahydro-3-benzazepine 0
                    7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one 0
                    8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol 0
                    9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one 0
                    9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 0
                    9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol 0
                    Astrocasine 0
                    Benalfocin 0
                    Epinorlycoramine 0
                    Fenoldopam mesylate 0
                    Fluperlapine 0
                    Lycoramine 0
                    N-Demethylnarwedine 0
                    N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol 1
                    N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepinium-7,8-diol 0
                    N-demethylmirtazapine 0
                    N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol 3
                    Narwedine 0
                    Norgalanthamine 0
                    Norsanguinine 0
                    SCH 23390 295
                    Sanguinine 0
                    azapetine 0
                    benazepril 75
                    benazeprilat + 75
                    benzazepine alkaloid + 30
                    capsazepine 54
                    conivaptan + 0
                    epinastine + 11
                    fenoldopam 59
                    ivabradine 2
                    lorcaserin 4
                    mirtazapine 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      p-block molecular entity 19696
                        carbon group molecular entity 19599
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  organic heteropolycyclic compound 17838
                                    organic heterobicyclic compound 16763
                                      benzazepine 506
                                        (3aR,10bR)-3a-[2-(benzenesulfonyl)ethyl]-2-[4-(3-hydroxypropoxy)phenyl]-5-prop-2-enyl-6,10b-dihydrooxazolo[4,5-d][2]benzazepin-4-one 0
                                        (3aR,10bR)-5-[2-(benzenesulfonyl)ethyl]-2-[4-(3-hydroxypropoxy)phenyl]-3a-(phenylmethyl)-6,10b-dihydrooxazolo[4,5-d][2]benzazepin-4-one 0
                                        (4R,5'R)-2-benzoyl-2'-[4-(3-hydroxypropoxy)phenyl]-5'-phenyl-3-spiro[1,5-dihydro-2-benzazepine-4,4'-5H-oxazole]one 0
                                        (5R)-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 0
                                        (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol 0
                                        (5R)-9-bromo-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol 0
                                        (5R)-9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 0
                                        (5S)-5-(7-benzofuranyl)-8-chloro-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol 0
                                        (6aS,13bR)-11-chloro-7-methyl-5,6,6a,8,9,13b-hexahydronaphtho[1,2-a][3]benzazepin-12-ol 0
                                        1-benzazepine 0
                                        1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol + 20
                                        11alpha-Hydroxygalanthamine 0
                                        3-[(3aS,10bS)-2-[4-(3-hydroxypropoxy)phenyl]-4-oxo-5-prop-2-enyl-6,10b-dihydrooxazolo[4,5-d][2]benzazepin-3a-yl]propanoic acid tert-butyl ester 0
                                        3-[3-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one 0
                                        4-(8-bromo-7-methoxy-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-5-yl)aniline 0
                                        4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid 0
                                        4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid 0
                                        5-[4-[bis(2-chloroethyl)amino]phenyl]-8-bromo-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol 0
                                        5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 0
                                        6-chloro-3-methyl-9-(3-methylbut-2-enoxy)-1,2,4,5-tetrahydro-3-benzazepine 0
                                        7,8-dimethoxy-1,3-dihydro-3-benzazepin-2-one 0
                                        8-bromo-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol 0
                                        9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one 0
                                        9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol 0
                                        9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol 0
                                        Astrocasine 0
                                        Benalfocin 0
                                        Epinorlycoramine 0
                                        Fenoldopam mesylate 0
                                        Fluperlapine 0
                                        Lycoramine 0
                                        N-Demethylnarwedine 0
                                        N-allyl-1-phenyl-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol 1
                                        N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepinium-7,8-diol 0
                                        N-demethylmirtazapine 0
                                        N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol 3
                                        Narwedine 0
                                        Norgalanthamine 0
                                        Norsanguinine 0
                                        SCH 23390 295
                                        Sanguinine 0
                                        azapetine 0
                                        benazepril 75
                                        benazeprilat + 75
                                        benzazepine alkaloid + 30
                                        capsazepine 54
                                        conivaptan + 0
                                        epinastine + 11
                                        fenoldopam 59
                                        ivabradine 2
                                        lorcaserin 4
                                        mirtazapine 21
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