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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1multiple interactionsEXP 6480464CTD[Resveratrol co-treated with Niacinamide] inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of NFKB1 mRNA]; Resveratrol inhibits the reaction [[Aflatoxin B1 co-treated with Ethanol] results in increased expression of NFKB1 mRNA]PMID:32894639
Nfkb1affects localizationISONFKB1 (Homo sapiens)6480464CTDresveratrol affects the localization of NFKB1 proteinPMID:12716675 PMID:15588712
Nfkb1decreases activityISONFKB1 (Homo sapiens)6480464CTDresveratrol results in decreased activity of NFKB1 proteinPMID:18222423
Nfkb1decreases expressionISONfkb1 (Mus musculus)6480464CTDresveratrol analog results in decreased expression of NFKB1 proteinPMID:15652768
Nfkb1decreases phosphorylationISONFKB1 (Homo sapiens)6480464CTDresveratrol results in decreased phosphorylation of NFKB1 proteinPMID:25692777 PMID:26310874
Nfkb1increases expressionISONFKB1 (Homo sapiens)6480464CTDresveratrol results in increased expression of NFKB1 mRNAPMID:26969377
Nfkb1increases phosphorylationISONFKB1 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of NFKB1 proteinPMID:12716675
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD3-(4-methylphenylsulfonyl)-2-propenenitrile promotes the reaction [Resveratrol results in decreased activity of NFKB1 protein]; [Doxorubicin co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA; [Plant Extracts co-treated with Resveratrol] results in increased expression of NFKB1 mRNA; [Resveratrol co-treated with Bortezomib] results in decreased activity of [RELA protein binds to NFKB1 protein]; [Resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]; [Resveratrol co-treated with TNF protein] results in increased phosphorylation of NFKB1 protein; [xanthohumol co-treated with Resveratrol] results in decreased expression of NFKB1 mRNA; Resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of NFKB1 protein]; Resveratrol inhibits the reaction [ALB protein modified form results in increased activity of NFKB1 protein]; Resveratrol inhibits the reaction [Fluorouracil results in increased phosphorylation of NFKB1 protein]; Resveratrol inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Resveratrol inhibits the reaction [Oxygen deficiency affects the localization of NFKB1 protein]; Resveratrol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Resveratrol inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Resveratrol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Resveratrol inhibits the reaction [TNFSF10 protein results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; Resveratrol inhibits the reaction [TNFSF10 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NFKB1 protein]; Resveratrol results in decreased activity of [RELA protein binds to NFKB1 protein]PMID:10843709 PMID:12208745 PMID:12689943 PMID:12716675 PMID:15489888 PMID:16614140 PMID:17164350 PMID:18222423 PMID:23452621 PMID:23557933 PMID:23936610 PMID:24035785 PMID:24895526 PMID:26310874 PMID:26969377 PMID:32070777
Nfkb1multiple interactionsISONfkb1 (Mus musculus)6480464CTDResveratrol inhibits the reaction [Cadmium Chloride results in increased expression of NFKB1 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of and results in increased localization of NFKB1 protein]; Resveratrol inhibits the reaction [Sodium Glutamate results in increased expression of NFKB1 mRNA]PMID:10188978 PMID:27279585 PMID:28708105
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