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EUK-134 - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EUK-134
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Accession:CHEBI:180692 term browser browse the term
Synonyms:xref_mesh: MESH:C433928


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EUK-134 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO EUK-134 inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in increased expression of BAX protein] CTD PMID:25005833 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of BCL2 protein] CTD PMID:25005833 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO EUK-134 inhibits the reaction [Capsaicin results in increased cleavage of CASP3 protein]; EUK-134 inhibits the reaction [evodiamine results in increased cleavage of CASP3 protein] CTD PMID:21647434 PMID:34808100 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO EUK-134 inhibits the reaction [Capsaicin results in increased cleavage of CASP9 protein]; EUK-134 inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in increased cleavage of CASP9 protein] CTD PMID:21647434 PMID:25005833 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO EUK-134 inhibits the reaction [diallyl trisulfide results in increased phosphorylation of and results in increased degradation of CDC25C protein] CTD PMID:16707465 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO EUK-134 affects the reaction [Vitamin K 3 results in increased expression of CDKN1A protein]; EUK-134 inhibits the reaction [Hydrogen Peroxide results in increased expression of CDKN1A protein] CTD PMID:25005833 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cygb cytoglobin multiple interactions ISO EUK-134 inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO EUK-134 inhibits the reaction [evodiamine results in increased expression of DDIT3 protein] CTD PMID:34808100 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO EUK-134 inhibits the reaction [evodiamine results in decreased expression of EIF2AK3 protein] CTD PMID:34808100 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO EUK-134 inhibits the reaction [Asbestos, Amosite results in increased expression of ERN1 protein]; EUK-134 inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein] CTD PMID:23885834 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in decreased activity of GSR protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]]; Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [EUK-134 results in decreased activity of GSR protein]]; EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]; EUK-134 inhibits the reaction [Paraquat results in decreased activity of GSR protein]; EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]; EUK-134 inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in decreased activity of GSR protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in decreased activity of GSR protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in decreased activity of GSR protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in decreased activity of GSR protein]] CTD PMID:25724285 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions EXP [Acetylcysteine co-treated with EUK-134] promotes the reaction [[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein]; [EUK-134 co-treated with Acetylcysteine] promotes the reaction [Paraquat results in increased activity of GSTA4 protein]; [EUK-134 co-treated with Acetylcysteine] promotes the reaction [Zinc Sulfate results in increased activity of GSTA4 protein] CTD PMID:25724285 NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions ISO EUK-134 inhibits the reaction [Hydrogen Peroxide results in increased expression of HES1 protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in increased expression of HES1 protein] CTD PMID:25005833 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
JBrowse link
G Iapp islet amyloid polypeptide decreases metabolic processing ISO EUK-134 results in decreased metabolism of IAPP protein CTD PMID:23528352 NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO EUK-134 inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein] CTD PMID:20962025 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO EUK-134 inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein] CTD PMID:20962025 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO EUK-134 inhibits the reaction [Hydrogen Peroxide results in decreased expression of MDM2 protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in decreased expression of MDM2 protein] CTD PMID:25005833 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased activity of MPO protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased activity of MPO protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased activity of MPO protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased activity of MPO protein]]; EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased activity of MPO protein]]; EUK-134 inhibits the reaction [Paraquat results in increased activity of MPO protein]; EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased activity of MPO protein]]; EUK-134 inhibits the reaction [Zinc Sulfate results in increased activity of MPO protein]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased activity of MPO protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased activity of MPO protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased activity of MPO protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased activity of MPO protein]] CTD PMID:25724285 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT1A mRNA]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT1A protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A mRNA]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT1A protein]]; EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]; EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A protein]]; EUK-134 inhibits the reaction [Paraquat results in increased expression of MT1A mRNA]; EUK-134 inhibits the reaction [Paraquat results in increased expression of MT1A protein]; EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A mRNA]]; EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A protein]]; EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]; EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT1A protein]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT1A protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT1A mRNA]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT1A protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A mRNA]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT1A protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT1A mRNA]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT1A protein]] CTD PMID:25724285 NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049
JBrowse link
G Mt2 metallothionein 2 multiple interactions EXP Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A protein]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]; Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]; EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]; EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]; EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]; EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A protein]; EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]; EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]; EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]; EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A protein]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]; EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]] CTD PMID:25724285 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO EUK-134 inhibits the reaction [evodiamine results in increased cleavage of PARP1 protein] CTD PMID:34808100 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO EUK-134 inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; EUK-134 inhibits the reaction [Vitamin K 3 results in increased expression of TP53 protein] CTD PMID:25005833 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link

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  CHEBI ontology 19887
    role 19858
      application 19697
        pharmaceutical 19534
          drug 19534
            protective agent 18256
              geroprotector 17431
                EUK-134 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      halogen 18694
                        chlorine atom 18473
                          chlorine molecular entity 18473
                            elemental chlorine 10071
                              monoatomic chlorine 10060
                                chloride 10060
                                  chloride salt 10060
                                    organic chloride salt 1109
                                      EUK-134 22
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