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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Quercetin inhibits the reaction [Atrazine results in increased expression of NFKB1 mRNA]; Quercetin inhibits the reaction [cypermethrin results in increased expression of NFKB1 mRNA]; Quercetin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]PMID:18090225 PMID:22372587 PMID:23070809 PMID:35337893 PMID:35876585
Nfkb1affects localizationISONFKB1 (Homo sapiens)6480464CTDQuercetin affects the localization of NFKB1 proteinPMID:23727915
Nfkb1decreases acetylationISONFKB1 (Homo sapiens)6480464CTDQuercetin results in decreased acetylation of NFKB1 proteinPMID:21857970
Nfkb1decreases expressionISONFKB1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of NFKB1 mRNAPMID:23727915
Nfkb1decreases phosphorylationISONFKB1 (Homo sapiens)6480464CTDQuercetin results in decreased phosphorylation of NFKB1 proteinPMID:35688186
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[bisphenol A co-treated with Quercetin metabolite] results in decreased expression of NFKB1 mRNA; [pterostilbene co-treated with Quercetin] results in decreased activity of [NFKB1 protein binds to RELA protein]; Quercetin inhibits the reaction [NFKB1 protein binds to PTGS2 promoter]PMID:18852136 PMID:21857970 PMID:36982678
Nfkb1multiple interactionsISONfkb1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein co-treated with NFKB1 protein]]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]PMID:10086329 PMID:16171798
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