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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:34887
Term: nickel dichloride
Definition: A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.
Chemical ID: MESH:C022838
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1affects expressionEXP 6480464CTDnickel chloride affects the expression of NFKB1 mRNAPMID:22546817
Nfkb1increases expressionISONFKB1 (Homo sapiens)6480464CTDnickel chloride results in increased expression of NFKB1 mRNAPMID:17312168
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[nickel chloride results in increased abundance of Nickel] which results in increased expression of NFKB1 protein; nickel chloride binds to and affects the localization of NFKB1 proteinPMID:23844176 PMID:30724446
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