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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:17967
Term: urethane
Definition: A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages.
Chemical ID: MESH:D014520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1decreases expressionISONfkb1 (Mus musculus)6480464CTDUrethane results in decreased expression of NFKB1 mRNA; Urethane results in decreased expression of NFKB1 proteinPMID:22797328
Nfkb1increases expressionISONfkb1 (Mus musculus)6480464CTDUrethane results in increased expression of NFKB1 mRNA; Urethane results in increased expression of NFKB1 proteinPMID:22797328
Nfkb1multiple interactionsISONfkb1 (Mus musculus)6480464CTDPhytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in decreased expression of NFKB1 protein]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 mRNA]; Phytic Acid inhibits the reaction [Urethane results in increased expression of NFKB1 protein]PMID:22797328
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