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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:101278
Term: diltiazem
Definition: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension.
Chemical ID: MESH:D004110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1affects localizationISONFKB1 (Homo sapiens)6480464CTDDiltiazem affects the localization of NFKB1 proteinPMID:15652234
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[Diltiazem co-treated with Lipopolysaccharides] affects the localization of NFKB1 protein; Diltiazem inhibits the reaction [[NFKB1 protein binds to RELA protein] which binds to IL12A promoter]; Diltiazem inhibits the reaction [[NFKB1 protein binds to RELA protein] which binds to IL12B promoter]; Diltiazem results in decreased activity of [NFKB1 protein binds to RELA protein]PMID:15652234
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