GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkb1 | decreases expression | EXP | | 6480464 | CTD | Simvastatin results in decreased expression of NFKB1 mRNA | PMID:21465237 | Nfkb1 | decreases activity | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Simvastatin results in decreased activity of NFKB1 protein | PMID:17038636 | Nfkb1 | decreases localization | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Simvastatin results in decreased localization of NFKB1 protein | PMID:12753293 | Nfkb1 | increases localization | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | Simvastatin results in increased localization of NFKB1 protein | PMID:18463201 | Nfkb1 | multiple interactions | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | artemisinin inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; artemisinin inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; parthenolide inhibits the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; parthenolide inhibits the reaction [Simvastatin results in increased localization of NFKB1 protein]; RHOA protein affects the reaction [Simvastatin results in increased localization of and results in increased activity of NFKB1 protein]; Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of and results in increased activity of NFKB1 protein]; Simvastatin promotes the reaction [Doxorubicin results in increased localization of NFKB1 protein]; Simvastatin results in increased localization of and results in increased activity of NFKB1 protein | PMID:17277159 PMID:18463201 | Nfkb1 | multiple interactions | ISO | Nfkb1 (Mus musculus) | 6480464 | CTD | Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]; zinc protoporphyrin inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides affects the localization of [RELA protein binds to NFKB1 protein]]] | PMID:21925249 | | ||||||||||||||||||||||
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