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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzazepine alkaloid
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Accession:CHEBI:38523 term browser browse the term
Synonyms:related_synonym: benzazepine alkaloids

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galanthamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
multiple interactions		 EXP
ISO		 Galantamine results in decreased activity of ACHE protein
Galantamine inhibits the reaction [Scopolamine results in increased activity of ACHE protein]
Galantamine binds to and results in decreased activity of ACHE protein; Galantamine inhibits the reaction [asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]; Galantamine inhibits the reaction [Obidoxime Chloride metabolite results in decreased activity of ACHE protein]; Galantamine promotes the reaction [Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]]		 CTD PMID:14535624 PMID:18571635 PMID:18573242 PMID:19345205 PMID:25522658 PMID:27238725 PMID:28837785 PMID:29886234 PMID:30905860 PMID:31125207 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Bche butyrylcholinesterase decreases activity EXP
ISO		 Galantamine results in decreased activity of BCHE protein CTD PMID:19345205 PMID:29886234 PMID:31125207 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Galantamine results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP Galantamine results in decreased expression of CHRM1 protein CTD PMID:28837785 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit affects binding
multiple interactions		 ISO Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]		 CTD PMID:15733544 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions		 ISO Galantamine binds to [CHRNA4 protein binds to CHRNB2 protein]
Galantamine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]		 CTD PMID:15733544 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785 		JBrowse link
omacetaxine mepesuccinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahi1 Abelson helper integration site 1 increases expression ISO Homoharringtonine results in increased expression of AHI1 protein alternative form CTD PMID:19379585 NCBI chr 1:16,478,127...16,601,769
Ensembl chr 1:16,478,127...16,601,769 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of AKT1 protein CTD PMID:31726078 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Homoharringtonine results in increased expression of BAD protein CTD PMID:31726078 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Homoharringtonine results in increased expression of BAX protein CTD PMID:31726078 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Homoharringtonine results in decreased expression of BCL2 protein CTD PMID:23980369 PMID:31726078 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage		 ISO Homoharringtonine results in increased expression of CASP3 protein
Homoharringtonine results in increased cleavage of CASP3 protein		 CTD PMID:23980369 PMID:31726078 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 increases cleavage ISO Homoharringtonine results in increased cleavage of CASP7 protein CTD PMID:31726078 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage		 ISO Homoharringtonine results in increased expression of CASP9 protein
Homoharringtonine results in increased cleavage of CASP9 protein		 CTD PMID:23980369 PMID:31726078 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Homoharringtonine results in decreased expression of CCNA2 protein CTD PMID:31726078 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Homoharringtonine results in decreased expression of CCNB1 protein CTD PMID:31726078 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO Homoharringtonine results in increased expression of CCNE1 protein CTD PMID:31726078 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Homoharringtonine results in increased expression of CDK1 protein CTD PMID:31726078 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Homoharringtonine results in increased expression of CDK2 protein CTD PMID:31726078 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Ephb4 EPH receptor B4 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homoharringtonine results in decreased expression of EPHB4 protein] CTD PMID:31726078 NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK1 protein CTD PMID:31726078 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MAPK3 protein CTD PMID:31726078 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Homoharringtonine results in decreased expression of MCL1 protein CTD PMID:23980369 PMID:31726078 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Homoharringtonine results in decreased expression of MKI67 protein CTD PMID:31726078 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Homoharringtonine results in decreased phosphorylation of MTOR protein CTD PMID:31726078 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO Homoharringtonine results in decreased expression of PIK3CA protein CTD PMID:31726078 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Homoharringtonine results in increased expression of PTEN protein CTD PMID:31726078 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Tyr tyrosinase increases expression ISO Homoharringtonine results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19783
    role 19728
      biological role 19728
        biochemical role 19314
          metabolite 19295
            alkaloid 5635
              benzazepine alkaloid 30
                LSM-1290 0
                LSM-5010 0
                cephalotaxine + 22
                galanthamine 8
                rheadan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19783
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic molecule 19510
                              organic cyclic compound 19336
                                organic heterocyclic compound 18517
                                  organic heteropolycyclic compound 17978
                                    organic heterobicyclic compound 16782
                                      benzazepine 506
                                        benzazepine alkaloid 30
                                          LSM-1290 0
                                          LSM-5010 0
                                          cephalotaxine + 22
                                          galanthamine 8
                                          rheadan 0
paths to the root