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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1increases activityEXP 6480464CTDIsoproterenol results in increased activity of NFKB1 proteinPMID:18487443
Nfkb1increases expressionEXP 6480464CTDIsoproterenol results in increased expression of NFKB1 mRNAPMID:35014750
Nfkb1multiple interactionsEXP 6480464CTD[Isoproterenol co-treated with POSTN protein] results in decreased expression of NFKB1 mRNAPMID:30303030
Nfkb1multiple interactionsISONfkb1 (Mus musculus)6480464CTDIsoproterenol results in increased activity of [NFKB1 protein binds to RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Isoproterenol results in increased activity of [NFKB1 protein binds to RELA protein]]PMID:15178407
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