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guanosine - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:guanosine
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Accession:CHEBI:16750 term browser browse the term
Definition:A purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.
Synonyms:related_synonym: 2(3H)-imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one;   2-amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one;   9-beta-D-ribofuranosyl-guanine;   Formula=C10H13N5O5;   G;   Guanine riboside;   Guanine-9-beta-D-ribofuranoside;   Guanosin;   Guo;   InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1;   InChIKey=NYHBQMYGNKIUIF-UUOKFMHZSA-N;   SMILES=Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
 alt_id: CHEBI:14375;   CHEBI:24444;   CHEBI:42840;   CHEBI:42847;   CHEBI:471737;   CHEBI:5564
 xref: CAS:118-00-3;   DrugBank:DB02857;   ECMDB:ECMDB00133;   Gmelin:55323;   HMDB:HMDB0000133;   KEGG:C00387;   KNApSAcK:C00019679
 xref_mesh: MESH:D006151
 xref: MetaCyc:GUANOSINE;   PDBeChem:GMP;   PMID:11434576;   PMID:15471343;   PMID:15920424;   PMID:17060520;   PMID:17202332;   PMID:18191898;   PMID:18549801;   PMID:21435378;   PMID:21500353;   PMID:21515778;   PMID:21671255;   PMID:21774919;   PMID:2559771;   Reaxys:625911;   Wikipedia:Guanosine;   YMDB:YMDB00509

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guanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP Guanosine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:25174304 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E affects binding
multiple interactions 		ISO Guanosine analog binds to EIF4E protein
Guanosine analog inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; Guanosine analog inhibits the reaction [RNA Caps binds to EIF4E protein] 		CTD PMID:27592390 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Glul glutamate-ammonia ligase multiple interactions ISO [Guanosine co-treated with Ketamine] results in increased activity of GLUL protein CTD PMID:36878458 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression EXP Guanosine results in decreased expression of IMPDH2 mRNA CTD PMID:11145582 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:179,916,255...179,949,613 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Guanosine results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:18456249 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Guanosine results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:18456249 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC] CTD PMID:9381980 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions ISO [Guanosine co-treated with Ketamine] results in increased expression of SLC1A2 protein CTD PMID:36878458 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO
EXP 		Guanosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:11085929 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Guanosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:211,756,588...211,764,561
Ensembl chr 1:202,327,354...202,335,171 		JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Guanosine CTD PMID:19164483 NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein] CTD PMID:32941855 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Upp1 uridine phosphorylase 1 increases metabolic processing ISO UPP1 protein results in increased metabolism of Guanosine CTD PMID:15772079 NCBI chr14:88,023,155...88,043,036
Ensembl chr14:83,809,960...83,829,462 		JBrowse link
2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein; Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein] CTD PMID:9297556 PMID:9403342 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO CYP1A1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO Deoxyguanosine analog results in decreased activity of MGMT protein CTD PMID:17880193 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        biochemical role 20261
          metabolite 20243
            fundamental metabolite 14725
              guanosine 20
                2'-deoxyguanosine + 6
                4-demethyl-7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                4-demethylwyosine 0
                7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine 5'-phosphate + 0
                N(2)-(ADP-D-ribosyl)-guanosine(2-) 0
                cytidylyl-(3'->5')-guanosine 0
                guanosine residue 0
                wybutosine 0
                wybutoxosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbohydrates and carbohydrate derivatives 15436
                                    carbohydrate 15436
                                      carbohydrate derivative 14453
                                        glycosyl compound 13161
                                          N-glycosyl compound 5900
                                            nucleoside 5753
                                              ribonucleoside 1160
                                                purine ribonucleoside 828
                                                  purines D-ribonucleoside 427
                                                    guanosine 20
                                                      2'-deoxyguanosine + 6
                                                      4-demethyl-7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      4-demethylwyosine 0
                                                      7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      7-(3-amino-3-carboxypropyl)wyosine 5'-monophosphate + 0
                                                      7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine 5'-phosphate + 0
                                                      N(2)-(ADP-D-ribosyl)-guanosine(2-) 0
                                                      cytidylyl-(3'->5')-guanosine 0
                                                      guanosine residue 0
                                                      wybutosine 0
                                                      wybutoxosine 0
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