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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glabridin
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Accession:CHEBI:5369 term browser browse the term
Definition:A member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively.
Synonyms:exact_synonym: 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]benzene-1,3-diol
 related_synonym: Formula=C20H20O4;   InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1;   InChIKey=LBQIJVLKGVZRIW-ZDUSSCGKSA-N;   SMILES=CC1(C)Oc2ccc3C[C@@H](COc3c2C=C1)c1ccc(O)cc1O
 xref: CAS:59870-68-7;   HMDB:HMDB0034188;   KEGG:C10421;   KNApSAcK:C00002529;   LIPID_MAPS_instance:LMPK12080012
 xref_mesh: MESH:C107601
 xref: PMID:24361284;   PMID:25737160;   Reaxys:7141956;   Wikipedia:Glabridin


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glabridin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO [glabridin affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin CTD PMID:18204840 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO glabridin results in increased expression of BAX protein
[glabridin co-treated with Paclitaxel] results in increased expression of BAX protein
Acetylcysteine inhibits the reaction [glabridin results in increased expression of BAX protein]; AKT activator SC79 inhibits the reaction [glabridin results in increased expression of BAX protein]		 CTD PMID:36029289 PMID:37419298 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [glabridin results in decreased expression of BCL2 protein]; AKT activator SC79 inhibits the reaction [glabridin results in decreased expression of BCL2 protein]
[glabridin co-treated with Paclitaxel] results in decreased expression of BCL2 protein		 CTD PMID:36029289 PMID:37419298 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Acetylcysteine inhibits the reaction [glabridin results in increased activity of CASP3 protein]; AKT activator SC79 inhibits the reaction [glabridin results in increased activity of CASP3 protein] CTD PMID:36029289 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO glabridin results in increased cleavage of CASP8 protein CTD PMID:29663662 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO glabridin results in increased cleavage of CASP9 protein
[glabridin co-treated with Paclitaxel] results in decreased expression of CASP9 protein; [glabridin co-treated with Paclitaxel] results in increased cleavage of CASP9 protein		 CTD PMID:29663662 PMID:37419298 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [glabridin co-treated with Paclitaxel] results in increased expression of CDH1 protein CTD PMID:37419298 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO glabridin inhibits the reaction [Antimycin A affects the localization of CYCS protein] CTD PMID:21621525 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [glabridin co-treated with Paclitaxel] results in decreased expression of CYP2C8 protein CTD PMID:37419298 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO [glabridin co-treated with Paclitaxel] results in decreased expression of CYP2J2 protein CTD PMID:37419298 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [glabridin co-treated with Paclitaxel] results in decreased expression of CYP3A4 protein CTD PMID:37419298 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO glabridin results in increased phosphorylation of MAPK1 protein CTD PMID:29663662 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO glabridin results in increased phosphorylation of MAPK3 protein CTD PMID:29663662 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ocln occludin multiple interactions ISO [glabridin co-treated with Paclitaxel] results in increased expression of OCLN protein CTD PMID:37419298 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO glabridin results in increased cleavage of PARP1 protein CTD PMID:29663662 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Tyr tyrosinase multiple interactions ISO glabridin inhibits the reaction [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of TYR protein]; glabridin inhibits the reaction [alpha-MSH results in increased activity of TYR protein] CTD PMID:28051915 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vim vimentin multiple interactions ISO [glabridin co-treated with Paclitaxel] results in decreased expression of VIM protein CTD PMID:37419298 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 multiple interactions ISO [glabridin co-treated with Paclitaxel] results in decreased expression of ZEB1 protein CTD PMID:37419298 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        antimicrobial agent 18260
          antimicrobial drug 11181
            antiprotozoal drug 7446
              antiplasmodial drug 2765
                glabridin 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic heterocyclic compound 18890
                                  oxacycle 17918
                                    benzopyran 11974
                                      1-benzopyran 11728
                                        isoflavonoid 3832
                                          isoflavans 136
                                            isoflavan 22
                                              (R)-isoflavan 22
                                                glabridin 22
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