GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfkb1 | multiple interactions | ISO | NFKB1 (Homo sapiens) | 6480464 | CTD | [arsenite results in increased activity of [NFKB1 protein binds to RELB protein]] which results in increased expression of CXCL8 mRNA; [arsenite results in increased activity of [NFKB1 protein binds to RELB protein]] which results in increased expression of TNFSF13B mRNA; arsenite results in increased activity of [NFKB1 protein binds to RELB protein] | PMID:18418899 | Nfkb1 | multiple interactions | ISO | Nfkb1 (Mus musculus) | 6480464 | CTD | FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]]]; FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite results in decreased degradation of and results in increased expression of MYC protein]]; FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite results in increased cleavage of CASP3 protein]]; MIR190A affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of CASP3 protein]]; MIR190A affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of PARP1 protein]]; MIR190A affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased expression of GADD45A protein]]; MYC protein inhibits the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite results in increased cleavage of CASP3 protein]]; MYC protein promotes the reaction [NFKB1 protein promotes the reaction [arsenite results in increased expression of GADD45A protein]]; NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]]; NFKB1 gene mutant form inhibits the reaction [arsenite results in decreased degradation of and results in increased expression of MYC protein]; NFKB1 gene mutant form inhibits the reaction [arsenite results in increased expression of GADD45A protein]; NFKB1 gene mutant form inhibits the reaction [arsenite results in increased expression of MYC protein]; NFKB1 protein affects the reaction [arsenite results in decreased expression of PHLPP1 protein]; NFKB1 protein affects the reaction [arsenite results in increased cleavage of CASP3 protein]; NFKB1 protein affects the reaction [arsenite results in increased cleavage of PARP1 protein]; NFKB1 protein affects the reaction [arsenite results in increased expression of and results in increased phosphorylation of TRP53 protein]; NFKB1 protein affects the reaction [arsenite results in increased expression of CDKN1A protein]; NFKB1 protein affects the reaction [arsenite results in increased expression of GADD45A protein]; NFKB1 protein affects the reaction [arsenite results in increased expression of MIR190A mRNA]; NFKB1 protein affects the reaction [arsenite results in increased phosphorylation of AKT1 protein]; NFKB1 protein affects the reaction [arsenite results in increased phosphorylation of RPS6 protein]; NFKB1 protein affects the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]; NFKB1 protein promotes the reaction [arsenite results in increased expression of GADD45A protein]; NFKB1 protein promotes the reaction [arsenite results in increased expression of MYC protein]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of CASP3 protein]]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of PARP1 protein]]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased expression of GADD45A protein]]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased expression of TRP53 protein]]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased phosphorylation of AKT1 protein]]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased phosphorylation of RPS6 protein]] | PMID:23396362 PMID:24457827 | | ||||||||||||||||||||||
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