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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:25195
Term: mercury atom
Definition: A zinc group element atom that has formula Hg.
Chemical ID: MESH:D008628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1multiple interactionsEXP 6480464CTD[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein; Mercury inhibits the reaction [Lipopolysaccharides results in increased activity of [RELA protein binds to NFKB1 protein]]; Mercury inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]PMID:15282405 PMID:37415728
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTDMercury inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased activity of NFKB1 protein]PMID:11437639
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