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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [Palmitic Acid results in increased expression of NFKB1 mRNA]PMID:30259999
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTDpyrazolanthrone affects the reaction [sodium arsenite affects the expression of NFKB1 protein]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]PMID:18507870 PMID:29528074
Nfkb1multiple interactionsISONfkb1 (Mus musculus)6480464CTDpyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Bee Venoms inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased localization of NFKB1 protein]]; pyrazolanthrone inhibits the reaction [sodium chromate(VI) results in increased phosphorylation of NFKB1 protein]PMID:18507870 PMID:22547200
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