CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: benzazepine alkaloid
Accession: CHEBI:38523
browse the term
Synonyms: related_synonym: benzazepine alkaloids
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Ache
acetylcholinesterase
decreases activity multiple interactions
EXP ISO
Galantamine results in decreased activity of ACHE protein Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein] Galantamine binds to and results in decreased activity of ACHE protein; Galantamine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Galantamine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Galantamine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]
CTD
PMID:14535624 PMID:18571635 PMID:18573242 PMID:19345205 PMID:25522658 PMID:27238725 PMID:28837785 PMID:29886234 PMID:30905860 PMID:31125207 More...
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
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Ager
advanced glycosylation end product-specific receptor
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon galanthamine inhibits the reaction [ethanol increases expression of RAGE protein in basal forebrain cholinergic neurons]
RGD
PMID:29572553 PMID:33716687
RGD:152995414 , RGD:597538457
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685
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App
amyloid beta precursor protein
multiple interactions
ISO
Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]
CTD
PMID:25881725
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Galantamine inhibits the reaction [Scopolamine results in increased expression of BAX protein]
CTD
PMID:27346436
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bche
butyrylcholinesterase
decreases activity
EXP ISO
Galantamine results in decreased activity of BCHE protein
CTD
PMID:19345205 PMID:29886234 PMID:31125207
NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon Galantamine inhibits the reaction [Scopolamine results in decreased expression of BCL2 protein]
CTD RGD
PMID:27346436 PMID:29572553
RGD:152995414
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Casp3
caspase 3
multiple interactions
EXP
Galantamine inhibits the reaction [Scopolamine results in increased cleavage of CASP3 protein]
CTD
PMID:27346436
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Cat
catalase
multiple interactions
EXP
Galantamine inhibits the reaction [Scopolamine results in decreased activity of CAT protein]
CTD
PMID:27346436
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
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Ces2h
carboxylesterase 2H
decreases activity
ISO
Galantamine results in decreased activity of CES2 protein
CTD
PMID:23123248
NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
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Chrm1
cholinergic receptor, muscarinic 1
decreases expression
EXP
Galantamine results in decreased expression of CHRM1 protein
CTD
PMID:28837785
NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:214,995,872...215,020,602
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
affects binding multiple interactions
ISO
Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein] Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:15733544
NCBI chr 3:188,506,802...188,535,558
Ensembl chr 3:188,501,209...188,535,105
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]]
CTD
PMID:25881725
NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
affects binding multiple interactions
ISO
Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein] Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:15733544
NCBI chr 2:177,479,091...177,487,306
Ensembl chr 2:177,479,091...177,491,326
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Hmgb1
high mobility group box 1
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327 Ensembl chr12:39,039,050...39,041,327
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Icam1
intercellular adhesion molecule 1
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
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Il10
interleukin 10
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
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Mpo
myeloperoxidase
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Galantamine inhibits the reaction [Scopolamine results in decreased expression of NFE2L2 protein]
CTD
PMID:27346436
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
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Ngf
nerve growth factor
multiple interactions
EXP
Galantamine promotes the reaction [Scopolamine results in decreased secretion of NGF protein]
CTD
PMID:27346436
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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Socs3
suppressor of cytokine signaling 3
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825
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Tnf
tumor necrosis factor
multiple interactions
EXP
Galan inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon
RGD
PMID:29572553
RGD:152995414
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Ahi1
Abelson helper integration site 1
increases expression
ISO
Homoharringtonine results in increased expression of AHI1 protein alternative form
CTD
PMID:19379585
NCBI chr 1:17,580,859...17,711,775
Ensembl chr 1:17,582,006...17,711,774
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of AKT1 protein
CTD
PMID:31726078
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
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Bad
BCL2-associated agonist of cell death
increases expression
ISO
Homoharringtonine results in increased expression of BAD protein
CTD
PMID:31726078
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
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Bak1
BCL2-antagonist/killer 1
decreases expression
ISO
Homoharringtonine results in decreased expression of BAK1 mRNA
CTD
PMID:32431164
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Homoharringtonine results in increased expression of BAX protein
CTD
PMID:31726078
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bbc3
Bcl-2 binding component 3
increases expression
ISO
Homoharringtonine results in increased expression of BBC3 mRNA
CTD
PMID:32431164
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Homoharringtonine results in decreased expression of BCL2 mRNA; Homoharringtonine results in decreased expression of BCL2 protein
CTD
PMID:23980369 PMID:31726078 PMID:32431164
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Casp3
caspase 3
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP3 protein Homoharringtonine results in increased cleavage of CASP3 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Casp7
caspase 7
increases cleavage
ISO
Homoharringtonine results in increased cleavage of CASP7 protein
CTD
PMID:31726078
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512
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Casp9
caspase 9
increases expression increases cleavage
ISO
Homoharringtonine results in increased expression of CASP9 protein Homoharringtonine results in increased cleavage of CASP9 protein
CTD
PMID:23980369 PMID:31726078
Ensembl chr 5:159,391,188...159,409,648
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Ccna2
cyclin A2
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNA2 protein
CTD
PMID:31726078
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701
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Ccnb1
cyclin B1
decreases expression
ISO
Homoharringtonine results in decreased expression of CCNB1 protein
CTD
PMID:31726078
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225
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Ccne1
cyclin E1
increases expression
ISO
Homoharringtonine results in increased expression of CCNE1 protein
CTD
PMID:31726078
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822
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Cd34
CD34 molecule
multiple interactions decreases expression
ISO
Arsenic Trioxide promotes the reaction [Homoharringtonine results in decreased expression of CD34 mRNA]
CTD
PMID:31307525
NCBI chr13:109,008,786...109,029,317
Ensembl chr13:109,008,623...109,029,315
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Cd38
CD38 molecule
increases expression multiple interactions
ISO
Homoharringtonine results in increased expression of CD38 mRNA [Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of CD38 mRNA
CTD
PMID:31307525
NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505
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Cd96
CD96 molecule
multiple interactions
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of CD96 mRNA
CTD
PMID:31307525
NCBI chr11:68,164,926...68,239,266
Ensembl chr11:68,164,872...68,241,937
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Cdk1
cyclin-dependent kinase 1
increases expression
ISO
Homoharringtonine results in increased expression of CDK1 protein
CTD
PMID:31726078
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455
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Cdk2
cyclin dependent kinase 2
increases expression
ISO
Homoharringtonine results in increased expression of CDK2 protein
CTD
PMID:31726078
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Homoharringtonine results in increased expression of CDKN1A mRNA
CTD
PMID:32431164
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions increases phosphorylation
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]; crenigacestat inhibits the reaction [Homoharringtonine results in increased phosphorylation of CHUK protein]
CTD
PMID:31307525
NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases expression
ISO
Homoharringtonine results in increased expression of CYP2C19 mRNA
CTD
PMID:32431164
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
ISO
Homoharringtonine results in increased expression of CYP2E1 mRNA
CTD
PMID:32431164
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases expression
ISO
Homoharringtonine results in increased expression of EIF2AK3 mRNA
CTD
PMID:32431164
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
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Ephb4
EPH receptor B4
multiple interactions decreases expression
ISO
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein]
CTD
PMID:31726078
NCBI chr12:24,963,174...24,988,473
Ensembl chr12:24,963,174...24,988,388
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Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression
ISO
Homoharringtonine results in increased expression of ERN1 mRNA
CTD
PMID:32431164
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
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Id4
inhibitor of DNA binding 4
increases expression
ISO
Homoharringtonine results in increased expression of ID4 mRNA
CTD
PMID:32431164
NCBI chr17:16,595,724...16,598,293
Ensembl chr17:16,595,724...16,598,492
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Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK1 protein
CTD
PMID:31726078
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MAPK3 protein
CTD
PMID:31726078
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
Homoharringtonine results in decreased expression of MCL1 protein
CTD
PMID:23980369 PMID:31726078
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
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Mki67
marker of proliferation Ki-67
decreases expression
ISO
Homoharringtonine results in decreased expression of MKI67 protein
CTD
PMID:31726078
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
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Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
Homoharringtonine results in decreased phosphorylation of MTOR protein
CTD
PMID:31726078
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
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Nfkb1
nuclear factor kappa B subunit 1
increases expression
ISO
Homoharringtonine results in increased expression of NFKB1 mRNA
CTD
PMID:32431164
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
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Nfkb2
nuclear factor kappa B subunit 2
multiple interactions increases expression
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NFKB2 protein]
CTD
PMID:31307525
NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637
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Notch1
notch receptor 1
multiple interactions increases expression
ISO
Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of NOTCH1 protein]
CTD
PMID:31307525
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613
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Notch2
notch receptor 2
multiple interactions
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of NOTCH2 protein
CTD
PMID:31307525
NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
decreases expression
ISO
Homoharringtonine results in decreased expression of PIK3CA protein
CTD
PMID:31726078
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
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Pten
phosphatase and tensin homolog
increases expression
ISO
Homoharringtonine results in increased expression of PTEN protein
CTD
PMID:31726078
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases expression
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in decreased expression of RELA protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of RELA protein]
CTD
PMID:31307525
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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Relb
RELB proto-oncogene, NF-kB subunit
increases expression multiple interactions
ISO
Homoharringtonine results in increased expression of RELB protein Arsenic Trioxide inhibits the reaction [Homoharringtonine results in increased expression of RELB protein]
CTD
PMID:31307525
NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:88,385,717...88,413,420
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Tnf
tumor necrosis factor
increases expression
ISO
Homoharringtonine results in increased expression of TNF mRNA
CTD
PMID:32431164
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
[Arsenic Trioxide co-treated with Homoharringtonine] results in increased expression of TP53 protein; crenigacestat inhibits the reaction [Homoharringtonine results in increased expression of TP53 protein]
CTD
PMID:31307525
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
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Traf2
Tnf receptor-associated factor 2
increases expression
ISO
Homoharringtonine results in increased expression of TRAF2 mRNA
CTD
PMID:32431164
NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691
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Tyr
tyrosinase
increases expression
ISO
Homoharringtonine results in increased expression of TYR mRNA
CTD
PMID:21071833
NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:150,527,687...150,622,857
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