Gene:	Nfkb1 ( Rattus norvegicus ) nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Description:	gene encodes a 105 kD protein that can be processed to create a 50 kD protein; the larger protein is a Rel protein-specific transcription inhibitor and the smaller protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex
Synonyms:	nuclear factor kappa B p105 subunit; NF-kappaB; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; NF-kB; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105;
ArrayIDs:	5803444; 6677103; 6503915; 1370968_at; 6465679; 5929776; L26267_at; 6740475; 6632870; 6724975; 6039362; A_44_P273061; 6538373; 5906117; 6320468; 6661295; A_44_P494130; 6042673; 5812030; 6486798; 6683751; A_43_P15232; A_43_P22260; 5754788; 6661372; 5854601; 5619706; 5988103; 6222253; 5644871; GE21708; 5671374; rc_AI235662_f_at; 6426937; 6051303;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Eau5 - Experimental allergic uveoretinitis QTL 5
primer pair:	632341
Homologs
Homo sapiens: NFKB1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Nfkb1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Nfkb1 Rat Celera Assembly 2 216226854 - 216317178     RGSC genome assembly v3.4 2 233091018 - 233211297     Cytogenetic 2 q43     genome assembly 3.1 2 233077759 - 233097514 Mus musculus Nfkb1 Mouse genome assembly build 36.1 3 135247619 - 135354511     Cytogenetic 3 3 G3 Homo sapiens NFKB1 human genome assembly 4 103779672 - 103895661     Human genome assembly build 36.2 4 103641518 - 103757507     Cytogenetic 4 q24   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference DNA binding subunit of NFkB1 transcription factor 70295 interacts with FSH-regulated RNAs 634428 Gene Ontology protein dimerization activity,  transcription factor activity,  protein homodimerization activity ...  (details...)
Biological Process	Note Reference may be involved in ductal involution 70295 required for protection from TNF-alpha mediated apoptosis 625669, 628339 may regulate genes that are involved in pathophysiology of inflammation, immune response and atherosclerosis 625669 involved in regulating transcription of cytokines, chemokines, leukocyte adhesion molecules and regulators of cell proliferation and survival 625669 Gene Ontology response to copper ion,  response to oxidative stress,  signal transduction ...  (details...)
Cellular Component	Gene Ontology protein complex,  nucleus,  nucleoplasm ...  (details...)
Disease	Note Reference expression level is related to breast cancer 625513 plays a role in the inhibition of breast cancer cells 70295 Ontology Aortic Aneurysm, Abdominal,  Melanoma,  Cerebral Hemorrhage ...  (details...)
Expression	Note Reference expressed at low levels in mammary glands during early lactation, increases after weaning 70295
Pathway	Ontology nuclear factor kappa B signaling pathway (details...)
Regulation	Note Reference activation negatively correlates with peripartum Amh (Anti - Mullerian hormone (Mullerian inhibiting substance)) type II receptor levels 70295 activity is downregulated by NOS inhibitor causing inhibition of apoptosis induced by helicobacter pylori in gastric parietal cells 625604, 625669 inhibition of glycogen synthase kinase-3 (GSK-3) downregulates transcription induced by TNF-alpha 625669, 628339 in hippocampal region is activated by oxidative stress caused by streptozotocin-induced diabetes; 625669
Drugs	Note Reference strongly inhibited by resveratrol (trans-3,4,5-trihydroxystilbene), a polyphenolic phytoalexin, which suppresses DMBA (7,12-Dimethylbenz(a)anthracene)-induced mammary carcinogenesis 625513 resveratrol (trans-3,4,5-trihydroxystilbene)a polyphenolic phytoalexin a potent inhibitor, was able to down regulate expression in DMBA (7,12-dimethylbenzaanthracene) induced rat mammary carcinogenesis and ductal carcinoma, it has a chemopreventive action 625669 dehydroepiandrosterone (DHEA), a steroid produced by brain, affects the activation and subsequent nuclear translocation of Nfkb1 by oxidative stress 625669
Other	Note Reference NFkB family consists of DNA binding subunit and transcriptional activators, including p65, p50, p52, and c-Rel, that share a Rel homology domain 70295
External Links
Databases	DATABASE ID SOURCE SMART: IPT IPI SMART: DEATH IPI SMART: ANK IPI PROSITE: REL_2 IPI PROSITE: REL_1 IPI PROSITE: ANK_REPEAT IPI PROSITE: ANK_REP_REGION IPI UNIPARC: UPI00005028D6 IPI UNIPARC: UPI00002519FD IPI UNIPARC: UPI0001B7BC98 IPI KEGG Report: rno:81736 ENTREZGENE HomoloGene Group ID: 2971 ENTREZGENE Germonline: 70498 Pfam: TIG IPI Pfam: Ank IPI Pfam: Death IPI Pfam: RHD IPI KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05222 ENTREZGENE InterPro: NF_Rel_dor. IPI InterPro: p53-like_TF_DNA-bd. IPI InterPro: RHD. IPI InterPro: IPT_TIG_rcpt. IPI InterPro: Ig_E-set. IPI InterPro: Ig-like_fold. IPI InterPro: DEATH-like. IPI InterPro: Death. IPI InterPro: Ankyrin_rpt-contain_dom. IPI InterPro: Ankyrin_rpt. IPI IPI: IPI00373434 IPI IPI: IPI00948798 IPI IPI: IPI00561207 IPI Ensembl Protein: ENSRNOP00000059907 IPI Ensembl Protein: ENSRNOP00000039305 IPI Ensembl Protein: ENSRNOP00000028944 IPI Gene3D-CATH: RHD IPI Gene3D-CATH: DEATH_like IPI Gene3D-CATH: ANK IPI Gene3D-CATH: Ig-like_fold IPI Entrez Gene: Nfkb1 ENTREZGENE UniProt: NFKB1_RAT IPI Ensembl Genes: ENSRNOG00000023258 IPI Superfamily-SCOP: DEATH_like IPI Superfamily-SCOP: Ig_E-set IPI Superfamily-SCOP: P53_like_DNA_bnd IPI Superfamily-SCOP: ANK IPI PRINTS: NFKBTNSCPFCT. IPI
Sequences	Nucleotide: XM_001075876 Get FASTA Search GEO Profiles Nucleotide: CH473952 Get FASTA Search GEO Profiles Nucleotide: L26267 Get FASTA Search GEO Profiles Nucleotide: XM_342346 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: EDL82272 Get FASTA Protein: EDL82271 Get FASTA Protein: XP_001075876 Get FASTA Protein: Q63369 Get FASTA Protein: EDL82273 Get FASTA Protein: EDL82274 Get FASTA Protein: AAA20684 Get FASTA Protein: XP_342347 Get FASTA (View all 8 Protein Accessions)
Clusters	UniGene: 2411
References
Curated References	26 references in RGD related to Nfkb1
Other References	163 other references at PubMed related to Nfkb1
Database Information
RGD ID	70498
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 24-SEP-08: Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 31-MAR-08: Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 Nfkb1 nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 14-DEC-04: Nfkb1 nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 nuclear factor kappa B p105 subunit APPROVED Name updated 1299863 10-JUN-02: Nfkb1 nuclear factor kappa B p105 subunit PROVISIONAL Symbol and Name status set to provisional 70585